BRPI0716088B8 - anticorpo isolado, composição, molécula de ácido nucléico isolada, vetor, método para produzir um anticorpo, hibridoma, e, kit - Google Patents
anticorpo isolado, composição, molécula de ácido nucléico isolada, vetor, método para produzir um anticorpo, hibridoma, e, kitInfo
- Publication number
- BRPI0716088B8 BRPI0716088B8 BRPI0716088A BRPI0716088A BRPI0716088B8 BR PI0716088 B8 BRPI0716088 B8 BR PI0716088B8 BR PI0716088 A BRPI0716088 A BR PI0716088A BR PI0716088 A BRPI0716088 A BR PI0716088A BR PI0716088 B8 BRPI0716088 B8 BR PI0716088B8
- Authority
- BR
- Brazil
- Prior art keywords
- hlight
- antibody
- antibodies
- fully human
- polypeptide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Pain & Pain Management (AREA)
Abstract
anticorpo isolado composição, molécula de ácido nucléico isolada, vetor, célula hospedeira, método para produzir um anticorpo, hibridoma, uso de uma composição, métodos para diminuir ou inibir a ligação de light a hvem, lt(beta)r, dcr3 ou qualquer combinação dos mesmos e para diminuir ou inibir a secreção de ccl20, il-8, rantes ou qualquer combinação dos mesmos e, kit. são aqui fornecidos anticorpos, tais como anticorpos totalmente humanos que imunoespecificamente se ligam a um polipeptídeo hlght. também são fornecidos ácidos nucléicos isolados que codificam anticorpos, tais como anticorpos totalmente humanos, que imunoespecificamente se ligam a um polipeptídeo hlight. além disso são fornecidos vetores e células hospedeiras que compreendem ácidos nucléicos que codificam anticorpos, tais como anticorpos totalmente humanos, que se imunoespecificamente se ligam a um polipeptídeo hlight. também são fornecidos métodos de fabricar anticorpos, tais como anticorpos totalmente humanos, que imunoespecificamente se ligam a um polipeptídeo hlight. também é aqui fornecido um método de tratar uma doença mediada por hlight em um paciente que compreende administrar ao paciente um anticorpo, tal como um anticorpo totalmente humano, que imunoespecificamente se liga a um polpeptídeo hlight. em forma de realização preferidas, estes anticorpos anti-hlight aqui fornecidos melhorado, neutralizado ou de outro modo inibirão a atividade biológica de hlight in vivo (por exemplo, a produção ou secreção mediadas por hlight de ccl20,il-8 ou rantes a partir de uma célula que expressa um receptor de hlight). também é aqui fornecido um método para a detecção de hlight em uma amostra assim como um método para melhorar, neutralizar ou de outro modo inibir a atividade de hlight, por exemplo, em um paciente humano que sofre de um distúrbio em que a atividade de hlight é prejudicial.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84077406P | 2006-08-28 | 2006-08-28 | |
| US60/840774 | 2006-08-28 | ||
| US89787507P | 2007-01-25 | 2007-01-25 | |
| US60/897875 | 2007-01-25 | ||
| PCT/US2007/018832 WO2008027338A2 (en) | 2006-08-28 | 2007-08-24 | Antagonistic human light-specific human monoclonal antibodies |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0716088A2 BRPI0716088A2 (pt) | 2013-10-01 |
| BRPI0716088A8 BRPI0716088A8 (pt) | 2020-03-31 |
| BRPI0716088B1 BRPI0716088B1 (pt) | 2020-12-08 |
| BRPI0716088B8 true BRPI0716088B8 (pt) | 2021-05-25 |
Family
ID=39126775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0716088A BRPI0716088B8 (pt) | 2006-08-28 | 2007-08-24 | anticorpo isolado, composição, molécula de ácido nucléico isolada, vetor, método para produzir um anticorpo, hibridoma, e, kit |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US8058402B2 (pt) |
| EP (3) | EP2064243A2 (pt) |
| JP (2) | JP5209625B2 (pt) |
| KR (2) | KR101374983B1 (pt) |
| AU (1) | AU2007290570C1 (pt) |
| BR (1) | BRPI0716088B8 (pt) |
| CA (1) | CA2661782C (pt) |
| CO (1) | CO6170363A2 (pt) |
| CR (1) | CR10652A (pt) |
| CY (1) | CY1114719T1 (pt) |
| DK (2) | DK2292663T3 (pt) |
| EA (1) | EA021255B1 (pt) |
| ES (2) | ES2439994T3 (pt) |
| GT (1) | GT200900043A (pt) |
| HK (1) | HK1153209A1 (pt) |
| HR (1) | HRP20131215T1 (pt) |
| IL (2) | IL197158A (pt) |
| MA (1) | MA31347B1 (pt) |
| MX (1) | MX2009002151A (pt) |
| MY (1) | MY162024A (pt) |
| NI (1) | NI200900027A (pt) |
| NO (1) | NO20091235L (pt) |
| NZ (2) | NZ575163A (pt) |
| PL (1) | PL2292663T3 (pt) |
| PT (1) | PT2292663E (pt) |
| RS (1) | RS53120B (pt) |
| SG (1) | SG170032A1 (pt) |
| TN (1) | TN2009000051A1 (pt) |
| TW (2) | TW201343676A (pt) |
| WO (1) | WO2008027338A2 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA018072B1 (ru) * | 2002-09-06 | 2013-05-30 | Амджен Инк. | Антитело к рецептору интерлейкина-1 типа 1 (il-1r1) и его применение |
| CA2661782C (en) * | 2006-08-28 | 2019-04-16 | La Jolla Institute For Allergy And Immunology | Antagonistic human light-specific human monoclonal antibodies |
| JP2010539243A (ja) * | 2007-09-18 | 2010-12-16 | ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー | 喘息、肺及び気道の炎症、呼吸器、間質性、肺性および線維性疾患の処置のためのｌｉｇｈｔ阻害剤 |
| US9700606B2 (en) * | 2008-07-08 | 2017-07-11 | La Jolla Institute For Allergy And Immunology | HVEM/BTLA, HVEM/CD 160 and HVEM/gD cis complexes and methods of use |
| KR20190064664A (ko) | 2008-10-02 | 2019-06-10 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Ｃｄ86 길항제 다중-표적 결합 단백질 |
| AU2010228990A1 (en) * | 2009-03-24 | 2011-10-27 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against LIGHT and uses thereof |
| EP2780360B1 (en) | 2011-11-15 | 2023-03-08 | Sanford Burnham Prebys Medical Discovery Institute | Compositions and methods for treating autoimmune and inflammatory disorders |
| US20130315913A1 (en) | 2012-03-26 | 2013-11-28 | Sanofi | Anti-light antibody therapy for inflammatory bowel disease |
| BR122019026701B1 (pt) * | 2012-03-26 | 2023-01-24 | Sanofi | Formulações de agentes de ligação à base de igg4 estáveis, kit, e dispositivo ou recipiente pré-cheios |
| US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| ES2702246T3 (es) * | 2012-03-26 | 2019-02-28 | Sanofi Sa | Formulaciones de agente de unión IgG4 estables |
| JP6153019B2 (ja) | 2013-01-31 | 2017-06-28 | 国立大学法人 東京大学 | リゾホスファチジルセリン受容体機能調節活性を有する化合物 |
| US10259880B2 (en) | 2014-01-14 | 2019-04-16 | Kymab Limited | Anti-LIGHT antibodies |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| TWI555513B (zh) * | 2014-05-27 | 2016-11-01 | 奇美醫療財團法人奇美醫院 | 管體窄化監測裝置及其監測方法 |
| JP6369721B2 (ja) | 2014-07-04 | 2018-08-08 | 国立大学法人 東京大学 | リゾホスファチジルセリン誘導体 |
| MA41414A (fr) * | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| EP3337465B1 (en) | 2015-08-21 | 2021-11-24 | The Children's Hospital of Philadelphia | Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| MX2019006864A (es) | 2016-12-14 | 2019-10-15 | Progenity Inc | Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de factor de necrosis tumoral (tnf). |
| GB201701194D0 (en) * | 2017-01-24 | 2017-03-08 | Capella Bioscience Ltd | Antigen binding molecules that bind light |
| US11312781B2 (en) | 2018-01-24 | 2022-04-26 | Capella Bioscience Ltd. | Antigen binding molecules that bind LIGHT |
| WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| BR112022004590A2 (pt) | 2019-09-13 | 2022-06-14 | Kyowa Kirin Co Ltd | Variante dcr3 |
| CA3162181A1 (en) * | 2019-11-21 | 2021-05-27 | Unity Biotechnology | Antibodies directed to tie-2 and methods of use |
| WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| JP2023520216A (ja) | 2020-04-01 | 2023-05-16 | アヴァロ セラピューティクス， インコーポレイテッド | 過剰な遊離ｌｉｇｈｔに関与する方法及び治療 |
| CA3240327A1 (en) * | 2022-01-05 | 2023-07-13 | Avalo Therapeutics, Inc. | Methods of treating asthma with anti-light antibodies |
| WO2024067344A1 (zh) * | 2022-09-27 | 2024-04-04 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别light的抗体及其应用 |
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