CN109153728A - 多特异性和多功能分子及其用途 - Google Patents

多特异性和多功能分子及其用途 Download PDF

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Publication number
CN109153728A
CN109153728A CN201780028089.4A CN201780028089A CN109153728A CN 109153728 A CN109153728 A CN 109153728A CN 201780028089 A CN201780028089 A CN 201780028089A CN 109153728 A CN109153728 A CN 109153728A
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Prior art keywords
molecule
polypeptide
polyspecific
adapter
cancer target
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CN201780028089.4A
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Chinese (zh)
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A.洛
B.E.瓦什
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Marengo Therapeutics Inc
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Elstar Therapeutics Inc
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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CN201780028089.4A 2016-03-21 2017-03-21 多特异性和多功能分子及其用途 Pending CN109153728A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662310929P 2016-03-21 2016-03-21
US201662310899P 2016-03-21 2016-03-21
US62/310,929 2016-03-21
US62/310,899 2016-03-21
PCT/US2017/023483 WO2017165464A1 (en) 2016-03-21 2017-03-21 Multispecific and multifunctional molecules and uses thereof

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CN109153728A true CN109153728A (zh) 2019-01-04

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US (2) US11291721B2 (https=)
EP (1) EP3433281A1 (https=)
JP (2) JP7082604B2 (https=)
CN (1) CN109153728A (https=)
AU (1) AU2017238172B2 (https=)
CA (1) CA3016563A1 (https=)
WO (1) WO2017165464A1 (https=)

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CN110256583A (zh) * 2019-07-11 2019-09-20 中国科学院生物物理研究所 一种il-2突变体与抗体的融合蛋白及其应用
CN110382542A (zh) * 2017-03-29 2019-10-25 豪夫迈·罗氏有限公司 针对共刺激性tnf受体的双特异性抗原结合分子
WO2020177627A1 (zh) * 2019-03-02 2020-09-10 上海一宸医药科技有限公司 一种双特异抗体
CN113924314A (zh) * 2019-04-25 2022-01-11 豪夫迈·罗氏有限公司 通过多肽链交换活化的治疗性多特异性多肽
CN114026122A (zh) * 2019-02-21 2022-02-08 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
CN114032252A (zh) * 2021-11-01 2022-02-11 武汉爱博泰克生物科技有限公司 一种重组状态人源mmp-7蛋白的表达方法及应用
CN114127111A (zh) * 2019-02-21 2022-03-01 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
CN114127112A (zh) * 2019-02-21 2022-03-01 马伦戈治疗公司 与t细胞结合的多功能分子及其治疗自身免疫性病症的用途
CN114127113A (zh) * 2019-02-21 2022-03-01 马伦戈治疗公司 与钙网蛋白结合的多功能分子及其用途
CN114174325A (zh) * 2019-06-04 2022-03-11 恩卡尔塔公司 用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合
CN114249836A (zh) * 2021-12-27 2022-03-29 上海鑫湾生物科技有限公司 双特异性t细胞衔接器、其重组溶瘤病毒及其用途
CN114341186A (zh) * 2019-07-30 2022-04-12 魁尔斯弗生物治疗股份有限公司 双特异性抗LRRC15和CD3ε抗体
WO2022174813A1 (zh) * 2021-02-19 2022-08-25 信达生物制药(苏州)有限公司 抗GPRC5DxBCMAxCD3三特异性抗体及其用途
WO2023020315A1 (zh) * 2021-08-19 2023-02-23 南京吉盛澳玛生物医药有限公司 靶向pd-l1/pd-1的抗体及其应用
WO2023036270A1 (zh) * 2021-09-09 2023-03-16 启愈生物技术(上海)有限公司 抗原靶向、抗cd16a和免疫效应细胞激活三功能融合蛋白及其应用
WO2023138620A1 (zh) * 2022-01-19 2023-07-27 黄浩旻 抗pdl1/igf1r双特异性抗体、其制备方法及用途
WO2023193800A1 (zh) * 2022-04-07 2023-10-12 恺兴生命科技(上海)有限公司 嵌合多肽及其应用
CN117069856A (zh) * 2023-08-08 2023-11-17 北京翊博生物集团有限公司 双特异性抗体及应用、组合物、激活和扩增t细胞的方法
WO2024056098A1 (zh) * 2022-09-16 2024-03-21 四川大学华西医院 NKG2D-NKp46细胞接合器分子及其用途
WO2024197709A1 (zh) * 2023-03-30 2024-10-03 中国科学院深圳先进技术研究院 一种t细胞衔接器及其制备方法和应用
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
CN119684472A (zh) * 2024-12-13 2025-03-25 北京干细胞与再生医学研究院 靶向CD33和mesothelin双靶点的嵌合抗原受体及其应用
US12286477B2 (en) 2018-07-03 2025-04-29 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2025168114A1 (en) * 2024-02-09 2025-08-14 Shanghai Epimab Biotherapeutics Co., Ltd. Multifunctional nk cell engager
WO2025201242A1 (en) * 2024-03-25 2025-10-02 Tavotek Biotherapeutics (Hong Kong) Limited Antibodies targeting fap and lrrc15 and fusion proteins targeting hyaluronan and uses thereof
US12486326B2 (en) 2020-01-03 2025-12-02 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof

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US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
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AU2015364396B2 (en) 2014-12-19 2018-08-09 Alkermes, Inc. Single chain Fc fusion proteins
MX389194B (es) 2015-10-06 2025-03-20 Univ Minnesota Compuestos terapéuticos y métodos.
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EP3411475B1 (en) 2016-02-06 2025-08-27 President and Fellows of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
WO2017165464A1 (en) 2016-03-21 2017-09-28 Elstar Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
JP7084881B2 (ja) 2016-06-22 2022-06-15 アルカームス インコーポレーテッド Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法
JP7308034B2 (ja) 2016-07-01 2023-07-13 リゾルブ セラピューティクス， エルエルシー 最適化二重ヌクレアーゼ融合物および方法
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JP2019512272A (ja) 2019-05-16
CA3016563A1 (en) 2017-09-28
US11291721B2 (en) 2022-04-05
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US20170368169A1 (en) 2017-12-28

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