CO6270313A2 - Acidos carboxilicos bifenil y derivados de los mismos - Google Patents

Acidos carboxilicos bifenil y derivados de los mismos

Info

Publication number
CO6270313A2
CO6270313A2 CO10055388A CO10055388A CO6270313A2 CO 6270313 A2 CO6270313 A2 CO 6270313A2 CO 10055388 A CO10055388 A CO 10055388A CO 10055388 A CO10055388 A CO 10055388A CO 6270313 A2 CO6270313 A2 CO 6270313A2
Authority
CO
Colombia
Prior art keywords
bifenil
derivatives
same
carboxilic acids
carboxilic
Prior art date
Application number
CO10055388A
Other languages
English (en)
Inventor
Chih Yung Ho
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CO6270313A2 publication Critical patent/CO6270313A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invencion se refiere a compuestos que tienen la Formula general (I) con las definiciones de R1, R2, R3, y R4 dadas a continuacion, y/o una sal o éster de éstos. Ademas, la invencion se refiere al uso de compuestos para el tratamiento de la enfermedad de Alzheimer y su uso para la modulacion de la actividad de la γ-secretasa.
CO10055388A 2007-10-17 2010-05-10 Acidos carboxilicos bifenil y derivados de los mismos CO6270313A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98058707P 2007-10-17 2007-10-17

Publications (1)

Publication Number Publication Date
CO6270313A2 true CO6270313A2 (es) 2011-04-20

Family

ID=40345060

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10055388A CO6270313A2 (es) 2007-10-17 2010-05-10 Acidos carboxilicos bifenil y derivados de los mismos

Country Status (18)

Country Link
US (1) US7897643B2 (es)
EP (1) EP2215044B8 (es)
JP (1) JP5404634B2 (es)
KR (1) KR101579744B1 (es)
CN (1) CN101861297B (es)
AU (1) AU2008312771B2 (es)
BR (1) BRPI0817424A2 (es)
CA (1) CA2702832A1 (es)
CO (1) CO6270313A2 (es)
CR (1) CR11432A (es)
DK (1) DK2215044T3 (es)
EA (1) EA017616B1 (es)
ES (1) ES2395083T3 (es)
IL (1) IL205047A (es)
MX (1) MX2010004261A (es)
NI (1) NI201000058A (es)
WO (1) WO2009051948A1 (es)
ZA (1) ZA201003432B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008312612B2 (en) * 2007-10-19 2013-11-28 Janssen Pharmaceutica, N.V. Piperidinyl and piperazinyl modulators of gamma-secretase
AU2008312355B2 (en) * 2007-10-19 2013-07-04 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
WO2009052350A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
AU5702201A (en) 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
WO2006004555A1 (en) 2004-06-30 2006-01-12 Paysetter Pte Ltd System and method for facilitating transfer of physical money and/or credit
DE102004033876B4 (de) 2004-07-13 2009-01-15 Christoph Kaesbohrer Dreidimensionales Struktursystem
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy

Also Published As

Publication number Publication date
EP2215044B8 (en) 2012-10-03
US7897643B2 (en) 2011-03-01
EA201070478A1 (ru) 2010-10-29
EP2215044B1 (en) 2012-08-29
WO2009051948A1 (en) 2009-04-23
JP2011500691A (ja) 2011-01-06
BRPI0817424A2 (pt) 2015-06-16
CN101861297B (zh) 2014-04-23
US20090105344A1 (en) 2009-04-23
CN101861297A (zh) 2010-10-13
ES2395083T3 (es) 2013-02-08
KR20100090264A (ko) 2010-08-13
NI201000058A (es) 2010-09-13
DK2215044T3 (da) 2012-11-26
AU2008312771B2 (en) 2012-11-01
AU2008312771A1 (en) 2009-04-23
MX2010004261A (es) 2010-04-30
ES2395083T8 (es) 2014-11-17
JP5404634B2 (ja) 2014-02-05
CR11432A (es) 2010-10-14
ZA201003432B (en) 2012-07-25
KR101579744B1 (ko) 2015-12-23
IL205047A0 (en) 2010-11-30
EA017616B1 (ru) 2013-01-30
CA2702832A1 (en) 2009-04-23
IL205047A (en) 2014-09-30
EP2215044A1 (en) 2010-08-11

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