ATE445586T1 - Terphenylderivate zur alzheimerbehandlung - Google Patents

Terphenylderivate zur alzheimerbehandlung

Info

Publication number
ATE445586T1
ATE445586T1 AT06112934T AT06112934T ATE445586T1 AT E445586 T1 ATE445586 T1 AT E445586T1 AT 06112934 T AT06112934 T AT 06112934T AT 06112934 T AT06112934 T AT 06112934T AT E445586 T1 ATE445586 T1 AT E445586T1
Authority
AT
Austria
Prior art keywords
terphenyl derivatives
alzheimer treatment
alzheimer
treatment
terphenyl
Prior art date
Application number
AT06112934T
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard Harrison
Mihiro Sunose
Remedios Hernadez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Formal Adeline Le
Andrew Cansfield
Svenja Burckhardt
Jess Taylor
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE445586(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Application granted granted Critical
Publication of ATE445586T1 publication Critical patent/ATE445586T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06112934T 2006-04-21 2006-04-21 Terphenylderivate zur alzheimerbehandlung ATE445586T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (de) 2006-04-21 2006-04-21 Terphenylderivate zur Alzheimerbehandlung

Publications (1)

Publication Number Publication Date
ATE445586T1 true ATE445586T1 (de) 2009-10-15

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06112934T ATE445586T1 (de) 2006-04-21 2006-04-21 Terphenylderivate zur alzheimerbehandlung

Country Status (34)

Country Link
US (1) US8106236B2 (de)
EP (2) EP1847524B1 (de)
JP (1) JP5422827B2 (de)
KR (1) KR101494906B1 (de)
CN (1) CN101484410B (de)
AR (1) AR060621A1 (de)
AT (1) ATE445586T1 (de)
AU (1) AU2007240382B2 (de)
BR (1) BRPI0710632A2 (de)
CA (1) CA2649845C (de)
CR (2) CR10376A (de)
CY (1) CY1109729T1 (de)
DE (1) DE602006009764D1 (de)
DK (1) DK1847524T3 (de)
EA (1) EA016908B1 (de)
ES (2) ES2333539T3 (de)
GE (1) GEP20115211B (de)
IL (2) IL194789A0 (de)
MA (1) MA30420B1 (de)
MX (1) MX2008013447A (de)
MY (1) MY148988A (de)
NO (1) NO20084516L (de)
NZ (1) NZ572999A (de)
PE (1) PE20080267A1 (de)
PL (1) PL1847524T3 (de)
PT (1) PT1847524E (de)
SI (1) SI1847524T1 (de)
SM (1) SMP200800062B (de)
TN (1) TNSN08414A1 (de)
TW (1) TWI435720B (de)
UA (1) UA95766C2 (de)
UY (1) UY30300A1 (de)
WO (1) WO2007124351A1 (de)
ZA (1) ZA200809857B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Ｇｓｍ 중간체
EA017119B1 (ru) 2007-10-19 2012-09-28 Янссен Фармацевтика, Н.В. МОДУЛЯТОРЫ АКТИВНОСТИ γ-СЕКРЕТАЗЫ ИЗ ГРУППЫ ПИПЕРИДИНИЛА И ПИПЕРАЗИНИЛА
MX2010004310A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de gamma-secretasa con enlaces de carbono.
EA018862B1 (ru) 2007-10-19 2013-11-29 Янссен Фармацевтика, Н.В. МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
AU2008335709A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
KR20100135711A (ko) 2007-12-20 2010-12-27 엔비보 파마슈티칼즈, 인코퍼레이티드 사중치환된 벤젠
AU2009224738A1 (en) * 2008-03-11 2009-09-17 Neurosearch A/S Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
EP2681208B1 (de) * 2011-03-03 2016-05-18 Denovamed Inc. Antimikrobielle hilfsstoffverbindungen
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
CN114340633A (zh) * 2019-05-15 2022-04-12 凯莫森特里克斯股份有限公司 用于治疗pd-l1疾病的三芳基化合物
WO2022114105A1 (ja) * 2020-11-27 2022-06-02 ミライラボバイオサイエンス株式会社 高純度βニコチンアミドモノヌクレオチド（ＮＭＮ）及びその製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
AU4537400A (en) 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
EP1278734A2 (de) * 2000-04-24 2003-01-29 Merck Frosst Canada & Co. Behandlungsverfahren unter verwendung von phenyl- und biarylderivaten als prostaglandin-e- inhibitoren und dafür nützliche verbindungen
WO2002066552A1 (en) * 2001-02-20 2002-08-29 Isis Innovation Limited Metal-containing dendrimers
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
CA2506114A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2004096220A1 (en) * 2003-04-30 2004-11-11 Merck Frosst Canada Ltd. 8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en) 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1917262B1 (de) * 2005-08-15 2011-12-14 F. Hoffmann-La Roche AG Piperidin- und piperazinderivate als p2x3-antagonisten
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.

Also Published As

Publication number Publication date
US20070254957A1 (en) 2007-11-01
MA30420B1 (fr) 2009-05-04
EA200802173A1 (ru) 2009-06-30
HK1134923A1 (en) 2010-05-20
TWI435720B (zh) 2014-05-01
AU2007240382B2 (en) 2013-05-02
ES2333539T3 (es) 2010-02-23
BRPI0710632A2 (pt) 2011-08-23
JP2009538275A (ja) 2009-11-05
CR10376A (es) 2009-02-26
IL194853A0 (en) 2009-08-03
UA95766C2 (ru) 2011-08-25
CN101484410B (zh) 2013-08-21
MY148988A (en) 2013-06-28
DK1847524T3 (da) 2010-01-11
NZ572999A (en) 2012-06-29
IL194789A0 (en) 2009-08-03
TNSN08414A1 (en) 2010-04-14
CY1109729T1 (el) 2014-09-10
UY30300A1 (es) 2007-08-31
KR101494906B1 (ko) 2015-02-24
WO2007124351A1 (en) 2007-11-01
TW200810746A (en) 2008-03-01
PT1847524E (pt) 2009-12-18
PE20080267A1 (es) 2008-05-16
AU2007240382A1 (en) 2007-11-01
GEP20115211B (en) 2011-04-26
CA2649845A1 (en) 2007-11-01
EP1847524A1 (de) 2007-10-24
CN101484410A (zh) 2009-07-15
US8106236B2 (en) 2012-01-31
EP2016039A1 (de) 2009-01-21
CA2649845C (en) 2014-09-16
CR10452A (es) 2009-02-23
ZA200809857B (en) 2009-08-26
KR20090024678A (ko) 2009-03-09
MX2008013447A (es) 2009-03-10
JP5422827B2 (ja) 2014-02-19
EP2016039B1 (de) 2012-08-01
SMP200800062B (it) 2009-07-14
EA016908B1 (ru) 2012-08-30
SI1847524T1 (sl) 2010-01-29
SMAP200800062A (it) 2008-11-19
PL1847524T3 (pl) 2010-03-31
DE602006009764D1 (de) 2009-11-26
EP1847524B1 (de) 2009-10-14
ES2392352T3 (es) 2012-12-10
AR060621A1 (es) 2008-07-02
NO20084516L (no) 2009-01-13

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