JPH11513023A - 2−オキサゾリジノン誘導体のワンポット合成 - Google Patents
2−オキサゾリジノン誘導体のワンポット合成Info
- Publication number
- JPH11513023A JPH11513023A JP9508226A JP50822697A JPH11513023A JP H11513023 A JPH11513023 A JP H11513023A JP 9508226 A JP9508226 A JP 9508226A JP 50822697 A JP50822697 A JP 50822697A JP H11513023 A JPH11513023 A JP H11513023A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- oxazolidinone
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(S)-4-{[3-[2-(ジメチルアミノ)エチル]-1H-インドール-5-イル]メチル}-2- オキサゾリジノンを調製するプロセスであって、以下の工程を包含するプロセス : a)炭酸ナトリウムまたは炭酸水素ナトリウムおよびn-ブチルクロロホルメー トを添加し反応させることにより、式(II)で表されるメチル4-ニトロ-(L)-フ ェニルアラニネートヒドロクロリドからカルバメートを形成し、 式(III)で表されるメチル(S)-N-ブトキシカルボニル-4-ニトロフェニルアラ ニネートを得る工程 b)式(III)の化合物を還元して、式(IV)で表されるメチル(S)-N-ブトキ シカルボニル-4-アミノフェニルアラニネートを得る工程 c)式(IV)の化合物中のメチルエステル基-CO2CH3を還元して、式(V)で表 される(S)-N-ブトキシカルボニル-4-アミノフェニルアラニノールを得る工程 d)式(V)の化合物を閉環し、式(VI)で表される(S)-4-(4-アミノベンジル) -2-オキサゾリジノンを得る工程 e)式(VI)の化合物のジアゾニウム塩を調製し、続いて還元し、式(VII)で 表されるヒドラジン(S)-4-(4-ヒドラジノベンジル)-2-オキサゾリジノンヒドロ クロリドを得る工程 f)式(VII)の化合物のフィッシャー反応により式(I)の化合物を得る工 程。 2.ワンポット手順を使用して工程a)からf)の1個以上の工程が実施される 、請求項1に記載のプロセス。 3.ワンポット手順によって工程a)からd)が実施され、続いて式(VI)の化 合物を単離し、次いで工程e)とf)とが第二のワンポット手順によって実施さ れる、請求項1または2に記載のプロセス。 4.炭酸ナトリウムを使用して、水性酢酸エチル溶媒の存在下で工程a)が実施 される、請求項1〜3のいずれか1項に記載のプロセス。 5.工程a)において炭酸ナトリウムを温度約20℃で添加し、およびN-ブチルク ロロホルメートを温度約30℃で添加する、請求項4に記載のプロセス。 6.工程b)が水素添加によって実施される、請求項1〜5のいずれか1項に記 載のプロセス。 7.工程c)の還元が水素化ホウ素ナトリウムを使用して行われる、請求項1〜 6のいずれか1項に記載のプロセス。 8.工程d)が式(V)の化合物の乾燥ブタノール溶液において実施される、請 求項1〜7のいずれか1項に記載のプロセス。 9.ナトリウムメトキシドの30%メタノール溶液を使用して、50〜120℃の範囲 の温度で閉環が実施される、請求項1〜8のいずれか1項に記載のプロセス。 10.工程e)が i)式(VI)の化合物を亜硝酸ナトリウムと反応させること、および ii)i)で生成したジアゾニウム塩を亜硫酸ナトリウムを使用して還元するこ と によって実施される、請求項1〜9のいずれか1項に記載のプロセス。 11.工程f)のフィッシャー反応が相対的に高い希釈度で実施される、請求項 1〜10のいずれか1項に記載のプロセス。 12.(S)-4-{[3-(ジメチルアミノ)エチル]-1H-インドール-5-イル]-メチル}-2- オキサゾリジノンの精製プロセスであって、以下の工程を包含するプロセス: a)酢酸エチル中のエタノールの還流混合物中に粗(S)-4-{[3-(ジメチルアミ ノ)エチル]-1H-インドール-5-イル]-メチル}-2-オキサゾリジノンを溶解し、そ してその熱溶液を濾過する工程 b)該濾過した溶液を約5℃の温度まで徐冷する工程 c)工程b)による生成物を遠心分離し、酢酸エチルで洗浄し、次いで乾燥す る工程;および d)アセトンで処理し、溶媒和した酢酸エチルを除去する工程。 13.溶媒和していない純粋な(S)-4-{[3-(ジメチルアミノエチル)-1H-インドー ル-5-イル]-メチル}-2-オキサゾリジノン。 14.式(III)の中間体 15.式(IV)の中間体 16.式(V)の中間体 17.式(VI)の中間体 18.式(III)の化合物を調製するプロセスであって、 式(II)の化合物を炭酸ナトリウムおよびn-ブチルクロロホルメートと反応させ る工程を包含するプロセス 19.式(IV)の化合物を調製するプロセスであって、 式(III)の化合物を還元する工程を包含するプロセス 20.式(V)の化合物を調製するプロセスであって、 式(IV)の化合物を還元する工程を包含するプロセス 21.式(VI)の化合物を調製するプロセスであって、 式(V)の化合物を閉環する工程を包含するプロセス 22.医薬使用のための組成物の製造における、請求項14に記載の中間体の使 用。 23.医薬使用のための組成物の製造における、請求項15に記載の中間体の使 用。 24.医薬使用のための組成物の製造における、請求項16に記載の中間体の使 用。 25.医薬使用のための組成物の製造における、請求項17に記載の中間体の使 用。 26.前記組成物が偏頭痛の治療および予防において使用される、請求項22〜 25のいずれか1項に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9516145.1 | 1995-08-07 | ||
GBGB9516145.1A GB9516145D0 (en) | 1995-08-07 | 1995-08-07 | Improved chemical synthesis |
PCT/GB1996/001885 WO1997006162A1 (en) | 1995-08-07 | 1996-08-02 | One pot synthesis of 2-oxazolidinone derivatives |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001228782A Division JP3739678B2 (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2001228781A Division JP2002037786A (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2002086955A Division JP2002308858A (ja) | 1995-08-07 | 2002-03-26 | 2−オキサゾリジノン誘導体のワンポット合成 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11513023A true JPH11513023A (ja) | 1999-11-09 |
JP3729503B2 JP3729503B2 (ja) | 2005-12-21 |
Family
ID=10778867
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50822697A Expired - Lifetime JP3729503B2 (ja) | 1995-08-07 | 1996-08-02 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2001228782A Expired - Lifetime JP3739678B2 (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2001228781A Withdrawn JP2002037786A (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2002086955A Withdrawn JP2002308858A (ja) | 1995-08-07 | 2002-03-26 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2005334990A Expired - Lifetime JP4634286B2 (ja) | 1995-08-07 | 2005-11-18 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2006152810A Withdrawn JP2006225406A (ja) | 1995-08-07 | 2006-05-31 | 2−オキサゾリジノン誘導体のワンポット合成 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001228782A Expired - Lifetime JP3739678B2 (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2001228781A Withdrawn JP2002037786A (ja) | 1995-08-07 | 2001-07-27 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2002086955A Withdrawn JP2002308858A (ja) | 1995-08-07 | 2002-03-26 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2005334990A Expired - Lifetime JP4634286B2 (ja) | 1995-08-07 | 2005-11-18 | 2−オキサゾリジノン誘導体のワンポット合成 |
JP2006152810A Withdrawn JP2006225406A (ja) | 1995-08-07 | 2006-05-31 | 2−オキサゾリジノン誘導体のワンポット合成 |
Country Status (34)
Country | Link |
---|---|
US (2) | US6084103A (ja) |
EP (2) | EP0843672B1 (ja) |
JP (6) | JP3729503B2 (ja) |
KR (1) | KR100670704B1 (ja) |
CN (3) | CN1244579C (ja) |
AR (2) | AR006515A1 (ja) |
AT (2) | ATE227723T1 (ja) |
AU (1) | AU718413B2 (ja) |
BR (1) | BR9609830A (ja) |
CA (2) | CA2572508C (ja) |
CZ (2) | CZ293050B6 (ja) |
DE (2) | DE69636107T2 (ja) |
DK (2) | DK0843672T3 (ja) |
ES (2) | ES2185790T3 (ja) |
GB (1) | GB9516145D0 (ja) |
HK (2) | HK1047094B (ja) |
HU (1) | HU229966B1 (ja) |
IL (4) | IL156733A (ja) |
IN (2) | IN185148B (ja) |
MX (1) | MX9801044A (ja) |
MY (1) | MY117571A (ja) |
NO (2) | NO311690B1 (ja) |
NZ (1) | NZ315040A (ja) |
PL (1) | PL188805B1 (ja) |
PT (2) | PT843672E (ja) |
RO (2) | RO119618B1 (ja) |
RU (1) | RU2167875C2 (ja) |
SI (2) | SI0843672T1 (ja) |
SK (1) | SK285052B6 (ja) |
TR (1) | TR199800182T1 (ja) |
TW (1) | TW358811B (ja) |
UA (1) | UA53625C2 (ja) |
WO (1) | WO1997006162A1 (ja) |
ZA (1) | ZA966711B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010540613A (ja) * | 2007-10-03 | 2010-12-24 | ジェネリクス・(ユーケー)・リミテッド | ゾルミトリプタン、その塩、及びその溶媒和物の調製方法 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004088A1 (fr) * | 1999-07-09 | 2001-01-18 | Chugai Seiyaku Kabushiki Kaisha | Procede de preparation de derives d'amiline |
ES2204302B2 (es) * | 2002-08-07 | 2005-03-01 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
EP1711493A2 (en) * | 2004-02-06 | 2006-10-18 | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement | Crystalline forms of zolmitriptan |
WO2006055964A2 (en) * | 2004-11-19 | 2006-05-26 | Teva Pharmaceutical Industries Ltd. | Zolmitriptan crystal forms |
WO2007023948A1 (ja) | 2005-08-25 | 2007-03-01 | Ube Industries, Ltd. | 光学活性(S又はR)-α-アミノ酸及び光学活性(R又はS)-α-アミノ酸エステルの製造方法 |
EP1981860B1 (en) * | 2006-01-19 | 2011-05-25 | Matrix Laboratories Ltd | Conversion of aromatic diazonium salt to aryl hydrazine |
WO2008007390A2 (en) * | 2006-07-10 | 2008-01-17 | Natco Pharma Limited | An improved process for purification of zolmitriptan |
WO2008018090A2 (en) * | 2006-08-09 | 2008-02-14 | Matrix Laboratories Ltd | An improved process for the preparation of zolmitriptan |
CZ301538B6 (cs) | 2007-02-26 | 2010-04-07 | Zentiva, A. S. | Zpusob prípravy zolmitriptanu |
CZ2007158A3 (cs) * | 2007-02-26 | 2008-10-22 | Zentiva, A. S. | Zpusob prípravy zolmitriptanu |
CN101230047B (zh) * | 2008-02-04 | 2010-08-04 | 江苏中威药业有限公司 | 一种4-取代手性噁唑烷酮类化合物的制备方法 |
US8906949B2 (en) | 2010-05-21 | 2014-12-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of zolmitriptan and process for preparing the same |
CN101948443B (zh) * | 2010-08-17 | 2012-08-22 | 河南师范大学 | 一种简单、高效合成4-取代噁唑烷酮衍生物的方法 |
US9193767B2 (en) | 2011-03-30 | 2015-11-24 | Brown University | Enopeptins, uses thereof, and methods of synthesis thereto |
WO2013057739A2 (en) * | 2011-09-02 | 2013-04-25 | Emcure Pharmaceuticals Limited | An improved process for preparation of zolmitriptan |
CN102964270B (zh) * | 2012-11-21 | 2015-01-07 | 合肥星宇化学有限责任公司 | 一种亚硫酸钠还原重氮盐合成肼的方法 |
CN103275075B (zh) * | 2013-06-24 | 2015-01-07 | 成都天台山制药有限公司 | 佐米曲普坦及其制备方法 |
WO2016037072A2 (en) * | 2014-09-04 | 2016-03-10 | Brown University | Enopeptin analogas and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
PL166214B1 (pl) * | 1990-06-07 | 1995-04-28 | Wellcome Found | Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL PL |
GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
GB9423682D0 (en) * | 1994-11-23 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
AU699281B2 (en) * | 1994-12-06 | 1998-11-26 | Merck Sharp & Dohme Limited | Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists |
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1995
- 1995-08-07 GB GBGB9516145.1A patent/GB9516145D0/en active Pending
-
1996
- 1996-02-08 UA UA98031096A patent/UA53625C2/uk unknown
- 1996-08-02 CN CNB011330929A patent/CN1244579C/zh not_active Expired - Lifetime
- 1996-08-02 US US09/011,045 patent/US6084103A/en not_active Expired - Lifetime
- 1996-08-02 WO PCT/GB1996/001885 patent/WO1997006162A1/en not_active Application Discontinuation
- 1996-08-02 NZ NZ315040A patent/NZ315040A/xx not_active IP Right Cessation
- 1996-08-02 DE DE69636107T patent/DE69636107T2/de not_active Expired - Lifetime
- 1996-08-02 DK DK96926465T patent/DK0843672T3/da active
- 1996-08-02 RO RO98-00214A patent/RO119618B1/ro unknown
- 1996-08-02 DE DE69624825T patent/DE69624825T2/de not_active Expired - Lifetime
- 1996-08-02 RU RU98104085/04A patent/RU2167875C2/ru active
- 1996-08-02 IL IL156733A patent/IL156733A/en not_active IP Right Cessation
- 1996-08-02 HU HU9900188A patent/HU229966B1/hu unknown
- 1996-08-02 EP EP96926465A patent/EP0843672B1/en not_active Expired - Lifetime
- 1996-08-02 BR BR9609830A patent/BR9609830A/pt not_active Application Discontinuation
- 1996-08-02 CA CA2572508A patent/CA2572508C/en not_active Expired - Lifetime
- 1996-08-02 AT AT96926465T patent/ATE227723T1/de active
- 1996-08-02 PT PT96926465T patent/PT843672E/pt unknown
- 1996-08-02 JP JP50822697A patent/JP3729503B2/ja not_active Expired - Lifetime
- 1996-08-02 CN CNB01112010XA patent/CN1142904C/zh not_active Expired - Lifetime
- 1996-08-02 CN CN96197237A patent/CN1092657C/zh not_active Expired - Lifetime
- 1996-08-02 ES ES96926465T patent/ES2185790T3/es not_active Expired - Lifetime
- 1996-08-02 PT PT02008427T patent/PT1227095E/pt unknown
- 1996-08-02 RO ROA200400914A patent/RO121816B1/ro unknown
- 1996-08-02 IL IL12317196A patent/IL123171A/xx not_active IP Right Cessation
- 1996-08-02 AU AU66634/96A patent/AU718413B2/en not_active Expired
- 1996-08-02 CZ CZ1998352A patent/CZ293050B6/cs not_active IP Right Cessation
- 1996-08-02 AT AT02008427T patent/ATE325121T1/de active
- 1996-08-02 PL PL96324881A patent/PL188805B1/pl unknown
- 1996-08-02 TR TR1998/00182T patent/TR199800182T1/xx unknown
- 1996-08-02 CA CA002227039A patent/CA2227039C/en not_active Expired - Lifetime
- 1996-08-02 SI SI9630560T patent/SI0843672T1/xx unknown
- 1996-08-02 EP EP02008427A patent/EP1227095B1/en not_active Expired - Lifetime
- 1996-08-02 ES ES02008427T patent/ES2261545T3/es not_active Expired - Lifetime
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Publication number | Priority date | Publication date | Assignee | Title |
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JP2010540613A (ja) * | 2007-10-03 | 2010-12-24 | ジェネリクス・(ユーケー)・リミテッド | ゾルミトリプタン、その塩、及びその溶媒和物の調製方法 |
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