CN1742021A - 治疗性人抗-il-1r1 单克隆抗体 - Google Patents
治疗性人抗-il-1r1 单克隆抗体 Download PDFInfo
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Abstract
Description
原来的残基 | 示意性置换 | 优选置换 |
Ala | Val,Leu,Ile | Val |
Arg | Lys,Gln,Asn | Lys |
Asn | Gln | Gln |
Asp | Glu | Glu |
Cys | Ser,Ala | Ser |
Gln | Asn | Asn |
Glu | Asp | Asp |
Gly | Pro,Ala | Ala |
His | Asn,Gln,Lys,Arg | Arg |
Ile | Leu,Val,Met,Ala,Phe,正亮氨酸 | Leu |
Leu | 正亮氨酸,Ile,Val,Met,Ala,Phe | Ile |
Lys | Arg、1,4-二氨基-丁酸、Gln、Asn | Arg |
Met | Leu,Phe,Ile | Leu |
Phe | Leu,Val,Ile,Ala,Tyr | Leu |
Pro | Ala | Gly |
Ser | Thr,Ala,Cys | Thr |
Thr | Ser | Ser |
Trp | Tyr,Phe | Tyr |
Tyr | Trp,Phe,Thr,Ser | Phe |
Val | Ile,Met,Leu,Phe,Ala,正亮氨酸 | Leu |
OA(阴性对照) | Hu slL-1R1(1+2+3结构域) | Hu slL-1R1(1+2结构域) | Hu slL-1Rll(1+2+3结构域) | 大鼠slL-1R1(1+2+3结构域) | |
抗体 | |||||
15C4 | × | √ | × | × | × |
26F5 | × | √ | × | × | × |
27F2 | × | √ | × | × | × |
24E12 | × | √ | × | × | × |
10H7 | × | √ | √ | × | × |
人抗-1L-1R1 | ||||||
15C4 | 26F5 | 27F2 | 24E12 | 10H7 | rIl-lra | |
IC50 | 96pM | 160pM | 333pM | 348pM | 5.3nM | 555pM |
95%置信范围 | 71pM到129pM | 118pM到219pM | 214pM到517pM | 223pM到542pM | 3.6nM到7.5nM | 414pM到743pM |
人抗-IL-1R1抗体 | ||||
15C4 | 27F2 | 26F5 | rIL-1ra | |
IC50 | 16pM | 32pM | 26pM | 32pM |
95%置信范围 | 15pM到18pM | 21pM到49pM | 19pM到36pM | 22pM到46pM |
人抗-IL-1R1抗体 | |||||
15C4 | 27F2 | 10H7 | 24E12 | rIL-ra | |
IC50 | 7pM | 28pM | 7.5pM | NA | 20pM |
95%置信范围 | 5.8pM到7.9pM | 22pM到35pM | 5.6nM到10nM | NA | 17pM到23pM |
供体 | 分析参数 | 15C4 | 26F5 | 27F2 | IL-1ra |
1047 | IC50 | 126pM | 410pM | 249pM | 241pM |
95%置信范围 | 47pM到339pM | 213pM到790pM | 88pM到703pM | 124pM到471pM | |
1319 | IC50 | 111pM | 174pM | 579pM | 381pM |
95%置信范围 | 59pM到1208pM | 60pM到501pM | 249pM到1.3nM | 167pM到875pM | |
复合的 | IC50 | 126pM | 372pM | 387pM | 264pM |
(合并的数据) | 95%置信范围 | 62pM到255pM | 187pM到739pM | 202pM到748pM | 134pM到517pM |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Gcnbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.Cell Biol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.Natl.Acad.Sci.U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J002400) |
4755到5468 | XbaI和SalI位点之间的15C4κ轻链cDNA |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Genbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.Cell Biol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.Natl.Acad.Sci.U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6158 | XbaI和SalI位点之间的rVh/hCh1重链cDNA。该重链片段序列在下面显示(SEQ ID NO:51),限制性位点序列用下划线标出:XbaITCTAG ACCACCATGG ACATCAGGCT CAGCTTAGTT TTCCTTGTCCTTTTCATAAA AGGTGTCCAG TGTGAGGTAG AACTGGTGGAGTCTGGGGGC GGCTTAGTAC AACCTGGAAG GTCCATGACACTCTCCTGTG CAGCCTCGGG ATTCACTTTC AGAACCTATG GCATGGCCTGGGTCCGCCAG GCCCCAACGA AGGGTCTGGA GTGGGTCTCA |
TCAATTACTG CTAGTGGTGG TACCACCTAC TATCGAGACT CCGTGAAGGGCCGCTTCACT ATTTTTAGGG ATAATGCAAA AAGTACCCTA TACCTGCAGATGGACAGTCC GAGGTCTGAG GACACGGCCA CTTATTTCTG TACATCAATTBsm B1TCGGAATACT GGGGCCACGG AGTCATGGTC AC CGTCTCTAGTGCCTCCACCAAGGGCCCA TCGGTCTTCC CCCTGGCACC CTCCTCCAAGAGCACCTCTGGGGGCACAGC GGCCCTGGGC TGCCTGGTCA AGGACTACTTCCCCGAACCG GTGACGGTGT CGTGGAACTC AGGCGCCCTGACCAGCGGCG TGCACACCTT CCCGGCTGTC CTACAGTCCT CAGGACTCTACTCCCTCAGC AGCGTGGTGACCGTGCCCTC CAGCAGCTTG GGCACCCAGACCTACATCTG CAACGTGAATCACAAGCCCA GCAACACCAAGGTGGACAAG AAAGTTGAGC CCAAATCTTG TGACAAAACTCACACATGCC CACCGTGCCC AGCACCTGAA CTCCTGGGGGGACCGTCAGT CTTCCTCTTC CCCCCAAAAC CCAAGGACAC CCTCATGATCTCCCGGACCC CTGAGGTCAC ATGCGTGGTG GTGGACGTGAGCCACGAAGACCCTGAGGTC AAGTTCAACT GGTACGTGGACGGCGTGGAG GTGCATAATG CCAAGACAAA GCCGCGGGAGGAGCAGTACA ACAGCACGTA CCGTGTGGTC AGCGTCCTCACCGTCCTGCA CCAGGACTGG CTGAATGGCAAGGAGTACAAGTGCAAGGTC TCCAACAAAG CCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAA AGGGCAGCCCCGAGAACCAC AGGTGTACAC CCTGCCCCCA TCCCGGGATGAGCTGACCAA GAACCAGGTC AGCCTGACCT GCCTGGTCAAAGGCTTCTAT CCCAGCGACA TCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACC ACGCCTCCCGTGCTGGACTC CGACGGCTCC TTCTTCCTCT ATAGCAAGCT CACCGTGGACAAGAGCAGGT GGCAGCAGGG GAACGTCTTC TCATGCTCCGTGATGCATGA GGCTCTGCAC AACCACTACA CGCAGAAGAGCCTCTCCCTG TCTCCGGGTASal IAATGATAA GT CGAC |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Gcnbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.Cell Biol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.Natl.Acad.Sci.U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6173 | Xbal和SalI位点之间的15C4重链IgG1 cDNA |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;(Genbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子,cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;MeGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.Ccll Biol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.Natl.Acad.Sci U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6164 | Xbal和SalI位点之间的hVh/hCh2重链cDNA。该重链片段序列在下面显示(SEQ ID NO:57),限制性位点序列用下划线标出:XbaI |
TCTAGA CCACCATGGA CATGAGGGTC CCCGCTCAGC TCCTGGGGCTCCTGCTATTG TGGTTGAGAG GTGCCAGATG TGAGGTCCAGCTGGTGCAGTCTGGGGGAGG CTTGGTACAT CCTGGGGGGT CCCTGAGACTCTCCTGTGCAGGCTCTGGAT TCACCTTCAG TGGCCATGCT TTGCACTGGGTTCGCCAGGCTCCAGGAAAA GGTCTGGAGT GGGTATCAGG TATTGGTACTCATGGTGGGACATACTATGC AGACTCCGTG AAGGGCCGAT TCACCATCTCCAGAGACAATGCCAAGAACT CCTTGTTTCT TCAAATGAAC AGCCTGAGCGCCGAGGACATGGCTGTGTAT TACTGTACAA GAAGAAACTGBsmB1GGGACAATTT GACTACTGGGGCCAGGGAAC CCTGGTCAC C GTCTCTAGTGCCTCCACCAA GGGCCCATCGGTCTTCCCCC TGGCGCCCTG CTCCAGGAGCACCTCCGAGA GCACAGCGGCCCTGGGCTGC CTGGTCAAGG ACTACTTCCCCGAACCGGTG ACGGTGTCGTGGAACTCAGG CGCTCTGACCAGCGGCGTGC ACACCTTCCC AGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGC GTGGTGACCG TGCCCTCCAGCAACTTCGGC ACCCAGACCTACACCTGCAA CGTAGATCAC AAGCCCAGCAACACCAAGGTGGACAAGACA GTTGAGCGCA AATGTTGTGTCGAGTGCCCACCGTGCCCAG CACCACCTGT GGCAGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCA TGATCTCCCG GACCCCTGAGGTCACGTGCGTGGTGGTGGA CGTGAGCCAC GAAGACCCCGAGGTCCAGTT CAACTGGTACGTGGACGGCG TGGAGGTGCATAATGCCAAG ACAAAGCCAC GGGAGGAGCAGTTCAACAGCACGTTCCGTG TGGTCAGCGT CCTCACCGTTGTGCACCAGGACTGGCTGAACGGCAAGGAG TACAAGTGCA AGGTCTCCAACAAAGGCCTCCCAGCCCCCA TCGAGAAAAC CATCTCCAAAACCAAAGGGC AGCCCCGAGAACCACAGGTG TACACCCTGCCCCCATCCCG GGAGGAGATG ACCAAGAACCAGGTCAGCCTGACCTGCCTG GTCAAAGGCT TC了ACCCCAG CGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAG AACAACTACAAGACCACACCTCCCATGCTG GACTCCGACG GCTCCTTCTT CCTCTACAGCAAGCTCACCGTGGACAAGAG CAGGTGGCAG CAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTC TGCACAACCA CTACACGCAGSalIAAGAGCCTCT CCCTGTCTCCGGGTAAATGA TAA GTCGAC | |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Gcnbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.(U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.Cell Biol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proe.Natl.Acad.Sci U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6161 | Xbal和SalI位点之间的15C4重链IgG2 cDNA |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Genbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Acad.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.CellBiol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.NatlAead.Sci.U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6167 | Xbal和SalI位点之间的hVh/hCh4重链cDNA。该重链片段的序列在下面显示(SEQ ID NO:58),限制性位点序列用下划线标出:XbaITCT AGACCACCAT GGACATGAGG GTCCCCGCTC AGCTCCTGGGGCTCCTGCTA TTGTGGTTGA GAGGTGCCAG ATGTGAGGTCCAGCTGGTGCAGTCTGGGGG AGGCTTGGTA CATCCIGGGGGGTCCCTGAG ACTCTCCTGTGCAGGCTCTG GATTCACCTT CAGTGGCCATGCTTTGCACT GGGTTCGCCAGGCTCCAGGA AAAGGTCTGG AGTGGGTATCAGGTATTGGT ACTCATGGTGGGACATACTA TGCAGACTCC GTGAAGGGCCGATTCACCAT CTCCAGAGACAATGCCAAGA ACTCCTTGTT TCTTCAAATGAACAGCCTGA GCGCCGAGGACATGGCTGTG TATTACTGTACAAGAAGAAA CTGGGGACAA TTTGACTACTGGGGCCAGGGBsmB1AACCCTGGTC AC CGTCTCTA GTGCCAGCAC CAAGGGGCCATCCGTCTTCC |
CCCTGGCGCC CTGCTCCAGG AGCACCTCCGAGAGCACAGCCGCCCTGGGC TGCCTGGTCA AGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGGCGCCCTGACCAGCGGCG TGCACACCTT CCCGGCTGTCCTACAGTCCT CAGGACTCTACTCCCTCAGC AGCGTGGTGA CCGTGCCCTCCAGCAGCTTG GGCACGAAGACCTACACCTG CAACGTAGAT CACAAGCCCAGCAACACCAAGGTGGACAAG AGAGTTGAGT CCAAATATGG TCCCCCATGCCCATCATGCCCAGCACCTGA GTTCCTGGGG GGACCATCAG TCTTCCTGTTCCCCCCAAAACCCAAGGACA CTCTCATGAT CTCCCGGACC CCTGAGGTCACGTGCGTGGTGGTGGACGTG AGCCAGGAAG ACCCCGAGGTCCAGTTCAACTGGTACGTGG ATGGCGTGGA GGTGCATAATGCCAAGACAA AGCCGCGGGAGGAGCAGTTC AACAGCACGTACCGTGTGGT CAGCGTCCTC ACCGTCCTGCACCAGGACTG GCTGAACGGCAAGGAGTACA AGTGCAAGGT CTCCAACAAAGGCCTCCCGTCCTCCATCGA GAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAGCCA CAGGTGTACA CCCTGCCCCCATCCCAGGAG GAGATGACCAAGAACCAGGT CAGCCTGACCTGCCTGGTCA AAGGCTTCTA CCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAG CCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACT CCGACGGCTC CTTCTTCCTCTACAGCAGGCTAACCGTGGA CAAGAGCAGG TGGCAGGAGGGGAATGTCTT CTCATGCTCCGTGATGCATG AGGCTCTGCA CAACCACTACSalIACACAGAAGA GCCTCTCCCTGTCTCTGGGT AAATGATAA G TCGAC |
2到881 | 牛垂体糖蛋白激素的α-亚单位(α-FSH)的转录终止/聚腺苷酸化信号(Goodwin等人,1983,Nucleic Acids Res.11:6873-82;Gcnbank记录号X00004) |
882到2027 | 含有内源小鼠DHFR启动子、cDNA编码序列,和DHFR转录终止/聚腺苷酸化信号的小鼠二氢叶酸还原酶(DHFR)小基因(Gasser等人,1982,Proc.Natl.Aead.Sci.U.S.A.79:6522-6;Nunberg等人,1980,Cell 19:355-64;Setzer等人,1982,J.Biol.Chem.257:5143-7;McGrogan等人,1985,J.Biol.Chem.260:2307-14) |
2031到3947 | 含有氨苄西林抗性标记基因和大肠杆菌中质粒的复制原点的pBR322序列(Genbank记录号J01749) |
3949到4292 | SV40早启动子、增强子和复制原点(Takebe等人,1988,Mol.CellBiol.8:466-72,Genbank记录号J02400) |
4299到4565 | 来自HTLV-1 LTR结构域的翻译增强子元件(Seiki等人,1983,Proc.Nall.Acad.Sei.U.S.A.80:3618-22,Genbank记录号J02029) |
4574到4730 | 来自SV40 16S、19S剪接供体/受体信号的内含子(Okayama和Berg,1983,Mol.Cell Biol.3:280-9,Genbank记录号J02400) |
4755到6164 | Xbal和SalI位点之间的15C4重链IgG4 cDNA |
抗体 | 重链可变区+重链恒定区 | 完整重链 |
26F5/IgG1(核苷酸) | SEQ ID NO:9+SEQ ID NO:1 | SEQ ID NO:19 |
26F5/IgG1(氨基酸) | SEQ ID NO:10+SEQ ID NO:2 | SEQ ID NO:20 |
26F5/IgG2(核苷酸) | SEQ ID NO:9+SEQ ID NO:5 | SEQ ID NO:21 |
2F5/IgG2(氨基酸) | SEQ ID NO:10+SEQ ID NO:6 | SEQ ID NO:22 |
26F5/IgG4(核苷酸) | SEQ ID NO:9+SEQ ID NO:7 | SEQ ID NO:23 |
26F5/IgG4(氨基酸) | SEQ ID NO:10+SEQ ID NO:8 | SEQ ID NO:24 |
27F2/Ig/G1(核苷酸) | SEQ ID NO:13+SEQ ID NO:1 | SEQ ID NO:25 |
27F2/IgG1(氨基酸) | SEQ ID NO:14+SEQ ID NO:2 | SEQ ID NO:26 |
27F2/IgG2(核苷酸) | SEQ ID NO:13+SEQ ID NO:5 | SBQ ID NO:27 |
27F2/IgG2(氨基酸) | SEQ ID NO:l4+SEQ ID NO:6 | SEQ ID NO:28 |
27F2/IgG4(核苷酸) | SEQ ID NO:13+SEQ ID NO:7 | SEQ ID NO:29 |
27F2/IgG4(氨基酸) | SEQ ID NO:14+SEQ ID NO:8 | SEQ ID NO:30 |
15C4/IgG1(核苷酸) | SEQ ID NO:15+SEQ ID NO:1 | SEQ ID NO:31 |
15C4/IgG1(氨基酸) | SEQ ID NO:16+SEQ ID NO:2 | SEQ ID NO:32 |
15C4/IgG2(核苷酸) | SEQ ID NO:15+SEQ ID NO:5 | SEQ ID NO:33 |
15C4/IgG2(氨基酸) | SEQ ID NO:16+SEQ ID NO:6 | SEQ ID NO:34 |
15C4/IgG4(核苷酸) | SEQ ID NO:15+SEQ ID NO:7 | SEQ ID NO:35 |
15C4/IgG4(氨基酸) | SEQ ID NO:16+SEQ ID NO:8 | SEQ ID NO:36 |
抗体 | 轻链可变区+轻链恒定区 | 完整轻链 |
26F5/27F2(核苷酸) | SEQ ID NO:11+SEQ ID NO:3 | SEQ ID NO:37 |
26F5/27F2(氨基酸) | SEQ ID NO:12+SEQ ID NO:4 | SEQ ID NO:38 |
15C4(核苷酸) | SEQ ID NO:17+SEQ ID NO:3 | SEQ ID NO:39 |
15C4(氨基酸) | SEQ ID NO:18+SEQ ID NO:4 | SEQ ID NO:40 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102439447A (zh) * | 2009-03-02 | 2012-05-02 | 日本烟草产业株式会社 | 对生物学样品中的物质进行检测的方法 |
CN103492416A (zh) * | 2011-04-15 | 2014-01-01 | 默克专利股份公司 | 用于癌症中使用的抗il-1r1抑制剂 |
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Effective date of registration: 20140320 Address after: California, USA Patentee after: AMGEN Inc. Patentee after: MEDAREX, Inc. Address before: California, USA Patentee before: Amgen Inc. Patentee before: Medarex, Inc. |
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Effective date of registration: 20180402 Address after: California, USA Co-patentee after: E.R. Squibb & Saints Co.,Ltd. Patentee after: AMGEN Inc. Address before: California, USA Co-patentee before: MEDAREX, Inc. Patentee before: Amgen Inc. |
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Granted publication date: 20090325 |