CS274420B2 - Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production - Google Patents

Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production Download PDF

Info

Publication number
CS274420B2
CS274420B2 CS96588A CS96588A CS274420B2 CS 274420 B2 CS274420 B2 CS 274420B2 CS 96588 A CS96588 A CS 96588A CS 96588 A CS96588 A CS 96588A CS 274420 B2 CS274420 B2 CS 274420B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
salt
dextrorotatory
tetrahydrothieno
pyridyl
Prior art date
Application number
CS96588A
Other languages
Czech (cs)
English (en)
Other versions
CS96588A2 (en
Inventor
Alain Badorc
Daniel Frehel
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26225786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS274420(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8702025A external-priority patent/FR2612929B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CS96588A2 publication Critical patent/CS96588A2/cs
Publication of CS274420B2 publication Critical patent/CS274420B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CS96588A 1987-02-17 1988-02-16 Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production CS274420B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8702025A FR2612929B1 (fr) 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant
FR878716516A FR2623810B2 (fr) 1987-02-17 1987-11-27 Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
CS96588A2 CS96588A2 (en) 1990-09-12
CS274420B2 true CS274420B2 (en) 1991-04-11

Family

ID=26225786

Family Applications (1)

Application Number Title Priority Date Filing Date
CS96588A CS274420B2 (en) 1987-02-17 1988-02-16 Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production

Country Status (36)

Country Link
US (1) US4847265A (de)
EP (1) EP0281459B1 (de)
JP (1) JPH0645622B2 (de)
KR (1) KR960003615B1 (de)
AR (1) AR243891A1 (de)
AT (1) ATE121745T1 (de)
AU (1) AU597784B2 (de)
CA (1) CA1336777C (de)
CS (1) CS274420B2 (de)
CY (1) CY2087B1 (de)
DE (2) DE3853643T2 (de)
DK (1) DK173636B1 (de)
ES (1) ES2071621T4 (de)
FI (1) FI87216C (de)
FR (1) FR2623810B2 (de)
HK (1) HK1000093A1 (de)
HR (1) HRP920923B1 (de)
HU (2) HU197909B (de)
IE (1) IE66922B1 (de)
IL (1) IL85294A (de)
LU (1) LU90324I2 (de)
LV (1) LV5804B4 (de)
MA (1) MA21184A1 (de)
MX (1) MX9203026A (de)
MY (1) MY103198A (de)
NL (1) NL990002I1 (de)
NO (2) NO165924C (de)
NZ (1) NZ223475A (de)
OA (1) OA08808A (de)
PH (1) PH25960A (de)
PL (1) PL156689B1 (de)
PT (1) PT86726B (de)
RO (1) RO99191B1 (de)
SI (1) SI8810231A8 (de)
TN (1) TNSN88012A1 (de)
YU (1) YU46748B (de)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065421A (en) * 1957-05-21 1962-11-20 John M Hart Radio-telephone communication system having means for automatic direct dispatch between mobile stations
US3009149A (en) * 1957-09-30 1961-11-14 Mcdonald Ramsey Automatic dial radio telephone system
US3105118A (en) * 1960-04-13 1963-09-24 Ericsson Telefon Ab L M Mobile radio stations interconnected with a wire telephone system
US4906756A (en) * 1988-05-10 1990-03-06 Syntex (U.S.A.) Inc. 2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
FR2672801B1 (fr) * 1991-02-14 1995-03-03 Sanofi Sa Utilisation de derives de tetrahydrothienopyridine comme inhibiteurs de l'angiogenese.
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
PT1087775E (pt) 1998-06-17 2005-11-30 Bristol Myers Squibb Co Prevencao de enfarte cerebral por administracao de uma combinacao de farmacos antiplaquetarios bloqueadores de receptores de adp e anti-hipertensivos
FR2792836B3 (fr) 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
IN191030B (de) * 2001-01-24 2003-09-13 Cadila Healthcare Ltd
MXPA03006133A (es) * 2001-01-24 2004-05-04 Cadila Healthcare Ltd Proceso para preparar clopidogrel.
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CA2363053C (en) 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
MXPA04006088A (es) * 2001-12-18 2004-09-27 Teva Pharma Polimorfo de sulfato de hidrogeno de clopidogrel.
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
AR039570A1 (es) 2002-04-16 2005-02-23 Schering Corp Antagonistas de los receptores de trombina
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
US20040067995A1 (en) * 2002-10-02 2004-04-08 Wong Pancras C. Novel combination of a factor Xa inhibitor and clopidogrel
US6812363B2 (en) * 2002-10-15 2004-11-02 Usv Limited Racemization of optically active 2-substituted phenyl glycine esters
ITMI20022228A1 (it) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A Sali di clopidogrel con acidi alchil-solforici.
WO2004048385A2 (en) * 2002-11-28 2004-06-10 Instytut Farmaceutyczny A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
EP1606231A1 (de) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Verfahren zur herstellung von clopidogrel, seine salze und pharmazeutische zusammensetzungen
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
EP1603920A1 (de) * 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorphe und amorphe form (s)-(+)-clopidogrel-bisulfat
US6858734B2 (en) * 2003-04-23 2005-02-22 Rhodia Pharma Solutions Inc. Preparation of (S)-Clopidogrel and related compounds
EP1618111B1 (de) * 2003-04-25 2014-12-24 Cadila Healthcare Limited Salze von clopidogrel und herstellungsverfahren
WO2005003138A2 (en) * 2003-07-02 2005-01-13 EGIS Gyógyszergyár Rt. Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
KR101155679B1 (ko) * 2003-07-02 2012-06-13 에지스 지오기스제르기아르 니일바노산 무코도 레스즈베니타르사사그 혈소판 응집 억제제 약물의 결정성 다형체를 제조하는 방법
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
AU2008200919B2 (en) * 2003-09-11 2009-05-21 Generics (Uk) Limited Novel crystalline polymorphs of clopidogrel
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
US8907090B2 (en) * 2003-11-03 2014-12-09 Cadila Healthcare Limited Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate
CA2454015C (en) * 2003-12-23 2009-11-24 Brantford Chemicals Inc. A process for the preparation of tetrahydrothieno [3,2-c] pyridine derivatives
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
WO2005080890A1 (de) * 2004-02-24 2005-09-01 Siegfried Generics International Ag Pharmakologisch akzeptierbare salze von clopidogrel
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
TW200534879A (en) * 2004-03-25 2005-11-01 Bristol Myers Squibb Co Coated tablet formulation and method
KR100563455B1 (ko) * 2004-04-09 2006-03-23 한미약품 주식회사 결정성 클로피도그렐 나프탈렌술폰산염 또는 이의 수화물,이의 제조방법 및 이를 함유하는 약학적 조성물
EP1732932B1 (de) * 2004-04-09 2012-03-21 Hanmi Holdings Co., Ltd. Kristallines clopidogrelnaphthalinsulfonat oder hydrat davon, verfahren zu dessen herstellung und pharmazeutische zusammensetzung, die dieses enthält
WO2005100364A1 (en) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
ZA200608569B (en) * 2004-04-20 2007-12-27 Sanofi Aventis Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
ZA200608035B (en) * 2004-04-20 2008-07-30 Sanofi Aventis Clopidogrel salt and polymorphic forms thereof
US7829720B2 (en) * 2004-05-04 2010-11-09 Bristol-Myers Squibb Company Process for preparing atazanavir bisulfate and novel forms
US20050256314A1 (en) * 2004-05-04 2005-11-17 Soojin Kim Process employing controlled crystallization in forming crystals of a pharmaceutical
US20050288343A1 (en) * 2004-05-19 2005-12-29 Andrew Rusowicz Process of preparing substituted carbamates and intermediates thereof
TWI415635B (zh) * 2004-05-28 2013-11-21 必治妥施貴寶公司 加衣錠片調製物及製備彼之方法
EP1750701A1 (de) * 2004-06-01 2007-02-14 IVAX Pharmaceuticals s.r.o. Amorphes clopidogrel-hydrochlorid und seine antithrombotische anwendung
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
US7446200B2 (en) * 2004-10-04 2008-11-04 Usv, Ltd. Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
EP1674468A1 (de) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphe von Clopidogrel Hydrobromid
CA2567806C (en) * 2005-02-15 2011-04-26 Usv Limited Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph - form i
EP1851231A2 (de) * 2005-02-24 2007-11-07 Teva Pharmaceutical Industries Ltd Zur pharmazeutischen formulierung geeignete clopidogrel-basis und deren herstellung
CZ299213B6 (cs) 2005-03-08 2008-05-21 Zentiva, A. S Zpusob racemizace R(-) izomeru methylesteru kyseliny (2-chlorfenyl)-6,7-dihydro-thieno[3,2-c]pyridin-5(4H)-octové
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
EP1888037A2 (de) * 2005-05-10 2008-02-20 Elan Pharma International Limited Clopidogrel-nanopartikelformulierungen
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
WO2007032023A2 (en) * 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
KR20070009851A (ko) * 2005-07-14 2007-01-19 씨제이 주식회사 클로피도그렐 황산수소염 함유 약학 조성물
EP1934229B1 (de) * 2005-09-05 2012-09-26 Cadila Healthcare Limited Verfahren zur herstellung verschiedener formen von (s)-(+)-clopidogrel-besylat
EP1926736A4 (de) * 2005-09-21 2010-08-25 Chong Kun Dang Pharm Corp Neuer resinat-komplex von s-clopidogrel und verfahren zu dessen herstellung
KR100783286B1 (ko) * 2005-09-26 2007-12-06 주식회사종근당 클로피도그렐 우선성 광학이성체의 유리염기를 함유하는고형의 약제학적 조성물
DE102005060690B4 (de) * 2005-12-15 2008-09-25 Capsulution Nanoscience Ag Salze von Clopidogrel mit Polyanionen und ihre Verwendung zur Herstellung pharmazeutischer Formulierungen
KR101235117B1 (ko) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물
US20070225320A1 (en) * 2006-03-27 2007-09-27 Eswaraiah Sajja Process for preparing clopidogrel
JP5844028B2 (ja) 2006-04-04 2016-01-13 ケージー アクキュイシチオン エルエルシー 抗血小板薬及び酸阻害薬を含む経口剤形
RU2008146758A (ru) * 2006-04-27 2010-06-10 Инд-Свифт Лэборетриз Лимитед (In) Способ получения полиморфных форм клопидогрела гидросульфата
EP1931682A2 (de) * 2006-08-03 2008-06-18 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von clopidogrel-bisulphat
EP2064217B1 (de) * 2006-09-04 2011-01-19 Ranbaxy Laboratories Limited Verbessertes verfahren zur herstellung von clopidogrel und pharmazeutisch unbedenklichen salzen davon
EP1900358A1 (de) * 2006-09-16 2008-03-19 Cimex Pharma AG Clopidogrel enthaltende Arzneiformulierungen
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
KR100978498B1 (ko) * 2006-10-17 2010-08-30 최중헌 클로피도그렐 황산수소염의 제조방법
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
CA2673228A1 (en) * 2006-12-22 2008-07-03 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
EP1970054A3 (de) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel-Tabletten
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP1980563A1 (de) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법
KR20150041173A (ko) 2007-04-27 2015-04-15 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
US20100297621A1 (en) * 2007-06-20 2010-11-25 University Of Utah Research Foundation Use of pre-mrna splicing in platelet cells for the diagnosis of disease
SI2178513T1 (sl) * 2007-06-22 2011-05-31 Bristol Myers Squibb Co Tabletni sestavki vsebujoäśi atazanavir
PT2170292E (pt) * 2007-06-22 2014-03-06 Bristol Myers Squibb Holdings Ireland Composições de comprimido contendo atazanavir
DE602008005316D1 (de) * 2007-06-22 2011-04-14 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
EP2178512B1 (de) * 2007-06-22 2011-03-09 Bristol-Myers Squibb Company Tablettierte atazanavirhaltige zusammensetzungen
KR20090022616A (ko) * 2007-08-31 2009-03-04 한올제약주식회사 베실산클로피도그렐 함유 경구투여용 약제
CA2709262A1 (en) * 2007-12-14 2009-06-25 Generics [Uk] Limited New hplc method
WO2009080469A1 (en) * 2007-12-24 2009-07-02 Sandoz Ag Process for the preparation of clopidogrel bisulphate form i
ATE530172T1 (de) * 2008-02-26 2011-11-15 Lesvi Laboratorios Sl Pharmazeutische formulierungen mit clopidogrel
EP2258364A4 (de) 2008-04-01 2012-07-25 Astellas Pharma Inc Prophylaktikum und/oder heilmittel für gefässkrankheiten
EP2107061A1 (de) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Herstellungsverfahren für optisch angereichertes Clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
KR100990949B1 (ko) * 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
US8299097B2 (en) * 2008-09-12 2012-10-30 The Brigham And Women's Hospital, Inc. Methods for treating inflammatory disorders
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
AU2010233089B2 (en) 2009-04-10 2016-05-26 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (MMP-1)
KR101743591B1 (ko) 2009-05-13 2017-06-20 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
CN101885730B (zh) * 2009-05-13 2012-07-04 连云港恒邦医药科技有限公司 抗血栓的化合物
CA2764172A1 (en) 2009-06-08 2010-12-16 Schering Corporation A thrombin receptor antagonist and clopidogrel fixed dose tablet
KR20120050437A (ko) 2009-06-25 2012-05-18 테트라, 시아 신규한 아세틸살리실산 염들
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
WO2011010318A1 (en) * 2009-07-23 2011-01-27 Praveen Laboratories Private Limited Process for the preparation of clopidogrel polymorphous form 1 using seed chrystals
WO2011042804A2 (en) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN102120744B (zh) * 2010-02-02 2013-01-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
WO2011101865A2 (en) 2010-02-19 2011-08-25 Cadila Healthcare Limited Stable pharmaceutical compositions of clopidogrel for parenteral delivery
CN101787033B (zh) * 2010-03-16 2011-08-31 天津市中央药业有限公司 一种硫酸氢氯吡格雷有关物质c的合成方法
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
EP2560644B1 (de) 2010-04-19 2016-06-29 Cadila Healthcare Limited Pharmazeutische zubereitung enthaltend thrombozytenhemmer und eine erythropoiese stimulierende verbindung
CN101863902B (zh) * 2010-06-29 2012-06-27 天津药物研究院 2-取代苯基-2-(4,5,6,7-四氢噻吩并[3,2-c]吡啶-5（4H）-基)乙酸(取代烷基醇)酯的制备方法和用途
WO2012007019A1 (en) 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102199160B (zh) * 2011-03-22 2016-06-22 浙江华海药业股份有限公司 一种制备ⅰ型硫酸氢氯吡格雷的方法
EP2675813A4 (de) 2011-06-27 2014-04-30 Ipca Lab Ltd Antithromboseverbindungen
RU2014127884A (ru) 2011-12-09 2016-02-10 Вокхардт Лимитед Способы лечения сердечно-сосудистого нарушения
CN103665042B (zh) * 2012-09-21 2016-03-16 北京普禄德医药科技有限公司 光学活性的2-羟基四氢噻吩并吡啶衍生物及其制备方法和用途
WO2014118802A1 (en) 2013-01-31 2014-08-07 Pharmazell Gmbh An improved process for the preparation of clopidogrel bisulfate form-i
CN104761567A (zh) * 2014-01-02 2015-07-08 上海医药工业研究院 一种硫酸氢氯吡格雷、其中间体及制备方法
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
KR102512494B1 (ko) 2017-06-30 2023-03-22 교와 가부시키가이샤 의약
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
DE3736664A1 (de) * 1987-10-29 1989-05-11 Boehringer Ingelheim Kg Tetrahydro-furo- und -thieno(2,3-c)pyridine, ihre verwendung als arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PL270677A1 (en) 1988-12-08
EP0281459A1 (de) 1988-09-07
ES2071621T3 (es) 1995-07-01
NO880666L (no) 1988-08-18
JPH0645622B2 (ja) 1994-06-15
PT86726B (pt) 1992-05-29
IL85294A (en) 1991-12-15
IL85294A0 (en) 1988-07-31
DK173636B1 (da) 2001-05-14
DK80088A (da) 1988-08-18
DK80088D0 (da) 1988-02-16
PT86726A (pt) 1988-03-01
KR960003615B1 (ko) 1996-03-20
HRP920923A2 (hr) 1994-04-30
KR880009969A (ko) 1988-10-06
SI8810231A8 (en) 1996-08-31
TNSN88012A1 (fr) 1990-07-10
ES2071621T4 (es) 2011-12-29
PL156689B1 (en) 1992-04-30
PH25960A (en) 1992-01-13
NZ223475A (en) 1989-05-29
AU1129288A (en) 1988-08-18
OA08808A (fr) 1989-03-31
DE19875053I2 (de) 2001-05-23
HU197909B (en) 1989-06-28
FI87216B (fi) 1992-08-31
CS96588A2 (en) 1990-09-12
US4847265A (en) 1989-07-11
NL990002I1 (nl) 1999-03-01
MA21184A1 (fr) 1988-10-01
IE880273L (en) 1988-08-17
LU90324I2 (fr) 1999-01-27
LV5804A4 (lv) 1997-02-20
YU23188A (en) 1989-08-31
FI880720A (fi) 1988-08-18
CY2087B1 (en) 2002-04-05
AU597784B2 (en) 1990-06-07
NO1999022I1 (no) 1999-10-11
EP0281459B1 (de) 1995-04-26
HUT47291A (en) 1989-02-28
LV5804B4 (lv) 1997-08-20
NO880666D0 (no) 1988-02-16
MY103198A (en) 1993-05-29
MX9203026A (es) 1992-07-01
HK1000093A1 (en) 1997-11-21
RO99191B1 (ro) 1990-07-30
HU210538A9 (en) 1995-04-28
IE66922B1 (en) 1996-02-07
NO165924B (no) 1991-01-21
YU46748B (sh) 1994-04-05
DE3853643D1 (de) 1995-06-01
DE3853643T2 (de) 1995-11-30
FI87216C (fi) 1992-12-10
FI880720A0 (fi) 1988-02-16
FR2623810B2 (fr) 1992-01-24
FR2623810A2 (fr) 1989-06-02
NO165924C (no) 1991-05-02
CA1336777C (en) 1995-08-22
JPS63203684A (ja) 1988-08-23
HRP920923B1 (en) 2001-12-31
AR243891A1 (es) 1993-09-30
ATE121745T1 (de) 1995-05-15

Similar Documents

Publication Publication Date Title
CS274420B2 (en) Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production
TWI290927B (en) 2-Acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine acid-additive salts
FI67369B (fi) Foerfarande foer framstaellning av nya terapeutiskt aktiva derivat av 3,4-dehydroprolin
CA3111725C (en) 2,6-diamino pyridine compounds
EP0567107B1 (de) Chinolin und Chinazolin Derivate zur Behandlung von Arthritis
EP0816338B1 (de) 3-(bis-substituierte-phenylmethylen)oxindol-derivate
PT91783B (pt) Processo para a preparacao de {(diarilmetoxi) alquil}-1-pirrolidinas e piperidinas
EP0011447B1 (de) Die Blutplättchenaggregation inhibierende Derivate der 1-Benzyl-1,2,5,6-tetrahydropyridin-3-carbonsäure und ihre Salze, diese Verbindungen enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
CZ290711B6 (cs) 1-Arylcykloalkylsulfidy, -sulfoxidy a -sulfony, způsob jejich přípravy, farmaceutický prostředek s jejich obsahem a použití
US4668674A (en) (+)-6-chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)-acetyl]-11H-dibenzo[b,][1,4]diazepin-11-one, the isolation thereof and its use as a pharmaceutical material
US4031223A (en) Trifluoromethylthio derivatives of cyproheptadine
JPH0559117B2 (de)
JPS6341460A (ja) 新規なジヒドロピリジン誘導体
US5310750A (en) Heterocyclic compounds useful as α2 -adrenoceptor antagonists
HU191938B (en) Process for production of new derivatives of 9 and 11 nitro-apovincamin acid
FR2555580A1 (fr) Nouveaux composes azabicycliques, procede pour les preparer et medicaments les contenant
KR100742134B1 (ko) 결정성Ｓ-(+)-메틸-2-(2-클로로페닐)-2-(6,7-디히드로티에노[3,2-ｃ]피리딘-5(4Ｈ)-일)아세테이트·캄실레이트를 포함하는약학적 조성물
CA1144545A (en) Carboxylic acid derivatives
IE893103A1 (en) "A process for the preparation of a 1,4-dihydropyridine derivative, namely (-)-2-{[2-(2-aminoethoxy)ethoxy] methyl}-4-(2,3-dichlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine, and its salts"
CN116947743A (zh) 一类亚硝基硫醇化合物及其合成方法、用途
JPS6021156B2 (ja) ベンゾチエピン誘導体およびその製法
FR2459242A1 (fr) Derives du benzimidazole portant en position 1 une chaine aralkyle substituee, leur procede de preparation et leur application en therapeutique
KR20050099445A (ko) 결정성 클로피도그렐 나프탈렌술폰산염 또는 이의 수화물,이의 제조방법 및 이를 함유하는 약학적 조성물
WO2004052966A1 (en) A novel polymorph of clopidogrel hydrogen sulfate
DD272085A5 (de) Verfahren zur herstellung des rechtsdrehenden isomeren von alpha-(4,5,6,7-tetrahydro-(3,2-c)-thieno-5-pyridyl)-(2-chlor-phenyl)-essigsaeure--methylester

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20080216