CN1211485C - 生产重组白蛋白的方法 - Google Patents

生产重组白蛋白的方法 Download PDF

Info

Publication number
CN1211485C
CN1211485C CNB008032920A CN00803292A CN1211485C CN 1211485 C CN1211485 C CN 1211485C CN B008032920 A CNB008032920 A CN B008032920A CN 00803292 A CN00803292 A CN 00803292A CN 1211485 C CN1211485 C CN 1211485C
Authority
CN
China
Prior art keywords
albumin
preferred
substratum
rha
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB008032920A
Other languages
English (en)
Chinese (zh)
Other versions
CN1339065A (zh
Inventor
亨德里克·范厄克
戴维·J·米德
菲利普·H·莫顿
安德鲁·J·卡特赖特
贾森·卡梅伦
戴维·J·巴兰斯
米歇尔·G·J·格兰德乔治
斯蒂芬·贝雷曾科
约翰·R·伍德罗
达雷尔·斯利普
让-卢克·B·维伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Publication of CN1339065A publication Critical patent/CN1339065A/zh
Application granted granted Critical
Publication of CN1211485C publication Critical patent/CN1211485C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CNB008032920A 1999-01-30 2000-01-31 生产重组白蛋白的方法 Expired - Lifetime CN1211485C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process
GB9902000.0 1999-01-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2005101086585A Division CN1810834B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CN2004100050153A Division CN1526732B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法

Publications (2)

Publication Number Publication Date
CN1339065A CN1339065A (zh) 2002-03-06
CN1211485C true CN1211485C (zh) 2005-07-20

Family

ID=10846743

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2005101086585A Expired - Lifetime CN1810834B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CNA2006101006640A Pending CN1974599A (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CN2004100050153A Expired - Lifetime CN1526732B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CNB008032920A Expired - Lifetime CN1211485C (zh) 1999-01-30 2000-01-31 生产重组白蛋白的方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN2005101086585A Expired - Lifetime CN1810834B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CNA2006101006640A Pending CN1974599A (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法
CN2004100050153A Expired - Lifetime CN1526732B (zh) 1999-01-30 2000-01-31 制备高纯度白蛋白溶液的方法

Country Status (16)

Country Link
US (3) US7993877B2 (US07993877-20110809-P00003.png)
EP (3) EP2272961A1 (US07993877-20110809-P00003.png)
JP (3) JP4586150B2 (US07993877-20110809-P00003.png)
KR (2) KR100886554B1 (US07993877-20110809-P00003.png)
CN (4) CN1810834B (US07993877-20110809-P00003.png)
AT (1) ATE416254T1 (US07993877-20110809-P00003.png)
AU (2) AU763899B2 (US07993877-20110809-P00003.png)
CA (1) CA2359705C (US07993877-20110809-P00003.png)
DE (1) DE60040967D1 (US07993877-20110809-P00003.png)
DK (1) DK2048234T3 (US07993877-20110809-P00003.png)
ES (1) ES2317827T3 (US07993877-20110809-P00003.png)
GB (1) GB9902000D0 (US07993877-20110809-P00003.png)
HK (2) HK1096691A1 (US07993877-20110809-P00003.png)
MX (1) MXPA01007719A (US07993877-20110809-P00003.png)
SG (2) SG119194A1 (US07993877-20110809-P00003.png)
WO (1) WO2000044772A2 (US07993877-20110809-P00003.png)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6926898B2 (en) 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
ITBO20010426A1 (it) * 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
ES2500918T3 (es) 2001-12-21 2014-10-01 Human Genome Sciences, Inc. Proteínas de fusión de albúmina e interferón beta
GB0202633D0 (en) * 2002-02-05 2002-03-20 Delta Biotechnology Ltd Stabilization of protein preparations
JP2005516607A (ja) 2002-02-07 2005-06-09 デルタ バイオテクノロジー リミテッド Hiv阻害タンパク質
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
ATE539086T1 (de) 2003-12-03 2012-01-15 Monika Kroez Interleukin-11-fusionsproteine
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
GB0329722D0 (en) * 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
WO2006066595A2 (en) * 2004-12-22 2006-06-29 Novozymes A/S Recombinant production of serum albumin
WO2007063129A2 (en) * 2005-12-02 2007-06-07 Novozymes A/S Insolation of peptides , polypeptides and proteins
JP2007284425A (ja) * 2006-03-20 2007-11-01 Nokodai Tlo Kk タンパク質の精製方法
US9139611B2 (en) 2006-07-13 2015-09-22 Novozymes Biopharma Dk A/S Process for preparing particles of proteinaceous material
WO2008012629A2 (en) 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
SG10201405420QA (en) * 2007-02-02 2014-10-30 Globeimmune Inc Methods for producing yeast-based vaccines
CA2695830A1 (en) 2007-08-08 2009-02-12 Novozymes Biopharma Dk A/S Transferrin variants and conjugates
EP2261661A4 (en) 2008-03-31 2011-04-20 Sekisui Medical Co Ltd CLEANED SERUM ALBUMIN AND IMMUNOLOGY MEASUREMENT PROCESS
CN101684459B (zh) * 2008-09-22 2012-01-25 上海普天欣生物技术有限公司 CehA突变体蛋白、基因、重组载体及其用途和制备方法
CN101747437B (zh) 2008-12-10 2012-09-26 浙江日升昌药业有限公司 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白
EP3243835B1 (en) 2009-02-11 2024-04-10 Albumedix Ltd Albumin variants and conjugates
AU2010215959A1 (en) 2009-02-20 2011-08-04 Ventria Bioscience Cell culture media containing combinations of proteins
CN102405279B (zh) 2009-04-09 2015-10-21 塞尔卡有限公司 改善单细胞克隆的方法
DK2427486T3 (en) * 2009-05-07 2015-05-26 Novozymes Biopharma Dk As A process for purifying albumin
CN101691581B (zh) * 2009-06-25 2012-10-03 南京农业大学 染色体无标记随机整合载体pUTTns及其应用
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
CA2776241A1 (en) 2009-10-30 2011-05-05 Novozymes Biopharma Dk A/S Albumin variants
WO2011124718A1 (en) 2010-04-09 2011-10-13 Novozymes A/S Albumin derivatives and variants
NZ603289A (en) * 2010-04-29 2014-07-25 Baxter Int Purification method for divalent cation binding proteins on anion exchange resin
US20130225496A1 (en) 2010-11-01 2013-08-29 Novozymes Biopharma Dk A/S Albumin Variants
CN102127164B (zh) * 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
GB2491006A (en) 2011-05-05 2012-11-21 Novozymes Biopharma Uk Ltd Albumin variants
CA2838964C (en) * 2011-07-05 2021-07-13 Novozymes Biopharma Dk A/S Albumin formulation and use
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
EP2788033B1 (en) * 2011-12-05 2017-05-31 Factor Bioscience Inc. Methods and products for transfecting cells
RS63244B1 (sr) 2011-12-16 2022-06-30 Modernatx Inc Kompozicije modifikovane mrna
US9944691B2 (en) 2012-03-16 2018-04-17 Albumedix A/S Albumin variants
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151664A1 (en) * 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501513B2 (en) * 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
CN102952836A (zh) * 2012-11-02 2013-03-06 浙江海正药业股份有限公司 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法
US20140128326A1 (en) 2012-11-08 2014-05-08 Novozymes Biopharma Dk A/S Albumin variants
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
RU2663587C2 (ru) * 2013-03-06 2018-08-07 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Клетки-хозяева и способы использования
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
SI3016970T1 (sl) 2013-07-04 2019-08-30 Glykos Finland Oy Nitaste glivične celice brez O-manoziltransferaze in postopki za uporabo le-teh
JP6306700B2 (ja) 2013-11-01 2018-04-04 ユニバーシティ オブ オスロUniversity of Oslo アルブミン改変体及びその使用
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
US9938319B2 (en) * 2014-04-23 2018-04-10 Alexion Pharmaceuticals, Inc. Egg white processing
WO2016012468A1 (en) 2014-07-21 2016-01-28 Novartis Ag Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3240798B8 (en) * 2015-01-01 2020-03-25 Shilpa Medicare Limited Novel method for efficient purification of human serum albumin
EP3543339A1 (en) 2015-02-13 2019-09-25 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CA2979397A1 (en) 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
WO2016207730A1 (en) 2015-06-22 2016-12-29 The University Of Oslo Targeting of vaccine antigen to an intracellular compartment
CN105037487B (zh) * 2015-08-12 2017-03-22 山东泰邦生物制品有限公司 一种人血白蛋白的制备方法
BR112018003179A2 (pt) 2015-08-20 2018-09-25 Albumedix As conjugados e variantes de albumina
CA3005953A1 (en) 2015-12-22 2017-06-29 Albumedix Ltd Improved protein expression strains
CN116115629A (zh) 2016-08-17 2023-05-16 菲克特生物科学股份有限公司 核酸产品及其施用方法
KR102662031B1 (ko) 2016-10-04 2024-05-03 알부메딕스 리미티드 재조합 효모-유래 혈청 알부민의 용도
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
CN110770251A (zh) * 2017-04-20 2020-02-07 诺和诺德股份有限公司 纯化白蛋白融合蛋白的方法
JP7282693B2 (ja) 2017-06-20 2023-05-29 アルブミディクス リミティド 改良されたタンパク質発現株
CN112368368B (zh) * 2018-06-15 2024-01-30 扶桑药品工业株式会社 辅助生殖医疗用培养基
US11369703B2 (en) 2018-08-31 2022-06-28 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
CN111229023B (zh) * 2018-11-29 2022-01-28 内蒙古东盛硅藻土科技创新产业园有限公司 一种化学降解添加剂
CN109879958A (zh) * 2019-03-08 2019-06-14 中国人民解放军军事科学院军事医学研究院 一种低糖基化血清白蛋白的制备方法
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
US20210096128A1 (en) * 2019-10-01 2021-04-01 Repligen Corporation Determination of protein concentration in a fluid
CN112858682B (zh) * 2019-11-27 2023-06-02 广东唯实生物技术有限公司 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法
WO2021111143A1 (en) 2019-12-04 2021-06-10 Albumedix Limited Methods and compositions produced thereby
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
CA3200066A1 (en) 2020-12-08 2022-06-16 Wei Xiang Method for purifying recombinant protein
CN112646045A (zh) * 2021-01-06 2021-04-13 海默斯(重庆)医学生物技术有限公司 一种重组角蛋白分离纯化方法
CN114907469A (zh) * 2021-02-08 2022-08-16 首都医科大学附属北京朝阳医院 一种人血清中白蛋白分离纯化方法
CN113735963A (zh) * 2021-09-10 2021-12-03 山东健通生物科技有限公司 一种重组人血清白蛋白纯化过程去除色素的方法
CN118166053A (zh) * 2024-03-15 2024-06-11 通化安睿特生物制药股份有限公司 一种制备低o-糖基化水平的重组人白蛋白的方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019919D0 (en) 1990-09-12 1990-10-24 Delta Biotechnology Ltd Purification of proteins
US5625041A (en) * 1990-09-12 1997-04-29 Delta Biotechnology Limited Purification of proteins
US2433905A (en) * 1943-11-01 1948-01-06 Jr Walter L Hughes Method for the crystallization of albumin and the preparation of protein products therefrom
AT317418B (de) 1972-06-16 1974-08-25 Brigitte Panhofer Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten
FR2190437B1 (US07993877-20110809-P00003.png) * 1972-07-05 1975-08-08 Merieux Inst
CA1044537A (en) 1973-05-09 1978-12-19 Amf Incorporated Filter medium and process
DE2537123A1 (de) 1975-08-20 1977-03-03 New Zealand Inventions Dev Verfahren zur herstellung von albumin
SE405549B (sv) * 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
US4043997A (en) * 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
US4075197A (en) * 1976-09-20 1978-02-21 Monsanto Company Serum albumin production
US4269605A (en) 1978-06-28 1981-05-26 Amicon Corporation Method and kit for separation of glycoproteins
IN150740B (US07993877-20110809-P00003.png) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4228154A (en) * 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
CA1149298A (en) 1979-04-12 1983-07-05 Eugene H. Wegner Production of yeast cells at high cell densities
US4222934A (en) * 1979-04-12 1980-09-16 American National Red Cross Preparation of albumin using ethanol
GB2053926B (en) 1979-07-20 1983-02-23 Atkinson A Albumin extraction by affinity chromatography
US4350156A (en) * 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4491946A (en) 1981-03-09 1985-01-01 Gould Inc. Multi-station token pass communication system
US4562251A (en) 1981-03-26 1985-12-31 Amicon Corporation Agarose derivatives of amino phenyl boronic acid
IL66614A (en) 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
US4391801A (en) * 1981-10-29 1983-07-05 Cutter Laboratories, Inc. Plasma protein fraction substantially free of acetate ions
FR2543448A1 (fr) * 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4748120A (en) * 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
DE3344656A1 (de) 1983-12-09 1985-06-13 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer serumproteinloesung
CA1286622C (en) 1986-04-28 1991-07-23 Chokyun Rha Method for clarifying and stabilizing cell culture media
JPS62294621A (ja) 1986-06-13 1987-12-22 Green Cross Corp:The アルブミンの回収方法
JPS6383100A (ja) 1986-09-26 1988-04-13 Green Cross Corp:The ヒト尿中アルブミンの製造方法
DE3888381T2 (de) 1987-04-09 1994-07-28 Delta Biotechnology Ltd Hefevektor.
US4833233A (en) 1987-08-20 1989-05-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Human serum albumin crystals and method of preparation
CA1293217C (en) 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
IL88326A (en) 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
GB2214508A (en) 1988-01-27 1989-09-06 Bayer Ag Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
WO1990001063A1 (en) 1988-07-23 1990-02-08 Delta Biotechnology Limited New secretory leader sequences
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
US5277818A (en) * 1988-10-31 1994-01-11 The Green Cross Corporation Albumin preparation and process for preparing the same
JP3554796B2 (ja) 1988-10-31 2004-08-18 三菱ウェルファーマ株式会社 アルブミン製剤及びその製造方法
US4891221A (en) 1988-11-23 1990-01-02 Edward Shanborm Whole blood antiviral process and composition
FR2648048B1 (fr) 1989-06-08 1994-06-03 Lille Transfusion Sanguine Procede de preparation de solutions d'albumine purifiee
GB8913586D0 (en) 1989-06-13 1989-08-02 Technicol Limited A method of determining the glycosylated protein level of a sample and an apparatus for use in the method
JPH0768137B2 (ja) 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
SE500110C2 (sv) * 1989-06-27 1994-04-18 Kabi Pharmacia Ab Sätt att rena ett protein från därtill bundna flervärda metalljoner
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
JPH0671434B2 (ja) 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
CA2022165C (en) 1989-10-05 1999-11-23 Chong E. Chang Albumin purification
US5250662A (en) * 1989-10-05 1993-10-05 Alpha Therapeutic Corporation Albumin purification
JP3127232B2 (ja) 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
DE69133399T2 (de) 1990-04-19 2005-06-30 Bayer Corp. Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin
SE9002212D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
JP3230091B2 (ja) 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
JP2982296B2 (ja) 1990-11-19 1999-11-22 吉富製薬株式会社 アルブミン含有水溶液の精製法
JP2949846B2 (ja) 1990-11-30 1999-09-20 吉富製薬株式会社 アルブミン製剤の保存方法
FR2672604B1 (fr) 1991-02-07 1995-05-05 Pasteur Merieux Serums Vacc Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue.
US5284777A (en) * 1991-03-04 1994-02-08 Isolab, Inc. Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate
JPH0671432B2 (ja) 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
DK0524681T3 (da) 1991-07-12 2000-04-10 Dsm Nv Fremgangsmåde til oprensning af serumalbumin
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
FR2686620B1 (fr) * 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
US5281582A (en) 1992-02-27 1994-01-25 Alliance Pharmaceuticals, Corp. Serum growth factor
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
DE69309275T3 (de) * 1992-06-24 2002-06-27 Notetry Ltd., Little Somerford Zyklonstaubsauger
JP3360315B2 (ja) 1992-07-31 2002-12-24 三菱ウェルファーマ株式会社 ヒト血清アルブミンの高度精製方法
WO1994003636A1 (en) 1992-08-03 1994-02-17 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
DE4226971C2 (de) * 1992-08-14 1997-01-16 Widmar Prof Dr Tanner Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2116385A1 (en) 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DE4308532A1 (de) 1993-03-17 1994-09-22 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen in vivo glykiertes Albumin
SE9301583D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Yeast strain and methods for expressing heterologous proteins in yeast
CA2136564C (en) 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
GB9404270D0 (en) 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
JP3702474B2 (ja) * 1994-06-01 2005-10-05 三菱ウェルファーマ株式会社 血清アルブミン製剤の製造方法
GB9411356D0 (en) 1994-06-07 1994-07-27 Delta Biotechnology Ltd Yeast strains
GB2308006B (en) * 1994-07-21 1998-07-22 Gregory Lowell Millspaugh Method of and system for controlling energy including in fusion
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
DE69532492T2 (de) 1994-08-31 2004-12-02 Mitsubishi Pharma Corp. Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin
DE4432689A1 (de) 1994-09-14 1996-03-21 Basf Ag Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden
US6068995A (en) * 1994-10-25 2000-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing protein
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
AU4837996A (en) * 1996-02-29 1997-09-16 Delta Biotechnology Limited High purity albumin production process
GB9721892D0 (en) 1997-10-15 1997-12-17 British Tech Group Apparatus for and method of testing a sample
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
SE520854C2 (sv) 2002-06-04 2003-09-02 Wexioedisk Ab Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska

Also Published As

Publication number Publication date
AU763899B2 (en) 2003-07-31
WO2000044772A3 (en) 2000-11-30
ATE416254T1 (de) 2008-12-15
EP2048234A1 (en) 2009-04-15
KR20020008114A (ko) 2002-01-29
SG119194A1 (en) 2006-02-28
EP2048234B1 (en) 2012-12-19
US20150056654A1 (en) 2015-02-26
WO2000044772A2 (en) 2000-08-03
KR20050061612A (ko) 2005-06-22
HK1042521B (zh) 2005-10-07
JP5474661B2 (ja) 2014-04-16
US20090171070A1 (en) 2009-07-02
KR100577493B1 (ko) 2006-05-10
EP1149163A2 (en) 2001-10-31
AU2120700A (en) 2000-08-18
CA2359705A1 (en) 2000-08-03
CN1810834A (zh) 2006-08-02
DK2048234T3 (da) 2013-03-04
CN1339065A (zh) 2002-03-06
US9555344B2 (en) 2017-01-31
HK1096691A1 (en) 2007-06-08
MXPA01007719A (es) 2003-06-24
EP2272961A1 (en) 2011-01-12
SG174629A1 (en) 2011-10-28
EP1149163B1 (en) 2008-12-03
JP2013135675A (ja) 2013-07-11
KR100886554B1 (ko) 2009-03-02
JP2002542761A (ja) 2002-12-17
AU2003248302B2 (en) 2006-09-07
US9029102B2 (en) 2015-05-12
GB9902000D0 (en) 1999-03-17
CN1526732B (zh) 2010-06-16
HK1042521A1 (en) 2002-08-16
CN1974599A (zh) 2007-06-06
JP4586150B2 (ja) 2010-11-24
DE60040967D1 (de) 2009-01-15
CN1810834B (zh) 2013-04-17
ES2317827T3 (es) 2009-05-01
JP2010246551A (ja) 2010-11-04
CN1526732A (zh) 2004-09-08
AU2003248302A1 (en) 2003-10-30
US7993877B2 (en) 2011-08-09
CA2359705C (en) 2011-06-14
JP5774612B2 (ja) 2015-09-09
US20110301329A1 (en) 2011-12-08

Similar Documents

Publication Publication Date Title
CN1211485C (zh) 生产重组白蛋白的方法
CN1198844C (zh) 高纯度白蛋白生产方法
CN1268741C (zh) 半乳糖苷酶a缺乏症的治疗
CN1151258C (zh) 通过内源基因活化制备促红细胞生成素
CN1033760C (zh) 产生具有第八因子活性的第八因子缺失突变体的方法
CN1230537C (zh) 来自曲霉属融合产物中经加工的重组乳铁蛋白和乳铁蛋白多肽片断的表达
CN1057534C (zh) 促红细胞生成素类似物
CN1166772C (zh) 调控由哺乳动物细胞培养物产生的蛋白质唾液酸化的方法
CN1280309C (zh) 具有高比活的促红细胞生成素
CN1050220A (zh) 提高了热酸和/或碱稳定性的突变微生物α淀粉酶
CN1628129A (zh) 蛋白质制剂的稳定化
CN1596302A (zh) 细胞培养方法
CN1596268A (zh) 重组人红细胞生成素的层析纯化
CN1039616A (zh) 巴斯德毕赤酵母醇氧化酶ii调节区
CN1541275A (zh) 糖蛋白及其制备方法
CN1596310A (zh) 产生重组多肽的方法
CN1681930A (zh) 具有包含fivsi基序的信号序列的多肽以及编码该基序的寡核苷酸
CN1990871A (zh) 重组人纤溶酶原Kringle 5(hk5)生产方法
CN1085253C (zh) 反式-4-羟基-l-脯氨酸的制造方法
CN1247230A (zh) 醋酸杆菌的木糖醇脱氢酶及其基因
CN1271390A (zh) 基因
CN1769456A (zh) 重组人那希力肽的生产方法
KR20050077689A (ko) 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법
AU2007200939A1 (en) Process
CN1757745A (zh) 一种利用甲醇酵母系统高效表达tPA等外源蛋白的方法及其表达产物的纯化制备技术

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NOVOZYMES UK BIO-PHARMACEUTICAL CO., LTD.

Free format text: FORMER NAME: NOWISON DARTA CO., LTD.

Owner name: NOWISON DARTA CO., LTD.

Free format text: FORMER NAME: DELTA BIOTECHNOLOGY CO., LTD.

CP03 Change of name, title or address

Address after: British Nottinghamshire

Patentee after: NOVOZYMES BIOPHARMA DK A/S

Address before: British Nottinghamshire

Patentee before: NOVOZYMES DELTA LTD.

Address after: British Nottinghamshire

Patentee after: NOVOZYMES DELTA LTD.

Address before: British Nottinghamshire

Patentee before: Delta Biotechnology Ltd.

ASS Succession or assignment of patent right

Owner name: NOVOZYMES BIOPOLYMER AS

Free format text: FORMER OWNER: NOVOZYMES BIOPHARMACEUTICAL UK CO., LTD.

Effective date: 20101216

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: NOTTINGHAM COUNTY, UK TO: BAGSVAERD, DENMARK

TR01 Transfer of patent right

Effective date of registration: 20101216

Address after: Denmark bagsvaerd

Patentee after: NOVOZYMES BIOPHARMA DK A/S

Address before: British Nottinghamshire

Patentee before: NOVOZYMES BIOPHARMA DK A/S

C56 Change in the name or address of the patentee
CP03 Change of name, title or address

Address after: Denmark rimbey

Patentee after: ALBUMEDIX A/S

Address before: Denmark bagsvaerd

Patentee before: Novozymes Biopharma DK A/S

CX01 Expiry of patent term

Granted publication date: 20050720

CX01 Expiry of patent term