RO75099A - Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina - Google Patents

Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina

Info

Publication number
RO75099A
RO75099A RO7893756A RO9375678A RO75099A RO 75099 A RO75099 A RO 75099A RO 7893756 A RO7893756 A RO 7893756A RO 9375678 A RO9375678 A RO 9375678A RO 75099 A RO75099 A RO 75099A
Authority
RO
Romania
Prior art keywords
stability
procedure
preparation
antibiotic
tetracycline
Prior art date
Application number
RO7893756A
Other languages
English (en)
French (fr)
Inventor
William W Armstrong
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of RO75099A publication Critical patent/RO75099A/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RO7893756A 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina RO75099A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
RO75099A true RO75099A (ro) 1980-12-30

Family

ID=25154289

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7893756A RO75099A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina
RO78102215A RO77953A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile continin clortetraciclina

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO78102215A RO77953A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile continin clortetraciclina

Country Status (38)

Country Link
US (1) US4126680A (ro)
JP (1) JPS53136514A (ro)
AR (1) AR217844A1 (ro)
AT (1) AT360148B (ro)
AU (1) AU503139B1 (ro)
BE (1) BE866419A (ro)
BG (1) BG47943A3 (ro)
CA (1) CA1100875A (ro)
CH (1) CH630260A5 (ro)
CS (1) CS199527B2 (ro)
DD (1) DD135445A5 (ro)
DE (1) DE2817335C3 (ro)
DK (1) DK155977C (ro)
EG (1) EG14348A (ro)
ES (1) ES468749A1 (ro)
FI (3) FI801197A7 (ro)
FR (1) FR2388561A1 (ro)
GB (1) GB1563478A (ro)
GR (1) GR70062B (ro)
HU (1) HU179050B (ro)
IE (1) IE47049B1 (ro)
IL (1) IL54581A0 (ro)
IN (1) IN148197B (ro)
IT (1) IT1094557B (ro)
LU (1) LU79547A1 (ro)
MX (1) MX6087E (ro)
NL (1) NL7804455A (ro)
NO (1) NO148280C (ro)
NZ (1) NZ187046A (ro)
OA (1) OA05949A (ro)
PH (1) PH12962A (ro)
PL (1) PL110459B1 (ro)
PT (1) PT67895B (ro)
RO (2) RO75099A (ro)
SE (1) SE443507B (ro)
YU (1) YU87178A (ro)
ZA (1) ZA782400B (ro)
ZM (1) ZM3878A1 (ro)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EA016099B1 (ru) 1999-09-14 2012-02-28 Трастис Оф Тафтс Коллидж Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CA2397863A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
IL151971A0 (en) * 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
EP2308863A1 (en) 2000-05-15 2011-04-13 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20020128238A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EA200300136A1 (ru) 2000-07-07 2003-06-26 Трастис Оф Тафтс Коллидж 13-замещенное соединение метациклина (варианты) и способ его получения (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
EP2166000A1 (en) 2000-07-07 2010-03-24 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
EA013908B1 (ru) 2000-07-07 2010-08-30 Трастис Оф Тафтс Коллидж Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
AU2001271642B2 (en) 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EA201000388A1 (ru) 2001-03-13 2010-10-29 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EP1379255A2 (en) * 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
EP2186793A1 (en) 2001-04-24 2010-05-19 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP1482926A4 (en) 2002-03-08 2006-04-12 Paratek Pharm Innc AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
KR101083498B1 (ko) 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
CA2492273C (en) 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
CA2502464A1 (en) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2005009944A1 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2319828A3 (en) 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
US7786099B2 (en) * 2004-01-15 2010-08-31 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
AU2005299569B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
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US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
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US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
JP2009524675A (ja) 2006-01-24 2009-07-02 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリンの経口バイオアベイラビリティーを増加する方法
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
AU2007249695A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
EP2452935A3 (en) 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
DK2120963T3 (en) 2006-12-21 2019-01-14 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS
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AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
AU2008239606A1 (en) * 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
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BRPI0823405A2 (pt) 2007-07-06 2012-12-25 Paratek Pharmaceuticals, Inc. mÉtodos para sintetizar compostos de tetraciclina substituÍda
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PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
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US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
EP2805732B1 (en) * 2013-05-20 2016-09-28 Fundación Comunidad Valenciana Centro de Investigación Principe Felipe Polymer-drug conjugates for the treatment of amyloidosis
MX2017012062A (es) 2015-03-23 2018-06-18 Biopharmx Inc Composicion farmaceutica de tetraciclina para uso dermatologico.
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US20200222432A1 (en) 2017-07-21 2020-07-16 Almirall, Llc. Treatment of non-inflammatory lesions
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Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
DK155977C (da) 1989-10-30
FI801197A7 (fi) 1981-01-01
IT1094557B (it) 1985-08-02
NO781457L (no) 1978-10-30
IL54581A0 (en) 1978-07-31
JPS53136514A (en) 1978-11-29
BE866419A (fr) 1978-10-26
IT7822720A0 (it) 1978-04-26
IN148197B (ro) 1980-11-29
OA05949A (fr) 1981-06-30
DK155977B (da) 1989-06-12
PH12962A (en) 1979-10-19
DK182578A (da) 1978-10-28
GB1563478A (en) 1980-03-26
PL110459B1 (en) 1980-07-31
BG47943A3 (bg) 1990-10-15
IE780828L (en) 1978-10-27
AU503139B1 (en) 1979-08-23
NO148280C (no) 1983-09-21
DE2817335C3 (de) 1982-04-22
CH630260A5 (fr) 1982-06-15
LU79547A1 (fr) 1979-11-07
YU87178A (en) 1984-04-30
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
MX6087E (es) 1984-11-08
DE2817335B2 (de) 1981-06-11
ZA782400B (en) 1979-04-25
DD135445A5 (de) 1979-05-09
NZ187046A (en) 1980-03-05
RO77953A (ro) 1981-12-25
FI781300A7 (fi) 1978-10-28
ES468749A1 (es) 1979-01-01
HU179050B (en) 1982-08-28
NL7804455A (nl) 1978-10-31
PT67895A (en) 1978-05-01
DE2817335A1 (de) 1978-11-16
CA1100875A (en) 1981-05-12
FI801196A7 (fi) 1981-01-01
IE47049B1 (en) 1983-12-14
AR217844A1 (es) 1980-04-30
CS199527B2 (en) 1980-07-31
PT67895B (en) 1979-11-14
EG14348A (en) 1984-09-30
SE443507B (sv) 1986-03-03
NO148280B (no) 1983-06-06
US4126680A (en) 1978-11-21
JPS5632290B2 (ro) 1981-07-27
FR2388561B1 (ro) 1980-07-18
GR70062B (ro) 1982-07-26
ZM3878A1 (en) 1978-11-21
FR2388561A1 (fr) 1978-11-24
AT360148B (de) 1980-12-29
ATA300478A (de) 1980-05-15

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