FR2612929B1 - Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant - Google Patents

Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant

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Publication number
FR2612929B1
FR2612929B1 FR8702025A FR8702025A FR2612929B1 FR 2612929 B1 FR2612929 B1 FR 2612929B1 FR 8702025 A FR8702025 A FR 8702025A FR 8702025 A FR8702025 A FR 8702025A FR 2612929 B1 FR2612929 B1 FR 2612929B1
Authority
FR
France
Prior art keywords
metyl
thieno
tetrahydro
pyridyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8702025A
Other languages
English (en)
Other versions
FR2612929A1 (fr
Inventor
Alain Badorc
Daniel Frehel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8702025A priority Critical patent/FR2612929B1/fr
Priority to FR878716516A priority patent/FR2623810B2/fr
Priority to IE27388A priority patent/IE66922B1/en
Priority to IL85294A priority patent/IL85294A/xx
Priority to AU11292/88A priority patent/AU597784B2/en
Priority to YU23188A priority patent/YU46748B/sh
Priority to SI8810231A priority patent/SI8810231A8/sl
Priority to MYPI88000121A priority patent/MY103198A/en
Priority to CA000558412A priority patent/CA1336777C/fr
Priority to PT86726A priority patent/PT86726B/pt
Priority to ZA880933A priority patent/ZA88933B/xx
Priority to NZ223475A priority patent/NZ223475A/xx
Priority to PH36488A priority patent/PH25960A/en
Priority to US07/155,550 priority patent/US4847265A/en
Priority to DD88312923A priority patent/DD272085A5/de
Priority to TNTNSN88012A priority patent/TNSN88012A1/fr
Priority to MA21421A priority patent/MA21184A1/fr
Priority to JP63034943A priority patent/JPH0645622B2/ja
Priority to AR88310091A priority patent/AR243891A1/es
Priority to CS96588A priority patent/CS274420B2/cs
Priority to KR1019880001714A priority patent/KR960003615B1/ko
Priority to AT88400346T priority patent/ATE121745T1/de
Priority to DE3853643T priority patent/DE3853643T2/de
Priority to PL1988270677A priority patent/PL156689B1/pl
Priority to HU88747A priority patent/HU197909B/hu
Priority to ES88400346T priority patent/ES2071621T4/es
Priority to EP88400346A priority patent/EP0281459B1/fr
Priority to NO880666A priority patent/NO165924C/no
Priority to RO132221A priority patent/RO99191B1/ro
Priority to DK198800800A priority patent/DK173636B1/da
Priority to FI880720A priority patent/FI87216C/fi
Priority to OA59285A priority patent/OA08808A/fr
Priority to DE1998175053 priority patent/DE19875053I2/de
Publication of FR2612929A1 publication Critical patent/FR2612929A1/fr
Application granted granted Critical
Publication of FR2612929B1 publication Critical patent/FR2612929B1/fr
Priority to MX9203026A priority patent/MX9203026A/es
Priority to HR920923A priority patent/HRP920923B1/xx
Priority to HU95P/P00071P priority patent/HU210538A9/hu
Priority to LV960270A priority patent/LV5804B4/xx
Priority to HK97101520A priority patent/HK1000093A1/xx
Priority to CY9800003A priority patent/CY2087B1/xx
Priority to LU90324C priority patent/LU90324I2/fr
Priority to NL990002C priority patent/NL990002I1/nl
Priority to NO1999022C priority patent/NO1999022I1/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8702025A 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant Expired - Lifetime FR2612929B1 (fr)

Priority Applications (42)

Application Number Priority Date Filing Date Title
FR8702025A FR2612929B1 (fr) 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant
FR878716516A FR2623810B2 (fr) 1987-02-17 1987-11-27 Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
IE27388A IE66922B1 (en) 1987-02-17 1988-02-01 Dextrorotatory enantiomer of alpha-(4,5,6,7-tetrahydrothieno [3,2-c]pyrid-5-yl) (2-chlorophenyl)methyl acetate a process for its preparation and the pharmaceutical compositions containing it
IL85294A IL85294A (en) 1987-02-17 1988-02-02 Dextro-rotatory enantiomer of methyl alpha-(4,5,6,7-tetrahydrothieno(3,2-c)(pyrid-5-yl)-(2-chlorophenyl)-acetate,its preparation and pharmaceutical composition containing it
AU11292/88A AU597784B2 (en) 1987-02-17 1988-02-04 Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c) thieno pyridyl) (2-chlorophenyl)-acetate, a process for its preparation and the pharmaceutical compositions containing it
SI8810231A SI8810231A8 (en) 1987-02-17 1988-02-05 Dextro-rotatory enantiomer of methyl alpha-(4,5,6,7-tetrahydro-thieno(3,2-c)pyrid-5-yl)-(2-chlorophenyl)- acetate, its salts and a process for its preparation
YU23188A YU46748B (sh) 1987-02-17 1988-02-05 Dekstrogiri enantiomer metil alfa (4,5,6,7-tetrahidro-tien/,3,2-c/ pirid-5-il)-(2-hlorofenil)-acetata, njegove soli i postupak za dobijanje
MYPI88000121A MY103198A (en) 1987-02-17 1988-02-08 Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate, a process for its preparation and the pharmaceutical compositions containing it
CA000558412A CA1336777C (fr) 1987-02-17 1988-02-08 Enantiomere dextrogyre de l'acetate de methyl-alpha-5-(4,5,6,7-tetrahydro-(2,3-c) compositions pharmaceutiques le renfermant
PT86726A PT86726B (pt) 1987-02-17 1988-02-09 Processo para a preparacao do enantiomero dextrogiro do alfa-(4,5,6,7-tetra-hidro-5-tieno(3,2-c)piridil)(2-clorofenil)-acetato de metilo
ZA880933A ZA88933B (en) 1987-02-17 1988-02-10 Dextro-rotatory enantiomer of methyl alpha-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl)(2-chlorophenyl)-acetate,a process for its preparation and the pharmaceutical compositions containing it
NZ223475A NZ223475A (en) 1987-02-17 1988-02-10 Dextrorotatory isomer of methyl alpha-5(4,5,6,7-tetrahydro (3,2-c) thienopyridyl) (2-chlorophenyl)-acetate and medicaments
PH36488A PH25960A (en) 1987-02-17 1988-02-11 Dextro-rotatory enantiomer of methyl alpha-5-(4,5-6,7-tetrahydro (3,2-C) thieno pyridyl (2-chloro-phenyl) acetate and the pharmaceutical compositions containing it
US07/155,550 US4847265A (en) 1987-02-17 1988-02-12 Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c) thieno pyridyl) (2-chlorophenyl)-acetate and the pharmaceutical compositions containing it
TNTNSN88012A TNSN88012A1 (fr) 1987-02-17 1988-02-15 Procede de preparation de l'enantiomere dextrogyre de l'alpha (tetrahydro-4,5,6,7 thieno (3,2-c) pyridyl - 5) (chloro -2 phenyl) acetate de methyle
MA21421A MA21184A1 (fr) 1987-02-17 1988-02-15 Procede de preparation de l'errantiomere dextrogyre de l'alpha-(tetrahydro-4,5,6,7thiero(3,2-c)pyridyl-5)(chloro-2 phenyl)-acetate de methyle.
DD88312923A DD272085A5 (de) 1987-02-17 1988-02-15 Verfahren zur herstellung des rechtsdrehenden isomeren von alpha-(4,5,6,7-tetrahydro-(3,2-c)-thieno-5-pyridyl)-(2-chlor-phenyl)-essigsaeure--methylester
DE1998175053 DE19875053I2 (de) 1987-02-17 1988-02-16 Rechtsdrehendes Enantiomer von alpha-(4,5,6,7-Tetrahydrothieno 3,2-c pyrid-5-yl)(2-chlorphenyl)methylacetat Verfahren zu seiner Herstellung und dieses enthaltende pharmazeutische Zubereitungen
CS96588A CS274420B2 (en) 1987-02-17 1988-02-16 Method of clock-wise isomer alpha-(4,5,6,7-tetrahydrothieno (3,2-c)-5-pyridyl)-)2-chlorphenyl) methylacetate production
KR1019880001714A KR960003615B1 (ko) 1987-02-17 1988-02-16 메틸 α-5(4,5,6,7-테트라하이드로(3,2-C)티에노 피리딜)(2-클로로페닐)-아세테이트의 우선성 광학이성체, 그 제법 및 그의 약제학적 조성물
AT88400346T ATE121745T1 (de) 1987-02-17 1988-02-16 Rechtsdrehendes enantiomer von alpha-(4,5,6,7- tetrahydrothieno(3,2-c>pyrid-5-yl)(2- chlorphenyl)methylacetat, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zubereitungen.
DE3853643T DE3853643T2 (de) 1987-02-17 1988-02-16 Rechtsdrehendes Enantiomer von alpha-(4,5,6,7-Tetrahydrothieno[3,2-c]pyrid-5-yl)(2-chlorphenyl)methylacetat, Verfahren zu seiner Herstellung und dieses enthaltende pharmazeutische Zubereitungen.
JP63034943A JPH0645622B2 (ja) 1987-02-17 1988-02-16 右旋性α−５−（４，５，６，７−テトラヒドロ［３，２−ｃチエノピリジル）−（２−クロロフェニル）酢酸メチル、その製法および医薬
HU88747A HU197909B (en) 1987-02-17 1988-02-16 Process for producing the dextrorotating enanthiomer and salts of methyl-alpha-square brackets open 5-(4,5,6,7-tetrahydrothieno square brackets open 3,2-c square brackets closed pyridyl) square brackets closed-alpha-(2-chlorophenyl)-acetate and pharmaceutical compositions comprising these compounds
ES88400346T ES2071621T4 (es) 1987-02-17 1988-02-16 Enantiómero dextrogiro del alfa-(tetrahidro-4,5,6,7-tieno-(3,2-c)-piridil-5)(cloro-2-fenil) acetato de metilo, su procedimiento de preparación y las composiciones farmacéuticas que lo contienen.
EP88400346A EP0281459B1 (fr) 1987-02-17 1988-02-16 Enantiomère dextrogyre de l'alpha-(tétrahydro-4,5,6,7 thiéno (3,2-c)pyridyl-5) (chloro-2 phényl)-acétate de méthyle, son procédé de préparation et les compositions pharmaceutiques le renfermant
NO880666A NO165924C (no) 1987-02-17 1988-02-16 Analogifremgangsmaate for fremstilling av den terapeutisk aktive hoeyredreiende enantiomer av metyl-alfa 5(4,5,6,7-tetrahydro (3,2-c)-tieno-pyridyl)-(2-klorfenyl)-acetat.
RO132221A RO99191B1 (ro) 1987-02-17 1988-02-16 Procedeu pentru prepararea enantiomerului dextrogir al alfa-(tetrahidro-4,5,6,7-tieno(3,2-c)-(5 piridil)-(2 clorfenil)-acetatului de metil
DK198800800A DK173636B1 (da) 1987-02-17 1988-02-16 Hydrogensulfatet af den højredrejende enantiomer af alfa-(4,5,6,7-tetrahydrothieno[3,2-c]-pyrid-5-yl)(2-chlorphenyl)-methylacetat, fremgangsmåde til fremtilling deraf og farmaceutiske præparater, der indeholder denne forbindelse
FI880720A FI87216C (fi) 1987-02-17 1988-02-16 Foerfarande foer framstaellning av en hoegervridande enantiomer av metyl-alfa-5-(4,5,6,7-tetrahydro(3,2-c)tienopyridyl)-(2-klorfenyl)acetat
OA59285A OA08808A (fr) 1987-02-17 1988-02-16 Enantiomère dextrogyre de l'alpha-(tétrahydro-4,5,6,7 thiéno (3,2-c) pyridyl-5) (chloro-2 phényl)-acétate de méthyle, son procédé de préparation et les compositions pharmaceutiques le renfermant.
AR88310091A AR243891A1 (es) 1987-02-17 1988-02-16 Procedimiento de preparacion del enantiomero dextrogiro del alfa-(tetrahidro-4,5,6,7-tieno)(3,2-c)-piridil-5-)-(cloro-2-fenil)-acetato de metilo.
PL1988270677A PL156689B1 (en) 1987-02-17 1988-02-16 Method for manufacturing dextrorotatory -(4,5,6,7-tetra-hydro)3,2-c(tienopyridyl-5)(2-chlorphenyl) methyl acetate
MX9203026A MX9203026A (es) 1987-02-17 1992-06-19 Enantiomero dextrogiro del alfa-(tetrahidro-4,5,5-tieno (3,2-c) piridil-5) (cloro-2 fenil)-acetato de metilo y composiciones farmaceuticas que lo contienen.
HR920923A HRP920923B1 (en) 1987-02-17 1992-10-02 Dextrorotatory enantiomer of alpha-(4,5,6,7-tetrahydrothieno/3,2-c/pyrid-5-yl) (2-chlorophenyl)methyl acetate, its salts, and process for its preparation
HU95P/P00071P HU210538A9 (en) 1987-02-17 1995-02-01 Dextro-rotatory enantiomer of methyl alpha-5 (4,5,6,7-tetrahydro (3,2-c) thieno pyridyl) (2-chlorophenyl)-acetate, a process for its preparation and the pharmaceutical compositions containing it
LV960270A LV5804B4 (lv) 1987-02-17 1996-07-18 Alfa-(4,5,6,7-Tetrahidrotieno Ú3,2-c¾pirid-5-il)(2-hlorfenil)metilacetata enantiomers (labais antipods), ta iegusanas panemiens un to saturosas farmaceitiskas kompozicijas
HK97101520A HK1000093A1 (en) 1987-02-17 1997-07-08 Dextrorotary enantiomer of alpha-(4,5,6,7-tetrahydrothienod3,2-capyrid-5-yl)(2-chlorophenyl)methyl acetate process for its preparation and pharmaceutical c
CY9800003A CY2087B1 (en) 1987-02-17 1998-04-13 Dextrorotatory enantiomer of alpha- (4,5,6,7-tetrahydrothienoA3,2-cuepyrid-5-yl) (2-chlorophenyl) methyl acetate process for its preparation and pharmace utical compositions containing it
LU90324C LU90324I2 (fr) 1987-02-17 1998-11-27 Plavix-clopidogrel
NL990002C NL990002I1 (nl) 1987-02-17 1999-01-07 Rechtsdraaiend enenantiomeer van alfa (4,5,6,7-tetrahydrothienoÄ3,2-cÄ007fÜ-pyrid-5-yl)(2-chloorfenyl) methylacetaat, werkwijze voor de bereiding daarvan en deze bevattende farmaceutische preparaten.
NO1999022C NO1999022I1 (no) 1987-02-17 1999-10-11 Clopidogrel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8702025A FR2612929B1 (fr) 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant

Publications (2)

Publication Number Publication Date
FR2612929A1 FR2612929A1 (fr) 1988-09-30
FR2612929B1 true FR2612929B1 (fr) 1990-02-09

Family

ID=9348009

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8702025A Expired - Lifetime FR2612929B1 (fr) 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant

Country Status (3)

Country Link
DD (1) DD272085A5 (fr)
FR (1) FR2612929B1 (fr)
ZA (1) ZA88933B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1980563A1 (fr) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procédure pour la préparation d'acétate de méthyle (+)-(S)-alpha-(O-chlorophényl)-6,7-dihydrothiéno-[3,2-C]pyridine-5(4H)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
FR2612929A1 (fr) 1988-09-30
DD272085A5 (de) 1989-09-27
ZA88933B (en) 1988-08-09

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