CN114983819A - 用来与原封未动的单独的注射小瓶释放工具一起使用的液体药物转移装置 - Google Patents
用来与原封未动的单独的注射小瓶释放工具一起使用的液体药物转移装置 Download PDFInfo
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Abstract
液体药物转移装置包括用于从初始的预压紧状态压缩到最终的压紧状态的一体的伸缩的小瓶转接器。在初始的预压紧状态，小瓶转接器伸缩地卡扣配合在初始的未穿刺的原封未动的单独的注射小瓶上，使它的注射小瓶瓶塞未穿刺。在最终的压紧状态，小瓶转接器穿刺注射小瓶瓶塞。该液体药物转移装置与原封未动的单独的注射小瓶释放工具一起使用，用于在初始的预压紧状态施加钳形的压紧，以方便地释放未穿刺的原封未动的单独的注射小瓶。该小瓶转接器包括用于在最终的压紧状态不可逆地夹紧小瓶转接器的夹紧装置。该小瓶转接器防止在它的最终的压紧状态释放被穿刺的单独的注射小瓶。
Description
技术领域
本发明涉及用来与单独的注射小瓶一起使用的液体药物转移装置。
背景技术
具有用来与包含药物的单独的注射小瓶一起使用的一体的小瓶转接器的液体药物转移装置可用于家庭使用、门诊使用、医院使用等。典型的具有一体的小瓶转接器的液体药物转移装置，除其他外，包括具有用来与无针注射器一起使用的母鲁尔连接头的母小瓶转接器、具有公鲁尔连接头的公小瓶转接器，液体药物转移装置具有一体的施用装置和注射器端口，该注射器端口用于将无针注射器连接到其上，液体药物转移装置用于混合两个注射小瓶的内含物以形成液体药物用于通过注射器端口抽吸到无针注射器，等。
单独的注射小瓶包括通常含有昂贵药物的一端闭合的小瓶管、具有瓶冠开口的管状的小瓶瓶冠和在小瓶管和小瓶瓶冠中间的小瓶瓶颈。单独的注射小瓶包括用于气密密封瓶冠开口的注射小瓶瓶塞和用于封住小瓶瓶冠的带。单独的注射小瓶通常包括弹开式篡改证据盖(flip-off tamper evidence cap)，该弹开式篡改证据盖准备在使用前不可恢复地直接移除以暴露最上面的注射小瓶表面，该注射小瓶表面在接近注射小瓶之前被灭菌。
小瓶转接器具有常规颠倒的杯形状，其包括最上面的横向的小瓶转接器壁和向下悬垂的小瓶瓶冠套，该小瓶瓶冠套用于限定小瓶瓶冠腔，该小瓶瓶冠腔用于在将小瓶转接器伸缩安装在单独的注射小瓶上时接收小瓶瓶冠。最上面的横向的小瓶转接器壁具有向下悬垂的穿刺套管，该向下悬垂的穿刺套管具有近端的穿刺套管开口和远端的穿刺套管尖，该远端的穿刺套管尖用于在将小瓶转接器伸缩地安装在单独的注射小瓶上时同时穿刺注射小瓶瓶塞。小瓶瓶冠套可以任选地具有一个或多个径向向内的小瓶瓶冠保持伸出物(radial inward vial crown holding protrusions)，用于在将小瓶转接器伸缩地卡扣配合在单独的注射小瓶上时卡扣配合在小瓶瓶冠下方以便更安全地安装。
一般情况下，在邻近病人准备立即施用它的药物时，将小瓶转接器伸缩地安装在单独的注射小瓶上进行了。基于以下几个原因，伸缩地安装被认为是一个相对麻烦的任务：首先，保健提供者不得不用戴手套的手灵巧地操作小瓶转接器和单独的注射小瓶。第二，保健提供者必须施加相当大的力用来同时将小瓶转接器伸缩地安装在单独的注射小瓶上，并穿刺它的注射小瓶瓶塞。第三，保健提供者容易错误地相对单独的注射小瓶对齐小瓶转接器，使得它的远端的穿刺套管尖不会穿刺注射小瓶瓶塞，而是将其嵌入注射小瓶瓶塞中。以及第四，在某些药物的情况下，施用速度是至关重要的，并且同时将小瓶转接器伸缩地安装在单独的注射小瓶上并且穿刺它的注射小瓶瓶塞可能需要花费相当长的时间。
有必要使液体药物转移装置的使用容易，该液体药物转移装置具有具有单独的注射小瓶的一体的小瓶转接器。
发明内容
本发明针对的是具有一体的伸缩的小瓶转接器的液体药物转移装置，该一体的伸缩的小瓶转接器用来与初始的未穿刺的原封未动的单独的注射小瓶一起使用。在它的预压紧状态，该小瓶转接器伸缩地卡扣配合在初始的未穿刺的原封未动的单独的注射小瓶上，而不穿刺它的注射小瓶瓶塞。在它的压紧状态，小瓶转接器穿刺注射小瓶瓶塞。将目前的同时伸缩安装和注射小瓶瓶塞穿刺的单个步骤划分为：将一体的伸缩的小瓶转接器伸缩地卡扣配合在单独的注射小瓶上的初始步骤和按压一体的伸缩的小瓶转接器用于穿刺它的注射小瓶瓶塞的随后步骤，使该两个步骤能够由同一个保健提供者或任选地由两个保健提供者执行。在后者情况下，第一个保健提供者可以位于药房、无菌室等，不接邻病人并且只有第二个保健提供者接邻病人用于施用目的。
唯一或第一个保健提供者负责将液体药物转移装置的一体的伸缩的小瓶转接器伸缩地卡扣配合在单独的注射小瓶上，以准备所谓的即用(Ready-To-Use)液体药物传移组合件，该液体药物传移组合件具有预先连接的未穿刺的原封未动的单独的注射小瓶。穿刺注射小瓶瓶塞需要比将小瓶转接器伸缩地卡扣配合在单独的注射小瓶上的力大得多的力，以便保健提供者在按压本发明的一体的伸缩的小瓶转接器期间可知道避免在卡扣配合在原封未动的单独的注射小瓶上后，疏忽地立即继续穿刺注射小瓶瓶塞。该一体的伸缩的小瓶转接器可以任选地被设置有安全卡件机构，该安全卡件机构需要释放动作用于启动安全卡件机构，以便实现按压。该释放动作可以包括相对旋转动作、相对线性移位动作、移除安全卡件等。唯一或第一个保健提供者可利用仪器(例如，夹具)等，以协助准备RTU液体药物转移组合件。在两个保健提供者的情况下，第二个保健提供者有接邻病人按压RTU液体药物转移组合件的一体的伸缩的小瓶转接器用于穿刺预先连接的未穿刺的原封未动的单独的注射小瓶的注射小瓶瓶塞用于施用目的的较为简单的任务。
将当前的同时伸缩安装和注射小瓶瓶塞穿刺划分成两个单独的步骤可以导致为特定病人准备的RTU液体药物转移组合件例如，由于该病人健康状况的改变而不再需要，。本发明设想将未穿刺的原封未动的单独的注射小瓶转移给新的液体药物转移装置用来为另一病人准备新的RTU液体药物转移组合件。换句话说，尽管它的篡改证据帽已不可恢复地被移除，只要它的注射小瓶瓶塞还未被穿刺，单独的注射小瓶仍被认为适合施用。因此，本发明的具有一体的伸缩的小瓶转接器的液体药物转移装置能够使预先连接的未穿刺的原封未动的单独的注射小瓶通过原封未动的单独的注射小瓶释放工具从该一体的伸缩的小瓶转接器拆除，该原封未动的单独的注射小瓶释放工具具有相对的一对向内指向的伸出物，用于施加钳形压紧(压紧力)。该原封未动的单独的注射小瓶释放工具可以配置为钳形手动工具。或者，该原封未动的单独的注射小瓶释放工具可以配置为用户操作的机电设备。原封未动的单独的注射小瓶释放工具用于从未使用的RTU液体药物转移组合件上拆除原封未动的单独的注射小瓶的使用使得批准的保健提供者只能拆除与新的液体药物转移装置一起使用的原封未动的单独的注射小瓶，用以准备新的RTU液体药物转移组合件。
附图的简要说明
为了理解本发明，并明白如何在实贱中实施它，现在将仅仅通过非限定性示例来描述优选的实施例，参照附图，其中类似的部件被做了同样编号，并且其中：
图1显示了施用装置的示图，该施用装置包括伸缩的母小瓶转接器、单独的注射小瓶、无针注射器和用于从伸缩的母小瓶转接器释放原封未动的单独的注射小瓶的钳形手动工具(pincers-like hand tool)；
图2是2-2单独的注射小瓶的沿图1中截面线的纵向截面；
图3是伸缩的母小瓶转接器在它的预压紧状态的的正面透视图；
图4A是伸缩的母小瓶转接器的分解的顶部透视图；
图4B是伸缩的母小瓶转接器的分解的底部透视图；
图5是伸缩的母小瓶转接器沿图3中截面线A-A的纵向截面，在它的预压紧状态伸缩地卡扣配合在未穿刺的原封未动的单独的注射小瓶上；
图6是伸缩的母小瓶转接器沿图3中截面线B-B的纵向截面，在它的预压紧状态伸缩地卡扣配合在未穿刺的原封未动的单独的注射小瓶上；
图7是显示了在预压紧状态的钳形手动工具用来释放未穿刺的原封未动的单独的注射小瓶的使用的正视图；
图8是沿图7中截面线C-C的纵向截面，显示了钳形手动工具用来释放未穿刺的原封未动的单独的注射小瓶的使用；
图9是伸缩的母小瓶转接器沿图3中截面线A-A的纵向横截面，在它的压紧状态穿刺单独的注射小瓶；
图10是伸缩的母小瓶转接器沿图3中截面线B-B的纵向横截面，在它的压紧状态穿刺单独的注射小瓶；
图11是配置用来与一对初始的未穿刺的原封未动的单独的注射小瓶和无针注射器一起使用的液体药物转移装置的前面透视图；
图12是图11的液体药物转移装置沿图11中截面线D-D的纵向截面；
图13是用来与输液容器和输液器一起使用的液体药物转移装置的示图；以及
图14是图13的液体药物转移装置沿图13中截面线E-E的纵向截面。
本发明的优选实施方式的详细描述
图1显示了输液器10，其包括无针注射器20、初始的未穿刺的原封未动的单独的注射小瓶30、配置为伸缩的母小瓶转接器的液体药物转移装置100A和用于从液体药物转移装置100A释放未穿刺的原封未动的单独的注射小瓶30的原封未动的单独的注射小瓶释放工具200。
图1显示了无针注射器20，其包括具有柱塞杆22的注射桶21和公连接头23。公连接头23优选为公鲁尔锁连接头(male Luer lock connector)。无针注射器20含有液体内含物。该液体内含物通常仅仅是稀释液。该液体内含物可包括活性成分。
图1和图2显示了注射小瓶30具有纵向的注射小瓶中心线31并且包括一端封闭的小瓶管32、具有瓶冠开口34的管状的小瓶瓶冠33，和在小瓶管32和小瓶瓶冠33中间的小瓶瓶颈36。单独的注射小瓶30包括用于气密地密封瓶冠开口34的注射小瓶瓶塞37。小瓶瓶冠33由带38封住。注射小瓶30含有呈粉状、液体等形式的药物39。药物39同注射器的液体内含物一起形成液体药物。注射小瓶30具有最上面的注射小瓶表面41，最上面的注射小瓶表面41在接近注射小瓶30用于形成液体药物之前灭菌。注射小瓶30包括弹开式篡改证据帽(flip-off tamper evidence cap)42，弹开式篡改证据帽42在使用前直接移除以暴露最上面的注射小瓶表面41。篡改证据帽42准备是一次性的，因此在移除后不能被放回。
图1显示了配置为钳形手动工具(pincers-like hand tool)的原封未动的单独的注射小瓶释放工具200，其包括钳形主体(a pincers-like body)201，钳形主体201具有相对的一对钳片(jaws)202，各自终止在向内指向的伸出物203处。相对的钳片202准备朝向彼此手动推动用于施加钳形的压紧用来释放未穿刺的原封未动的单独的注射小瓶30，如下文参照图7和图8进行的描述。
图3至图10显示了液体药物转移装置100A，液体药物转移装置100A包括具有纵向的小瓶转接器中心线101A的一体的伸缩的小瓶转接器101。一体的伸缩的小瓶转接器101包括内小瓶转接器主体102，外小瓶转接器主体103和用于在压紧状态不可逆地夹住小瓶转接器101的夹紧装置104。
内小瓶转接器主体102具有颠倒的杯形状，其具有最上面的横向的环形的内小瓶转接器主体壁(uppermost transverse annular inner vial adapter body wall)106和具有最下面的小瓶瓶冠套边107A的向下悬垂的小瓶瓶冠套107。内小瓶转接器主体102限定小瓶瓶冠腔108，以便在将内小瓶转接器主体102伸缩地卡扣配合在小瓶瓶冠33上时在小瓶瓶冠腔108中紧贴地接收小瓶瓶冠33。最上面的横向的环形的内小瓶转接器主体壁106具有沿纵向的小瓶转接器中心线101A的中心的最上面的横向的内小瓶转接器主体壁贯穿孔106A，在伸缩地卡扣配合在单独的注射小瓶30上时，其在最上面的注射小瓶表面41的上方。
小瓶瓶冠套107具有主要的小瓶瓶冠套围绕物109，主要的小瓶瓶冠套围绕物109具有相邻的第一对纵向的狭缝111A和相邻的第二对纵向的狭缝111B用于相应地形成正好相反的一对小瓶瓶冠保持部件112A和112B。该正好相反的一对小瓶瓶冠保持构件112相对主要的小瓶瓶冠套围绕物109是枢转的，使得每一小瓶瓶冠保持部件112具有近端的小瓶瓶冠保持部件部分113和远端的小瓶瓶冠保持部件部分114。最上面的横向的环形的内小瓶转接器主体壁106优选地具有正好相反的一对贯穿开口(throughgoing cutouts)116，贯穿开口116相对正好相反的一对小瓶瓶冠保持部件112向内，使得正好相反的一对小瓶瓶冠保持部件112在最上面的横向的环形的内小瓶转接器主体壁106上枢转。远端的小瓶瓶冠保持部件部分114各自具有朝向最下面的小瓶瓶冠套边107A的径向向内的小瓶瓶冠保持伸出物117，用于在将内小瓶转接器主体102伸缩地卡扣配合在初始的未穿刺的原封未动的单独的注射小瓶30上时卡扣配合在小瓶瓶冠33下面。
最上面的横向的环形的内小瓶转接器主体壁106包括相应地与正好相反的一对小瓶瓶冠保持部件112A和112B正交的正好相反的一对直立的限位物118A和118B。小瓶瓶冠套107包括正好相反的一对夹紧部件119A和119B，正好相反的一对夹紧部件119A和119B朝向最下面的小瓶瓶冠套边107A并且相应地与正好相反的一对小瓶瓶冠保持部件112A和112B正交。正好相反的一对夹紧部件119构成夹紧装置104的组件。
外小瓶转接器主体103具有颠倒的杯形状，其具有最上面的横向的外小瓶转接器主体壁121和向下悬垂的裙122。外小瓶转接器主体103限定内小瓶转接器主体腔123，用于在将小瓶转接器101从预压紧状态按压到压紧状态时在内小瓶转接器主体腔123中紧贴地收缩地接收内小瓶转接器主体102。向下悬垂的裙122具有最下面的裙边122A。
最上面的横向的外小瓶转接器主体壁121具有向下悬垂的穿刺套管124，向下悬垂的穿刺套管124具有近端的穿刺套管开口124A和远端的穿刺套管尖124B，用于穿刺注射小瓶瓶塞37用来与小瓶管32流体连通。最上面的横向的外小瓶转接器主体壁121具有与近端的穿刺套管开口124A流体连通的直立的液体转移端口125。直立的液体转移端口125被配置为用来与无针注射器20一起使用的母连接头。母连接头125优选地被配置为母鲁尔连接头(female Luer connector)。
向下悬挂的裙122包括相邻的第一对纵向的狭缝126A和相邻的第二对纵向的狭缝126B，用于相应地形成正好相反的一对内小瓶转接器主体保持部件127A和127B。该正好相反的一对内小瓶转接器主体保持部件127A和127B相应地包括内部纵向的凹槽128A和128B。正好相反的一对内小瓶转接器主体保持部件127与它们的内部纵向的凹槽128构成夹紧装置104的组件。正好相反的一对内部纵向的凹槽128A和128B相应地包括正好相反的一对最下面的凹槽边129A和129B。向下悬垂的裙122包括与正好相反的一对内小瓶转接器主体保持部件127A和127B正交的正好相反的一对贯穿的单独的注射小瓶释放孔131A和131B。
图5和图6显示了在初始的预压紧状态，正好相反的一对直立的限位物118被放置在正好相反的一对最下面的凹槽边129处，用于防止内小瓶转接器主体102被疏忽地从外小瓶转接器主体103移除。远端的穿刺套管尖124B位于未穿刺的注射小瓶瓶塞37的上方。正好相反的一对近端的小瓶瓶冠保持部件部分113与正好相反的一对贯穿的单独的注射小瓶释放孔131对齐。小瓶转接器101在最上面的横向的外小瓶转接器主体壁121和最下面的向下悬垂的小瓶瓶冠套边107A之间具有预压紧高度H1。
如果决定不施用药物并重新使用未穿刺的原封未动的单独的注射小瓶30，保健提供者采取图7和图8中所示的步骤：保健提供者将钳形手动工具200与小瓶转接器101对齐，用于将它的相对的一对向内指向的伸出物203插入正好相反的一对贯穿的单独的注射小瓶释放孔131中。保健提供者对正好相反的一对近端的小瓶瓶冠保持部件部分113施加钳形压紧，以朝向纵向的小瓶转接器中心线101A推动他们(如箭头A所示)。正好相反的一对小瓶瓶冠保持部件112相对主要的小瓶瓶冠套围绕物109枢转从而使正好相反的一对径向向内的小瓶瓶冠保持伸出物117远离纵向的小瓶转接器中心线101A一定距离(如箭头B所示)，从而释放出未穿刺的原封未动的单独的注射小瓶30。保健提供者从内小瓶转接器主体102取下未穿刺的原封未动的单独的注射小瓶30(如箭头C所示)。
图9和图10显示了在最终的压紧状态，正好相反的一对夹紧部件119被放置在正好相反的一对最下面的凹槽边129处，以防止伸缩的小瓶转接器101回复到它的预压紧状态。远端的穿刺套管尖124B穿刺通过注射小瓶瓶塞37，从而提供直立的母鲁尔连接头125和小瓶管32之间的流体连通。正好相反的一对近端的小瓶瓶冠保持部件部分113被设置在最上面的横向的外小瓶转接器主体壁121和正好相反的一对贯穿的单独的注射小瓶释放孔131之间，从而防止接近贯穿的单独的注射小瓶释放孔131，用于施加钳形压紧。小瓶转接器101具有压缩高度为H2，H2等于，当在外小瓶转接器主体103中完全伸缩地插入内小瓶转接器主体102时，外小瓶转接器主体103的高度，其中H2＜H1。
在最终的压紧状态，保健提供者可以将无针注射器20螺纹拧进母鲁尔连接头125中，用于将它的液体内含物引入到单独的注射小瓶30中，以在注射小瓶30中形成液体药物。此后，保健提供者可以从单独的注射小瓶30抽吸液体药物用于施用目的。
图11和图12显示了液体药物转移装置100B，液体药物转移装置100B在结构上类似共同拥有的美国专利号6,379,340(Zinger等)，下文称为Zinger装置。该Zinger装置与一对注射小瓶和初始空的无针注射器一起使用。一个注射小瓶包括液体内含物(下文称为液体瓶)，并且另一个注射小瓶包括负压下的药物(下文称为药瓶)。该Zinger装置具有纵向的壳体，该纵向的壳体具有中心流体控制部件端口和在侧端的一对小瓶转接器。该流体控制部件端口包括流体控制部件，该流体控制部件具有用于螺纹连接无针注射器的注射器端口。该流体控制部件通过注射器端口从第一操作位置可旋转，以便实现该小瓶转接器之间的流体连通并且从第二操作位置可旋转以便实现小瓶转接器和该注射器端口之间的流体连通。
Zinger使用说明(IFU)如下：液体瓶初始地被插入到一个小瓶转接器中并且随后药瓶被插入到另一个小瓶转接器中。药瓶将液体内含物从液体瓶抽到药瓶中以形成液体药物。初始的空的无针注射器被连接到注射器端口，该注射器端口通过四分之一转动旋转以实现液体药物从药瓶抽吸到无针注射器中。该无针注射器从Zinger装置拆除，用于施用液体药物。
液体药物转移装置100B包括加长的壳体141，加长的壳体141具有中心的流体控制元件端口142和在侧端的一对一体的伸缩的小瓶转接器101。液体药物传移装置100B包括流体控制部件143，流体控制部件143具有可旋转地安装在流体控制部件端口142中的注射器端口144。一体的伸缩的小瓶转接器101各自具有与中心的流体控制部件端口142流动连接的液体转移端口125。液体药物转移装置100B的使用与Zinger装置相同，除了后者100B能够准备RTU液体药物组件并释放未穿刺的原封未动的单独的注射小瓶之外。
图13和图14显示了用来与输液容器和输液器一起使用的液体药物转移装置100C。输液容器50由静脉注射(IV)袋构成，该静脉注射(IV)袋具有IV或施用端口51和注射端口52，并含有输液液体53。为了施用目的，IV端口51被拧开帽(twist-offcap)54密封用来插入IV矛状物。注射端口52终止在注射端口尖56中，注射端口尖56具有密封件密封塞(seal-sealing plug)57准备用于注射器内含物的针头插入到IV袋50中。输液器60包括IV矛状物61，并且还包括第一管子62、夹子63、滴注室64、第二管子66、滚动夹子67和公鲁尔连接头68。
液体药物转移装置100C在结构上类似共同拥有的美国专利申请公开号2016/0166824(Lev等)中公开的液体转移装置。下文被称为Lev装置，参见图4和图5。Lev装置包括三叉的Y形连接头主体，该连接头主体具有IV矛状物，该IV矛状物用于密封插入到IV端口51、小瓶转接器端口和拧开替代IV端口(twist-off substitute IV port)中。小瓶转接器端口具有具有穿刺套管的一体的小瓶转接器。连接头主体具有终止在IV矛状物处的内腔，与穿刺套管流体连通的内腔和终止在替代IV端口处的内腔。该三个内腔在三个指向上并且是连续的流体连接。替代IV端口由合适的柔性的塑料材料(例如，PVC等)制成，用于密封接收IV矛状物61。替代IV端口包括准备当插入IV矛状物61时被穿刺的膜。替代IV端口包括近端部分和远端部分。在使用时，该远端部分被拧动并且从近端部分上断开，从而暴露膜，用于被输液器的IV矛状物61穿刺。
液体药物转移装置100C包括三叉的Y形连接头主体151，连接头主体151具有用于密封插入到IV端口51、小瓶转接器端口153，和拧开替代IV端口154中的IV矛状物152。小瓶转接器端口153具有一体的伸缩的小瓶转接器101。连接头主体151具有在IV矛状物152终止的内腔156、与一体的伸缩的小瓶转接器101流体连通的内腔157和在替代IV端口154处终止的腔158。三个内腔156、157和158在三个指向上并且是连续的流体连接。
一体的伸缩的小瓶转接器101具有与小瓶转接器端口153流动连接的液体转移端口125。该一体的伸缩的小瓶转接器101优选地包括安装在穿刺套管124上的密封部件159，用于保持远端的穿刺套管尖124B无菌，并延长可使用RTU液体药物转移组件的时间长度。一体的伸缩的小瓶转接器101优选还包括安全卡件机构161，以防止疏忽地从预压紧状态按压到压紧状态。安全卡件机构161需要旋转动作，用于相对外小瓶转接器主体103旋转内小瓶转接器主体102，以启动一体的伸缩的小瓶转接器101准备用于压紧。
液体药物转移装置100C的使用与Lev装置相同，除了后者100C能够准备RTU液体药物组合件和释放未穿刺的原封未动的单独的注射小瓶30。
虽然举例说明和描述本发明的具体实施方案，对于本领域技术人员来说，很明显，可以在不背离本发明的精神和范围的情况下进行各种其他的改变和修改。
Claims (7)
1.原封未动的单独的注射小瓶释放工具，其具有相对的一对向内指向的伸出物，用来与液体药物转移装置一起使用，原封未动的单独的注射小瓶释放工具被配置为钳形手动工具，所述钳形手动工具具有相对的一对钳片，所述相对的一对钳片具有相对的一对向内指向的伸出物，
所述液体药物转移装置与初始未穿刺的原封未动的单独的注射小瓶和原封未动的单独的注射小瓶释放工具一起使用，所述初始未穿刺的原封未动的单独的注射小瓶具有包含药物的一端闭合的小瓶管、具有由未穿刺的注射小瓶瓶塞塞住的瓶冠开口的管状的小瓶瓶冠和最上面的注射小瓶表面，所述原封未动的单独的注射小瓶释放工具将所述未穿刺的原封未动的单独的注射小瓶从所述液体药物转移装置释放，
所述液体药物转移装置包括：
(a)一体的伸缩的小瓶转接器，所述一体的伸缩的小瓶转接器具有纵向的小瓶转接器中心线并且包括：
i)内小瓶转接器主体，所述内小瓶转接器主体具有颠倒的杯形，所述内小瓶转接器主体具有最上面的横向的环形的内小瓶转接器主体壁和具有最下面的小瓶瓶冠套边的向下悬垂的小瓶瓶冠套，
所述内小瓶转接器主体限定小瓶瓶冠腔，所述小瓶瓶冠腔用于当将所述内小瓶转接器主体伸缩地卡扣配合在所述小瓶瓶冠上时接收所述小瓶瓶冠，
所述小瓶瓶冠套具有主要的小瓶瓶冠套围绕物和正好相反的一对小瓶瓶冠保持部件，所述正好相反的一对小瓶瓶冠保持部件相对所述主要的小瓶瓶冠套围绕物枢转，使得每个所述小瓶瓶冠保持部件具有近端的小瓶瓶冠保持部件部分和远端的小瓶瓶冠保持部件部分，
每个所述远端的小瓶瓶冠保持部件部分具有朝向所述最下面的小瓶瓶冠套边的径向向内的小瓶瓶冠保持伸出物，所述径向向内的小瓶瓶冠保持伸出物用于当将所述内小瓶转接器主体伸缩地卡扣配合在所述初始未穿刺的原封未动的单独的注射小瓶上时卡扣配合在所述小瓶瓶冠下面，
所述正好相反的一对小瓶瓶冠保持部件相对所述主要的小瓶瓶冠套围绕物枢转，使得对所述正好相反的一对近端的小瓶瓶冠保持部件部分朝向所述纵向的小瓶转接器中心线施加钳形压紧，使所述正好相反的一对径向向内的小瓶瓶冠保持伸出物与所述纵向的小瓶转接器中心线分开一定距离，以及
ii)外小瓶转接器主体，所述外小瓶转接器主体具有颠倒的杯形状并且具有最上面的横向的外小瓶转接器主体壁和向下悬垂的裙，
所述外小瓶转接器主体限定内小瓶转接器主体腔，用于当将所述一体的伸缩的小瓶转接器从具有预压紧高度H1的初始的预压紧状态按压到具有压紧高度H2的最终压紧状态时，在所述内小瓶转接器主体腔内紧贴地伸缩地接收所述内小瓶转接器主体，其中H1>H2，
所述最上面的横向的外小瓶转接器主体壁具有向下悬垂的穿刺套管，所述向下悬垂的穿刺套管具有近端的穿刺套管开口和远端的穿刺套管尖，所述远端的穿刺套管尖用于穿刺所述注射小瓶瓶塞以与所述小瓶管流体连通，以及
iii)夹紧装置，所述夹紧装置用于不可逆地在所述最终压紧状态夹紧所述小瓶转接器，
所述小瓶转接器被配置使得在所述预压紧状态，所述远端的穿刺套管尖位于所述未穿刺的注射小瓶瓶塞上方，并且所述正好相反的一对近端的小瓶瓶冠保持部件部分获得所述钳形压紧，用于从所述内小瓶转接器主体释放所述未穿刺的原封未动的单独的注射小瓶，并且在所述最终压紧状态，所述远端的穿刺套管尖穿刺通过所述注射小瓶瓶塞，用来与所述小瓶管流体连通，并且所述向下悬垂的裙防止接近所述正好相反的一对近端的小瓶瓶冠保持部件部分；和
b)液体转移端口，所述液体转移端口与所述近端的穿刺套管开口流体连通。
2.根据权利要求1所述的工具，其中所述向下悬垂的裙包括正好相反的一对贯穿的单独的注射小瓶释放孔，所述贯穿的单独的注射小瓶释放孔经设计形状和尺寸用于提供进入所述原封未动的单独的注射小瓶释放工具的通道，用于在所述小瓶转接器的所述初始的预压紧状态对所述正好相反的一对近端的小瓶瓶冠保持部件部分施加所述钳形压紧。
3.根据权利要求1或2所述的工具，其中当所述施加所述钳形压紧时，所述正好相反的一对小瓶瓶冠保持部件在所述最上面的横向的环形的内小瓶转接器主体壁上枢转。
4.根据权利要求1或2中任一项所述的工具，其中所述一体的伸缩的小瓶转接器包括安全卡件机构，所述安全卡件机构需要释放动作，用于实现所述一体的伸缩的小瓶转接器从所述预压紧状态到所述最终压缩状态的压紧。
5.根据权利要求1或2中任一项所述的工具，其中所述液体药物转移装置被配置为小瓶转接器，并且所述液体转移端口是连接头。
6.根据权利要求1或2中任一项所述的工具，其中所述液体药物转移装置被配置用来与一对初始未穿刺的原封未动的单独的注射小瓶和无针注射器一起使用。
7.根据权利要求1或2中任一项所述的工具，其中所述液体药物转移装置被配置用来与输液容器和输液器一起使用。
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| IL249408A IL249408A0 (en) | 2016-12-06 | 2016-12-06 | A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it |
| IL249408 | 2016-12-06 | ||
| PCT/IL2017/051299 WO2018104930A1 (en) | 2016-12-06 | 2017-11-29 | Liquid drug transfer devices for use with intact discrete injection vial release tool |
| CN201780075811.XA CN110167508B (zh) | 2016-12-06 | 2017-11-29 | 用来与原封未动的单独的注射小瓶释放工具一起使用的液体药物转移装置 |
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| CN202210436542.8A Pending CN114983819A (zh) | 2016-12-06 | 2017-11-29 | 用来与原封未动的单独的注射小瓶释放工具一起使用的液体药物转移装置 |
| CN202210337592.0A Pending CN114767531A (zh) | 2016-12-06 | 2017-11-30 | 具有用来与输液容器和单独的注射小瓶一起使用的一体的伸缩的小瓶转接器的液体转移装置 |
| CN201780075812.4A Active CN110167509B (zh) | 2016-12-06 | 2017-11-30 | 具有用来与输液容器和单独的注射小瓶一起使用的一体的伸缩的小瓶转接器的液体转移装置 |
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| CN201780075812.4A Active CN110167509B (zh) | 2016-12-06 | 2017-11-30 | 具有用来与输液容器和单独的注射小瓶一起使用的一体的伸缩的小瓶转接器的液体转移装置 |
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- 2017-11-29 CN CN201780075811.XA patent/CN110167508B/zh active Active
- 2017-11-29 CN CN202210436542.8A patent/CN114983819A/zh active Pending
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| IL266436B (en) | 2022-02-01 |
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| JP2019536535A (ja) | 2019-12-19 |
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| JP7038117B2 (ja) | 2022-03-17 |
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| CN110167508B (zh) | 2022-05-10 |
| IL266437A (en) | 2019-06-30 |
| JP7499800B2 (ja) | 2024-06-14 |
| US11786443B2 (en) | 2023-10-17 |
| CN110167509A (zh) | 2019-08-23 |
| EP3551156A1 (en) | 2019-10-16 |
| US10772797B2 (en) | 2020-09-15 |
| EP3551157A1 (en) | 2019-10-16 |
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| CN110167509B (zh) | 2022-05-06 |
| IL290701A (en) | 2022-04-01 |
| IL290701B2 (en) | 2023-07-01 |
| CN114767531A (zh) | 2022-07-22 |
| IL266436A (en) | 2019-06-30 |
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