MA30420B1 - Derives de terphenyle pour le traitment de la maladie d'alzheimer - Google Patents
Derives de terphenyle pour le traitment de la maladie d'alzheimerInfo
- Publication number
- MA30420B1 MA30420B1 MA31394A MA31394A MA30420B1 MA 30420 B1 MA30420 B1 MA 30420B1 MA 31394 A MA31394 A MA 31394A MA 31394 A MA31394 A MA 31394A MA 30420 B1 MA30420 B1 MA 30420B1
- Authority
- MA
- Morocco
- Prior art keywords
- alzheimer
- disease
- treatment
- terphenyl derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
L'INVENTION CONCERNE LES COMPOSÉS DE FORMULE GÉNÉRALE (I), DANS LAQUELLE X, Y, R1, R2, R3, R4, R9, R10 SONT TELS QUE DÉFINIS CI-DESSOUS, AINSI QUE LES SOLVATES, HYDRATES, ESTERS ET SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI. DE PLUS, L'INVENTION CONCERNE L'UTILISATION DESDITS COMPOSÉS DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER AINSI QUE DANS LA MODULATION DE L'ACTIVITÉ DE LA &GGR;-SÉCRÉTASE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06112934A EP1847524B1 (fr) | 2006-04-21 | 2006-04-21 | Derives de terphényle pour le traitement de l' Alzheimer |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30420B1 true MA30420B1 (fr) | 2009-05-04 |
Family
ID=36293499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31394A MA30420B1 (fr) | 2006-04-21 | 2008-11-20 | Derives de terphenyle pour le traitment de la maladie d'alzheimer |
Country Status (35)
Country | Link |
---|---|
US (1) | US8106236B2 (fr) |
EP (2) | EP1847524B1 (fr) |
JP (1) | JP5422827B2 (fr) |
KR (1) | KR101494906B1 (fr) |
CN (1) | CN101484410B (fr) |
AR (1) | AR060621A1 (fr) |
AT (1) | ATE445586T1 (fr) |
AU (1) | AU2007240382B2 (fr) |
BR (1) | BRPI0710632A2 (fr) |
CA (1) | CA2649845C (fr) |
CR (2) | CR10376A (fr) |
CY (1) | CY1109729T1 (fr) |
DE (1) | DE602006009764D1 (fr) |
DK (1) | DK1847524T3 (fr) |
EA (1) | EA016908B1 (fr) |
ES (2) | ES2333539T3 (fr) |
GE (1) | GEP20115211B (fr) |
HK (1) | HK1134923A1 (fr) |
IL (2) | IL194853A0 (fr) |
MA (1) | MA30420B1 (fr) |
MX (1) | MX2008013447A (fr) |
MY (1) | MY148988A (fr) |
NO (1) | NO20084516L (fr) |
NZ (1) | NZ572999A (fr) |
PE (1) | PE20080267A1 (fr) |
PL (1) | PL1847524T3 (fr) |
PT (1) | PT1847524E (fr) |
SI (1) | SI1847524T1 (fr) |
SM (1) | SMP200800062B (fr) |
TN (1) | TNSN08414A1 (fr) |
TW (1) | TWI435720B (fr) |
UA (1) | UA95766C2 (fr) |
UY (1) | UY30300A1 (fr) |
WO (1) | WO2007124351A1 (fr) |
ZA (1) | ZA200809857B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1847524T3 (da) | 2006-04-21 | 2010-01-11 | Cellzome Ltd | Terphenylderivater til behandling af Alzheimers sygdom |
KR101618068B1 (ko) | 2007-10-19 | 2016-05-04 | 얀센 파마슈티카 엔.브이. | γ-세크레타아제의 탄소 결합된 조절제 |
US20090306392A1 (en) * | 2007-10-19 | 2009-12-10 | Chih Yung Ho | Gsm intermediates |
EP2212277B1 (fr) | 2007-10-19 | 2016-08-31 | Janssen Pharmaceutica, N.V. | Modulateurs de la g-secrétase liés à une amine |
EP2212287B1 (fr) | 2007-10-19 | 2012-02-01 | Janssen Pharmaceutica, N.V. | MODULATEUR DE PIPÉRIDINYL ET DE PIPÉRAZINYL DE LA y-SECRÉTASE |
WO2009067493A2 (fr) * | 2007-11-19 | 2009-05-28 | Envivo Pharmaceuticals, Inc. | Benzènes 1,3,5-trisubstitués pour le traitement de la maladie d'alzheimer et d'autres troubles |
CN101896461A (zh) * | 2007-12-13 | 2010-11-24 | 安姆根有限公司 | γ分泌酶调节剂 |
CA2710477A1 (fr) | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Benzenes tetrasubstitues |
BRPI0908837A2 (pt) * | 2008-03-11 | 2015-07-21 | Neurosearch As | Derivado de triarila, composição farmacêutica, uso de um derivado de triarila, e, método para tratar, prevenir ou para o alívio de uma doença, um distúrbio ou uma condição de um corpo de animal vivo |
US7968725B2 (en) * | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
ES2583093T3 (es) * | 2011-03-03 | 2016-09-19 | Denovamed Inc. | Compuestos antimicrobianos/adyuvantes |
CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
WO2015109109A1 (fr) | 2014-01-15 | 2015-07-23 | Forum Pharmaceuticals Inc. | Morpholino-pyrimidines fusionnées et leurs procédés d'utilisation |
US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
CN116528696A (zh) * | 2020-11-27 | 2023-08-01 | 未来实验室生物科学有限公司 | 高纯度β烟酰胺单核苷酸(NMN)及其制造方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08325182A (ja) * | 1995-05-31 | 1996-12-10 | Fuji Yakuhin Kogyo Kk | 置換テルフェニル誘導体とそれらを含有する抗血栓剤 |
FR2767525B1 (fr) * | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
WO2000069823A1 (fr) | 1999-05-12 | 2000-11-23 | Neurosearch A/S | Agents de modulation de canal ionique |
EP1284729A4 (fr) | 2000-04-13 | 2007-12-19 | Mayo Foundation | Agents de reduction de a(beta)42 |
JP2003531194A (ja) * | 2000-04-24 | 2003-10-21 | メルク フロスト カナダ アンド カンパニー | プロスタグランジンe阻害薬としてフェニルおよびビアリール誘導体を用いる治療方法および該方法に有用な化合物 |
CA2438745C (fr) * | 2001-02-20 | 2010-11-30 | Isis Innovation Limited | Dendrimeres contenant du metal |
FR2838439B1 (fr) * | 2002-04-11 | 2005-05-20 | Sanofi Synthelabo | Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant |
EP1569954A1 (fr) * | 2002-12-05 | 2005-09-07 | Axys Pharmaceuticals, Inc. | Derives de cyanomethyle en tant qu'inhibiteurs de la protease a cysteine |
GB0305918D0 (en) | 2003-03-14 | 2003-04-23 | Glaxo Group Ltd | Novel compounds |
CN100441185C (zh) * | 2003-04-30 | 2008-12-10 | 麦克弗罗斯特加拿大有限公司 | 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂 |
WO2005110963A1 (fr) * | 2004-05-19 | 2005-11-24 | Cellzome Ag | Acides (biphenyl-3-yl)-carboxyliques et derives de ceux-ci ainsi que leur utilisation en therapie |
GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
EP1917262B1 (fr) * | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Derives de piperidine et de piperazine en tant qu'antagonistes de p2x3 |
JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
DK1847524T3 (da) | 2006-04-21 | 2010-01-11 | Cellzome Ltd | Terphenylderivater til behandling af Alzheimers sygdom |
-
2006
- 2006-04-21 DK DK06112934T patent/DK1847524T3/da active
- 2006-04-21 EP EP06112934A patent/EP1847524B1/fr not_active Not-in-force
- 2006-04-21 ES ES06112934T patent/ES2333539T3/es active Active
- 2006-04-21 DE DE602006009764T patent/DE602006009764D1/de active Active
- 2006-04-21 AT AT06112934T patent/ATE445586T1/de active
- 2006-04-21 PT PT06112934T patent/PT1847524E/pt unknown
- 2006-04-21 PL PL06112934T patent/PL1847524T3/pl unknown
- 2006-04-21 SI SI200630509T patent/SI1847524T1/sl unknown
-
2007
- 2007-04-19 MX MX2008013447A patent/MX2008013447A/es active IP Right Grant
- 2007-04-19 EP EP07760900A patent/EP2016039B1/fr active Active
- 2007-04-19 KR KR1020087028470A patent/KR101494906B1/ko not_active IP Right Cessation
- 2007-04-19 EA EA200802173A patent/EA016908B1/ru not_active IP Right Cessation
- 2007-04-19 AU AU2007240382A patent/AU2007240382B2/en not_active Ceased
- 2007-04-19 ES ES07760900T patent/ES2392352T3/es active Active
- 2007-04-19 US US11/737,475 patent/US8106236B2/en not_active Expired - Fee Related
- 2007-04-19 CN CN2007800184982A patent/CN101484410B/zh not_active Expired - Fee Related
- 2007-04-19 JP JP2009506772A patent/JP5422827B2/ja not_active Expired - Fee Related
- 2007-04-19 UA UAA200813475A patent/UA95766C2/ru unknown
- 2007-04-19 CA CA2649845A patent/CA2649845C/fr not_active Expired - Fee Related
- 2007-04-19 BR BRPI0710632-7A patent/BRPI0710632A2/pt not_active IP Right Cessation
- 2007-04-19 GE GEAP200710984A patent/GEP20115211B/en unknown
- 2007-04-19 WO PCT/US2007/066951 patent/WO2007124351A1/fr active Application Filing
- 2007-04-19 MY MYPI20084202A patent/MY148988A/en unknown
- 2007-04-19 NZ NZ572999A patent/NZ572999A/en not_active IP Right Cessation
- 2007-04-19 SM SM200800062T patent/SMP200800062B/it unknown
- 2007-04-20 AR ARP070101724A patent/AR060621A1/es not_active Application Discontinuation
- 2007-04-20 TW TW096114164A patent/TWI435720B/zh not_active IP Right Cessation
- 2007-04-20 UY UY30300A patent/UY30300A1/es unknown
- 2007-04-20 PE PE2007000497A patent/PE20080267A1/es not_active Application Discontinuation
-
2008
- 2008-10-17 TN TNP2008000414A patent/TNSN08414A1/en unknown
- 2008-10-17 CR CR10376A patent/CR10376A/es not_active Application Discontinuation
- 2008-10-22 IL IL194853A patent/IL194853A0/en unknown
- 2008-10-22 IL IL194789A patent/IL194789A0/en not_active IP Right Cessation
- 2008-10-27 NO NO20084516A patent/NO20084516L/no not_active Application Discontinuation
- 2008-11-19 ZA ZA200809857A patent/ZA200809857B/xx unknown
- 2008-11-20 MA MA31394A patent/MA30420B1/fr unknown
- 2008-11-21 CR CR10452A patent/CR10452A/es unknown
-
2009
- 2009-12-23 HK HK09112111.0A patent/HK1134923A1/xx not_active IP Right Cessation
-
2010
- 2010-01-14 CY CY20101100039T patent/CY1109729T1/el unknown
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