MX2010004261A - Acidos carboxilicos bifenil y derivados de los mismos. - Google Patents

Acidos carboxilicos bifenil y derivados de los mismos.

Info

Publication number
MX2010004261A
MX2010004261A MX2010004261A MX2010004261A MX2010004261A MX 2010004261 A MX2010004261 A MX 2010004261A MX 2010004261 A MX2010004261 A MX 2010004261A MX 2010004261 A MX2010004261 A MX 2010004261A MX 2010004261 A MX2010004261 A MX 2010004261A
Authority
MX
Mexico
Prior art keywords
derivatives
carboxylic acids
biphenyl carboxylic
compounds
relates
Prior art date
Application number
MX2010004261A
Other languages
English (en)
Inventor
Chih Yung Ho
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2010004261A publication Critical patent/MX2010004261A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

(Ver f?rmula) La presente invenci?n se refiere a compuestos que tienen la F?rmula general (I) con las definiciones de R1, R2, R3, y R4 dadas a continuaci?n, y/o una sal o ?ster de ?stos; adem?s, la invenci?n se refiere al uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y su uso para la modulaci?n de la actividad de la y-secretasa.
MX2010004261A 2007-10-17 2008-09-26 Acidos carboxilicos bifenil y derivados de los mismos. MX2010004261A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98058707P 2007-10-17 2007-10-17
PCT/US2008/077779 WO2009051948A1 (en) 2007-10-17 2008-09-26 Biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
MX2010004261A true MX2010004261A (es) 2010-04-30

Family

ID=40345060

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004261A MX2010004261A (es) 2007-10-17 2008-09-26 Acidos carboxilicos bifenil y derivados de los mismos.

Country Status (18)

Country Link
US (1) US7897643B2 (es)
EP (1) EP2215044B8 (es)
JP (1) JP5404634B2 (es)
KR (1) KR101579744B1 (es)
CN (1) CN101861297B (es)
AU (1) AU2008312771B2 (es)
BR (1) BRPI0817424A2 (es)
CA (1) CA2702832A1 (es)
CO (1) CO6270313A2 (es)
CR (1) CR11432A (es)
DK (1) DK2215044T3 (es)
EA (1) EA017616B1 (es)
ES (1) ES2395083T3 (es)
IL (1) IL205047A (es)
MX (1) MX2010004261A (es)
NI (1) NI201000058A (es)
WO (1) WO2009051948A1 (es)
ZA (1) ZA201003432B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252935B2 (en) * 2007-10-19 2012-08-28 Janssen Pharmaceutica N.V. Piperidinyl and piperazinyl modulators of γ-secretase
WO2009052334A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
BRPI0817837A2 (pt) * 2007-10-19 2015-04-07 Janssen Pharmaceutica Nv Moduladores de gama-secretase ligados a amida

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
US20080313061A1 (en) 2004-06-30 2008-12-18 Paysetter Pte Ltd System and Method for Facilitating Transfer of Physical Money and/or Credit
DE102004033876B4 (de) 2004-07-13 2009-01-15 Christoph Kaesbohrer Dreidimensionales Struktursystem
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy

Also Published As

Publication number Publication date
DK2215044T3 (da) 2012-11-26
EA017616B1 (ru) 2013-01-30
CN101861297B (zh) 2014-04-23
JP2011500691A (ja) 2011-01-06
KR101579744B1 (ko) 2015-12-23
CO6270313A2 (es) 2011-04-20
EP2215044B1 (en) 2012-08-29
KR20100090264A (ko) 2010-08-13
WO2009051948A1 (en) 2009-04-23
EA201070478A1 (ru) 2010-10-29
CA2702832A1 (en) 2009-04-23
JP5404634B2 (ja) 2014-02-05
AU2008312771A1 (en) 2009-04-23
IL205047A0 (en) 2010-11-30
CN101861297A (zh) 2010-10-13
IL205047A (en) 2014-09-30
ES2395083T8 (es) 2014-11-17
ES2395083T3 (es) 2013-02-08
EP2215044B8 (en) 2012-10-03
NI201000058A (es) 2010-09-13
US7897643B2 (en) 2011-03-01
AU2008312771B2 (en) 2012-11-01
EP2215044A1 (en) 2010-08-11
US20090105344A1 (en) 2009-04-23
CR11432A (es) 2010-10-14
ZA201003432B (en) 2012-07-25
BRPI0817424A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
TNSN07148A1 (en) (biphenyl) carboxylic acids and derivatives thereof
MY148953A (en) Substituted biphenyl carboxylic acids and derivatives thereof
UA95766C2 (ru) Производные терфенила для лечения болезни альцгеймера
CO6311079A2 (es) Derivados de aminodihidrotiazina como inhibidores de la enzima bace para el tratamiento de la enfermedad de alzheimer
MX2008014101A (es) Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinilamino, metodo para su produccion y su uso como medicamentos.
MY148258A (en) Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments
MX2013001614A (es) Compuestos heterociclico.
EA201001585A1 (ru) Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк)
TN2011000053A1 (en) Organic compounds
ECSP099755A (es) Derivados de pirrolopiridina y su uso como inhibidores de bace
EA201001733A1 (ru) Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк)
MX2008010884A (es) Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1.
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
MX2013008699A (es) Compuestos para reducir la produccion de beta-amiloide.
TW200724567A (en) Amide-containing polymers for rheology control
MX2010004261A (es) Acidos carboxilicos bifenil y derivados de los mismos.
MX2010004318A (es) Moduladores de la gamma-secretasa con enlaces de amina.
ATE479691T1 (de) 4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3- modulatoren
UA94574C2 (ru) (бифенил) карбоновые кислоты и их производные
ATE502947T1 (de) 4,5,6,7-tetrahydrothienoä3,2-cüpyridinderivate als h3-modulatoren
UA35571U (en) 4-(2-diethylaminoethoxycarbonyl)phenylamides of 5-aryliden-4-oxo-2-thioxotiazolidine-3-ylalkane carboxylic acids having anticancer activity
UA43602U (ru) Применение производных 1,2,3-триазол(1н) -4-карбоновых кислот как ноотропных средств
CR9070A (es) Acidos (bifenil) carboxilicos y derivados de estos
MX2007008392A (es) Esteres de acido propano-fosfinico sustituido.

Legal Events

Date Code Title Description
FG Grant or registration