FR2388561A1 - Nouvelles compositions antibiotiques a base d'une tetracycline - Google Patents
Nouvelles compositions antibiotiques a base d'une tetracyclineInfo
- Publication number
- FR2388561A1 FR2388561A1 FR7812299A FR7812299A FR2388561A1 FR 2388561 A1 FR2388561 A1 FR 2388561A1 FR 7812299 A FR7812299 A FR 7812299A FR 7812299 A FR7812299 A FR 7812299A FR 2388561 A1 FR2388561 A1 FR 2388561A1
- Authority
- FR
- France
- Prior art keywords
- tetracycline
- antibiotic compositions
- compositions based
- new antibiotic
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
L'invention concerne de nouvelles compositions antibiotiques. Les compositions de l'invention sont des solutions aqueuses d'oxytétracycline, de doxycycline ou de chlortétracycline dans le caprolactame ou la 2-pipéridone. L'utilisation des solvants ci-dessus permet l'utilisation du volume minimal par dose et la composition résultante, dont la viscosité est faible, se prête très bien à l'administration par injection à l'aide d'une seringue.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/791,627 US4126680A (en) | 1977-04-27 | 1977-04-27 | Tetracycline antibiotic compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2388561A1 true FR2388561A1 (fr) | 1978-11-24 |
FR2388561B1 FR2388561B1 (fr) | 1980-07-18 |
Family
ID=25154289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7812299A Granted FR2388561A1 (fr) | 1977-04-27 | 1978-04-26 | Nouvelles compositions antibiotiques a base d'une tetracycline |
Country Status (38)
Country | Link |
---|---|
US (1) | US4126680A (fr) |
JP (1) | JPS53136514A (fr) |
AR (1) | AR217844A1 (fr) |
AT (1) | AT360148B (fr) |
AU (1) | AU503139B1 (fr) |
BE (1) | BE866419A (fr) |
BG (1) | BG47943A3 (fr) |
CA (1) | CA1100875A (fr) |
CH (1) | CH630260A5 (fr) |
CS (1) | CS199527B2 (fr) |
DD (1) | DD135445A5 (fr) |
DE (1) | DE2817335C3 (fr) |
DK (1) | DK155977C (fr) |
EG (1) | EG14348A (fr) |
ES (1) | ES468749A1 (fr) |
FI (1) | FI781300A (fr) |
FR (1) | FR2388561A1 (fr) |
GB (1) | GB1563478A (fr) |
GR (1) | GR70062B (fr) |
HU (1) | HU179050B (fr) |
IE (1) | IE47049B1 (fr) |
IL (1) | IL54581A0 (fr) |
IN (1) | IN148197B (fr) |
IT (1) | IT1094557B (fr) |
LU (1) | LU79547A1 (fr) |
MX (1) | MX6087E (fr) |
NL (1) | NL7804455A (fr) |
NO (1) | NO148280C (fr) |
NZ (1) | NZ187046A (fr) |
OA (1) | OA05949A (fr) |
PH (1) | PH12962A (fr) |
PL (1) | PL110459B1 (fr) |
PT (1) | PT67895B (fr) |
RO (2) | RO75099A (fr) |
SE (1) | SE443507B (fr) |
YU (1) | YU87178A (fr) |
ZA (1) | ZA782400B (fr) |
ZM (1) | ZM3878A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0621033A1 (fr) * | 1993-04-20 | 1994-10-26 | Nostras S.A. | Composition antibiotique contenant de l'oxytétracycline et du glycofurol |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4386083A (en) * | 1980-04-10 | 1983-05-31 | Walter Hacke | Injectable oxytetracycline compositions |
US4399127A (en) * | 1980-04-10 | 1983-08-16 | Diamond Shamrock Corporation | Injectable oxytetracycline compositions |
US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
EP1666453A1 (fr) | 1999-09-14 | 2006-06-07 | Trustees Of Tufts College | Techniques de preparation de tetracyclines substituees avec des solutions chimiques a base de metal de transition |
WO2001052858A1 (fr) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Composes de tetracycline pour le traitement de troubles afferents au cryptosporidium parvum |
US6818634B2 (en) * | 2000-03-31 | 2004-11-16 | Paratek Pharmaceuticals, Inc. | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
EP1286954B1 (fr) * | 2000-05-15 | 2004-04-14 | Paratek Pharmaceuticals, Inc. | Composes tretracycliniques a anneaux condenses, substitues en position 7 |
US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20020128238A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
CN100473644C (zh) | 2000-07-07 | 2009-04-01 | 塔夫茨大学信托人 | 9-取代的二甲胺四环素化合物 |
EP1303479B1 (fr) | 2000-07-07 | 2011-04-06 | Trustees Of Tufts College | Composes de tetracycline substitues en 7, 8 et 9 |
CN102336679A (zh) | 2000-07-07 | 2012-02-01 | 塔夫茨大学信托人 | 7-取代的四环素化合物 |
WO2002004405A2 (fr) | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | Composes methacycline 13-substitues |
AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
JP2005506291A (ja) | 2001-03-13 | 2005-03-03 | パラテック ファーマシューティカルズ, インク. | 7,9−置換テトラサイクリン化合物 |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
WO2002072031A2 (fr) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques |
EP1379255A2 (fr) | 2001-03-14 | 2004-01-14 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitues, en tant qu'agents antifongiques |
US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
CA2444899C (fr) | 2001-04-24 | 2011-06-21 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substitues destines au traitement de la malaria |
EP2995610A1 (fr) | 2002-01-08 | 2016-03-16 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline 4-dedimethylamino |
EP2311451A1 (fr) | 2002-03-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline à substitution amino-méthyle |
IL164180A0 (en) | 2002-03-21 | 2005-12-18 | Paratek Pharm Innc | Substituted tetracycline compounds |
CA2492273C (fr) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | Composes de tetracycline substituee en 3, 10, et 12a |
EP2277504A1 (fr) | 2002-10-24 | 2011-01-26 | Paratek Pharmaceuticals, Inc. | Composes tetracycline substituee servant au traitement du paludisme |
EA201001081A1 (ru) | 2003-07-09 | 2011-02-28 | Пэрэтек Фамэсьютикэлс, Инк. | Соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
EP2292590A3 (fr) | 2003-07-09 | 2012-05-02 | Paratek Pharmaceuticals, Inc. | Promédicaments de composés de tétracycline 9-aminométhylé |
CN1893956A (zh) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | 多西环素金属络合物固体剂型 |
JP5010284B2 (ja) * | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族a環誘導体 |
TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
EP2284156A3 (fr) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline substituée |
EP2301912A3 (fr) | 2004-10-25 | 2012-07-11 | Paratek Pharmaceuticals, Inc. | 4-aminotétracyclines et procédés d'utilisation associés |
JP2008530023A (ja) | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の11a,12−誘導体 |
US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US7544373B2 (en) * | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
EP1991236A2 (fr) | 2006-01-24 | 2008-11-19 | Paratek Pharmaceuticals, Inc. | Procede permettant d'accroitre la biodisponibilite orale de tetracyclines |
US20070244335A1 (en) * | 2006-04-17 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Isolation of tetracycline derivatives |
EP2857386B1 (fr) * | 2006-04-24 | 2017-02-22 | Teva Pharmaceutical Industries Ltd | Formes cristallines de tigécycline et leurs procédés de préparation |
US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
EP2431469A3 (fr) * | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Procédés de régulation de l'expression des gènes ou produits génétiques utilisant des composés tétracyclines substitués |
ES2315123B1 (es) * | 2006-09-25 | 2009-12-30 | Divasa-Farmavic, S.A. | Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos. |
WO2008045507A2 (fr) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis |
EP2452935A3 (fr) | 2006-12-21 | 2012-08-29 | Paratek Pharmaceuticals, Inc. | Dérivés de tétracycline pour le traitement d'infections bactériennes, virales et parasites |
CA2892739A1 (fr) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Utilisation de composes a base de tetracycline substituee dans le traitement d'affections cutanees inflammatoires |
JP5395052B2 (ja) * | 2007-03-23 | 2014-01-22 | モレキュラー リサーチ センター インコーポレイテッド | 炎症を処置するための組成物および方法 |
AU2012230089B2 (en) * | 2007-03-23 | 2013-11-21 | Molecular Research Center, Inc. | Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy |
US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
EP2144614A1 (fr) | 2007-04-12 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines. |
AU2008246119A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
BRPI0823405A2 (pt) | 2007-07-06 | 2012-12-25 | Paratek Pharm Innc | mÉtodos para sintetizar compostos de tetraciclina substituÍda |
WO2009111064A2 (fr) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Composés de minocycline et procédés d’utilisation de ceux-ci |
PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
CA2721399A1 (fr) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Composes a base de tetracyclines substituees |
TW202332671A (zh) | 2008-05-23 | 2023-08-16 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
WO2010017310A1 (fr) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Procédé pour le traitement de l'acné, et certaines formes posologiques de celui-ci |
EA201170425A1 (ru) * | 2008-09-19 | 2011-10-31 | Паратек Фармасьютикалс, Инк. | Тетрациклиновые соединения для лечения ревматоидного артрита и связанные с ними способы лечения |
AU2010233089B2 (en) | 2009-04-10 | 2016-05-26 | Tufts Medical Center, Inc. | Par-1 activation by metalloproteinase-1 (MMP-1) |
EP3574908B8 (fr) | 2011-05-12 | 2024-09-11 | Almirall LLC | Composition pharmaceutique pour adminstration par voie orale comprenant des sels cristallins d'amide de l'acide (4s,4as,5ar,12as)-4-diméthylamino- 3,10,12,12a-tétrahydroxy-7-[(méthoxy(méthyl)amino)-méthyl]- 1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphtacène-2-carboxylique |
US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
ES2611185T3 (es) * | 2013-05-20 | 2017-05-05 | Fundación Comunidad Valenciana Centro De Investigación Principe Felipe | Conjugados polímero-fármaco para el tratamiento de la amiloidosis |
JP6793715B2 (ja) | 2015-03-23 | 2020-12-02 | バイオファーミクス・インコーポレイテッドBioPharmX, Inc. | テトラサイクリンの皮膚用医薬組成物 |
EP3534908A4 (fr) | 2016-11-01 | 2020-05-27 | Paratek Pharmaceuticals, Inc. | Composés de 9-aminométhylminocycline et leur utilisation dans le traitement de la pneumonie bactérienne d'acquisition communautaire (cabp) |
JP2020527607A (ja) | 2017-07-21 | 2020-09-10 | アルミラール・リミテッド・ライアビリティ・カンパニーAlmirall, Llc | 非炎症性病変の処置 |
CN113655052B (zh) * | 2021-08-03 | 2023-12-12 | 哈尔滨工程大学 | 基于高活性MgO对四环素类抗生素可视化检测的方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB381012A (en) * | 1931-12-04 | 1932-09-29 | Andrew Home Morton | Process for the manufacture of stable concentrated solutions for therapeutic use |
US1913323A (en) * | 1931-02-28 | 1933-06-06 | Hoffmann La Roche | Stable concentrated solution for therapeutic purposes |
DE647766C (de) * | 1931-03-01 | 1937-07-12 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide |
DE662812C (de) * | 1931-12-08 | 1938-07-22 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen |
DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
GB1019164A (en) * | 1963-01-30 | 1966-02-02 | Chugai Pharmaceutical Co Ltd | Hemostatic preparation for injection and process for the production thereof |
FR2258187A1 (fr) * | 1974-01-19 | 1975-08-18 | Norbrook Lab Ltd | |
GB1427882A (en) * | 1973-01-11 | 1976-03-10 | Rosco As | Oxytetracycline solutions |
US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
-
1977
- 1977-04-27 US US05/791,627 patent/US4126680A/en not_active Expired - Lifetime
-
1978
- 1978-02-16 SE SE7801816A patent/SE443507B/sv not_active IP Right Cessation
- 1978-03-30 IN IN234/DEL/78A patent/IN148197B/en unknown
- 1978-04-03 PH PH20970A patent/PH12962A/en unknown
- 1978-04-07 MX MX787004U patent/MX6087E/es unknown
- 1978-04-07 DD DD78204656A patent/DD135445A5/xx unknown
- 1978-04-08 RO RO7893756A patent/RO75099A/fr unknown
- 1978-04-08 RO RO78102215A patent/RO77953A/fr unknown
- 1978-04-11 ZM ZM38/78A patent/ZM3878A1/xx unknown
- 1978-04-12 YU YU00871/78A patent/YU87178A/xx unknown
- 1978-04-12 PT PT67895A patent/PT67895B/pt unknown
- 1978-04-13 ES ES468749A patent/ES468749A1/es not_active Expired
- 1978-04-13 PL PL1978206050A patent/PL110459B1/pl unknown
- 1978-04-13 HU HU78PI616A patent/HU179050B/hu not_active IP Right Cessation
- 1978-04-14 BG BG039431A patent/BG47943A3/xx unknown
- 1978-04-14 AR AR271783A patent/AR217844A1/es active
- 1978-04-14 CS CS782444A patent/CS199527B2/cs unknown
- 1978-04-15 EG EG256/78A patent/EG14348A/xx active
- 1978-04-20 DE DE2817335A patent/DE2817335C3/de not_active Expired
- 1978-04-21 NZ NZ187046A patent/NZ187046A/xx unknown
- 1978-04-24 JP JP4865978A patent/JPS53136514A/ja active Granted
- 1978-04-24 AU AU35378/78A patent/AU503139B1/en not_active Expired
- 1978-04-25 CA CA301,904A patent/CA1100875A/fr not_active Expired
- 1978-04-25 GB GB16167/78A patent/GB1563478A/en not_active Expired
- 1978-04-26 DK DK182578A patent/DK155977C/da active
- 1978-04-26 AT AT300478A patent/AT360148B/de not_active IP Right Cessation
- 1978-04-26 CH CH453678A patent/CH630260A5/fr not_active IP Right Cessation
- 1978-04-26 FI FI781300A patent/FI781300A/fi not_active Application Discontinuation
- 1978-04-26 IT IT22720/78A patent/IT1094557B/it active
- 1978-04-26 IL IL54581A patent/IL54581A0/xx not_active IP Right Cessation
- 1978-04-26 IE IE828/78A patent/IE47049B1/en not_active IP Right Cessation
- 1978-04-26 GR GR56113A patent/GR70062B/el unknown
- 1978-04-26 FR FR7812299A patent/FR2388561A1/fr active Granted
- 1978-04-26 BE BE187143A patent/BE866419A/fr not_active IP Right Cessation
- 1978-04-26 OA OA56480A patent/OA05949A/fr unknown
- 1978-04-26 NO NO781457A patent/NO148280C/no unknown
- 1978-04-26 NL NL7804455A patent/NL7804455A/xx not_active Application Discontinuation
- 1978-04-26 ZA ZA00782400A patent/ZA782400B/xx unknown
- 1978-04-27 LU LU79547A patent/LU79547A1/fr unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1913323A (en) * | 1931-02-28 | 1933-06-06 | Hoffmann La Roche | Stable concentrated solution for therapeutic purposes |
DE647766C (de) * | 1931-03-01 | 1937-07-12 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide |
GB381012A (en) * | 1931-12-04 | 1932-09-29 | Andrew Home Morton | Process for the manufacture of stable concentrated solutions for therapeutic use |
DE662812C (de) * | 1931-12-08 | 1938-07-22 | Hoffmanni La Roche & Co Akt Ge | Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen |
DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
GB1019164A (en) * | 1963-01-30 | 1966-02-02 | Chugai Pharmaceutical Co Ltd | Hemostatic preparation for injection and process for the production thereof |
GB1427882A (en) * | 1973-01-11 | 1976-03-10 | Rosco As | Oxytetracycline solutions |
FR2258187A1 (fr) * | 1974-01-19 | 1975-08-18 | Norbrook Lab Ltd | |
US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0621033A1 (fr) * | 1993-04-20 | 1994-10-26 | Nostras S.A. | Composition antibiotique contenant de l'oxytétracycline et du glycofurol |
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