BRPI0716088A2 - anticorpo isolado, composiÇço, molÉcula de Ácido nuclÉico isolada, vetor, cÉlula hospedeira, mÉtodo para produzir um anticorpo, hibridoma, mÉtodos para aliviar um ou mais sintomas de doenÇa, e para diminuir ou inibir a ligaÇço de hlight a hvem, ltbr, dcr3 ou qualquer combinaÇço dos mesmos, e para diminuir ou inibir a secreÇço de ccl20, il-8, rantes ou qualquer combinaÇço dos mesmos, e, kit - Google Patents
anticorpo isolado, composiÇço, molÉcula de Ácido nuclÉico isolada, vetor, cÉlula hospedeira, mÉtodo para produzir um anticorpo, hibridoma, mÉtodos para aliviar um ou mais sintomas de doenÇa, e para diminuir ou inibir a ligaÇço de hlight a hvem, ltbr, dcr3 ou qualquer combinaÇço dos mesmos, e para diminuir ou inibir a secreÇço de ccl20, il-8, rantes ou qualquer combinaÇço dos mesmos, e, kitInfo
- Publication number
- BRPI0716088A2 BRPI0716088A2 BRPI0716088-7A2A BRPI0716088A BRPI0716088A2 BR PI0716088 A2 BRPI0716088 A2 BR PI0716088A2 BR PI0716088 A BRPI0716088 A BR PI0716088A BR PI0716088 A2 BRPI0716088 A2 BR PI0716088A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- antibody
- ltbr
- dcr3
- ccl20
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84077406P | 2006-08-28 | 2006-08-28 | |
US60/840774 | 2006-08-28 | ||
US89787507P | 2007-01-25 | 2007-01-25 | |
US60/897875 | 2007-01-25 | ||
PCT/US2007/018832 WO2008027338A2 (en) | 2006-08-28 | 2007-08-24 | Antagonistic human light-specific human monoclonal antibodies |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0716088A2 true BRPI0716088A2 (pt) | 2013-10-01 |
BRPI0716088A8 BRPI0716088A8 (pt) | 2020-03-31 |
BRPI0716088B1 BRPI0716088B1 (pt) | 2020-12-08 |
BRPI0716088B8 BRPI0716088B8 (pt) | 2021-05-25 |
Family
ID=39126775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0716088A BRPI0716088B8 (pt) | 2006-08-28 | 2007-08-24 | anticorpo isolado, composição, molécula de ácido nucléico isolada, vetor, método para produzir um anticorpo, hibridoma, e, kit |
Country Status (30)
Country | Link |
---|---|
US (4) | US8058402B2 (pt) |
EP (3) | EP2064243A2 (pt) |
JP (2) | JP5209625B2 (pt) |
KR (2) | KR101374983B1 (pt) |
AU (1) | AU2007290570C1 (pt) |
BR (1) | BRPI0716088B8 (pt) |
CA (1) | CA2661782C (pt) |
CO (1) | CO6170363A2 (pt) |
CR (1) | CR10652A (pt) |
CY (1) | CY1114719T1 (pt) |
DK (2) | DK2292663T3 (pt) |
EA (1) | EA021255B1 (pt) |
ES (2) | ES2439994T3 (pt) |
GT (1) | GT200900043A (pt) |
HK (1) | HK1153209A1 (pt) |
HR (1) | HRP20131215T1 (pt) |
IL (2) | IL197158A (pt) |
MA (1) | MA31347B1 (pt) |
MX (1) | MX2009002151A (pt) |
MY (1) | MY162024A (pt) |
NI (1) | NI200900027A (pt) |
NO (1) | NO20091235L (pt) |
NZ (2) | NZ575163A (pt) |
PL (1) | PL2292663T3 (pt) |
PT (1) | PT2292663E (pt) |
RS (1) | RS53120B (pt) |
SG (1) | SG170032A1 (pt) |
TN (1) | TN2009000051A1 (pt) |
TW (2) | TW201343676A (pt) |
WO (1) | WO2008027338A2 (pt) |
Families Citing this family (31)
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EA018072B1 (ru) * | 2002-09-06 | 2013-05-30 | Амджен Инк. | Антитело к рецептору интерлейкина-1 типа 1 (il-1r1) и его применение |
CA2661782C (en) * | 2006-08-28 | 2019-04-16 | La Jolla Institute For Allergy And Immunology | Antagonistic human light-specific human monoclonal antibodies |
JP2010539243A (ja) * | 2007-09-18 | 2010-12-16 | ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー | 喘息、肺及び気道の炎症、呼吸器、間質性、肺性および線維性疾患の処置のためのlight阻害剤 |
US9700606B2 (en) * | 2008-07-08 | 2017-07-11 | La Jolla Institute For Allergy And Immunology | HVEM/BTLA, HVEM/CD 160 and HVEM/gD cis complexes and methods of use |
KR20190064664A (ko) | 2008-10-02 | 2019-06-10 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd86 길항제 다중-표적 결합 단백질 |
AU2010228990A1 (en) * | 2009-03-24 | 2011-10-27 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against LIGHT and uses thereof |
EP2780360B1 (en) | 2011-11-15 | 2023-03-08 | Sanford Burnham Prebys Medical Discovery Institute | Compositions and methods for treating autoimmune and inflammatory disorders |
US20130315913A1 (en) | 2012-03-26 | 2013-11-28 | Sanofi | Anti-light antibody therapy for inflammatory bowel disease |
BR122019026701B1 (pt) * | 2012-03-26 | 2023-01-24 | Sanofi | Formulações de agentes de ligação à base de igg4 estáveis, kit, e dispositivo ou recipiente pré-cheios |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
ES2702246T3 (es) * | 2012-03-26 | 2019-02-28 | Sanofi Sa | Formulaciones de agente de unión IgG4 estables |
JP6153019B2 (ja) | 2013-01-31 | 2017-06-28 | 国立大学法人 東京大学 | リゾホスファチジルセリン受容体機能調節活性を有する化合物 |
US10259880B2 (en) | 2014-01-14 | 2019-04-16 | Kymab Limited | Anti-LIGHT antibodies |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
TWI555513B (zh) * | 2014-05-27 | 2016-11-01 | 奇美醫療財團法人奇美醫院 | 管體窄化監測裝置及其監測方法 |
JP6369721B2 (ja) | 2014-07-04 | 2018-08-08 | 国立大学法人 東京大学 | リゾホスファチジルセリン誘導体 |
MA41414A (fr) * | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
EP3337465B1 (en) | 2015-08-21 | 2021-11-24 | The Children's Hospital of Philadelphia | Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
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GB201701194D0 (en) * | 2017-01-24 | 2017-03-08 | Capella Bioscience Ltd | Antigen binding molecules that bind light |
US11312781B2 (en) | 2018-01-24 | 2022-04-26 | Capella Bioscience Ltd. | Antigen binding molecules that bind LIGHT |
WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
BR112022004590A2 (pt) | 2019-09-13 | 2022-06-14 | Kyowa Kirin Co Ltd | Variante dcr3 |
CA3162181A1 (en) * | 2019-11-21 | 2021-05-27 | Unity Biotechnology | Antibodies directed to tie-2 and methods of use |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
JP2023520216A (ja) | 2020-04-01 | 2023-05-16 | アヴァロ セラピューティクス, インコーポレイテッド | 過剰な遊離lightに関与する方法及び治療 |
CA3240327A1 (en) * | 2022-01-05 | 2023-07-13 | Avalo Therapeutics, Inc. | Methods of treating asthma with anti-light antibodies |
WO2024067344A1 (zh) * | 2022-09-27 | 2024-04-04 | 舒泰神(北京)生物制药股份有限公司 | 特异性识别light的抗体及其应用 |
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