DE602006009764D1 - Terphenylderivate zur Alzheimerbehandlung - Google Patents

Terphenylderivate zur Alzheimerbehandlung

Info

Publication number
DE602006009764D1
DE602006009764D1 DE602006009764T DE602006009764T DE602006009764D1 DE 602006009764 D1 DE602006009764 D1 DE 602006009764D1 DE 602006009764 T DE602006009764 T DE 602006009764T DE 602006009764 T DE602006009764 T DE 602006009764T DE 602006009764 D1 DE602006009764 D1 DE 602006009764D1
Authority
DE
Germany
Prior art keywords
terphenylderivate
alzheimer
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006009764T
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernadez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Formal Adeline Le
Andrew Cansfield
Svenja Burckhardt
Jess Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellzome Ltd
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006009764(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Publication of DE602006009764D1 publication Critical patent/DE602006009764D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
DE602006009764T 2006-04-21 2006-04-21 Terphenylderivate zur Alzheimerbehandlung Active DE602006009764D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (de) 2006-04-21 2006-04-21 Terphenylderivate zur Alzheimerbehandlung

Publications (1)

Publication Number Publication Date
DE602006009764D1 true DE602006009764D1 (de) 2009-11-26

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006009764T Active DE602006009764D1 (de) 2006-04-21 2006-04-21 Terphenylderivate zur Alzheimerbehandlung

Country Status (35)

Country Link
US (1) US8106236B2 (de)
EP (2) EP1847524B1 (de)
JP (1) JP5422827B2 (de)
KR (1) KR101494906B1 (de)
CN (1) CN101484410B (de)
AR (1) AR060621A1 (de)
AT (1) ATE445586T1 (de)
AU (1) AU2007240382B2 (de)
BR (1) BRPI0710632A2 (de)
CA (1) CA2649845C (de)
CR (2) CR10376A (de)
CY (1) CY1109729T1 (de)
DE (1) DE602006009764D1 (de)
DK (1) DK1847524T3 (de)
EA (1) EA016908B1 (de)
ES (2) ES2333539T3 (de)
GE (1) GEP20115211B (de)
HK (1) HK1134923A1 (de)
IL (2) IL194853A0 (de)
MA (1) MA30420B1 (de)
MX (1) MX2008013447A (de)
MY (1) MY148988A (de)
NO (1) NO20084516L (de)
NZ (1) NZ572999A (de)
PE (1) PE20080267A1 (de)
PL (1) PL1847524T3 (de)
PT (1) PT1847524E (de)
SI (1) SI1847524T1 (de)
SM (1) SMP200800062B (de)
TN (1) TNSN08414A1 (de)
TW (1) TWI435720B (de)
UA (1) UA95766C2 (de)
UY (1) UY30300A1 (de)
WO (1) WO2007124351A1 (de)
ZA (1) ZA200809857B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.
EP2212287B1 (de) 2007-10-19 2012-02-01 Janssen Pharmaceutica, N.V. Piperidinyl- und piperazinylmodulatoren von g-sekretase
KR101618068B1 (ko) 2007-10-19 2016-05-04 얀센 파마슈티카 엔.브이. γ-세크레타아제의 탄소 결합된 조절제
EA201070497A1 (ru) * 2007-10-19 2010-12-30 Янссен Фармацевтика, Н.В. Промежуточные продукты мгс
CN101903335A (zh) 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
WO2009075874A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
MX2010009755A (es) * 2008-03-11 2010-09-30 Neurosearch As Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
CN103619836A (zh) * 2011-03-03 2014-03-05 德诺瓦姆德有限公司 抗菌剂/抗菌佐剂化合物及其方法
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof
KR20230113770A9 (ko) * 2020-11-27 2024-03-25 미라이랩 바이오사이언스 인코퍼레이티드 고순도 β 니코틴아미드 모노뉴클레오티드(NMN) 및 그 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
AU4537400A (en) 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents
CA2406383A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research A.beta.42 lowering agents
EP1278734A2 (de) * 2000-04-24 2003-01-29 Merck Frosst Canada & Co. Behandlungsverfahren unter verwendung von phenyl- und biarylderivaten als prostaglandin-e- inhibitoren und dafür nützliche verbindungen
CA2438745C (en) * 2001-02-20 2010-11-30 Isis Innovation Limited Metal-containing dendrimers
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
CA2506114A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
CN100441185C (zh) * 2003-04-30 2008-12-10 麦克弗罗斯特加拿大有限公司 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂
WO2005110963A1 (en) 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
WO2007020194A1 (en) * 2005-08-15 2007-02-22 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as p2x3 antagonists
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.

Also Published As

Publication number Publication date
DK1847524T3 (da) 2010-01-11
JP2009538275A (ja) 2009-11-05
BRPI0710632A2 (pt) 2011-08-23
HK1134923A1 (en) 2010-05-20
US20070254957A1 (en) 2007-11-01
PT1847524E (pt) 2009-12-18
AR060621A1 (es) 2008-07-02
CR10452A (es) 2009-02-23
EP1847524B1 (de) 2009-10-14
PL1847524T3 (pl) 2010-03-31
SMAP200800062A (it) 2008-11-19
TW200810746A (en) 2008-03-01
SMP200800062B (it) 2009-07-14
EA200802173A1 (ru) 2009-06-30
MX2008013447A (es) 2009-03-10
JP5422827B2 (ja) 2014-02-19
MY148988A (en) 2013-06-28
NZ572999A (en) 2012-06-29
EP1847524A1 (de) 2007-10-24
KR101494906B1 (ko) 2015-02-24
CN101484410A (zh) 2009-07-15
AU2007240382B2 (en) 2013-05-02
KR20090024678A (ko) 2009-03-09
PE20080267A1 (es) 2008-05-16
EP2016039A1 (de) 2009-01-21
CA2649845C (en) 2014-09-16
TNSN08414A1 (en) 2010-04-14
CR10376A (es) 2009-02-26
TWI435720B (zh) 2014-05-01
CY1109729T1 (el) 2014-09-10
ES2333539T3 (es) 2010-02-23
WO2007124351A1 (en) 2007-11-01
EA016908B1 (ru) 2012-08-30
MA30420B1 (fr) 2009-05-04
ATE445586T1 (de) 2009-10-15
CN101484410B (zh) 2013-08-21
US8106236B2 (en) 2012-01-31
AU2007240382A1 (en) 2007-11-01
GEP20115211B (en) 2011-04-26
EP2016039B1 (de) 2012-08-01
UA95766C2 (ru) 2011-08-25
CA2649845A1 (en) 2007-11-01
SI1847524T1 (sl) 2010-01-29
UY30300A1 (es) 2007-08-31
IL194853A0 (en) 2009-08-03
ES2392352T3 (es) 2012-12-10
NO20084516L (no) 2009-01-13
ZA200809857B (en) 2009-08-26
IL194789A0 (en) 2009-08-03

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Legal Events

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