RO77953A - Procedeu de preparare a unor compozitii stabile continin clortetraciclina - Google Patents

Procedeu de preparare a unor compozitii stabile continin clortetraciclina

Info

Publication number
RO77953A
RO77953A RO78102215A RO10221578A RO77953A RO 77953 A RO77953 A RO 77953A RO 78102215 A RO78102215 A RO 78102215A RO 10221578 A RO10221578 A RO 10221578A RO 77953 A RO77953 A RO 77953A
Authority
RO
Romania
Prior art keywords
chlortetracycline
compositions
stable
preparation
stable chlortetracycline
Prior art date
Application number
RO78102215A
Other languages
English (en)
French (fr)
Inventor
William W Amstrong
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of RO77953A publication Critical patent/RO77953A/ro

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
RO78102215A 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile continin clortetraciclina RO77953A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
RO77953A true RO77953A (ro) 1981-12-25

Family

ID=25154289

Family Applications (2)

Application Number Title Priority Date Filing Date
RO78102215A RO77953A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile continin clortetraciclina
RO7893756A RO75099A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7893756A RO75099A (ro) 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina

Country Status (38)

Country Link
US (1) US4126680A (ro)
JP (1) JPS53136514A (ro)
AR (1) AR217844A1 (ro)
AT (1) AT360148B (ro)
AU (1) AU503139B1 (ro)
BE (1) BE866419A (ro)
BG (1) BG47943A3 (ro)
CA (1) CA1100875A (ro)
CH (1) CH630260A5 (ro)
CS (1) CS199527B2 (ro)
DD (1) DD135445A5 (ro)
DE (1) DE2817335C3 (ro)
DK (1) DK155977C (ro)
EG (1) EG14348A (ro)
ES (1) ES468749A1 (ro)
FI (1) FI781300A (ro)
FR (1) FR2388561A1 (ro)
GB (1) GB1563478A (ro)
GR (1) GR70062B (ro)
HU (1) HU179050B (ro)
IE (1) IE47049B1 (ro)
IL (1) IL54581A0 (ro)
IN (1) IN148197B (ro)
IT (1) IT1094557B (ro)
LU (1) LU79547A1 (ro)
MX (1) MX6087E (ro)
NL (1) NL7804455A (ro)
NO (1) NO148280C (ro)
NZ (1) NZ187046A (ro)
OA (1) OA05949A (ro)
PH (1) PH12962A (ro)
PL (1) PL110459B1 (ro)
PT (1) PT67895B (ro)
RO (2) RO77953A (ro)
SE (1) SE443507B (ro)
YU (1) YU87178A (ro)
ZA (1) ZA782400B (ro)
ZM (1) ZM3878A1 (ro)

Families Citing this family (80)

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US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
ATE323671T1 (de) 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
CA2397863A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
EA200201046A1 (ru) 2000-03-31 2003-04-24 Трастис Оф Тафтс Коллидж 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
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US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US6624168B2 (en) 2000-07-07 2003-09-23 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
ATE544745T1 (de) 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
CN1452611A (zh) 2000-07-07 2003-10-29 塔夫茨大学信托人 13-取代甲烯土霉素化合物
CZ2003343A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7045507B2 (en) 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
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CA2444899C (en) 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP1482926A4 (en) 2002-03-08 2006-04-12 Paratek Pharm Innc AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
KR101025400B1 (ko) 2002-03-21 2011-03-28 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
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EP1848685A1 (en) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
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PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
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US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
BRPI0720569B8 (pt) 2006-12-21 2021-05-25 Paratek Pharm Innc compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
KR20090122994A (ko) * 2007-03-23 2009-12-01 몰레큘러 리서치 센터, 인크. 테트라사이클린류를 함유하는 항염증성 조성물 및 이의 치료 용도
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
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JP2010525069A (ja) 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
ES2386926T3 (es) 2007-07-06 2012-09-06 Paratek Pharmaceuticals, Inc. Métodos para sintetizar minociclina9-sustituida
US20090253660A1 (en) 2008-03-05 2009-10-08 Paratek Pharmaceuticals, Inc. Minocycline Compounds and Methods of Use Thereof
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JP6574572B2 (ja) 2011-05-12 2019-09-11 パラテック ファーマシューティカルズ インコーポレイテッド (4s,4as,5ar,12as)−4−ジメチルアミノ−3,10,12,12a−テトラヒドロキシ−7−[(メトキシ(メチル)アミノ)−メチル]−1,11−ジオキソ−1,4,4a,5,5a,6,11,12a−オクタヒドロ−ナフタセン−2−カルボン酸アミドの結晶塩及びそれを使用する方法
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
EP2805732B1 (en) * 2013-05-20 2016-09-28 Fundación Comunidad Valenciana Centro de Investigación Principe Felipe Polymer-drug conjugates for the treatment of amyloidosis
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RU2019113715A (ru) 2016-11-01 2020-12-03 Паратек Фармасьютикалс, Инк. 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп)
CN111343991A (zh) 2017-07-21 2020-06-26 阿尔米雷尔有限责任公司 非炎性病变的治疗
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
NO148280C (no) 1983-09-21
FR2388561A1 (fr) 1978-11-24
FI781300A (fi) 1978-10-28
PT67895A (en) 1978-05-01
NO781457L (no) 1978-10-30
EG14348A (en) 1984-09-30
ES468749A1 (es) 1979-01-01
AR217844A1 (es) 1980-04-30
DE2817335A1 (de) 1978-11-16
MX6087E (es) 1984-11-08
LU79547A1 (fr) 1979-11-07
CS199527B2 (en) 1980-07-31
ZM3878A1 (en) 1978-11-21
NO148280B (no) 1983-06-06
GB1563478A (en) 1980-03-26
PL110459B1 (en) 1980-07-31
CA1100875A (en) 1981-05-12
DD135445A5 (de) 1979-05-09
ATA300478A (de) 1980-05-15
SE443507B (sv) 1986-03-03
AT360148B (de) 1980-12-29
IT1094557B (it) 1985-08-02
BE866419A (fr) 1978-10-26
BG47943A3 (en) 1990-10-15
JPS5632290B2 (ro) 1981-07-27
IE780828L (en) 1978-10-27
DK182578A (da) 1978-10-28
ZA782400B (en) 1979-04-25
DE2817335C3 (de) 1982-04-22
CH630260A5 (fr) 1982-06-15
OA05949A (fr) 1981-06-30
NL7804455A (nl) 1978-10-31
DK155977B (da) 1989-06-12
DK155977C (da) 1989-10-30
IE47049B1 (en) 1983-12-14
IT7822720A0 (it) 1978-04-26
JPS53136514A (en) 1978-11-29
US4126680A (en) 1978-11-21
PH12962A (en) 1979-10-19
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
IL54581A0 (en) 1978-07-31
NZ187046A (en) 1980-03-05
IN148197B (ro) 1980-11-29
PT67895B (en) 1979-11-14
GR70062B (ro) 1982-07-26
FR2388561B1 (ro) 1980-07-18
HU179050B (en) 1982-08-28
DE2817335B2 (de) 1981-06-11
AU503139B1 (en) 1979-08-23
RO75099A (ro) 1980-12-30
YU87178A (en) 1984-04-30

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