OA05949A - Procédé de préparation de compositions antibiotiques stables de tétracyclines. - Google Patents
Procédé de préparation de compositions antibiotiques stables de tétracyclines.Info
- Publication number
- OA05949A OA05949A OA56480A OA56480A OA05949A OA 05949 A OA05949 A OA 05949A OA 56480 A OA56480 A OA 56480A OA 56480 A OA56480 A OA 56480A OA 05949 A OA05949 A OA 05949A
- Authority
- OA
- OAPI
- Prior art keywords
- tetracyclines
- preparing stable
- antibiotic compositions
- stable antibiotic
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/791,627 US4126680A (en) | 1977-04-27 | 1977-04-27 | Tetracycline antibiotic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
OA05949A true OA05949A (fr) | 1981-06-30 |
Family
ID=25154289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA56480A OA05949A (fr) | 1977-04-27 | 1978-04-26 | Procédé de préparation de compositions antibiotiques stables de tétracyclines. |
Country Status (38)
Country | Link |
---|---|
US (1) | US4126680A (fr) |
JP (1) | JPS53136514A (fr) |
AR (1) | AR217844A1 (fr) |
AT (1) | AT360148B (fr) |
AU (1) | AU503139B1 (fr) |
BE (1) | BE866419A (fr) |
BG (1) | BG47943A3 (fr) |
CA (1) | CA1100875A (fr) |
CH (1) | CH630260A5 (fr) |
CS (1) | CS199527B2 (fr) |
DD (1) | DD135445A5 (fr) |
DE (1) | DE2817335C3 (fr) |
DK (1) | DK155977C (fr) |
EG (1) | EG14348A (fr) |
ES (1) | ES468749A1 (fr) |
FI (1) | FI781300A (fr) |
FR (1) | FR2388561A1 (fr) |
GB (1) | GB1563478A (fr) |
GR (1) | GR70062B (fr) |
HU (1) | HU179050B (fr) |
IE (1) | IE47049B1 (fr) |
IL (1) | IL54581A0 (fr) |
IN (1) | IN148197B (fr) |
IT (1) | IT1094557B (fr) |
LU (1) | LU79547A1 (fr) |
MX (1) | MX6087E (fr) |
NL (1) | NL7804455A (fr) |
NO (1) | NO148280C (fr) |
NZ (1) | NZ187046A (fr) |
OA (1) | OA05949A (fr) |
PH (1) | PH12962A (fr) |
PL (1) | PL110459B1 (fr) |
PT (1) | PT67895B (fr) |
RO (2) | RO77953A (fr) |
SE (1) | SE443507B (fr) |
YU (1) | YU87178A (fr) |
ZA (1) | ZA782400B (fr) |
ZM (1) | ZM3878A1 (fr) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4386083A (en) * | 1980-04-10 | 1983-05-31 | Walter Hacke | Injectable oxytetracycline compositions |
US4399127A (en) * | 1980-04-10 | 1983-08-16 | Diamond Shamrock Corporation | Injectable oxytetracycline compositions |
US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
EP0621033A1 (fr) * | 1993-04-20 | 1994-10-26 | Nostras S.A. | Composition antibiotique contenant de l'oxytétracycline et du glycofurol |
US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
ATE323671T1 (de) | 1999-09-14 | 2006-05-15 | Tufts College | Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
CA2397863A1 (fr) | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Composes de tetracycline pour le traitement de troubles afferents au cryptosporidium parvum |
EA200201046A1 (ru) | 2000-03-31 | 2003-04-24 | Трастис Оф Тафтс Коллидж | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
US6642270B2 (en) * | 2000-05-15 | 2003-11-04 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
WO2001098236A2 (fr) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | Composes de tetracycline 7-phenyl-substituee |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
US6624168B2 (en) | 2000-07-07 | 2003-09-23 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
ATE544745T1 (de) | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
CN1452611A (zh) | 2000-07-07 | 2003-10-29 | 塔夫茨大学信托人 | 13-取代甲烯土霉素化合物 |
CZ2003343A3 (cs) | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 7-Substituované tetracyklinové sloučeniny |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
CZ20032780A3 (cs) | 2001-03-13 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | 7,9- Substituované tetracyklinové sloučeniny |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
US7045507B2 (en) | 2001-03-14 | 2006-05-16 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
US6841546B2 (en) * | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
CA2444899C (fr) | 2001-04-24 | 2011-06-21 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitues destines au traitement de la malaria |
AU2003235759A1 (en) | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
EP1482926A4 (fr) | 2002-03-08 | 2006-04-12 | Paratek Pharm Innc | Composes a base de tetracycline a substitution aminomethyle |
KR101025400B1 (ko) | 2002-03-21 | 2011-03-28 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
EP2277504A1 (fr) | 2002-10-24 | 2011-01-26 | Paratek Pharmaceuticals, Inc. | Composes tetracycline substituee servant au traitement du paludisme |
US20050137174A1 (en) | 2003-07-09 | 2005-06-23 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2319829A1 (fr) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Composés tétracyclines substitués em position 9 |
AU2004261143B2 (en) * | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
CA2553510C (fr) | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Derives a cycle aromatique a provenant de composes de tetracycline |
TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
CA2585418A1 (fr) * | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines et procedes d'utilisation |
EP2284151A3 (fr) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline substituée |
EP1848685A1 (fr) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | Derives 11a, 12 de composes de tetracycline |
US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
US7544373B2 (en) * | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
AU2007208214B2 (en) * | 2006-01-24 | 2013-02-14 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
US20070244335A1 (en) * | 2006-04-17 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Isolation of tetracycline derivatives |
US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
PT2016045E (pt) * | 2006-04-24 | 2015-02-05 | Teva Pharma | Forma cristalina de tigeciclina e processos para a sua preparação |
EP2537934A3 (fr) * | 2006-05-15 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Procédés de régulation de lýexpression des gènes ou produits génétiques utilisant des composés tétracyclines substitués |
ES2315123B1 (es) * | 2006-09-25 | 2009-12-30 | Divasa-Farmavic, S.A. | Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos. |
US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
BRPI0720569B8 (pt) | 2006-12-21 | 2021-05-25 | Paratek Pharm Innc | compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária |
US8513223B2 (en) | 2006-12-21 | 2013-08-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
AU2012230089B2 (en) * | 2007-03-23 | 2013-11-21 | Molecular Research Center, Inc. | Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy |
KR20090122994A (ko) * | 2007-03-23 | 2009-12-01 | 몰레큘러 리서치 센터, 인크. | 테트라사이클린류를 함유하는 항염증성 조성물 및 이의 치료 용도 |
US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
WO2008127722A1 (fr) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines. |
JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
ES2386926T3 (es) | 2007-07-06 | 2012-09-06 | Paratek Pharmaceuticals, Inc. | Métodos para sintetizar minociclina9-sustituida |
US20090253660A1 (en) | 2008-03-05 | 2009-10-08 | Paratek Pharmaceuticals, Inc. | Minocycline Compounds and Methods of Use Thereof |
PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
AU2009236631A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
WO2010017310A1 (fr) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Procédé pour le traitement de l'acné, et certaines formes posologiques de celui-ci |
AU2009292986A1 (en) * | 2008-09-19 | 2010-03-25 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
EP3061460A1 (fr) | 2009-04-10 | 2016-08-31 | Tufts Medical Center, Inc. | Activation de par-1 par la métalloprotéinase-1 (mmp-1) |
JP6574572B2 (ja) | 2011-05-12 | 2019-09-11 | パラテック ファーマシューティカルズ インコーポレイテッド | (4s,4as,5ar,12as)−4−ジメチルアミノ−3,10,12,12a−テトラヒドロキシ−7−[(メトキシ(メチル)アミノ)−メチル]−1,11−ジオキソ−1,4,4a,5,5a,6,11,12a−オクタヒドロ−ナフタセン−2−カルボン酸アミドの結晶塩及びそれを使用する方法 |
US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
EP2805732B1 (fr) * | 2013-05-20 | 2016-09-28 | Fundación Comunidad Valenciana Centro de Investigación Principe Felipe | Conjugués médicament-polymère pour le traitement de l'amyloïdose |
US9918998B2 (en) | 2015-03-23 | 2018-03-20 | BioPharmX, Inc. | Pharmaceutical tetracycline composition for dermatological use |
RU2019113715A (ru) | 2016-11-01 | 2020-12-03 | Паратек Фармасьютикалс, Инк. | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
CN111343991A (zh) | 2017-07-21 | 2020-06-26 | 阿尔米雷尔有限责任公司 | 非炎性病变的治疗 |
CN113655052B (zh) * | 2021-08-03 | 2023-12-12 | 哈尔滨工程大学 | 基于高活性MgO对四环素类抗生素可视化检测的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1913323A (en) * | 1931-02-28 | 1933-06-06 | Hoffmann La Roche | Stable concentrated solution for therapeutic purposes |
DE647766C (de) * | 1931-03-01 | 1937-07-12 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide |
GB381012A (en) * | 1931-12-04 | 1932-09-29 | Andrew Home Morton | Process for the manufacture of stable concentrated solutions for therapeutic use |
DE662812C (de) * | 1931-12-08 | 1938-07-22 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen |
DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
GB1019164A (en) * | 1963-01-30 | 1966-02-02 | Chugai Pharmaceutical Co Ltd | Hemostatic preparation for injection and process for the production thereof |
DK129969B (da) * | 1973-01-11 | 1974-12-09 | Rosco Ak | Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin. |
GB1508601A (en) * | 1974-01-19 | 1978-04-26 | Norbrook Labor Ltd | Oxytetracycline solution |
US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
-
1977
- 1977-04-27 US US05/791,627 patent/US4126680A/en not_active Expired - Lifetime
-
1978
- 1978-02-16 SE SE7801816A patent/SE443507B/sv not_active IP Right Cessation
- 1978-03-30 IN IN234/DEL/78A patent/IN148197B/en unknown
- 1978-04-03 PH PH20970A patent/PH12962A/en unknown
- 1978-04-07 MX MX787004U patent/MX6087E/es unknown
- 1978-04-07 DD DD78204656A patent/DD135445A5/xx unknown
- 1978-04-08 RO RO78102215A patent/RO77953A/fr unknown
- 1978-04-08 RO RO7893756A patent/RO75099A/fr unknown
- 1978-04-11 ZM ZM38/78A patent/ZM3878A1/xx unknown
- 1978-04-12 YU YU00871/78A patent/YU87178A/xx unknown
- 1978-04-12 PT PT67895A patent/PT67895B/pt unknown
- 1978-04-13 HU HU78PI616A patent/HU179050B/hu not_active IP Right Cessation
- 1978-04-13 ES ES468749A patent/ES468749A1/es not_active Expired
- 1978-04-13 PL PL1978206050A patent/PL110459B1/pl unknown
- 1978-04-14 BG BG39431A patent/BG47943A3/xx unknown
- 1978-04-14 CS CS782444A patent/CS199527B2/cs unknown
- 1978-04-14 AR AR271783A patent/AR217844A1/es active
- 1978-04-15 EG EG256/78A patent/EG14348A/xx active
- 1978-04-20 DE DE2817335A patent/DE2817335C3/de not_active Expired
- 1978-04-21 NZ NZ187046A patent/NZ187046A/xx unknown
- 1978-04-24 JP JP4865978A patent/JPS53136514A/ja active Granted
- 1978-04-24 AU AU35378/78A patent/AU503139B1/en not_active Expired
- 1978-04-25 GB GB16167/78A patent/GB1563478A/en not_active Expired
- 1978-04-25 CA CA301,904A patent/CA1100875A/fr not_active Expired
- 1978-04-26 GR GR56113A patent/GR70062B/el unknown
- 1978-04-26 FR FR7812299A patent/FR2388561A1/fr active Granted
- 1978-04-26 ZA ZA00782400A patent/ZA782400B/xx unknown
- 1978-04-26 FI FI781300A patent/FI781300A/fi not_active Application Discontinuation
- 1978-04-26 CH CH453678A patent/CH630260A5/fr not_active IP Right Cessation
- 1978-04-26 BE BE187143A patent/BE866419A/fr not_active IP Right Cessation
- 1978-04-26 IE IE828/78A patent/IE47049B1/en not_active IP Right Cessation
- 1978-04-26 NO NO781457A patent/NO148280C/no unknown
- 1978-04-26 DK DK182578A patent/DK155977C/da active
- 1978-04-26 IL IL54581A patent/IL54581A0/xx not_active IP Right Cessation
- 1978-04-26 AT AT300478A patent/AT360148B/de not_active IP Right Cessation
- 1978-04-26 IT IT22720/78A patent/IT1094557B/it active
- 1978-04-26 NL NL7804455A patent/NL7804455A/xx not_active Application Discontinuation
- 1978-04-26 OA OA56480A patent/OA05949A/fr unknown
- 1978-04-27 LU LU79547A patent/LU79547A1/fr unknown
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