CN1092657C - 一釜法合成2－噁唑烷酮衍生物 - Google Patents

一釜法合成2－噁唑烷酮衍生物 Download PDF

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Publication number
CN1092657C
CN1092657C CN96197237A CN96197237A CN1092657C CN 1092657 C CN1092657 C CN 1092657C CN 96197237 A CN96197237 A CN 96197237A CN 96197237 A CN96197237 A CN 96197237A CN 1092657 C CN1092657 C CN 1092657C
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CN
China
Prior art keywords
formula
compound
carried out
methyl ester
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96197237A
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English (en)
Chinese (zh)
Other versions
CN1201460A (zh
Inventor
R·帕特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
AstraZeneca AB
Original Assignee
Zeneca Ltd
AstraZeneca AB
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Filing date
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Publication of CN1201460A publication Critical patent/CN1201460A/zh
Application granted granted Critical
Publication of CN1092657C publication Critical patent/CN1092657C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
CN96197237A 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物 Expired - Lifetime CN1092657C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9516145.1 1995-08-07
GBGB9516145.1A GB9516145D0 (en) 1995-08-07 1995-08-07 Improved chemical synthesis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB011330929A Division CN1244579C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物
CNB01112010XA Division CN1142904C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物的中间体及其制备方法

Publications (2)

Publication Number Publication Date
CN1201460A CN1201460A (zh) 1998-12-09
CN1092657C true CN1092657C (zh) 2002-10-16

Family

ID=10778867

Family Applications (3)

Application Number Title Priority Date Filing Date
CN96197237A Expired - Lifetime CN1092657C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物
CNB01112010XA Expired - Lifetime CN1142904C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物的中间体及其制备方法
CNB011330929A Expired - Lifetime CN1244579C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB01112010XA Expired - Lifetime CN1142904C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物的中间体及其制备方法
CNB011330929A Expired - Lifetime CN1244579C (zh) 1995-08-07 1996-08-02 一釜法合成2－噁唑烷酮衍生物

Country Status (34)

Country Link
US (2) US6084103A (enExample)
EP (2) EP1227095B1 (enExample)
JP (6) JP3729503B2 (enExample)
KR (1) KR100670704B1 (enExample)
CN (3) CN1092657C (enExample)
AR (2) AR006515A1 (enExample)
AT (2) ATE227723T1 (enExample)
AU (1) AU718413B2 (enExample)
BR (1) BR9609830A (enExample)
CA (2) CA2572508C (enExample)
CZ (2) CZ301603B6 (enExample)
DE (2) DE69636107T2 (enExample)
DK (2) DK0843672T3 (enExample)
ES (2) ES2261545T3 (enExample)
GB (1) GB9516145D0 (enExample)
HK (1) HK1047094B (enExample)
HU (1) HU229966B1 (enExample)
IL (4) IL148030A (enExample)
IN (2) IN185148B (enExample)
MX (1) MX9801044A (enExample)
MY (1) MY117571A (enExample)
NO (2) NO311690B1 (enExample)
NZ (1) NZ315040A (enExample)
PL (1) PL188805B1 (enExample)
PT (2) PT1227095E (enExample)
RO (2) RO119618B1 (enExample)
RU (1) RU2167875C2 (enExample)
SI (2) SI1227095T1 (enExample)
SK (1) SK285052B6 (enExample)
TR (1) TR199800182T1 (enExample)
TW (1) TW358811B (enExample)
UA (1) UA53625C2 (enExample)
WO (1) WO1997006162A1 (enExample)
ZA (1) ZA966711B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103275075A (zh) * 2013-06-24 2013-09-04 成都天台山制药有限公司 佐米曲普坦及其制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004088A1 (en) * 1999-07-09 2001-01-18 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of aniline derivatives
GB9928578D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
ES2204302B2 (es) * 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
EP1711493A2 (en) * 2004-02-06 2006-10-18 CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement Crystalline forms of zolmitriptan
WO2006055964A2 (en) * 2004-11-19 2006-05-26 Teva Pharmaceutical Industries Ltd. Zolmitriptan crystal forms
US8143052B2 (en) 2005-08-25 2012-03-27 Ube Industries, Ltd. Process for preparing optically active (S or R)-α amino acid and (R or S)-α amino acid ester in one phase organic reaction medium
US20110313171A1 (en) * 2006-01-19 2011-12-22 Chandra Purna Ray Conversion of aromatic diazonium salt to aryl hydrazine
WO2008007390A2 (en) * 2006-07-10 2008-01-17 Natco Pharma Limited An improved process for purification of zolmitriptan
WO2008018090A2 (en) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd An improved process for the preparation of zolmitriptan
CZ301538B6 (cs) 2007-02-26 2010-04-07 Zentiva, A. S. Zpusob prípravy zolmitriptanu
CZ2007158A3 (cs) * 2007-02-26 2008-10-22 Zentiva, A. S. Zpusob prípravy zolmitriptanu
AU2008306604A1 (en) * 2007-10-03 2009-04-09 Generics [Uk] Limited Process for the preparation of zolmitriptan, salts and solvates thereof
CN101230047B (zh) * 2008-02-04 2010-08-04 江苏中威药业有限公司 一种4-取代手性噁唑烷酮类化合物的制备方法
EP2387993B1 (en) * 2010-05-21 2012-11-07 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of zolmitriptan and process for preparing the same
CN101948443B (zh) * 2010-08-17 2012-08-22 河南师范大学 一种简单、高效合成4-取代噁唑烷酮衍生物的方法
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
US9006453B2 (en) 2011-09-02 2015-04-14 Emcure Pharmaceuticals Limited Process for preparation of zolmitriptan
CN102964270B (zh) * 2012-11-21 2015-01-07 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
WO2016037072A2 (en) * 2014-09-04 2016-03-10 Brown University Enopeptin analogas and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018897A1 (en) * 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
GB1478108A (en) * 1975-10-30 1977-06-29 Nippon Chemipar Co Ltd 5-benzyl-2-oxazolidone derivatives and a process for producing the same
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB9012672D0 (en) * 1990-06-07 1990-08-01 Wellcome Found Therapeutic heterocyclic compounds
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
AU699281B2 (en) * 1994-12-06 1998-11-26 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018897A1 (en) * 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103275075A (zh) * 2013-06-24 2013-09-04 成都天台山制药有限公司 佐米曲普坦及其制备方法
CN103275075B (zh) * 2013-06-24 2015-01-07 成都天台山制药有限公司 佐米曲普坦及其制备方法

Also Published As

Publication number Publication date
SI0843672T1 (en) 2003-04-30
ATE325121T1 (de) 2006-06-15
US6160123A (en) 2000-12-12
CA2227039C (en) 2007-12-04
NZ315040A (en) 2000-01-28
HUP9900188A3 (en) 1999-11-29
CZ35298A3 (cs) 1998-06-17
DE69624825T2 (de) 2003-09-04
GB9516145D0 (en) 1995-10-04
ATE227723T1 (de) 2002-11-15
TR199800182T1 (xx) 1998-05-21
DE69624825D1 (de) 2002-12-19
NO20005187L (no) 1998-02-06
KR19990036165A (ko) 1999-05-25
RU2167875C2 (ru) 2001-05-27
CN1244579C (zh) 2006-03-08
IN189756B (enExample) 2003-04-19
JP2002097178A (ja) 2002-04-02
NO980522D0 (no) 1998-02-06
SI1227095T1 (sl) 2006-08-31
HK1009129A1 (en) 1999-05-28
IL148030A0 (en) 2002-09-12
SK15498A3 (en) 1998-06-03
NO20005187D0 (no) 2000-10-16
AR046236A2 (es) 2005-11-30
PT1227095E (pt) 2006-08-31
EP1227095A2 (en) 2002-07-31
SK285052B6 (sk) 2006-05-04
AU718413B2 (en) 2000-04-13
IL148030A (en) 2010-05-17
JP2002308858A (ja) 2002-10-23
JP4634286B2 (ja) 2011-02-16
JP2006225406A (ja) 2006-08-31
JP2002037786A (ja) 2002-02-06
BR9609830A (pt) 1999-03-09
RO121816B1 (ro) 2008-05-30
DK0843672T3 (da) 2003-02-17
IL123171A (en) 2003-10-31
HUP9900188A2 (hu) 1999-05-28
IL123171A0 (en) 1998-09-24
DE69636107D1 (de) 2006-06-08
TW358811B (en) 1999-05-21
RO119618B1 (ro) 2005-01-28
ES2185790T3 (es) 2003-05-01
EP0843672B1 (en) 2002-11-13
MY117571A (en) 2004-07-31
JPH11513023A (ja) 1999-11-09
MX9801044A (es) 1998-05-31
DE69636107T2 (de) 2007-05-03
CZ293050B6 (cs) 2004-01-14
PT843672E (pt) 2003-03-31
DK1227095T3 (da) 2006-07-31
UA53625C2 (uk) 2003-02-17
HK1047094A1 (en) 2003-02-07
EP0843672A1 (en) 1998-05-27
CZ301603B6 (cs) 2010-04-28
EP1227095A3 (en) 2003-11-19
NO311691B1 (no) 2002-01-07
NO980522L (no) 1998-02-06
NO311690B1 (no) 2002-01-07
ZA966711B (en) 1997-02-18
US6084103A (en) 2000-07-04
IN185148B (enExample) 2000-11-25
JP3729503B2 (ja) 2005-12-21
WO1997006162A1 (en) 1997-02-20
EP1227095B1 (en) 2006-05-03
KR100670704B1 (ko) 2007-07-11
JP2006077025A (ja) 2006-03-23
CA2572508A1 (en) 1997-02-20
ES2261545T3 (es) 2006-11-16
CN1403455A (zh) 2003-03-19
CN1317480A (zh) 2001-10-17
IL156733A (en) 2007-07-04
CA2227039A1 (en) 1997-02-20
AR006515A1 (es) 1999-09-08
AU6663496A (en) 1997-03-05
PL324881A1 (en) 1998-06-22
PL188805B1 (pl) 2005-04-29
CA2572508C (en) 2010-03-30
HK1047094B (en) 2006-10-13
HU229966B1 (hu) 2015-03-30
IL156733A0 (en) 2004-02-08
JP3739678B2 (ja) 2006-01-25
CN1142904C (zh) 2004-03-24
CN1201460A (zh) 1998-12-09

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Address after: Swedish Sodertalje

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