ATE104863T1 - Pharmazeutische formulierung von plasminogenaktivatorproteinen. - Google Patents

Pharmazeutische formulierung von plasminogenaktivatorproteinen.

Info

Publication number
ATE104863T1
ATE104863T1 AT9090903109T AT90903109T ATE104863T1 AT E104863 T1 ATE104863 T1 AT E104863T1 AT 9090903109 T AT9090903109 T AT 9090903109T AT 90903109 T AT90903109 T AT 90903109T AT E104863 T1 ATE104863 T1 AT E104863T1
Authority
AT
Austria
Prior art keywords
pharmaceutical formulation
plasminogen activator
activator proteins
proteins
excipients
Prior art date
Application number
AT9090903109T
Other languages
English (en)
Inventor
Benjamin S Isaacs
Himakshi Middlesex Stree Patel
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE104863T1 publication Critical patent/ATE104863T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
AT9090903109T 1989-01-27 1990-01-26 Pharmazeutische formulierung von plasminogenaktivatorproteinen. ATE104863T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/302,846 US4980165A (en) 1989-01-27 1989-01-27 Pharmaceutical formulations of plasminogen activator proteins
PCT/US1990/000467 WO1990008557A1 (en) 1989-01-27 1990-01-26 Pharmaceutical formulations of plasminogen activator proteins

Publications (1)

Publication Number Publication Date
ATE104863T1 true ATE104863T1 (de) 1994-05-15

Family

ID=23169461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9090903109T ATE104863T1 (de) 1989-01-27 1990-01-26 Pharmazeutische formulierung von plasminogenaktivatorproteinen.

Country Status (9)

Country Link
US (1) US4980165A (de)
EP (1) EP0455725B1 (de)
JP (1) JP2636499B2 (de)
AT (1) ATE104863T1 (de)
CA (1) CA2045562A1 (de)
DE (1) DE69008513T2 (de)
DK (1) DK0455725T3 (de)
ES (1) ES2055902T3 (de)
WO (1) WO1990008557A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
DE3942145A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa-solubilisierung
US5366730A (en) * 1989-12-20 1994-11-22 Boehringer Mannheim Gmbh Stabilized compositions having human tissue type plasminogen activator enzymatic activity
DE3942143A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa pro stabilisierung
DE3942141A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh K2p pro-stabilisierung
DE59204945D1 (de) * 1991-04-16 1996-02-15 Boehringer Mannheim Gmbh Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
KR100236393B1 (ko) 1996-02-02 1999-12-15 나까니시 히로유끼 사람성장호르몬을 함유하는 의약제제
WO2008152764A1 (ja) * 2007-06-14 2008-12-18 Pola Pharma Inc. 医薬組成物
DE102007057543A1 (de) 2007-11-29 2009-06-04 Merck Patent Gmbh a-Aminosäurederivate zur Löslichkeitsverbesserung
JP5730211B2 (ja) 2008-11-20 2015-06-03 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． ウイルスのアルギニン不活化
CN111973484A (zh) * 2013-03-12 2020-11-24 普莱玛疗法公司 包含螯合剂和碱的牙用组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54147916A (en) * 1978-05-12 1979-11-19 Sumitomo Chem Co Ltd Preparation of urokinase injection
DE3203775A1 (de) * 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
ES8706443A1 (es) * 1985-05-28 1987-07-01 Wellcome Found Un procedimiento para preparar una solucion parenteral de activador de plasminogeno de tejido (t-pa)
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
EP0238551A4 (de) * 1985-09-06 1988-02-01 Codon Wiedergewinnungsverfahren von gewebeplasminogen-aktivator.
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US4857320A (en) * 1987-02-19 1989-08-15 Monsanto Company Method of enhancing the solubility of tissue plasminogen activator
DE3718889A1 (de) * 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator

Also Published As

Publication number Publication date
EP0455725B1 (de) 1994-04-27
US4980165A (en) 1990-12-25
JP2636499B2 (ja) 1997-07-30
CA2045562A1 (en) 1990-07-28
DE69008513T2 (de) 1994-11-24
ES2055902T3 (es) 1994-09-01
DK0455725T3 (da) 1994-09-05
WO1990008557A1 (en) 1990-08-09
EP0455725A1 (de) 1991-11-13
JPH04503070A (ja) 1992-06-04
DE69008513D1 (de) 1994-06-01

Similar Documents

Publication Publication Date Title
ATE104863T1 (de) Pharmazeutische formulierung von plasminogenaktivatorproteinen.
DE69921102D1 (de) Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen
GEP20043200B (en) Therapeutic Agent Comprising a Botulinum Neurotoxin
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
ATE87319T1 (de) Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate.
EP0850648A3 (de) Zusammensetzungen aus einer thrombolytisch wirkende Substanz und Antikoagulantien, und ihre Verwendungen
EP0693924A4 (de) Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
FR2710840B1 (fr) Compositions viscoélastiques hautement concentrées en composés fluorés, leur préparation et leurs utilisations dans le domaine médical et en cosmétique.
DE69521693T2 (de) Taxanderivate enthaltende arzneizubereitungen
ES2037136T3 (es) Procedimiento para la preparacion de una solucion con elevada actividad volumetrica de una proteina con actividad de activador de plasminogeno de tejidos (t-pa).
DK0684812T3 (da) Kondenseret-fase mikropartikel-præparat og fremgangsmåde
KR900700124A (ko) 흑색종 치료용 il-2 및 dtic의 치료 조성물
DE3854290D1 (de) Stabilisierung von therapeutisch wirksamen Proteinen in pharmazeutischen Zubereitungen.
FI913909A0 (fi) t-PA pro:n stabilointi
DE3780357D1 (de) Plasminogen-aktivator und thrombolytische zusammensetzung.
DE69113049D1 (de) Varianten des gewebeplasminogenaktivators mit vermindertem abbau.
KR920700683A (ko) t-PA의 가용화
SE8703788L (sv) Farmaceutiska kompositioner och anvendning av dessa
GB1166956A (en) Acceleration of Post-Surgical Healing

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee