SI3207043T1 - Dihidropirolopiridinovi inhibitorji za ROR-gama - Google Patents

Dihidropirolopiridinovi inhibitorji za ROR-gama

Info

Publication number
SI3207043T1
SI3207043T1 SI201530636T SI201530636T SI3207043T1 SI 3207043 T1 SI3207043 T1 SI 3207043T1 SI 201530636 T SI201530636 T SI 201530636T SI 201530636 T SI201530636 T SI 201530636T SI 3207043 T1 SI3207043 T1 SI 3207043T1
Authority
SI
Slovenia
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
Prior art date
Application number
SI201530636T
Other languages
English (en)
Slovenian (sl)
Inventor
David A. Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Stephen D. Lotesta
Andrew Marcus
Suresh B. Singh
Colin M. Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals, Inc. filed Critical Vitae Pharmaceuticals, Inc.
Publication of SI3207043T1 publication Critical patent/SI3207043T1/sl

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
SI201530636T 2014-10-14 2015-10-14 Dihidropirolopiridinovi inhibitorji za ROR-gama SI3207043T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma
EP15785013.2A EP3207043B3 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

Publication Number Publication Date
SI3207043T1 true SI3207043T1 (sl) 2019-04-30

Family

ID=54352515

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530636T SI3207043T1 (sl) 2014-10-14 2015-10-14 Dihidropirolopiridinovi inhibitorji za ROR-gama

Country Status (28)

Country Link
US (3) US9796710B2 (cg-RX-API-DMAC7.html)
EP (1) EP3207043B3 (cg-RX-API-DMAC7.html)
JP (1) JP6564029B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170066628A (cg-RX-API-DMAC7.html)
CN (1) CN107074852B (cg-RX-API-DMAC7.html)
AU (1) AU2015333610B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017007460A2 (cg-RX-API-DMAC7.html)
CA (1) CA2963140A1 (cg-RX-API-DMAC7.html)
CL (1) CL2017000902A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017004525A2 (cg-RX-API-DMAC7.html)
CY (1) CY1121413T1 (cg-RX-API-DMAC7.html)
DK (1) DK3207043T6 (cg-RX-API-DMAC7.html)
EA (1) EA031967B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP17029371A (cg-RX-API-DMAC7.html)
ES (1) ES2715458T7 (cg-RX-API-DMAC7.html)
HU (1) HUE042335T2 (cg-RX-API-DMAC7.html)
IL (1) IL251584B (cg-RX-API-DMAC7.html)
MX (1) MX371304B (cg-RX-API-DMAC7.html)
MY (1) MY182454A (cg-RX-API-DMAC7.html)
PH (1) PH12017500583B1 (cg-RX-API-DMAC7.html)
PL (1) PL3207043T6 (cg-RX-API-DMAC7.html)
PT (1) PT3207043T (cg-RX-API-DMAC7.html)
SG (1) SG11201702362SA (cg-RX-API-DMAC7.html)
SI (1) SI3207043T1 (cg-RX-API-DMAC7.html)
TW (1) TWI675032B (cg-RX-API-DMAC7.html)
UA (1) UA118989C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016061160A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201702237B (cg-RX-API-DMAC7.html)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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SG11201607839UA (en) 2014-03-26 2016-10-28 Hoffmann La Roche Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
EA031967B1 (ru) 2014-10-14 2019-03-29 Вайтаи Фармасьютиклз, Инк. ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ
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JP6684516B2 (ja) 2015-05-15 2020-04-22 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ Ｒｏｒガンマ調節物質としての置換型テトラヒドロキノリン化合物
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JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
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TN2018000188A1 (en) 2015-12-15 2019-10-04 Astrazeneca Ab Isoindole compounds
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
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