CS235018B2 - Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation - Google Patents

Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation Download PDF

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Publication number
CS235018B2
CS235018B2 CS823735A CS373582A CS235018B2 CS 235018 B2 CS235018 B2 CS 235018B2 CS 823735 A CS823735 A CS 823735A CS 373582 A CS373582 A CS 373582A CS 235018 B2 CS235018 B2 CS 235018B2
Authority
CS
Czechoslovakia
Prior art keywords
guanine
formula
propoxymethyl
compound
dihydroxy
Prior art date
Application number
CS823735A
Other languages
Czech (cs)
English (en)
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS235018(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of CS235018B2 publication Critical patent/CS235018B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS823735A 1981-05-21 1982-05-20 Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation CS235018B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
CS235018B2 true CS235018B2 (en) 1985-04-16

Family

ID=23017790

Family Applications (4)

Application Number Title Priority Date Filing Date
CS823735A CS235018B2 (en) 1981-05-21 1982-05-20 Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation
CS834404A CS235044B2 (en) 1981-05-21 1982-05-20 Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production
CS834402A CS235042B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3- dihydroxy-2-propomethyl ) p-guanin preparation
CS834403A CS235043B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3-dihydroxy-2-propoxymethyl)p-guanin preparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
CS834404A CS235044B2 (en) 1981-05-21 1982-05-20 Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production
CS834402A CS235042B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3- dihydroxy-2-propomethyl ) p-guanin preparation
CS834403A CS235043B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3-dihydroxy-2-propoxymethyl)p-guanin preparation

Country Status (33)

Country Link
US (1) US4355032B2 (ja)
EP (1) EP0066208B1 (ja)
JP (2) JPS57203086A (ja)
KR (1) KR890004663B1 (ja)
AR (1) AR244227A1 (ja)
AT (1) ATE15899T1 (ja)
AU (1) AU572086B2 (ja)
BR (1) BR8202931A (ja)
CA (3) CA1305140C (ja)
CS (4) CS235018B2 (ja)
DD (2) DD203052A5 (ja)
DE (1) DE3266644D1 (ja)
DK (2) DK150304C (ja)
ES (7) ES512414A0 (ja)
FI (1) FI73682C (ja)
GR (1) GR76459B (ja)
HK (1) HK67088A (ja)
HU (2) HU188000B (ja)
IE (1) IE53731B1 (ja)
IL (1) IL65836A (ja)
IN (1) IN156469B (ja)
LU (1) LU88334I2 (ja)
MY (1) MY8700793A (ja)
NL (2) NL930022I1 (ja)
NO (2) NO161740C (ja)
NZ (1) NZ200691A (ja)
PH (1) PH17975A (ja)
PL (4) PL136579B1 (ja)
PT (1) PT74934B (ja)
RO (2) RO87387B (ja)
SG (1) SG81687G (ja)
SU (1) SU1176841A3 (ja)
ZA (1) ZA823532B (ja)

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NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
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US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
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SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
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ATE123285T1 (de) * 1988-12-19 1995-06-15 Wellcome Found Antivirale pyrimidin- und purinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate.
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
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ATE178605T1 (de) * 1993-06-23 1999-04-15 Merrell Pharma Inc Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
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US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
NZ201547A (en) * 1981-08-11 1986-01-24 Wellcome Found Purine derivatives and antiviral compositions

Also Published As

Publication number Publication date
ES524899A0 (es) 1985-09-16
ES8701496A1 (es) 1987-01-01
NL930022I1 (nl) 1993-05-03
AU572086B2 (en) 1988-05-05
CS235044B2 (en) 1985-04-16
ES8507549A1 (es) 1985-09-16
DD213218A5 (de) 1984-09-05
DK504183A (da) 1983-11-03
LU88334I2 (fr) 1994-09-09
CS235043B2 (en) 1985-04-16
ES8606869A1 (es) 1986-05-16
ES533821A0 (es) 1985-06-16
SG81687G (en) 1989-07-07
DE3266644D1 (en) 1985-11-07
BR8202931A (pt) 1983-05-03
NO161740C (no) 1989-09-20
PL136332B1 (en) 1986-02-28
AU8389282A (en) 1982-11-25
JPS57203086A (en) 1982-12-13
DK227782A (da) 1982-11-22
IN156469B (ja) 1985-08-10
DD203052A5 (de) 1983-10-12
HU188000B (en) 1986-03-28
ES8404355A1 (es) 1984-05-01
CA1305140C (en) 1992-07-14
NL930139I2 (nl) 1997-07-01
IL65836A0 (en) 1982-08-31
PT74934B (en) 1984-05-08
CS235042B2 (en) 1985-04-16
GR76459B (ja) 1984-08-10
ES8601204A1 (es) 1985-11-16
US4355032B1 (ja) 1983-06-14
PL136004B1 (en) 1986-01-31
RO84860B (ro) 1984-10-30
IE821210L (en) 1982-11-21
ES529383A0 (es) 1986-05-16
NO161740B (no) 1989-06-12
FI821794A0 (fi) 1982-05-20
DK149001C (da) 1988-11-28
EP0066208A1 (en) 1982-12-08
RO87387A (ro) 1985-08-31
ES524900A0 (es) 1985-11-16
JPH04217983A (ja) 1992-08-07
PL136579B1 (en) 1986-02-28
FI73682B (fi) 1987-07-31
FI73682C (fi) 1987-11-09
SU1176841A3 (ru) 1985-08-30
NZ200691A (en) 1986-11-12
MY8700793A (en) 1987-12-31
ES8505681A1 (es) 1985-06-16
DK150304C (da) 1988-01-04
DK504183D0 (da) 1983-11-03
PL242101A1 (en) 1984-07-16
CA1305139C (en) 1992-07-14
AR244227A1 (es) 1993-10-29
JPH0529399B2 (ja) 1993-04-30
PH17975A (en) 1985-02-22
RO87387B (ro) 1985-08-31
ES520849A0 (es) 1984-11-01
PL246770A1 (en) 1984-08-27
HU186514B (en) 1985-08-28
PL242100A1 (en) 1984-04-24
NO1994005I1 (no) 1994-07-29
PL136637B1 (en) 1986-03-31
ES512414A0 (es) 1984-05-01
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
IE53731B1 (en) 1989-02-01
ES529384A0 (es) 1987-01-01
US4355032A (en) 1982-10-19
KR830010112A (ko) 1983-12-26
NL930139I1 (nl) 1993-11-01
NO821676L (no) 1982-11-22
US4355032B2 (en) 1990-10-30
ZA823532B (en) 1983-03-30
PT74934A (en) 1982-06-01
JPH046195B2 (ja) 1992-02-05
IL65836A (en) 1991-04-15
KR890004663B1 (ko) 1989-11-24
ES8500276A1 (es) 1984-11-01
ATE15899T1 (de) 1985-10-15
PL236521A1 (en) 1984-01-02
RO84860A (ro) 1984-09-29
DK149001B (da) 1985-12-16
HK67088A (en) 1988-09-02
CA1305141C (en) 1992-07-14

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