ES468749A1 - Un procedimiento para preparar una composicion antibiotica - Google Patents

Un procedimiento para preparar una composicion antibiotica

Info

Publication number
ES468749A1
ES468749A1 ES468749A ES468749A ES468749A1 ES 468749 A1 ES468749 A1 ES 468749A1 ES 468749 A ES468749 A ES 468749A ES 468749 A ES468749 A ES 468749A ES 468749 A1 ES468749 A1 ES 468749A1
Authority
ES
Spain
Prior art keywords
antibiotic
solution
alkaline earth
compound
tetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468749A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES468749A1 publication Critical patent/ES468749A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un procedimiento para preparar una composición antibiótica estable que contiene una alta concentración del antibiótico en solución; caracterizado por hacer reaccionar un antibiótico de tetraciclina con una suspensión espesa que consiste de un compuesto alcalinotérreo farmacéuticamente aceptable y, si se desea, pirrolidona de polivinilo, en caprolactama o 2-piperidona acuosa para formar un quelato de metal alcalinotérreo/tetraciclina y ajustar el valor del pH, si es necesario para lograr una solución, el antibiótico se selecciona de oxitetraciclina, oxiciclina, clortetraciclina y las sales de adición de ácido farmacéuticamente aceptables de los mismos, con la condición de que cuando el antibiótico es clortetraciclina, el compuesto alcalinotérreo sea un compuesto de calcio soluble en la solución y cuando el antibiótico es oxitetraciclina o doxiciclina, el compuesto alcalinotérreo sea un compuesto de magnesio, soluble en esa solución.
ES468749A 1977-04-27 1978-04-13 Un procedimiento para preparar una composicion antibiotica Expired ES468749A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
ES468749A1 true ES468749A1 (es) 1979-01-01

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468749A Expired ES468749A1 (es) 1977-04-27 1978-04-13 Un procedimiento para preparar una composicion antibiotica

Country Status (38)

Country Link
US (1) US4126680A (es)
JP (1) JPS53136514A (es)
AR (1) AR217844A1 (es)
AT (1) AT360148B (es)
AU (1) AU503139B1 (es)
BE (1) BE866419A (es)
BG (1) BG47943A3 (es)
CA (1) CA1100875A (es)
CH (1) CH630260A5 (es)
CS (1) CS199527B2 (es)
DD (1) DD135445A5 (es)
DE (1) DE2817335C3 (es)
DK (1) DK155977C (es)
EG (1) EG14348A (es)
ES (1) ES468749A1 (es)
FI (1) FI781300A (es)
FR (1) FR2388561A1 (es)
GB (1) GB1563478A (es)
GR (1) GR70062B (es)
HU (1) HU179050B (es)
IE (1) IE47049B1 (es)
IL (1) IL54581A0 (es)
IN (1) IN148197B (es)
IT (1) IT1094557B (es)
LU (1) LU79547A1 (es)
MX (1) MX6087E (es)
NL (1) NL7804455A (es)
NO (1) NO148280C (es)
NZ (1) NZ187046A (es)
OA (1) OA05949A (es)
PH (1) PH12962A (es)
PL (1) PL110459B1 (es)
PT (1) PT67895B (es)
RO (2) RO75099A (es)
SE (1) SE443507B (es)
YU (1) YU87178A (es)
ZA (1) ZA782400B (es)
ZM (1) ZM3878A1 (es)

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US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
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CA2444899C (en) 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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Also Published As

Publication number Publication date
DE2817335B2 (de) 1981-06-11
IT7822720A0 (it) 1978-04-26
EG14348A (en) 1984-09-30
IE47049B1 (en) 1983-12-14
AR217844A1 (es) 1980-04-30
GR70062B (es) 1982-07-26
FR2388561A1 (fr) 1978-11-24
PT67895A (en) 1978-05-01
CH630260A5 (fr) 1982-06-15
DD135445A5 (de) 1979-05-09
ZA782400B (en) 1979-04-25
JPS53136514A (en) 1978-11-29
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
OA05949A (fr) 1981-06-30
US4126680A (en) 1978-11-21
ZM3878A1 (en) 1978-11-21
AT360148B (de) 1980-12-29
BG47943A3 (en) 1990-10-15
CS199527B2 (en) 1980-07-31
CA1100875A (en) 1981-05-12
LU79547A1 (fr) 1979-11-07
PH12962A (en) 1979-10-19
RO75099A (ro) 1980-12-30
NO781457L (no) 1978-10-30
NZ187046A (en) 1980-03-05
YU87178A (en) 1984-04-30
DK182578A (da) 1978-10-28
DE2817335C3 (de) 1982-04-22
NO148280C (no) 1983-09-21
NL7804455A (nl) 1978-10-31
PL110459B1 (en) 1980-07-31
IL54581A0 (en) 1978-07-31
IE780828L (en) 1978-10-27
FR2388561B1 (es) 1980-07-18
IT1094557B (it) 1985-08-02
PT67895B (en) 1979-11-14
DK155977B (da) 1989-06-12
HU179050B (en) 1982-08-28
DE2817335A1 (de) 1978-11-16
NO148280B (no) 1983-06-06
GB1563478A (en) 1980-03-26
RO77953A (ro) 1981-12-25
DK155977C (da) 1989-10-30
FI781300A (fi) 1978-10-28
MX6087E (es) 1984-11-08
AU503139B1 (en) 1979-08-23
IN148197B (es) 1980-11-29
JPS5632290B2 (es) 1981-07-27
ATA300478A (de) 1980-05-15
SE443507B (sv) 1986-03-03
BE866419A (fr) 1978-10-26

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