MXPA01007719A - Procedimiento. - Google Patents

Procedimiento.

Info

Publication number
MXPA01007719A
MXPA01007719A MXPA01007719A MXPA01007719A MXPA01007719A MX PA01007719 A MXPA01007719 A MX PA01007719A MX PA01007719 A MXPA01007719 A MX PA01007719A MX PA01007719 A MXPA01007719 A MX PA01007719A MX PA01007719 A MXPA01007719 A MX PA01007719A
Authority
MX
Mexico
Prior art keywords
albumin
exchange chromatography
positive mode
negative
coding sequence
Prior art date
Application number
MXPA01007719A
Other languages
English (en)
Inventor
David James Ballance
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Publication of MXPA01007719A publication Critical patent/MXPA01007719A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Se provee un procedimiento para la preparacion de una solucion de albumina altamente pura, el procedimiento comprende someter la albumina (preferiblemente expresada y secretada mediante levadura transformada) a una serie de pasos cromatograficos; preferiblemente el procedimiento comprende los pasos de cromatografia de intercambio cationico de modo positivo, cromatografia de intercambio anionico de modo positivo, cromatografia de afinidad de modo positivo, cromatografia de afinidad de modo negativo (preferiblemente utilizando acido aminofenilboronico inmovilizado), cromatografia de intercambio cationico de modo negativo y cromatografia de intercambio anionico de modo negativo o positivo; se describe tambien, un procedimiento para reducir el nivel de niquel en una solucion de albumina ya que es una secuencia que codifica la albumina recombinante que comprende dos o mas codones de paro de traduccion en marco de lectura; tambien se describe un procedimiento para producir albumina recombinante, el procedimiento comprende cultivar una celula fungal que expresa una secuencia que codifica la albumina recombinante, en donde la celula tiene una capacidad reducida de manosilacion de la albumina que se expresa de manera recombinante.
MXPA01007719A 1999-01-30 2000-01-31 Procedimiento. MXPA01007719A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process
PCT/GB2000/000257 WO2000044772A2 (en) 1999-01-30 2000-01-31 Human serum albumin

Publications (1)

Publication Number Publication Date
MXPA01007719A true MXPA01007719A (es) 2003-06-24

Family

ID=10846743

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA01007719A MXPA01007719A (es) 1999-01-30 2000-01-31 Procedimiento.

Country Status (16)

Country Link
US (3) US7993877B2 (es)
EP (3) EP2272961A1 (es)
JP (3) JP4586150B2 (es)
KR (2) KR100886554B1 (es)
CN (4) CN1810834B (es)
AT (1) ATE416254T1 (es)
AU (2) AU763899B2 (es)
CA (1) CA2359705C (es)
DE (1) DE60040967D1 (es)
DK (1) DK2048234T3 (es)
ES (1) ES2317827T3 (es)
GB (1) GB9902000D0 (es)
HK (2) HK1096691A1 (es)
MX (1) MXPA01007719A (es)
SG (2) SG119194A1 (es)
WO (1) WO2000044772A2 (es)

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KR20020008114A (ko) 2002-01-29
SG119194A1 (en) 2006-02-28
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US20150056654A1 (en) 2015-02-26
WO2000044772A2 (en) 2000-08-03
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HK1042521B (zh) 2005-10-07
JP5474661B2 (ja) 2014-04-16
US20090171070A1 (en) 2009-07-02
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EP1149163A2 (en) 2001-10-31
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