DE60040967D1 - Chromatographisches verfahren zur reinigung von albumin - Google Patents
Chromatographisches verfahren zur reinigung von albuminInfo
- Publication number
- DE60040967D1 DE60040967D1 DE60040967T DE60040967T DE60040967D1 DE 60040967 D1 DE60040967 D1 DE 60040967D1 DE 60040967 T DE60040967 T DE 60040967T DE 60040967 T DE60040967 T DE 60040967T DE 60040967 D1 DE60040967 D1 DE 60040967D1
- Authority
- DE
- Germany
- Prior art keywords
- albumin
- cell
- coding sequence
- disclosed
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9902000A GB9902000D0 (en) | 1999-01-30 | 1999-01-30 | Process |
PCT/GB2000/000257 WO2000044772A2 (en) | 1999-01-30 | 2000-01-31 | Human serum albumin |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60040967D1 true DE60040967D1 (de) | 2009-01-15 |
Family
ID=10846743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60040967T Expired - Lifetime DE60040967D1 (de) | 1999-01-30 | 2000-01-31 | Chromatographisches verfahren zur reinigung von albumin |
Country Status (16)
Country | Link |
---|---|
US (3) | US7993877B2 (de) |
EP (3) | EP1149163B1 (de) |
JP (3) | JP4586150B2 (de) |
KR (2) | KR100577493B1 (de) |
CN (4) | CN1974599A (de) |
AT (1) | ATE416254T1 (de) |
AU (2) | AU763899B2 (de) |
CA (1) | CA2359705C (de) |
DE (1) | DE60040967D1 (de) |
DK (1) | DK2048234T3 (de) |
ES (1) | ES2317827T3 (de) |
GB (1) | GB9902000D0 (de) |
HK (2) | HK1042521B (de) |
MX (1) | MXPA01007719A (de) |
SG (2) | SG119194A1 (de) |
WO (1) | WO2000044772A2 (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
ITBO20010426A1 (it) | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
CA2471363C (en) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
AU2003244516A1 (en) | 2002-02-07 | 2003-09-02 | Novozymes Delta Limited | Hiv inhibiting proteins |
SE526227C2 (sv) * | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
GB0304576D0 (en) | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
ES2380022T3 (es) | 2003-12-03 | 2012-05-07 | Monika KRÖZ | Proteínas de fusión a interleucina-11 |
GB0329722D0 (en) * | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
EP1831373A2 (de) * | 2004-12-22 | 2007-09-12 | Novozymes A/S | Rekombinante serumalbuminproduktion |
DK2330200T3 (en) | 2004-12-23 | 2017-07-24 | Albumedix As | GENE EXPRESSION TECHNIQUE |
WO2007063129A2 (en) * | 2005-12-02 | 2007-06-07 | Novozymes A/S | Insolation of peptides , polypeptides and proteins |
JP2007284425A (ja) * | 2006-03-20 | 2007-11-01 | Nokodai Tlo Kk | タンパク質の精製方法 |
AU2007274035A1 (en) * | 2006-07-13 | 2008-01-17 | Novozymes Biopharma Dk A/S | Process for preparing particles of proteinaceous material |
CA2658654A1 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
JP5256199B2 (ja) | 2006-08-07 | 2013-08-07 | テヴァ バイオファーマシューティカルズ ユーエスエー,インコーポレーティッド | アルブミン−インスリン融合タンパク質 |
AU2008214029B2 (en) | 2007-02-02 | 2014-01-30 | Globelmmune, Inc. | Methods for producing yeast-based vaccines |
EP2604623A3 (de) | 2007-08-08 | 2013-10-02 | Novozymes Biopharma DK A/S | Transferrinvarianten und Konjugate |
WO2009123060A1 (ja) | 2008-03-31 | 2009-10-08 | 積水メディカル株式会社 | 精製血清アルブミン及び免疫学的測定方法 |
CN101684459B (zh) * | 2008-09-22 | 2012-01-25 | 上海普天欣生物技术有限公司 | CehA突变体蛋白、基因、重组载体及其用途和制备方法 |
CN101747437B (zh) | 2008-12-10 | 2012-09-26 | 浙江日升昌药业有限公司 | 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白 |
EP3243835B1 (de) | 2009-02-11 | 2024-04-10 | Albumedix Ltd | Varianten und konjugate von albumin |
US20120315697A1 (en) | 2009-02-20 | 2012-12-13 | Ventria Bioscience | Cell Culture Media Containing Combinations of Proteins |
WO2010115634A1 (en) | 2009-04-09 | 2010-10-14 | Cellca Gmbh | Method for improved single cell cloning |
US9403898B2 (en) | 2009-05-07 | 2016-08-02 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
CN101691581B (zh) * | 2009-06-25 | 2012-10-03 | 南京农业大学 | 染色体无标记随机整合载体pUTTns及其应用 |
US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
CN101690801B (zh) | 2009-10-26 | 2012-08-01 | 上海交通大学 | 白细胞介素-1受体拮抗剂的用途及其药物组合物 |
GB2488077A (en) | 2009-10-30 | 2012-08-15 | Novozymes Biopharma Dk As | Albumin variants |
JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
CN106967150B (zh) * | 2010-04-29 | 2020-12-04 | 百深公司 | 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法 |
EP2635598A1 (de) | 2010-11-01 | 2013-09-11 | Novozymes Biopharma DK A/S | Albuminvarianten |
CN102127164B (zh) * | 2010-12-20 | 2013-01-30 | 武汉禾元生物科技有限公司 | 一种从水稻种子中提取重组人血清白蛋白的方法 |
CN102532254B (zh) | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
CA2830660A1 (en) | 2011-05-05 | 2012-11-08 | Novozymes Biopharma Dk A/S | Albumin variants |
BR112014000042A2 (pt) | 2011-07-05 | 2017-02-21 | Novozymes Biopharma Dk As | composição, meio de cultura celular, uso de uma composição, e, método para cultivar células |
US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
EP3835420A1 (de) * | 2011-12-05 | 2021-06-16 | Factor Bioscience Inc. | Verfahren und produkte zur transfektion von zellen |
EP2791160B1 (de) | 2011-12-16 | 2022-03-02 | ModernaTX, Inc. | Modifizierte mrna zusammensetzungen |
MX2014010278A (es) | 2012-03-16 | 2015-03-05 | Novozymes Biopharma Dk As | Variantes de albumina. |
US10501513B2 (en) * | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
AU2013243946A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of membrane proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
CN102952836A (zh) * | 2012-11-02 | 2013-03-06 | 浙江海正药业股份有限公司 | 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法 |
CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
CN103880947B (zh) | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
CA2903739A1 (en) * | 2013-03-06 | 2014-09-12 | Glaxosmithkline Llc | Host cells and methods of use |
CA2916594C (en) | 2013-07-04 | 2020-03-10 | Novartis Ag | O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof |
CN105992770B (zh) | 2013-11-01 | 2021-06-25 | 奥斯陆大学 | 白蛋白的变体及其用途 |
TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
US9938319B2 (en) * | 2014-04-23 | 2018-04-10 | Alexion Pharmaceuticals, Inc. | Egg white processing |
CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
EP3240798B8 (de) * | 2015-01-01 | 2020-03-25 | Shilpa Medicare Limited | Neuartiges verfahren zur effizienten aufreinigung von humanem serumalbumin |
EP3543339A1 (de) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nukleinsäureprodukte und verabreichungsverfahren dafür |
US10627415B2 (en) | 2015-03-12 | 2020-04-21 | Board Of Trustees Of Michigan State University | Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease |
WO2016207730A1 (en) | 2015-06-22 | 2016-12-29 | The University Of Oslo | Targeting of vaccine antigen to an intracellular compartment |
CN105037487B (zh) * | 2015-08-12 | 2017-03-22 | 山东泰邦生物制品有限公司 | 一种人血白蛋白的制备方法 |
AU2016308504A1 (en) | 2015-08-20 | 2018-01-18 | Albumedix Ltd. | Albumin variants and conjugates |
CA3005953A1 (en) | 2015-12-22 | 2017-06-29 | Albumedix Ltd | Improved protein expression strains |
IL264439B1 (en) | 2016-08-17 | 2024-04-01 | Factor Bioscience Inc | A suitable viral preparation containing a synthetic messenger RNA encoding a gene editing protein for use in cancer treatment and a synthetic messenger RNA encoding a gene editing protein for use in therapy |
EP3603391A1 (de) | 2016-10-04 | 2020-02-05 | Albumedix Ltd | Verwendungen von rekombinantem, von hefe abgeleitetem serumalbumin |
WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
MA50141A (fr) * | 2017-04-20 | 2020-07-29 | Novo Nordisk As | Procédés de purification de protéines de fusion d'albumine |
JP7282693B2 (ja) | 2017-06-20 | 2023-05-29 | アルブミディクス リミティド | 改良されたタンパク質発現株 |
KR20210021004A (ko) * | 2018-06-15 | 2021-02-24 | 후소 야쿠힝 고교 가부시끼가이샤 | 생식 보조 의료용 배지 |
BR112021003420A2 (pt) | 2018-08-31 | 2021-05-18 | Genzyme Corporation | resina cromatográfica estéril e uso da mesma em processos de manufatura |
CN111229023B (zh) * | 2018-11-29 | 2022-01-28 | 内蒙古东盛硅藻土科技创新产业园有限公司 | 一种化学降解添加剂 |
CN109879958A (zh) * | 2019-03-08 | 2019-06-14 | 中国人民解放军军事科学院军事医学研究院 | 一种低糖基化血清白蛋白的制备方法 |
US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
EP4038349A4 (de) * | 2019-10-01 | 2022-12-28 | Repligen Corporation | Bestimmung der proteinkonzentration in einer flüssigkeit |
CN112858682B (zh) * | 2019-11-27 | 2023-06-02 | 广东唯实生物技术有限公司 | 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法 |
EP4069200A1 (de) | 2019-12-04 | 2022-10-12 | Albumedix Ltd | Verfahren und damit hergestellte zusammensetzungen |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
CN112062833A (zh) * | 2020-10-09 | 2020-12-11 | 国药集团武汉血液制品有限公司 | 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法 |
CN114885608A (zh) | 2020-12-08 | 2022-08-09 | 通化安睿特生物制药股份有限公司 | 纯化重组蛋白的方法 |
CN112646045A (zh) * | 2021-01-06 | 2021-04-13 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白分离纯化方法 |
CN114907469A (zh) * | 2021-02-08 | 2022-08-16 | 首都医科大学附属北京朝阳医院 | 一种人血清中白蛋白分离纯化方法 |
CN113735963A (zh) * | 2021-09-10 | 2021-12-03 | 山东健通生物科技有限公司 | 一种重组人血清白蛋白纯化过程去除色素的方法 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
US5625041A (en) | 1990-09-12 | 1997-04-29 | Delta Biotechnology Limited | Purification of proteins |
US2433905A (en) | 1943-11-01 | 1948-01-06 | Jr Walter L Hughes | Method for the crystallization of albumin and the preparation of protein products therefrom |
AT317418B (de) | 1972-06-16 | 1974-08-25 | Brigitte Panhofer | Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten |
FR2190437B1 (de) | 1972-07-05 | 1975-08-08 | Merieux Inst | |
CA1044537A (en) | 1973-05-09 | 1978-12-19 | Amf Incorporated | Filter medium and process |
DE2537123A1 (de) | 1975-08-20 | 1977-03-03 | New Zealand Inventions Dev | Verfahren zur herstellung von albumin |
SE405549B (sv) | 1975-10-09 | 1978-12-18 | Pharmacia Fine Chemicals Ab | Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering |
US4043997A (en) | 1976-05-28 | 1977-08-23 | Cutter Laboratories, Inc. | Method for isolating albumin using insoluble supports coupled to a dye |
US4075197A (en) | 1976-09-20 | 1978-02-21 | Monsanto Company | Serum albumin production |
US4269605A (en) | 1978-06-28 | 1981-05-26 | Amicon Corporation | Method and kit for separation of glycoproteins |
IN150740B (de) | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
US4228154A (en) | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
US4222934A (en) | 1979-04-12 | 1980-09-16 | American National Red Cross | Preparation of albumin using ethanol |
CA1149298A (en) | 1979-04-12 | 1983-07-05 | Eugene H. Wegner | Production of yeast cells at high cell densities |
GB2053926B (en) | 1979-07-20 | 1983-02-23 | Atkinson A | Albumin extraction by affinity chromatography |
US4350156A (en) | 1980-05-29 | 1982-09-21 | Japan Foundation For Artificial Organs | Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid |
NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
US4491946A (en) | 1981-03-09 | 1985-01-01 | Gould Inc. | Multi-station token pass communication system |
US4562251A (en) | 1981-03-26 | 1985-12-31 | Amicon Corporation | Agarose derivatives of amino phenyl boronic acid |
IL66614A (en) | 1981-08-28 | 1985-09-29 | Genentech Inc | Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it |
US4391801A (en) | 1981-10-29 | 1983-07-05 | Cutter Laboratories, Inc. | Plasma protein fraction substantially free of acetate ions |
FR2543448A1 (fr) | 1983-04-01 | 1984-10-05 | Rhone Poulenc Spec Chim | Procede de fractionnement du plasma |
US4748120A (en) | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
DE3344656A1 (de) | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
CA1286622C (en) | 1986-04-28 | 1991-07-23 | Chokyun Rha | Method for clarifying and stabilizing cell culture media |
JPS62294621A (ja) | 1986-06-13 | 1987-12-22 | Green Cross Corp:The | アルブミンの回収方法 |
JPS6383100A (ja) | 1986-09-26 | 1988-04-13 | Green Cross Corp:The | ヒト尿中アルブミンの製造方法 |
HU213344B (en) | 1987-04-09 | 1997-05-28 | Delta Biotechnology Ltd | Process for producing of stable dezintegrating plasmid-vectors |
US4833233A (en) | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
CA1293217C (en) | 1987-11-09 | 1991-12-17 | Sooyoung Stanford Lee | Controlled growth rate fermentation |
IL88326A (en) | 1987-11-18 | 1993-03-15 | Gist Brocades Nv | Purification of serum albumin |
GB2214508A (en) | 1988-01-27 | 1989-09-06 | Bayer Ag | Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences. |
JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法 |
US4990447A (en) | 1988-06-24 | 1991-02-05 | Gist-Brocades Nv | Process for the purification of serum albumin |
AU633020B2 (en) | 1988-07-23 | 1993-01-21 | Novozymes Delta Limited | New secretory leader sequences |
FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
US5277818A (en) | 1988-10-31 | 1994-01-11 | The Green Cross Corporation | Albumin preparation and process for preparing the same |
JP3554796B2 (ja) | 1988-10-31 | 2004-08-18 | 三菱ウェルファーマ株式会社 | アルブミン製剤及びその製造方法 |
US4891221A (en) | 1988-11-23 | 1990-01-02 | Edward Shanborm | Whole blood antiviral process and composition |
FR2648048B1 (fr) | 1989-06-08 | 1994-06-03 | Lille Transfusion Sanguine | Procede de preparation de solutions d'albumine purifiee |
GB8913586D0 (en) | 1989-06-13 | 1989-08-02 | Technicol Limited | A method of determining the glycosylated protein level of a sample and an apparatus for use in the method |
JPH0768137B2 (ja) | 1989-06-15 | 1995-07-26 | 株式会社ミドリ十字 | アルブミン製剤及びその製法 |
SE500110C2 (sv) * | 1989-06-27 | 1994-04-18 | Kabi Pharmacia Ab | Sätt att rena ett protein från därtill bundna flervärda metalljoner |
GB8927480D0 (en) | 1989-12-05 | 1990-02-07 | Delta Biotechnology Ltd | Mutant fungal strain detection and new promoter |
JPH0671434B2 (ja) | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
US5250662A (en) | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
CA2022165C (en) | 1989-10-05 | 1999-11-23 | Chong E. Chang | Albumin purification |
JP3127232B2 (ja) | 1990-03-08 | 2001-01-22 | ウェルファイド株式会社 | 蛋白質製剤の製造法 |
EP0452753B1 (de) | 1990-04-19 | 2004-06-23 | Bayer Corporation | Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin |
SE9002212D0 (sv) | 1990-06-21 | 1990-06-21 | Hightech Receptor Ab | Igg binding protein |
JP3230091B2 (ja) | 1990-06-25 | 2001-11-19 | ウェルファイド株式会社 | ヒト血清アルブミンの着色抑制方法 |
JP2982296B2 (ja) | 1990-11-19 | 1999-11-22 | 吉富製薬株式会社 | アルブミン含有水溶液の精製法 |
JP2949846B2 (ja) | 1990-11-30 | 1999-09-20 | 吉富製薬株式会社 | アルブミン製剤の保存方法 |
FR2672604B1 (fr) | 1991-02-07 | 1995-05-05 | Pasteur Merieux Serums Vacc | Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue. |
US5284777A (en) * | 1991-03-04 | 1994-02-08 | Isolab, Inc. | Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate |
JPH0671432B2 (ja) | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
US5330901A (en) | 1991-04-26 | 1994-07-19 | Research Corporation Technologies, Inc. | Expression of human serum albumin in Pichia pastoris |
ATE186547T1 (de) | 1991-07-12 | 1999-11-15 | Dsm Nv | Verfahren zur reinigung von serumalbumin |
US5260308A (en) * | 1991-11-06 | 1993-11-09 | Mayo Foundation For Medical Education And Research | Method to increase permeability of the blood-nerve/brain barriers to proteins |
FR2686620B1 (fr) | 1992-01-27 | 1995-06-23 | Rhone Poulenc Rorer Sa | Serum-albumine humaine, preparation et utilisation. |
US5281582A (en) | 1992-02-27 | 1994-01-25 | Alliance Pharmaceuticals, Corp. | Serum growth factor |
JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
SG46302A1 (en) * | 1992-06-24 | 1998-02-20 | Notetry Ltd | Vacuum cleaner |
JP3360315B2 (ja) | 1992-07-31 | 2002-12-24 | 三菱ウェルファーマ株式会社 | ヒト血清アルブミンの高度精製方法 |
CA2140331C (en) | 1992-08-03 | 2000-01-18 | John J. Carrino | Detecting and amplifying target nucleic acids using exonucleolytic activity |
DE4226971C2 (de) * | 1992-08-14 | 1997-01-16 | Widmar Prof Dr Tanner | Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte |
US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
CA2116385A1 (en) | 1993-02-25 | 1994-08-26 | Akinori Sumi | Human serum albumin and process for producing the same |
DE4308532A1 (de) | 1993-03-17 | 1994-09-22 | Boehringer Mannheim Gmbh | Monoklonale Antikörper gegen in vivo glykiertes Albumin |
SE9301583D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Yeast strain and methods for expressing heterologous proteins in yeast |
CA2136564C (en) | 1993-11-26 | 2008-04-08 | Kaoru Kobayashi | Process for producing human serum albumin |
GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
JPH07308199A (ja) | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | ヒト血清アルブミンの製造方法 |
JP3702474B2 (ja) | 1994-06-01 | 2005-10-05 | 三菱ウェルファーマ株式会社 | 血清アルブミン製剤の製造方法 |
GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
AU2628595A (en) * | 1994-07-21 | 1996-02-22 | Gregory Lowell Millspaugh | Method of and system for controlling energy, including in fusion reactors |
US5561115A (en) | 1994-08-10 | 1996-10-01 | Bayer Corporation | Low temperature albumin fractionation using sodium caprylate as a partitioning agent |
DK0699687T3 (da) | 1994-08-31 | 2004-04-26 | Mitsubishi Pharma Corp | Fremgangsmåde til oprensning af rekombinant humant serumalbumin |
DE4432689A1 (de) | 1994-09-14 | 1996-03-21 | Basf Ag | Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden |
US6068995A (en) * | 1994-10-25 | 2000-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Method for producing protein |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
WO1997031947A1 (en) * | 1996-02-29 | 1997-09-04 | Delta Biotechnology Limited | High purity albumin production process |
GB9721892D0 (en) | 1997-10-15 | 1997-12-17 | British Tech Group | Apparatus for and method of testing a sample |
GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
JP4798832B2 (ja) | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
US6693173B2 (en) | 2000-12-26 | 2004-02-17 | Alpha Therapeutic Corporation | Method to remove citrate and aluminum from proteins |
SE0201680L (sv) | 2002-06-04 | 2003-09-02 | Wexioedisk Ab | Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska |
-
1999
- 1999-01-30 GB GB9902000A patent/GB9902000D0/en not_active Ceased
-
2000
- 2000-01-31 JP JP2000596028A patent/JP4586150B2/ja not_active Expired - Lifetime
- 2000-01-31 CA CA2359705A patent/CA2359705C/en not_active Expired - Lifetime
- 2000-01-31 KR KR1020017009551A patent/KR100577493B1/ko active IP Right Grant
- 2000-01-31 CN CNA2006101006640A patent/CN1974599A/zh active Pending
- 2000-01-31 MX MXPA01007719A patent/MXPA01007719A/es active IP Right Grant
- 2000-01-31 KR KR1020057009776A patent/KR100886554B1/ko active IP Right Grant
- 2000-01-31 EP EP00901252A patent/EP1149163B1/de not_active Expired - Lifetime
- 2000-01-31 ES ES00901252T patent/ES2317827T3/es not_active Expired - Lifetime
- 2000-01-31 EP EP20080166355 patent/EP2048234B1/de not_active Expired - Lifetime
- 2000-01-31 EP EP20100075421 patent/EP2272961A1/de not_active Withdrawn
- 2000-01-31 AU AU21207/00A patent/AU763899B2/en not_active Expired
- 2000-01-31 CN CN2004100050153A patent/CN1526732B/zh not_active Expired - Lifetime
- 2000-01-31 SG SG200304297A patent/SG119194A1/en unknown
- 2000-01-31 AT AT00901252T patent/ATE416254T1/de not_active IP Right Cessation
- 2000-01-31 WO PCT/GB2000/000257 patent/WO2000044772A2/en active IP Right Grant
- 2000-01-31 DK DK08166355T patent/DK2048234T3/da active
- 2000-01-31 CN CNB008032920A patent/CN1211485C/zh not_active Expired - Lifetime
- 2000-01-31 DE DE60040967T patent/DE60040967D1/de not_active Expired - Lifetime
- 2000-01-31 SG SG2007061591A patent/SG174629A1/en unknown
- 2000-01-31 CN CN2005101086585A patent/CN1810834B/zh not_active Expired - Lifetime
-
2002
- 2002-06-04 HK HK02104220.2A patent/HK1042521B/zh unknown
- 2002-06-04 HK HK07101272A patent/HK1096691A1/xx not_active IP Right Cessation
-
2003
- 2003-09-23 AU AU2003248302A patent/AU2003248302B2/en not_active Expired
-
2008
- 2008-09-09 US US12/207,325 patent/US7993877B2/en not_active Expired - Fee Related
-
2010
- 2010-05-27 JP JP2010121914A patent/JP5474661B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-01 US US13/175,155 patent/US9029102B2/en not_active Expired - Fee Related
-
2013
- 2013-01-15 JP JP2013004867A patent/JP5774612B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-14 US US14/330,703 patent/US9555344B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60040967D1 (de) | Chromatographisches verfahren zur reinigung von albumin | |
DE69939947D1 (de) | Verfahren zur herstellung von polypeptiden in mutierten aspergillus zellen | |
CA2174746A1 (en) | Embryonic stem cells capable of differentiating into desired cell lines | |
DE3586189T2 (de) | Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute. | |
JPS6447381A (en) | Preparation of liposome containing sealed gene | |
WO2000003000A3 (en) | Serum-free medium for culturing animal cells | |
ATE203270T1 (de) | Verfahren für die herstellung von proteinen | |
AU2485500A (en) | Method for producing ascorbic acid intermediates | |
AU2969095A (en) | Thermophilic fungal expression system | |
AU4200897A (en) | Novel host cells and methods of producing proteins | |
FI885679A (fi) | Samuttryckning i eukariotiska celler. | |
ATE37196T1 (de) | Bier und verfahren zu dessen herstellung. | |
DE69723855D1 (de) | Verfahren zur herstellung von polypeptiden in surfaktinmutanten von bacillus zellen | |
ATE353953T1 (de) | Wirtszelle, die reduzierte mengen einer metalloprotease exprimiert und methoden zur verwendung dieser wirtszelle zur proteinproduktion | |
KR840008697A (ko) | 상동 효모 신호를 이용한 이종단백질의 합성, 분비 및 표현매개체 제조방법 | |
CA2011833A1 (en) | Novel polypeptide and production thereof | |
EP0649900A3 (de) | Verfahren zur Herstellung von Proteinen. | |
AU7546687A (en) | Method for producing a new proteolytic complex stimulating the activity of the pancreas and its applications in zootechny | |
CO5241325A1 (es) | Procedimiento de cultivo masivo de celulas de mamifero para la obtencion de eritropoyetina humana recombinante y la eritropoyetina humana recombinante obtenida con tal procedimiento | |
WO2002016584A3 (en) | Process for the preparation of neutrophil inhibitory factor | |
WO1997040173A3 (en) | Pi 3-kinase fusion mutants and uses thereof | |
ATE266733T1 (de) | Verfahren zur herstellung von heterologen polypeptiden in transformierten hefezellen | |
PL335975A1 (en) | Method of obtaining a heterologous protein | |
TNSN01128A1 (en) | Process for the preparation of a neutrophil inhibitory factor | |
DE3868712D1 (de) | Ein neues antibiotikum, fumifungin, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVOZYMES BIOPHARMA DK A/S, BAGSVAERD, DK |