CN1444658A - 提高微生物发酵生产乙醇的方法 - Google Patents
提高微生物发酵生产乙醇的方法 Download PDFInfo
- Publication number
- CN1444658A CN1444658A CN01813372A CN01813372A CN1444658A CN 1444658 A CN1444658 A CN 1444658A CN 01813372 A CN01813372 A CN 01813372A CN 01813372 A CN01813372 A CN 01813372A CN 1444658 A CN1444658 A CN 1444658A
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- Prior art keywords
- ethanol
- bioreactor
- acetic acid
- gas
- rate
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Links
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- 238000000034 method Methods 0.000 title claims abstract description 145
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- 230000000813 microbial effect Effects 0.000 title description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 652
- 235000015097 nutrients Nutrition 0.000 claims abstract description 119
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 9
- 239000008346 aqueous phase Substances 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
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- 150000003839 salts Chemical class 0.000 description 21
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 17
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- FAPWYRCQGJNNSJ-CTWWJBIBSA-L calcium;3-[[(2s)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Ca+2].OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-CTWWJBIBSA-L 0.000 description 6
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- 238000010521 absorption reaction Methods 0.000 description 5
- CDXSJGDDABYYJV-UHFFFAOYSA-N acetic acid;ethanol Chemical compound CCO.CC(O)=O CDXSJGDDABYYJV-UHFFFAOYSA-N 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 5
- 241000589877 Campylobacter coli Species 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
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- 238000000926 separation method Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
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- 108010020056 Hydrogenase Proteins 0.000 description 2
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
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- 239000012138 yeast extract Substances 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
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- 241000863391 Methylophilus Species 0.000 description 1
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- 241000206591 Peptococcus Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- SXRRAEDIIGNDNU-FJXQXJEOSA-M calcium;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O SXRRAEDIIGNDNU-FJXQXJEOSA-M 0.000 description 1
- OKTJSMMVPCPJKN-YPZZEJLDSA-N carbon-10 atom Chemical compound [10C] OKTJSMMVPCPJKN-YPZZEJLDSA-N 0.000 description 1
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- 239000003638 chemical reducing agent Substances 0.000 description 1
- 150000001868 cobalt Chemical class 0.000 description 1
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- 230000001419 dependent effect Effects 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
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- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
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- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
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- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 description 1
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- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- C—CHEMISTRY; METALLURGY
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
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- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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- C12M43/00—Combinations of bioreactors or fermenters with other apparatus
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Abstract
Description
成分 | 每升含量 |
2g/l FeCl2·4H2O | 10ml |
85% H3PO4 | 0.05ml |
MPFN痕量矿物a | 20ml |
(NH4)2HPO4 | 0.60g |
NH4Cl | 2.00g |
NaCl | 0.20g |
KCl | 0.15g |
MgCl2·6H2O | 0.50g |
CaCl2·2H2O | 0.20g |
半胱氨酸HCl·H2O | 0.25g |
维生素溶液b | 可变c |
实施例号 | 控制机制 | 产物浓度 | 乙醇产率(g/L·天) | 提供的泛酸盐(微克泛酸盐/g产生的细胞) | 提供的钴(微克钴/g产生的细胞) | H2进料(2CO转化+3CO2转化) | 排出气体中的H2分压(atm) | 比CO摄取(mmol/g·细胞·分钟) | |
乙醇(g/L) | 乙酸(g/L) | ||||||||
3 | 物质转移 | 0 | 10-13 | 0 | 1575-3150 | 1734-3468 | 0.46 | 0.06-0.07 | 0.275-0.48 |
3 | 物质转移 | 0 | 10-14 | 0 | 2250-3600 | 62-99 | 0.875 | 0.11-0.20 | 0.33-0.40 |
4 | 泛酸盐 | 15-19 | 1.5 | 11.5-14.5 | 18-24 | 5000-6660 | 1.03 | 0.55-0.64 | 0.23-0.30 |
4 | 泛酸盐 | 18 | 3 | 17.4 | 8.1 | 3960 | 1.14 | 0.60-0.65 | 0.33 |
5 | 钴 | 26 | 4 | 15.6 | 15.2 | 33 | 0.94 | 0.63 | 0.37 |
5 | 钴 | 18 | 4 | 27.0 | 85.7 | 47.6 | 1.03 | 0.60 | 0.50 |
6 | 过量CO | 9.9 | 2.6 | 29.0 | 97 | 83.6 | 1.09 | 1.6 | 1.34 |
6 | 过量CO | 12.0 | 2.7 | 60.0 | 294 | 735 | 0.30 | 0.6 | 0.67 |
7 | 过量H2 | 10.0 | 3.3 | 6.7 | 900-1125 | 991-1239 | 1.96 | 0.7-0.87 | 0.28-0.35 |
7 | 过量H2 | 25.96 | 2.85 | 215-400 | 46 | 460 | 5.67 | 2.61 | 1.68 |
杨氏梭菌 | 培养基 | 细胞浓度* | 气体转化 | 产物浓度 | ||
菌株 | 限制 | (g/L) | CO | H2 | 乙醇 | 乙酸 |
ERI2 | 乙酸增强 | 1.1 | 90 | 80 | 0 | 10 |
ERI2 | 泛酸盐限制 | 0.3 | 88 | 20 | 2.5 | 0 |
ERI2 | 乙酸增强 | 0.55 | 90 | 85 | 1.0 | 5.5 |
ERI2 | 泛酸盐限制 | 0.5 | 90 | 20 | 10 | 1.0 |
ERI2 | 乙酸增强 | 0.8 | 100 | 93 | 1 | 7 |
ERI2 | 钴限制 | 1.3 | 80 | 20 | 9 | 3 |
C-01 | 乙酸增强 | 1.2 | 96 | 90 | 1 | 8 |
C-01 | 泛酸盐限制 | 0.8 | 60 | 30 | 4 | 0 |
C-01 | 钴限制 | 2.5 | 80 | 20 | 17 | 2 |
C-01 | 乙酸增强 | 1.2 | 96 | 90 | <1 | 9 |
PETC | 乙酸增强 | 0.8 | 65 | 55 | 2 | 10 |
PETC | 钴限制 | 1.0 | 95 | 55 | 8 | 1 |
GRT | LRT | 搅拌速率 | 细胞浓度* | 气体转化(%) | 产物(g/L) | 乙醇产率 | ||
(min) | (hr) | (rpm) | (g/L) | CO | H2 | 乙醇 | 乙酸 | (g/L·天) |
13 | 32.4 | 700 | 2.44 | 91 | 57 | 21.6 | 3.9 | 16.0 |
11.93 | 25.7 | 750 | 2.51 | 92 | 54 | 20.6 | 3.6 | 19.2 |
12.67 | 25.6 | 750 | 2.60 | 93 | 61 | 18.7 | 4.7 | 17.6 |
10 | 24.5 | 750 | 2.75 | 92 | 43 | 20.4 | 6.1 | 20.0 |
11.54 | 23.8 | 750 | 2.65 | 92 | 40 | 20.4 | 5.3 | 20.6 |
12.10 | 23.8 | 750 | 2.77 | 88 | 18 | 21 | 3.1 | 21.1 |
13.8 | 23.8 | 750 | 2.70 | 90 | 25 | 18 | 2.5 | 18.2 |
12.7 | 23.8 | 750 | 2.70 | 92 | 35 | 20 | 3.8 | 20.2 |
13.3 | 24.0 | 800 | 2.70 | 85 | 10 | 17.5 | 5.0 | 17.5 |
14.81 | 31 | 750 | 2.50 | 92 | 30 | 25 | 2.5 | 19.4 |
16.9 | 31 | 750 | 3.60 | 90 | 18 | 23 | 3.0 | 17.8 |
18.5 | 33 | 750 | 2.60 | 94 | 50 | 24 | 3.5 | 17.5 |
17.2 | 34 | 750 | 2.50 | 91 | 40 | 24 | 3.5 | 16.9 |
18.5 | 34 | 750 | 2.30 | 95 | 63 | 23 | 4.0 | 16.2 |
19.2 | 40.6 | 750 | 2.70 | 94 | 50 | 28.5 | 4.0 | 17.4 |
19.0 | 55 | 750 | 2.70 | 94 | 20 | 33 | 4.0 | 14.4 |
GRT | LRT | 搅拌速率 | 细胞浓度* | 气体转化(%) | 产物(g/L) | 乙醇产率 | ||
(min) | (hr) | (rpm) | (g/L) | CO | H2 | 乙醇 | 乙酸 | (g/L·天) |
8.89 | 23.8 | 750 | 2.3 | 84 | 57 | 11 | 2.5 | 11.1 |
8.3 | 23.8 | 900 | 2.6 | 89 | 55 | 12 | 2.0 | 12.1 |
8.3 | 27.7 | 900 | 2.7 | 89 | 47 | 15 | 3.0 | 13.0 |
7.1 | 33.3 | 900 | 3.0 | 86 | 37 | 19 | 3.0 | 13.7 |
7.4 | 33.3 | 900 | 3.0 | 87 | 40 | 19.5 | 3.0 | 14.1 |
6.34 | 33.3 | 900 | 3.0 | 86 | 37 | 21 | 3.5 | 15.1 |
6.18 | 33.3 | 900 | 3.0 | 86 | 41 | 20.9 | 3.1 | 15.1 |
5.72 | 34.3 | 900 | 3.0 | 85 | 40 | 22.1 | 3.8 | 15.5 |
5.12 | 33 | 900 | 3.7 | 85 | 40 | 25.0 | 4.0 | 18.2 |
4.59 | 33 | 900 | 4.1 | 83 | 33 | 25 | 3.5 | 18.2 |
4.59 | 29 | 900 | 4.0 | 80 | 35 | 23 | 4.0 | 19.0 |
4.76 | 29 | 900 | 3.9 | 90 | 35 | 19 | 5.0 | 15.7 |
4.25 | 28 | 900 | 4.2 | 80 | 30 | 23 | 3.0 | 19.7 |
5.5 | 37 | 900 | 3.4 | 84 | 40 | 23 | 3.0 | 14.9 |
5.26 | 31 | 900 | 3.8 | 84 | 50 | 23 | 3.0 | 17.8 |
5.71 | 31 | 900 | 3.7 | 80 | 28 | 26 | 3.5 | 20.1 |
6.25 | 31 | 900 | 3.75 | 82 | 30 | 25.5 | 3.0 | 19.7 |
6.66 | 31 | 900 | 3.6 | 86 | 64 | 22 | 4.0 | 17.0 |
GRT | XRT | LRT | 细胞浓度* | 气体转化(%) | 产物(g/L) | 乙醇产率 | ||
(min) | (hr) | (hr) | (g/L) | CO | H2 | 乙醇 | 乙酸 | (g/L·天) |
12.5 | 46.4 | 23.2 | 3.8 | 96.3 | 81.2 | 20.4 | 4.4 | 21.1 |
9.7 | 43.2 | 17.3 | 4.9 | 86.7 | 49.9 | 21.1 | 3.5 | 29.3 |
9.2 | 43.2 | 17.3 | 4.6 | 89.4 | 64.5 | 20.5 | 5.1 | 28.4 |
7.5 | 43.2 | 17.3 | 5.0 | 81.8 | 42.1 | 22.2 | 3.7 | 30.8 |
9.2 | 49.4 | 17.3 | 4.6 | 85.3 | 52.1 | 21.1 | 4.4 | 29.3 |
8.4 | 46.0 | 16.1 | 4.5 | 85.2 | 61.4 | 20.8 | 5.1 | 31.0 |
6.8 | 54.3 | 16.3 | 4.7 | 84.7 | 57.7 | 23.4 | 5.7 | 34.5 |
7.2 | 54.3 | 16.3 | 4.0 | 83.1 | 55.2 | 19.0 | 4.4 | 28.0 |
6.4 | 55.6 | 16.7 | 5.6 | 83.3 | 53.1 | 23.5 | 4.9 | 33.8 |
6.2 | 41.6 | 14.5 | 5.7 | 82.5 | 55.0 | 20.1 | 5.0 | 33.3 |
6.0 | 41.6 | 14.5 | 6.0 | 82.5 | 50.0 | 21.5 | 3.0 | 35.6 |
6.0 | 34.2 | 12.0 | 5.7 | 84.0 | 56.0 | 19.5 | 4.5 | 39.0 |
5.7 | 34.2 | 12.0 | 5.7 | 81.0 | 45.0 | 18.0 | 4.5 | 36.0 |
时间 | pH | 细胞浓度*(g/L) | 乙醇(g/L) | 乙酸(g/L) | 丁醇(g/L) |
0 | 4.69 | 2.4 | 10.3 | 3.1 | 0.3 |
30 | 5.28 | 11.4 | 1.5 | 0.3 | |
35 | 5.28 | 2.4 | 11.6 | 1.6 | 0.3 |
50 | 4.98 | 11.3 | 1.8 | 0.3 | |
80 | 4.73 | 2.4 | 10.9 | 2.9 | 0.3 |
时间(hr) | %水回收 | 细胞浓度*(g/L) | 气体转化 | 产物 | 乙醇产率 | |||
CO(%) | H2(%) | 乙醇(g/L) | 乙酸(g/L) | 纯乙酸(g/L) | (g/L·天) | |||
0-75 | 25 | 2.1 | 95 | 68 | 12 | 4 | 4 | 12 |
75-193 | 50 | 2.1 | 95 | 75 | 15 | 6 | 5 | 15 |
193-462 | 75 | 2.1 | 92 | 60 | 17 | 5 | 4 | 17 |
462-554 | 50 | 1.6 | 85 | 30 | 17→13 | 5 | 3 | 12-16 |
554-669 | 75 | 2.6 | 92 | 75 | 13→19 | 5 | 3 | 12-18 |
669-943 | 100 | 3.0 | 92 | 70 | 23 | 6 | 3 | 23 |
943-1087 | 100 | 3.0 | 92 | 60 | 23 | 6 | 0 | 23 |
1087-1232 | 100 | 2.7 | 92 | 60 | 23 | 6 | -0 | 23 |
1232-1375 | 100 | 3.0 | 91 | 60 | 27 | 6 | -1 | 27 |
1375-1534 | 100 | 3.5 | 88 | 35 | 23 | 5 | 0 | 23 |
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