EA201070496A1 - УГЛЕРОД-СВЯЗАННЫЕ МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ - Google Patents
УГЛЕРОД-СВЯЗАННЫЕ МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫInfo
- Publication number
- EA201070496A1 EA201070496A1 EA201070496A EA201070496A EA201070496A1 EA 201070496 A1 EA201070496 A1 EA 201070496A1 EA 201070496 A EA201070496 A EA 201070496A EA 201070496 A EA201070496 A EA 201070496A EA 201070496 A1 EA201070496 A1 EA 201070496A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon
- secretase modulators
- compounds
- formula
- secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к соединениям с общей формулой (I), как показано ниже, определения А, X, R, R, R, R, R, R, Rи Rприведены в спецификации. Соединения с формулой (I) могут применяться для лечения заболеваний, связанных с активностью γ-секретазы, включая болезнь Альцгеймера.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98120907P | 2007-10-19 | 2007-10-19 | |
PCT/US2008/080241 WO2009052334A1 (en) | 2007-10-19 | 2008-10-17 | Carbon linked modulators of y-secretase |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070496A1 true EA201070496A1 (ru) | 2010-10-29 |
EA019710B1 EA019710B1 (ru) | 2014-05-30 |
Family
ID=40338749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070496A EA019710B1 (ru) | 2007-10-19 | 2008-10-17 | ПРОИЗВОДНЫЕ 2-АРИЛ-4-МЕТИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ γ-СЕКРЕТАЗЫ |
Country Status (17)
Country | Link |
---|---|
US (1) | US8692017B2 (ru) |
EP (1) | EP2215043B1 (ru) |
JP (1) | JP5417334B2 (ru) |
KR (1) | KR101618068B1 (ru) |
CN (1) | CN101896452B (ru) |
AU (1) | AU2008312355B2 (ru) |
BR (1) | BRPI0818773A2 (ru) |
CA (1) | CA2702959C (ru) |
CO (1) | CO6280527A2 (ru) |
CR (1) | CR11448A (ru) |
EA (1) | EA019710B1 (ru) |
ES (1) | ES2401833T3 (ru) |
IL (1) | IL205046A (ru) |
MX (1) | MX2010004310A (ru) |
NI (1) | NI201000065A (ru) |
WO (1) | WO2009052334A1 (ru) |
ZA (1) | ZA201003520B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1799672B1 (en) * | 2004-10-07 | 2013-01-02 | Merck Sharp & Dohme Corp. | Cgrp receptor antagonists |
AU2008312612B2 (en) | 2007-10-19 | 2013-11-28 | Janssen Pharmaceutica, N.V. | Piperidinyl and piperazinyl modulators of gamma-secretase |
AU2008312355B2 (en) | 2007-10-19 | 2013-07-04 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
WO2009052350A1 (en) | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | Amine linked modulators of y-secretase |
CN105801350B (zh) * | 2016-04-29 | 2018-07-27 | 宜春学院 | 二芳基甲醇类化合物的合成方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790287A (fr) * | 1971-10-28 | 1973-04-19 | Delalande Sa | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique |
BE826017R (fr) * | 1974-03-19 | 1975-08-26 | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique | |
US4252951A (en) * | 1979-10-09 | 1981-02-24 | Eli Lilly And Company | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
US5391817A (en) * | 1993-12-21 | 1995-02-21 | Bristol-Myers Squibb | Biaryl phospholipase A2 inhibitors |
US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
AU5702201A (en) * | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
CN1829521B (zh) * | 2003-06-16 | 2011-01-26 | 安纳考尔医药公司 | 耐水解的含硼治疗剂和使用方法 |
WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
DE102004033876B4 (de) | 2004-07-13 | 2009-01-15 | Christoph Kaesbohrer | Dreidimensionales Struktursystem |
GB0416508D0 (en) * | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
SI1849762T1 (sl) | 2006-04-21 | 2009-12-31 | Cellzome Ltd | Substituirane bifenil karboksilne kisline in derivati le-teh |
ATE445586T1 (de) | 2006-04-21 | 2009-10-15 | Cellzome Ltd | Terphenylderivate zur alzheimerbehandlung |
CA2654784A1 (en) * | 2006-06-09 | 2007-12-13 | Icos Corporation | Substituted phenylacetic acids as dp-2 antagonists |
EA200802417A1 (ru) | 2006-06-09 | 2009-06-30 | Икос Корпорейшн | Замещенные фенилуксусные кислоты как dp-2-антагонисты |
AU2008312771B2 (en) * | 2007-10-17 | 2012-11-01 | Janssen Pharmaceutica, N.V. | Biphenyl carboxylic acids and derivatives thereof |
AU2008312612B2 (en) * | 2007-10-19 | 2013-11-28 | Janssen Pharmaceutica, N.V. | Piperidinyl and piperazinyl modulators of gamma-secretase |
US7951843B2 (en) * | 2007-10-19 | 2011-05-31 | Janssen Pharmaceutica N.V. | Amide linked modulators of γ-secretase |
AU2008312355B2 (en) | 2007-10-19 | 2013-07-04 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
AU2008312362A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | Gsm intermediates |
WO2009052350A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | Amine linked modulators of y-secretase |
US7968725B2 (en) | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
-
2008
- 2008-10-17 AU AU2008312355A patent/AU2008312355B2/en not_active Ceased
- 2008-10-17 EP EP08839085A patent/EP2215043B1/en active Active
- 2008-10-17 EA EA201070496A patent/EA019710B1/ru not_active IP Right Cessation
- 2008-10-17 MX MX2010004310A patent/MX2010004310A/es active IP Right Grant
- 2008-10-17 US US12/253,264 patent/US8692017B2/en not_active Expired - Fee Related
- 2008-10-17 CA CA2702959A patent/CA2702959C/en not_active Expired - Fee Related
- 2008-10-17 WO PCT/US2008/080241 patent/WO2009052334A1/en active Application Filing
- 2008-10-17 JP JP2010530127A patent/JP5417334B2/ja not_active Expired - Fee Related
- 2008-10-17 KR KR1020107010870A patent/KR101618068B1/ko not_active IP Right Cessation
- 2008-10-17 BR BRPI0818773 patent/BRPI0818773A2/pt not_active IP Right Cessation
- 2008-10-17 ES ES08839085T patent/ES2401833T3/es active Active
- 2008-10-17 CN CN2008801208993A patent/CN101896452B/zh not_active Expired - Fee Related
-
2010
- 2010-04-13 IL IL205046A patent/IL205046A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000065A patent/NI201000065A/es unknown
- 2010-04-26 CO CO10048726A patent/CO6280527A2/es not_active Application Discontinuation
- 2010-05-18 ZA ZA2010/03520A patent/ZA201003520B/en unknown
- 2010-05-19 CR CR11448A patent/CR11448A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2702959C (en) | 2016-07-26 |
CN101896452B (zh) | 2013-07-31 |
JP5417334B2 (ja) | 2014-02-12 |
ES2401833T3 (es) | 2013-04-24 |
CA2702959A1 (en) | 2009-04-23 |
US8692017B2 (en) | 2014-04-08 |
NI201000065A (es) | 2010-09-13 |
MX2010004310A (es) | 2010-05-03 |
EA019710B1 (ru) | 2014-05-30 |
IL205046A0 (en) | 2010-11-30 |
EP2215043A1 (en) | 2010-08-11 |
AU2008312355A1 (en) | 2009-04-23 |
US20090105288A1 (en) | 2009-04-23 |
KR20100090688A (ko) | 2010-08-16 |
CO6280527A2 (es) | 2011-05-20 |
AU2008312355B2 (en) | 2013-07-04 |
BRPI0818773A2 (pt) | 2015-04-14 |
WO2009052334A1 (en) | 2009-04-23 |
ZA201003520B (en) | 2012-07-25 |
CN101896452A (zh) | 2010-11-24 |
EP2215043B1 (en) | 2013-03-06 |
KR101618068B1 (ko) | 2016-05-04 |
CR11448A (es) | 2011-01-14 |
JP2011500719A (ja) | 2011-01-06 |
IL205046A (en) | 2014-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE502633T1 (de) | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen | |
EA201071045A1 (ru) | Соединения оксадиазоантрацена для лечения диабета | |
EA201000950A1 (ru) | Азолилметилоксираны, их применение, а также содержащие их средства | |
EA201270225A1 (ru) | СОЕДИНЕНИЯ ДЛЯ УМЕНЬШЕНИЯ ПРОДУКЦИИ β-АМИЛОИДА | |
EA201190217A1 (ru) | Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение | |
MA32811B1 (fr) | Nouveaux composés | |
EA201070158A1 (ru) | Сульфонамиды в качестве trpm8 модуляторов | |
EA200802054A1 (ru) | Ингибиторы фермента | |
EA201071243A1 (ru) | Комбинированные композиции для лечения болезни альцгеймера и родственных заболеваний зонизамидом и акампросатом | |
CY1112083T1 (el) | Υποκαθιστουμενα ν-φαινυλο-διπυρρολιδινο καρβοξαμιδια και η θεραπευτικη τους χρηση | |
DK2212282T3 (da) | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf | |
TW200716152A (en) | Substituted 1,2-ethylendiamines, medicaments comprising said compound, their use and their method of manufacture | |
ATE554076T1 (de) | Sulfoximinsubstituierte chinazolinderivate als immunmodulatoren, ihre herstellung und ihre verwendung als medikamente | |
BRPI0415203A (pt) | pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios | |
EA201070496A1 (ru) | УГЛЕРОД-СВЯЗАННЫЕ МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ | |
CR11447A (es) | Moduladores de piperidinil y piperazinil de y secretasa | |
NO20076405L (no) | Anvendelse av 24-nor-UDCA | |
EA201070494A1 (ru) | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ | |
ATE392471T1 (de) | Behandlung neurodegenerativer krankheiten durch verwendung von scd4-inhibitoren | |
BRPI0512732A (pt) | formulações tópicas para tratamento de doenças alérgicas | |
NI201000067A (es) | Intermediarios de gsm. | |
WO2010011626A3 (en) | Pyridinyl modulators of ϒ-secretase | |
EA201070498A1 (ru) | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ | |
DK1596879T3 (da) | Anvendelse af kahalalidforbindelser til fremstilling af et medikament til behandling af psoriasis | |
BRPI0402756A (pt) | método para o tratamento de distúrbios cognitivos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): KZ RU |