CY1109160T1 - Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης - Google Patents

Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης

Info

Publication number
CY1109160T1
CY1109160T1 CY20091100644T CY091100644T CY1109160T1 CY 1109160 T1 CY1109160 T1 CY 1109160T1 CY 20091100644 T CY20091100644 T CY 20091100644T CY 091100644 T CY091100644 T CY 091100644T CY 1109160 T1 CY1109160 T1 CY 1109160T1
Authority
CY
Cyprus
Prior art keywords
pyridinoamines
angiogenesis regulators
pyrimidine derivatives
angiogenesis
regulators
Prior art date
Application number
CY20091100644T
Other languages
English (en)
Inventor
Amogh Boloor
Mui Cheung
Ronda Davis
Philip Anthony Harris
Kevin Hinkle
Robert Anthony Mook, Jr.
Jeffrey Alan Stafford
James Martin Veal
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26946028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109160(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CY1109160T1 publication Critical patent/CY1109160T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Παράγωγα πυριμιδίνης τα οποία είναι χρήσιμα ως αναστολείς VEGFR2 περιγράφονται στο παρόν. Η περιγραφόμενη εφεύρεση επίσης περιλαμβάνει μεθόδους κατασκευής τέτοιων παραγώγων πυριμιδίνης, καθώς επίσης μεθόδους χρήσης αυτών στη θεραπεία υπερπολλαπλασιαστικών ασθενειών.
CY20091100644T 2000-12-21 2009-06-18 Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης CY1109160T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25752600P 2000-12-21 2000-12-21
US26240301P 2001-01-16 2001-01-16
PCT/US2001/049367 WO2002059110A1 (en) 2000-12-21 2001-12-19 Pyrimidineamines as angiogenesis modulators

Publications (1)

Publication Number Publication Date
CY1109160T1 true CY1109160T1 (el) 2012-01-25

Family

ID=26946028

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100644T CY1109160T1 (el) 2000-12-21 2009-06-18 Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης
CY2010014C CY2010014I1 (el) 2000-12-21 2010-07-29 Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2010014C CY2010014I1 (el) 2000-12-21 2010-07-29 Πυρiδinοamiνες ως ρυθμιστες αγγειογενεσης

Country Status (28)

Country Link
US (6) US7105530B2 (el)
EP (2) EP2311825B1 (el)
JP (1) JP4253188B2 (el)
KR (1) KR100847169B1 (el)
CN (1) CN1307173C (el)
AT (1) ATE430742T1 (el)
AU (1) AU2002246723B2 (el)
BE (1) BE2010C030I2 (el)
BR (1) BR0116452A (el)
CA (1) CA2432000C (el)
CY (2) CY1109160T1 (el)
CZ (1) CZ304059B6 (el)
DE (2) DE122010000038I1 (el)
DK (2) DK1343782T3 (el)
ES (2) ES2556946T3 (el)
FR (1) FR10C0037I2 (el)
HK (2) HK1059926A1 (el)
HU (2) HU230574B1 (el)
IL (2) IL156306A0 (el)
LU (1) LU91710I2 (el)
MX (1) MXPA03005696A (el)
NO (3) NO325987B1 (el)
NZ (1) NZ526542A (el)
PL (1) PL214667B1 (el)
PT (2) PT2311825E (el)
SI (2) SI2311825T1 (el)
WO (1) WO2002059110A1 (el)
ZA (1) ZA200304482B (el)

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ATE430742T1 (de) 2009-05-15
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JP2004517925A (ja) 2004-06-17
NO20032831L (no) 2003-08-15
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PL363243A1 (en) 2004-11-15
US20070292513A1 (en) 2007-12-20
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BR0116452A (pt) 2003-09-30
KR100847169B1 (ko) 2008-07-17
ES2324981T3 (es) 2009-08-21
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CZ20031748A3 (en) 2004-04-14
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US20040242578A1 (en) 2004-12-02
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CA2432000A1 (en) 2002-08-01
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