KR20030036638A - 미생물 발효로부터 에탄올의 생산을 증가시키기 위한 방법 - Google Patents
미생물 발효로부터 에탄올의 생산을 증가시키기 위한 방법 Download PDFInfo
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- KR20030036638A KR20030036638A KR10-2003-7001116A KR20037001116A KR20030036638A KR 20030036638 A KR20030036638 A KR 20030036638A KR 20037001116 A KR20037001116 A KR 20037001116A KR 20030036638 A KR20030036638 A KR 20030036638A
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- South Korea
- Prior art keywords
- ethanol
- bioreactor
- gas
- rate
- production
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 926
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 336
- 239000007789 gas Substances 0.000 claims abstract description 240
- 235000015097 nutrients Nutrition 0.000 claims abstract description 116
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/04—Bioreactors or fermenters specially adapted for specific uses for producing gas, e.g. biogas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/12—Bioreactors or fermenters specially adapted for specific uses for producing fuels or solvents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/02—Percolation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M43/00—Combinations of bioreactors or fermenters with other apparatus
- C12M43/02—Bioreactors or fermenters combined with devices for liquid fuel extraction; Biorefineries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
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- Oil, Petroleum & Natural Gas (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims (31)
- 가스 기질의 혐기성 세균 발효로부터 에탄올을 제조하기 위한 안정되고 연속적인 방법으로서,발효 바이오리액터에서 액체 영양분 배지에서 혐기성, 아세토제닉 세균을 배양하고 일산화탄소와 수소로 구성되는 군으로부터 선택된 한가지 이상의 환원 가스를 포함하는 상기 가스 기질을 상기 바이오리액터로 공급하는 단계; 및상기 세균이 상기 바이오리액터에서 안정된 세포 농도를 달성한 후에, 발효육즙에서 산화 환원 포텐샬을 줄이거나, NAD(P)H TO NAD(P) 비율을 증가시킴으로써, 상기 바이오리액터의 상기 세균을 조작하는 단계를 포함하고, 여기서 상기 바이오리액터에서 상기 유리 아세트산 농도는 5 g/L 유리 산 이하이고,상기 배양 및 조작 단계들은 상기 바이오리액터에서 상기 세균이 발효육즙에서 하루에 lOg/L 이상의 생산율로 에탄올을 생산하도록 만들고 여기서 에탄올과 아세테이트 모두는 상기 배양액에서 1: 1 내지 20 : 1의 범위의 에탄올 대 아세테이트비로 제조되는 것을 특징으로 하는 방법.
- 제 1항에 있어서, 상기 발효 바이오리액터가 상기 발효육즙을 대부분의 상기 에탄올이 제조되는 두번째 발효 바이오리액터로 공급하는 성장 리액터를 포함하는 것을 특징으로 하는 방법.
- 제 1항에 있어서, 상기 발효육즙을 상기 바이오리액터로부터 제거하는 단계, 상기액으로부터 에탄올을 증류하고 상기 에탄올을 회수하는 단계를 더욱 포함하는 것을 특징으로 하는 방법.
- 제 3항에 있어서, 상기 증류 단계로부터 아세테이트를 함유하는 물을 바이오리액터로 되돌리는 재순환 단계를 더욱 포함하는 것을 특징으로 하는 방법.
- 제 1항에 있어서, 상기 세균은 하기로 구성되는 군으로부터 선택되는 것을 특징으로 하는 방법.Acetobacterium woodii, Butyribacterium methylotrophicum, Clostridium Aceticum, C.acetobutylicum, C.thermoaceticum, Eubacterium limosum, Clostridium ljungdahlii및Peptostreptococcus productus.
- 제 5항에 있어서, 상기Clostridium ljungdahlii가 PETC, ERI2, O-52 및 C-01로 구성되는 균주로부터 선택되는 것을 특징으로 하는 방법.
- 제 1항에 있어서, 상기 가스 기질은 (a)일산화탄소, (b)일산화탄소 및 수소, (c)이산화탄소 및 수소, (d)일산화탄소, 이산화탄소 및 수소로 구성되는 군으로부터 선택되는 것을 특징으로 하는 방법.
- 제 7항에 있어서, 상기 기질은 추가적으로 질소 또는 메탄을 포함하는 것을 특징으로 하는 방법.
- 제 1항에 있어서, 상기 조작 단계는 영양분 배지 함량, 영양분 공급 속도, 수성 원료 속도, 작동 압력, 작동 pH, 가스 기질 함량, 가스 공급 속도, 발효육즙 교반 속도, 생산물 억제 단계, 세포 밀도, 기질 억제 및 그들의 조합으로 구성되는 군으로부터 선택된 하나 이상의 매개 변수를 변경하는 것을 더욱 포함하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 상기 조작 단계가 상기 배양균의 pH를 4.5 이상으로 올리는 것을 포함하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 상기 조작 단계는 상기 바이오리액터로부터 세균 세포를 상기 바이오리액터에서 모든 환원 가스 또는 영양분 기질을 이용하는 상기 안정된 농도 이하의 세포 농도로 주기적으로 퍼징하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 발효육즙에 존재하는 아세테이트의 유리 아세트산의 몫이 2 g/L을 초과할때, 수성 원료 속도를 증가시키고, 그로써 상기 유리 아세트산의 농도에서 어떠한 원치않는 증가를 억제하는 것을 포함하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 과도한 일산화탄소를 제거하고, 기질 억제를 완화하고, 상기 생산율을 유지하기 위해 상기 가스 기질 공급 속도를 줄이는 것을 포함하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 과도한 일산화탄소를 제거하고, 기질 억제를 완화하고, 상기 생산율을 유지하기 위해 상기 교반 속도가 감소되는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 상기 조작 단계는 상기 바이오리액터/분에서 0.3 내지 2 mmol CO/세균의 건조 세포의 그램의 속도로 환원 가스 일산화탄소를 포함하는 상기 가스 기질을 상기 바이오리액터에 공급하는 것을 포함하는 것을 특징으로 하는 방법.
- 제 15항에 있어서, 상기 바이오리액터에 존재하는 상기 CO의 양은 제공된 CO를 완전히 이용하는 안정된 세균 농도로 상기 세균을 유지하는데 필요한 양보다 더 큰 것을 특징으로 하는 방법.
- 제 15항에 있어서, 상기 바이오리액터에 존재하는 상기 CO의 양은 아세테이트 제조보다 우선적으로 에탄올 제조를 유지하는 것을 특징으로 하는 방법.
- 제 15항에 있어서, 상기 속도는 상기 바이오리액터/분에서 0.5 내지 1.5mmol CO/세균의 건조 세포의 그램의 범위인 것을 특징으로 하는 방법.
- 제 15항에 있어서, 상기 가스 기질은 상기 일산화탄소에 비해 초과량의 수소 환원 가스를 더욱 포함하고, 여기서 상기 과잉 수소가 상기 세균이 상기 발효육즙에서 높은 아세테이트에 대한 에탄올 비율을 제조하도록 하는 원인이 되는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 상기 조작 단계는 상기 발효 바이오리액터 안으로 0.5 내지 50 μg/상기 바이오리액터에서 제조된 세균의 건조 세포의 그램의 범위에 있는 칼슘 판토테네이트의 양을 포함하는 상기 영양분 배지를 공급하는 것을 포함하는 것을 특징으로 하는 방법.
- 제 20항에 있어서, 칼슘 판토테네이트의 상기 양은 제조된 칼슘 판토테네이트를 완전히 이용하는 안정된 세균 농도에서 상기 세균을 유지하는데 필요한 것 이하인 것을 특징으로 하는 방법.
- 제 20항에 있어서, 칼슘 판토테네이트의 상기 양은 아세테이트 제조보다 우선적으로 에탄올 제조를 유지하는 것을 특징으로 하는 방법.
- 제 20항에 있어서, 상기 양은 1 내지 25 μg 칼슘 판토테네이트/제조된 세균의 건조 세포의 그램인 것을 특징으로 하는 방법.
- 제 20항에 있어서, 상기 양은 2 내지 25 μg 칼슘 판토테네이트/제조된 세균의 건조 세포의 그램인 것을 특징으로 하는 방법.
- 제 20항에 있어서, 상기 바이오리액터에서 일정한 칼슘 판토테네이트 농도를 유지하고 가스 속도, 액체 속도, 교반 속도 및 수소 가스 부분 압력으로 구성되는 군으로부터 선택되는 매개 변수들을 조절함으로써 상기 칼슘 판토테네이트 양에 대한 상기 세균의 순응을 예방하는 단계를 더욱 포함하는 것을 특징으로 하는 방법.
- 제 20항에 있어서, 상기 양의 칼슘 판토테네이트를 제공하기에 앞서 과도한 수소 환원 가스를 상기 바이오리엑터로 공급하는 것을 더욱 포함하는 것을 특징으로 하는 방법.
- 제 9항에 있어서, 상기 조작 단계는 5 내지 100 μg 코발트/상기 바이오리액터에서 제조된 세균의 건조 세포의 그램의 범위의 코발트의 양을 포함하는 상기 영양분 배지를 상기 발효 바이오리엑터 안으로 공급하는 것을 포함하는 것을 특징으로 하는 방법.
- 제 27항에 있어서, 상기 코발트의 양은 제공된 코발트를 완전히 이용하는 안정된 세균 농도에서 상기 세균을 유지하는데 필요한 것 이하인 것을 특징으로 하는 방법.
- 제 27항에 있어서, 상기 양의 코발트는 아세테이트보다 우선적으로 에탄올 제조를 유지하는 것을 특징으로 하는 방법.
- 제 27항에 있어서, 상기 양은 20 내지 50 μg 칼슘 판토테네이트/제조된 세균의 건조 세포의 그램인 것을 특징으로 하는 방법.
- 제 27항에 있어서, 일정한 코발트 농도를 유지하고 가스 속도, 액체 속도, 교반 속도 및 수소 가스 부분 압력으로 구성되는 군으로부터 선택된 매개변수들을 조절함으로써 상기 바이오리액터에서 상기 양의 코발트에 대한 상기 세균의 순응을 예방하는 단계를 더욱 포함하는 것을 특징으로 하는 방법.
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US22079400P | 2000-07-25 | 2000-07-25 | |
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PCT/US2001/023149 WO2002008438A2 (en) | 2000-07-25 | 2001-07-23 | Methods for increasing the production of ethanol from microbial fermentation |
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