CY1109729T1 - Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer - Google Patents

Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer

Info

Publication number
CY1109729T1
CY1109729T1 CY20101100039T CY101100039T CY1109729T1 CY 1109729 T1 CY1109729 T1 CY 1109729T1 CY 20101100039 T CY20101100039 T CY 20101100039T CY 101100039 T CY101100039 T CY 101100039T CY 1109729 T1 CY1109729 T1 CY 1109729T1
Authority
CY
Cyprus
Prior art keywords
alzheimer
trefinyl
products
disease treatment
compounds
Prior art date
Application number
CY20101100039T
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernadez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Formal Adeline Le
Andrew Cansfield
Svenja Burckhardt
Jess Taylor
Original Assignee
Cellzome Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109729(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Limited filed Critical Cellzome Limited
Publication of CY1109729T1 publication Critical patent/CY1109729T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Abstract

Η παρούσα εφεύρεση αφορά ενώσεις που έχουν το γενικό τύπο (I) με τους ορισμούς των Χ, Υ, R1, R2, R3, R4, R9, R10 να δίνονται παρακάτω και διαλυτώματα, υδρίτες, εστέρες και φαρμακευτικώς αποδεκτά άλατα αυτών. Επιπλέον η εφεύρεση αφορά τη χρήση των εν λόγω ενώσεων για τη θεραπεία της νόσου του Alzheimer και χρήση τους για την ρύθμιση της δραστικότητας της γ-εκκριματάσης.
CY20101100039T 2006-04-21 2010-01-14 Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer CY1109729T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number Publication Date
CY1109729T1 true CY1109729T1 (el) 2014-09-10

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100039T CY1109729T1 (el) 2006-04-21 2010-01-14 Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer

Country Status (35)

Country Link
US (1) US8106236B2 (el)
EP (2) EP1847524B1 (el)
JP (1) JP5422827B2 (el)
KR (1) KR101494906B1 (el)
CN (1) CN101484410B (el)
AR (1) AR060621A1 (el)
AT (1) ATE445586T1 (el)
AU (1) AU2007240382B2 (el)
BR (1) BRPI0710632A2 (el)
CA (1) CA2649845C (el)
CR (2) CR10376A (el)
CY (1) CY1109729T1 (el)
DE (1) DE602006009764D1 (el)
DK (1) DK1847524T3 (el)
EA (1) EA016908B1 (el)
ES (2) ES2333539T3 (el)
GE (1) GEP20115211B (el)
HK (1) HK1134923A1 (el)
IL (2) IL194853A0 (el)
MA (1) MA30420B1 (el)
MX (1) MX2008013447A (el)
MY (1) MY148988A (el)
NO (1) NO20084516L (el)
NZ (1) NZ572999A (el)
PE (1) PE20080267A1 (el)
PL (1) PL1847524T3 (el)
PT (1) PT1847524E (el)
SI (1) SI1847524T1 (el)
SM (1) SMP200800062B (el)
TN (1) TNSN08414A1 (el)
TW (1) TWI435720B (el)
UA (1) UA95766C2 (el)
UY (1) UY30300A1 (el)
WO (1) WO2007124351A1 (el)
ZA (1) ZA200809857B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1847524T3 (da) 2006-04-21 2010-01-11 Cellzome Ltd Terphenylderivater til behandling af Alzheimers sygdom
US8252935B2 (en) 2007-10-19 2012-08-28 Janssen Pharmaceutica N.V. Piperidinyl and piperazinyl modulators of γ-secretase
WO2009052341A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Gsm intermediates
AU2008312371B2 (en) 2007-10-19 2013-06-20 Janssen Pharmaceutica, N.V. Amine linked modulators of gamma-secretase
WO2009052334A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2707492A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
JP2011513460A (ja) * 2008-03-11 2011-04-28 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体のモジュレーターとして有用な新規のトリアリール誘導体
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
WO2012116452A1 (en) * 2011-03-03 2012-09-07 Denovamed Inc. Antimicrobial/adjuvant compounds and methods
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
WO2022114105A1 (ja) * 2020-11-27 2022-06-02 ミライラボバイオサイエンス株式会社 高純度βニコチンアミドモノヌクレオチド（ＮＭＮ）及びその製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
EP1178963A1 (en) 1999-05-12 2002-02-13 Neurosearch A/S Ion channel modulating agents
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
JP2003531194A (ja) * 2000-04-24 2003-10-21 メルク フロスト カナダ アンド カンパニー プロスタグランジンｅ阻害薬としてフェニルおよびビアリール誘導体を用いる治療方法および該方法に有用な化合物
DE60239730D1 (de) * 2001-02-20 2011-05-26 Isis Innovation Metall enthaltende dendrimere
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
EP1569954A1 (en) * 2002-12-05 2005-09-07 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
CN100441185C (zh) * 2003-04-30 2008-12-10 麦克弗罗斯特加拿大有限公司 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
CA2618340C (en) * 2005-08-15 2013-11-19 F.Hoffmann-La Roche Ag Piperidine and piperazine derivatives as p2x3 antagonists
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
DK1847524T3 (da) 2006-04-21 2010-01-11 Cellzome Ltd Terphenylderivater til behandling af Alzheimers sygdom

Also Published As

Publication number Publication date
EP2016039A1 (en) 2009-01-21
AU2007240382B2 (en) 2013-05-02
JP5422827B2 (ja) 2014-02-19
TWI435720B (zh) 2014-05-01
CA2649845C (en) 2014-09-16
ES2392352T3 (es) 2012-12-10
IL194853A0 (en) 2009-08-03
TW200810746A (en) 2008-03-01
PE20080267A1 (es) 2008-05-16
DE602006009764D1 (de) 2009-11-26
WO2007124351A1 (en) 2007-11-01
US20070254957A1 (en) 2007-11-01
JP2009538275A (ja) 2009-11-05
UY30300A1 (es) 2007-08-31
MX2008013447A (es) 2009-03-10
EP1847524B1 (en) 2009-10-14
AU2007240382A1 (en) 2007-11-01
GEP20115211B (en) 2011-04-26
BRPI0710632A2 (pt) 2011-08-23
EP1847524A1 (en) 2007-10-24
CR10376A (es) 2009-02-26
IL194789A0 (en) 2009-08-03
SI1847524T1 (sl) 2010-01-29
NO20084516L (no) 2009-01-13
MY148988A (en) 2013-06-28
ZA200809857B (en) 2009-08-26
DK1847524T3 (da) 2010-01-11
MA30420B1 (fr) 2009-05-04
PT1847524E (pt) 2009-12-18
SMAP200800062A (it) 2008-11-19
US8106236B2 (en) 2012-01-31
CN101484410A (zh) 2009-07-15
HK1134923A1 (en) 2010-05-20
EA016908B1 (ru) 2012-08-30
TNSN08414A1 (en) 2010-04-14
UA95766C2 (ru) 2011-08-25
EA200802173A1 (ru) 2009-06-30
SMP200800062B (it) 2009-07-14
EP2016039B1 (en) 2012-08-01
CR10452A (es) 2009-02-23
ATE445586T1 (de) 2009-10-15
CN101484410B (zh) 2013-08-21
KR101494906B1 (ko) 2015-02-24
CA2649845A1 (en) 2007-11-01
KR20090024678A (ko) 2009-03-09
NZ572999A (en) 2012-06-29
AR060621A1 (es) 2008-07-02
ES2333539T3 (es) 2010-02-23
PL1847524T3 (pl) 2010-03-31

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