CS199527B2 - Manufacturing process of the steady antibiotic agent - Google Patents

Manufacturing process of the steady antibiotic agent Download PDF

Info

Publication number
CS199527B2
CS199527B2 CS782444A CS244478A CS199527B2 CS 199527 B2 CS199527 B2 CS 199527B2 CS 782444 A CS782444 A CS 782444A CS 244478 A CS244478 A CS 244478A CS 199527 B2 CS199527 B2 CS 199527B2
Authority
CS
Czechoslovakia
Prior art keywords
solution
doxycycline
magnesium
oxytetracycline
caprolactam
Prior art date
Application number
CS782444A
Other languages
Czech (cs)
English (en)
Inventor
William W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS199527B2 publication Critical patent/CS199527B2/cs

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CS782444A 1977-04-27 1978-04-14 Manufacturing process of the steady antibiotic agent CS199527B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
CS199527B2 true CS199527B2 (en) 1980-07-31

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
CS782444A CS199527B2 (en) 1977-04-27 1978-04-14 Manufacturing process of the steady antibiotic agent

Country Status (38)

Country Link
US (1) US4126680A (ro)
JP (1) JPS53136514A (ro)
AR (1) AR217844A1 (ro)
AT (1) AT360148B (ro)
AU (1) AU503139B1 (ro)
BE (1) BE866419A (ro)
BG (1) BG47943A3 (ro)
CA (1) CA1100875A (ro)
CH (1) CH630260A5 (ro)
CS (1) CS199527B2 (ro)
DD (1) DD135445A5 (ro)
DE (1) DE2817335C3 (ro)
DK (1) DK155977C (ro)
EG (1) EG14348A (ro)
ES (1) ES468749A1 (ro)
FI (3) FI801196A7 (ro)
FR (1) FR2388561A1 (ro)
GB (1) GB1563478A (ro)
GR (1) GR70062B (ro)
HU (1) HU179050B (ro)
IE (1) IE47049B1 (ro)
IL (1) IL54581A0 (ro)
IN (1) IN148197B (ro)
IT (1) IT1094557B (ro)
LU (1) LU79547A1 (ro)
MX (1) MX6087E (ro)
NL (1) NL7804455A (ro)
NO (1) NO148280C (ro)
NZ (1) NZ187046A (ro)
OA (1) OA05949A (ro)
PH (1) PH12962A (ro)
PL (1) PL110459B1 (ro)
PT (1) PT67895B (ro)
RO (2) RO77953A (ro)
SE (1) SE443507B (ro)
YU (1) YU87178A (ro)
ZA (1) ZA782400B (ro)
ZM (1) ZM3878A1 (ro)

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US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP1666453A1 (en) 1999-09-14 2006-06-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CA2397863A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
ES2288945T3 (es) * 2000-03-31 2008-02-01 Trustees Of Tufts College Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos.
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AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
EA006170B1 (ru) 2000-07-07 2005-10-27 Трастис Оф Тафтс Коллидж Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1301465A2 (en) 2000-07-07 2003-04-16 Trustees Of Tufts College 13-substituted methacycline compounds
DE60144375D1 (de) 2000-07-07 2011-05-19 Trustees Of Tufts College Medford 7-, 8- und 9-substitutierte tetracyclinverbindungen
SI1301467T1 (sl) 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US6683068B2 (en) * 2001-03-13 2004-01-27 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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CA2440757A1 (en) 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
US6841546B2 (en) 2001-03-14 2005-01-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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JP2005526754A (ja) 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
JP2005520846A (ja) 2002-03-21 2005-07-14 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物。
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AU2003287218C1 (en) 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
PT2109602E (pt) 2006-12-21 2014-05-23 Paratek Pharm Innc Derivados de tetraciclina para o tratamento de infecções bacterianas, virais e parasitárias
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US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
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GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
DK155977B (da) 1989-06-12
AU503139B1 (en) 1979-08-23
DD135445A5 (de) 1979-05-09
NZ187046A (en) 1980-03-05
AT360148B (de) 1980-12-29
JPS5632290B2 (ro) 1981-07-27
IN148197B (ro) 1980-11-29
IE47049B1 (en) 1983-12-14
IL54581A0 (en) 1978-07-31
DE2817335B2 (de) 1981-06-11
ES468749A1 (es) 1979-01-01
EG14348A (en) 1984-09-30
IT7822720A0 (it) 1978-04-26
IT1094557B (it) 1985-08-02
US4126680A (en) 1978-11-21
PT67895A (en) 1978-05-01
PL110459B1 (en) 1980-07-31
JPS53136514A (en) 1978-11-29
LU79547A1 (fr) 1979-11-07
ATA300478A (de) 1980-05-15
RO75099A (ro) 1980-12-30
BE866419A (fr) 1978-10-26
NO781457L (no) 1978-10-30
MX6087E (es) 1984-11-08
GB1563478A (en) 1980-03-26
NO148280B (no) 1983-06-06
HU179050B (en) 1982-08-28
FI801197A7 (fi) 1981-01-01
ZM3878A1 (en) 1978-11-21
FI781300A7 (fi) 1978-10-28
CH630260A5 (fr) 1982-06-15
FI801196A7 (fi) 1981-01-01
NO148280C (no) 1983-09-21
DE2817335A1 (de) 1978-11-16
IE780828L (en) 1978-10-27
YU87178A (en) 1984-04-30
GR70062B (ro) 1982-07-26
RO77953A (ro) 1981-12-25
BG47943A3 (bg) 1990-10-15
DK182578A (da) 1978-10-28
AR217844A1 (es) 1980-04-30
PT67895B (en) 1979-11-14
FR2388561A1 (fr) 1978-11-24
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
PH12962A (en) 1979-10-19
CA1100875A (en) 1981-05-12
OA05949A (fr) 1981-06-30
DE2817335C3 (de) 1982-04-22
FR2388561B1 (ro) 1980-07-18
NL7804455A (nl) 1978-10-31
ZA782400B (en) 1979-04-25
DK155977C (da) 1989-10-30
SE443507B (sv) 1986-03-03

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