PE20030226A1 - Compuestos arilicos sustituidos con quinuclidinas para el tratamiento de enfermedades - Google Patents

Compuestos arilicos sustituidos con quinuclidinas para el tratamiento de enfermedades

Info

Publication number
PE20030226A1
PE20030226A1 PE2001000840A PE2001000840A PE20030226A1 PE 20030226 A1 PE20030226 A1 PE 20030226A1 PE 2001000840 A PE2001000840 A PE 2001000840A PE 2001000840 A PE2001000840 A PE 2001000840A PE 20030226 A1 PE20030226 A1 PE 20030226A1
Authority
PE
Peru
Prior art keywords
alkyl
halogenated
substituted
cycloalkyl
oct
Prior art date
Application number
PE2001000840A
Other languages
English (en)
Inventor
Jason K Myers
Jr Vincent E Groppi
David W Piotrowski
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030226A1 publication Critical patent/PE20030226A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS ARILICOS SUSTITUIDOS CON QUINUCLIDINAS DE FORMULA I DONDE X ES O, S; R1 ES H, ALQUILO, CICLOALQUILO, ALQUILO HALOGENADO, ARILO; R2 ES H, ALQUILO, HALOGENADO, ALQUILO SUSTITUIDO, CICLOALQUILO, BENCILO, ARILO; R3 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, HETEROCICLOALQUILO, ALQUILO HALOGENADO, ALQUENILO, HALOGENADO, ENTRE OTROS; R4 ES -O-R5, -S-R5, -S(O)-R5 SUSTITUIDO DON ALQUILO EN EL CARBONO w CON R5, DONDE DICHO w SE DETERMINA CONTANDO LA CADENA MAS LARGA SIENDO C-1 EL CARBONO UNIDO AL ANILLO FENILO DE LA MOLECULA CENTRAL Y w EL MAS ALEJADO; R5 ES ARILO, R7 O R9; R7 ES UN HETEROAROMATICO MONOCICLICO DE 5 MIEMBROS CON 1-3 HETEROATOMOS SELECCIONADO DE O, N, ENTRE OTROS; R9 ES UN GRUPO HETEROAROMATICO MONOCICLICO DE 6 MIEMBROS CON 1-3 HETEROATOMOS. SON COMPUESTOS PREFERIDOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(HIDROXIFENOXI)BENZAMIDA, N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-[4-(ACETAMIDOFENOXI)BENZAMIDA. N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-4-FENOXIBENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS TIENEN MAYOR EFECTO SOBRE LOS RECEPTORES DE LA ACETILCOLINA O7 NICOTINICOS Y SON UTILES PARA EL TRATAMIENTO DE ESQUIZOFRENIA , PSICOSIS
PE2001000840A 2000-08-18 2001-08-21 Compuestos arilicos sustituidos con quinuclidinas para el tratamiento de enfermedades PE20030226A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22616400P 2000-08-18 2000-08-18
US28496601P 2001-04-19 2001-04-19

Publications (1)

Publication Number Publication Date
PE20030226A1 true PE20030226A1 (es) 2003-03-14

Family

ID=26920268

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000840A PE20030226A1 (es) 2000-08-18 2001-08-21 Compuestos arilicos sustituidos con quinuclidinas para el tratamiento de enfermedades

Country Status (6)

Country Link
US (1) US6479510B2 (es)
EP (1) EP1381603A2 (es)
JP (1) JP2004506735A (es)
AU (1) AU2001282874A1 (es)
PE (1) PE20030226A1 (es)
WO (1) WO2002016358A2 (es)

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Also Published As

Publication number Publication date
US20020049225A1 (en) 2002-04-25
AU2001282874A1 (en) 2002-03-04
EP1381603A2 (en) 2004-01-21
JP2004506735A (ja) 2004-03-04
WO2002016358A2 (en) 2002-02-28
US6479510B2 (en) 2002-11-12
WO2002016358A3 (en) 2002-07-18

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