CN113699151B - B型肝炎病毒（HBV）iRNA组合物及其使用方法 - Google Patents
B型肝炎病毒（HBV）iRNA组合物及其使用方法 Download PDFInfo
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| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| TWI659040B (zh) | 2011-06-30 | 2019-05-11 | 美商艾羅海德製藥公司 | 用於抑制ｂ型肝炎病毒基因表現之組合物及方法 |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| JP6892433B2 (ja) | 2015-04-03 | 2021-06-23 | ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | 十分に安定化された非対称ｓｉｒｎａ |
| CN115957337A (zh) | 2015-08-07 | 2023-04-14 | 箭头药业股份有限公司 | 乙型肝炎病毒感染的RNAi疗法 |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| JP7749201B6 (ja) | 2016-01-31 | 2025-10-21 | ユニバーシティー オブ マサチューセッツ | 分岐オリゴヌクレオチド |
| MA45478A (fr) | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
| CN107703197B (zh) * | 2016-08-08 | 2020-01-17 | 西南医科大学附属中医医院 | 一种快速检测乙肝环状dna的方法 |
| MA46422A (fr) * | 2016-09-14 | 2019-07-24 | Janssen Biopharma Inc | Oligonucléotides modifiés et méthodes d'utilisation |
| JP2019533472A (ja) * | 2016-11-11 | 2019-11-21 | ヤンセン バイオファーマ インク． | Ｈｂｖ ｃｃｃｄｎａのオリゴヌクレオチド標的化戦略 |
| CN110177544A (zh) | 2016-11-29 | 2019-08-27 | 普尔泰克健康有限公司 | 用于递送治疗剂的外泌体 |
| TWI826365B (zh) * | 2017-01-10 | 2023-12-21 | 美商愛羅海德製藥公司 | α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法 |
| JP2020516296A (ja) * | 2017-04-11 | 2020-06-11 | アルブータス・バイオファーマー・コーポレイション | 標的化組成物 |
| CA3059446A1 (en) * | 2017-04-18 | 2018-10-25 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (hbv) infection |
| JP7688480B2 (ja) * | 2017-04-18 | 2025-06-04 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | Ｂ型肝炎ウイルス（ｈｂｖ）感染を有する対象を処置する方法 |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| CA3065518A1 (en) * | 2017-05-31 | 2018-12-06 | Arbutus Biopharma Corporation | Therapeutic compositions and methods for treating hepatitis b |
| US10844377B2 (en) | 2017-06-23 | 2020-11-24 | University Of Massachusetts | Two-tailed self-delivering siRNA |
| EP3682007A2 (en) * | 2017-09-14 | 2020-07-22 | Janssen BioPharma, Inc. | Galnac derivatives |
| IL282881B2 (en) | 2017-10-20 | 2024-10-01 | Dicerna Pharmaceuticals Inc | Methods for treating hepatitis b infection |
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