RO77953A - Procedeu de preparare a unor compozitii stabile continin clortetraciclina - Google Patents
Procedeu de preparare a unor compozitii stabile continin clortetraciclinaInfo
- Publication number
- RO77953A RO77953A RO78102215A RO10221578A RO77953A RO 77953 A RO77953 A RO 77953A RO 78102215 A RO78102215 A RO 78102215A RO 10221578 A RO10221578 A RO 10221578A RO 77953 A RO77953 A RO 77953A
- Authority
- RO
- Romania
- Prior art keywords
- chlortetracycline
- compositions
- stable
- preparation
- stable chlortetracycline
- Prior art date
Links
- 239000004099 Chlortetracycline Substances 0.000 title 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 title 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 title 1
- 229960004475 chlortetracycline Drugs 0.000 title 1
- 235000019365 chlortetracycline Nutrition 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/791,627 US4126680A (en) | 1977-04-27 | 1977-04-27 | Tetracycline antibiotic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO77953A true RO77953A (ro) | 1981-12-25 |
Family
ID=25154289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7893756A RO75099A (ro) | 1977-04-27 | 1978-04-08 | Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina |
| RO78102215A RO77953A (ro) | 1977-04-27 | 1978-04-08 | Procedeu de preparare a unor compozitii stabile continin clortetraciclina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7893756A RO75099A (ro) | 1977-04-27 | 1978-04-08 | Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US4126680A (ro) |
| JP (1) | JPS53136514A (ro) |
| AR (1) | AR217844A1 (ro) |
| AT (1) | AT360148B (ro) |
| AU (1) | AU503139B1 (ro) |
| BE (1) | BE866419A (ro) |
| BG (1) | BG47943A3 (ro) |
| CA (1) | CA1100875A (ro) |
| CH (1) | CH630260A5 (ro) |
| CS (1) | CS199527B2 (ro) |
| DD (1) | DD135445A5 (ro) |
| DE (1) | DE2817335C3 (ro) |
| DK (1) | DK155977C (ro) |
| EG (1) | EG14348A (ro) |
| ES (1) | ES468749A1 (ro) |
| FI (3) | FI801197A7 (ro) |
| FR (1) | FR2388561A1 (ro) |
| GB (1) | GB1563478A (ro) |
| GR (1) | GR70062B (ro) |
| HU (1) | HU179050B (ro) |
| IE (1) | IE47049B1 (ro) |
| IL (1) | IL54581A0 (ro) |
| IN (1) | IN148197B (ro) |
| IT (1) | IT1094557B (ro) |
| LU (1) | LU79547A1 (ro) |
| MX (1) | MX6087E (ro) |
| NL (1) | NL7804455A (ro) |
| NO (1) | NO148280C (ro) |
| NZ (1) | NZ187046A (ro) |
| OA (1) | OA05949A (ro) |
| PH (1) | PH12962A (ro) |
| PL (1) | PL110459B1 (ro) |
| PT (1) | PT67895B (ro) |
| RO (2) | RO75099A (ro) |
| SE (1) | SE443507B (ro) |
| YU (1) | YU87178A (ro) |
| ZA (1) | ZA782400B (ro) |
| ZM (1) | ZM3878A1 (ro) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4386083A (en) * | 1980-04-10 | 1983-05-31 | Walter Hacke | Injectable oxytetracycline compositions |
| US4399127A (en) * | 1980-04-10 | 1983-08-16 | Diamond Shamrock Corporation | Injectable oxytetracycline compositions |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| EP0621033A1 (en) * | 1993-04-20 | 1994-10-26 | Nostras S.A. | Antibiotic composition containing oxytetracycline and glycofurol |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| EA016099B1 (ru) | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| CA2397863A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| CN1430600A (zh) | 2000-03-31 | 2003-07-16 | 塔夫茨大学信托人 | 7－和9－氨基甲酸酯、脲、硫脲、硫代氨基甲酸酯,和杂芳基－氨基取代的四环素化合物 |
| JP2003533504A (ja) | 2000-05-15 | 2003-11-11 | パラテック ファーマシューティカルズ インコーポレイテッド | ７置換型縮合環テトラサイクリン化合物 |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| WO2001098236A2 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| BRPI0112269B8 (pt) | 2000-07-07 | 2021-05-25 | Paratek Pharm Innc | composto de minociclina 9-aminometila substituída, e, composição farmacêutica |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| JP4963771B2 (ja) | 2000-07-07 | 2012-06-27 | トラスティーズ・オブ・タフツ・カレッジ | ７、８および９−置換テトラサイクリン化合物 |
| US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| EP2289871A1 (en) | 2000-07-07 | 2011-03-02 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
| IL153674A0 (en) | 2000-07-07 | 2003-07-06 | Tufts College | 13-substituted methacycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EP2301914A1 (en) | 2001-03-13 | 2011-03-30 | Paratek Pharmaceuticals, Inc. | 7,9-Substituted tetracycline compounds |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| CA2440757A1 (en) | 2001-03-14 | 2002-09-19 | Michael Draper | Substituted tetracycline compounds as synergistic antifungal agents |
| EP1379255A2 (en) | 2001-03-14 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| WO2002085303A2 (en) | 2001-04-24 | 2002-10-31 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP1474380A4 (en) * | 2002-01-08 | 2007-04-18 | Paratek Pharm Innc | 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS |
| CN101307017A (zh) | 2002-03-08 | 2008-11-19 | 帕拉特克药品公司 | 氨基-甲基取代的四环素类化合物 |
| CA2479877C (en) | 2002-03-21 | 2012-08-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
| JP2006503898A (ja) | 2002-10-24 | 2006-02-02 | パラテック ファーマシューティカルズ， インク． | マラリア治療のための置換テトラサイクリン化合物 |
| AU2004259659B2 (en) | 2003-07-09 | 2011-11-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2004259661B2 (en) | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US7485319B2 (en) * | 2003-07-25 | 2009-02-03 | Warner Chilcott Company, Inc. | Doxycycline metal complex in a solid dosage form |
| US7786099B2 (en) * | 2004-01-15 | 2010-08-31 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| EP2949644A3 (en) | 2004-10-25 | 2016-04-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7858601B2 (en) * | 2004-10-25 | 2010-12-28 | Paratek Pharmaceuticals, Inc. | 4-substituted tetracyclines and methods of use thereof |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
| US20080242642A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7544373B2 (en) * | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| WO2007087416A2 (en) * | 2006-01-24 | 2007-08-02 | Paratek Pharaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| EP2007713A2 (en) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolation of tetracycline derivatives |
| CN101479235B (zh) * | 2006-04-24 | 2013-09-18 | 特瓦制药工业有限公司 | 替加环素晶形及其制备方法 |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| EP2026776A2 (en) * | 2006-05-15 | 2009-02-25 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| ES2315123B1 (es) * | 2006-09-25 | 2009-12-30 | Divasa-Farmavic, S.A. | Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos. |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| EP2450347B1 (en) | 2006-12-21 | 2015-06-24 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| AU2007338681B2 (en) | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| JP5395052B2 (ja) * | 2007-03-23 | 2014-01-22 | モレキュラー リサーチ センター インコーポレイテッド | 炎症を処置するための組成物および方法 |
| AU2012230089B2 (en) * | 2007-03-23 | 2013-11-21 | Molecular Research Center, Inc. | Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy |
| US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
| CA2688725A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| CA2688662A1 (en) | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2192111A3 (en) | 2007-07-06 | 2010-10-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing substituted tetracycline compounds |
| RU2010140682A (ru) | 2008-03-05 | 2012-04-10 | Пэрэтек Фамэсьютикэлс, Инк. (US) | Способ лечения пациента от инфекции, фармацевтическая композиция (варианты) и лекарственное средство |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| TW202332671A (zh) | 2008-05-19 | 2023-08-16 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| EP2341771A4 (en) * | 2008-09-19 | 2012-08-15 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED THERAPEUTIC METHODS |
| JP2012523438A (ja) | 2009-04-10 | 2012-10-04 | タフツ メディカル センター インコーポレイテッド | メタロプロテイナーゼ−１（ｍｍｐ−１）によるｐａｒ−１活性化 |
| US9255068B2 (en) | 2011-05-12 | 2016-02-09 | Warner Chilcott Company, Llc | Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| ES2611185T3 (es) * | 2013-05-20 | 2017-05-05 | Fundación Comunidad Valenciana Centro De Investigación Principe Felipe | Conjugados polímero-fármaco para el tratamiento de la amiloidosis |
| TW201705962A (zh) | 2015-03-23 | 2017-02-16 | 生物製藥Ｘ公司 | 皮膚用四環素醫藥組成物 |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| ES2962380T3 (es) | 2017-07-21 | 2024-03-18 | Almirall Llc | Sareciclina para el tratamiento de lesiones de acné no inflamatorias |
| CN113655052B (zh) * | 2021-08-03 | 2023-12-12 | 哈尔滨工程大学 | 基于高活性MgO对四环素类抗生素可视化检测的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1913323A (en) * | 1931-02-28 | 1933-06-06 | Hoffmann La Roche | Stable concentrated solution for therapeutic purposes |
| DE647766C (de) * | 1931-03-01 | 1937-07-12 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide |
| GB381012A (en) * | 1931-12-04 | 1932-09-29 | Andrew Home Morton | Process for the manufacture of stable concentrated solutions for therapeutic use |
| DE662812C (de) * | 1931-12-08 | 1938-07-22 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen |
| DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
| GB1019164A (en) * | 1963-01-30 | 1966-02-02 | Chugai Pharmaceutical Co Ltd | Hemostatic preparation for injection and process for the production thereof |
| DK129969B (da) * | 1973-01-11 | 1974-12-09 | Rosco Ak | Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin. |
| GB1508601A (en) * | 1974-01-19 | 1978-04-26 | Norbrook Labor Ltd | Oxytetracycline solution |
| US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
-
1977
- 1977-04-27 US US05/791,627 patent/US4126680A/en not_active Expired - Lifetime
-
1978
- 1978-02-16 SE SE7801816A patent/SE443507B/sv not_active IP Right Cessation
- 1978-03-30 IN IN234/DEL/78A patent/IN148197B/en unknown
- 1978-04-03 PH PH20970A patent/PH12962A/en unknown
- 1978-04-07 DD DD78204656A patent/DD135445A5/xx unknown
- 1978-04-07 MX MX787004U patent/MX6087E/es unknown
- 1978-04-08 RO RO7893756A patent/RO75099A/ro unknown
- 1978-04-08 RO RO78102215A patent/RO77953A/ro unknown
- 1978-04-11 ZM ZM38/78A patent/ZM3878A1/xx unknown
- 1978-04-12 YU YU00871/78A patent/YU87178A/xx unknown
- 1978-04-12 PT PT67895A patent/PT67895B/pt unknown
- 1978-04-13 HU HU78PI616A patent/HU179050B/hu not_active IP Right Cessation
- 1978-04-13 PL PL1978206050A patent/PL110459B1/pl unknown
- 1978-04-13 ES ES468749A patent/ES468749A1/es not_active Expired
- 1978-04-14 CS CS782444A patent/CS199527B2/cs unknown
- 1978-04-14 AR AR271783A patent/AR217844A1/es active
- 1978-04-14 BG BG039431A patent/BG47943A3/xx unknown
- 1978-04-15 EG EG256/78A patent/EG14348A/xx active
- 1978-04-20 DE DE2817335A patent/DE2817335C3/de not_active Expired
- 1978-04-21 NZ NZ187046A patent/NZ187046A/xx unknown
- 1978-04-24 JP JP4865978A patent/JPS53136514A/ja active Granted
- 1978-04-24 AU AU35378/78A patent/AU503139B1/en not_active Expired
- 1978-04-25 CA CA301,904A patent/CA1100875A/en not_active Expired
- 1978-04-25 GB GB16167/78A patent/GB1563478A/en not_active Expired
- 1978-04-26 CH CH453678A patent/CH630260A5/fr not_active IP Right Cessation
- 1978-04-26 NO NO781457A patent/NO148280C/no unknown
- 1978-04-26 FR FR7812299A patent/FR2388561A1/fr active Granted
- 1978-04-26 NL NL7804455A patent/NL7804455A/xx not_active Application Discontinuation
- 1978-04-26 FI FI801197A patent/FI801197A7/fi not_active Application Discontinuation
- 1978-04-26 GR GR56113A patent/GR70062B/el unknown
- 1978-04-26 DK DK182578A patent/DK155977C/da active
- 1978-04-26 BE BE187143A patent/BE866419A/xx not_active IP Right Cessation
- 1978-04-26 IT IT22720/78A patent/IT1094557B/it active
- 1978-04-26 AT AT300478A patent/AT360148B/de not_active IP Right Cessation
- 1978-04-26 ZA ZA00782400A patent/ZA782400B/xx unknown
- 1978-04-26 FI FI781300A patent/FI781300A7/fi not_active Application Discontinuation
- 1978-04-26 FI FI801196A patent/FI801196A7/fi not_active Application Discontinuation
- 1978-04-26 IL IL54581A patent/IL54581A0/xx not_active IP Right Cessation
- 1978-04-26 IE IE828/78A patent/IE47049B1/en not_active IP Right Cessation
- 1978-04-26 OA OA56480A patent/OA05949A/xx unknown
- 1978-04-27 LU LU79547A patent/LU79547A1/xx unknown
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| RO81037A (ro) | Procedeu de preparare a unor 4-dezacelil-vincaleucoblastin-c3-carboxuhydrazide | |
| BE865808A (fr) | Procede de preparation de l'ethylene-glycol | |
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| LU80459A1 (fr) | Procede de preparation de compositions tensio-actives cationiques | |
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| BE866662A (fr) | Procede de preparation de 3,5-dihalogenanilines | |
| LU79540A1 (fr) | Procede de preparation d'agents antibacteriens | |
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| BE865667A (fr) | Procede de preparation de trihalogenures de monohydrocarbyletain | |
| BE866904A (fr) | Procede de preparation de 3-bromophtalide | |
| BE871068A (fr) | Nouveau procede de preparation de 4-chloroquinoleines | |
| PT71701A (fr) | Procede de preparation de compositions insecticides lave-surfaces | |
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