CN107074852B - ROR-γ的二氢吡咯并吡啶抑制剂 - Google Patents

ROR-γ的二氢吡咯并吡啶抑制剂 Download PDF

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Publication number
CN107074852B
CN107074852B CN201580056193.5A CN201580056193A CN107074852B CN 107074852 B CN107074852 B CN 107074852B CN 201580056193 A CN201580056193 A CN 201580056193A CN 107074852 B CN107074852 B CN 107074852B
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mixture
compound
tert
mmol
pharmaceutically acceptable
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CN107074852A (zh
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大卫·A·克莱蒙
劳伦斯·韦恩·迪拉德
董成国
范怡
贾兰齐
斯蒂芬·D·罗特斯塔
安德鲁·马库斯
苏雷什·B·辛格
科林·M·泰斯
苑晶
赵伟
郑亚军
庄凌航
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Life Medicine Co Ltd
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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CN201580056193.5A 2014-10-14 2015-10-14 ROR-γ的二氢吡咯并吡啶抑制剂 Expired - Fee Related CN107074852B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US62/063,912 2014-10-14
US201462074406P 2014-11-03 2014-11-03
US62/074,406 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

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CN107074852A CN107074852A (zh) 2017-08-18
CN107074852B true CN107074852B (zh) 2019-08-16

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US (3) US9796710B2 (cg-RX-API-DMAC7.html)
EP (1) EP3207043B3 (cg-RX-API-DMAC7.html)
JP (1) JP6564029B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170066628A (cg-RX-API-DMAC7.html)
CN (1) CN107074852B (cg-RX-API-DMAC7.html)
AU (1) AU2015333610B2 (cg-RX-API-DMAC7.html)
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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
UA118201C2 (uk) 2013-11-26 2018-12-10 Ф. Хоффманн-Ля Рош Аг НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ
DK3102576T3 (da) 2014-02-03 2019-07-22 Vitae Pharmaceuticals Llc Dihydropyrrolopyridininhibitorer af ror-gamma
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MX371304B (es) 2014-10-14 2020-01-24 Vitae Pharmaceuticals Llc Dihidropirrolopiridinas inhibidoras del receptor huérfano-gamma.
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TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
TW202220968A (zh) * 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
CR20190423A (es) 2017-03-16 2019-11-01 Hoffmann La Roche Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
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JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド
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