EA200600372A1 - Конденсированные с гетероарилом пиридины, пиразины и пиримидины в качестве лигандов рецептора кортикотропин-рилизинг-фактора (crf 1) - Google Patents
Конденсированные с гетероарилом пиридины, пиразины и пиримидины в качестве лигандов рецептора кортикотропин-рилизинг-фактора (crf 1)Info
- Publication number
- EA200600372A1 EA200600372A1 EA200600372A EA200600372A EA200600372A1 EA 200600372 A1 EA200600372 A1 EA 200600372A1 EA 200600372 A EA200600372 A EA 200600372A EA 200600372 A EA200600372 A EA 200600372A EA 200600372 A1 EA200600372 A1 EA 200600372A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disorders
- crf
- compounds
- pyridine
- pirasins
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title abstract 2
- 101000957724 Catostomus commersonii Corticoliberin-1 Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 230000004807 localization Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- -1 heteroaryl pyridine Chemical compound 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 238000001525 receptor binding assay Methods 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Предложены замещенные конденсированные с гетероарилом пиридиновые, пиразиновые и пиримидиновые соединения, которые действуют в качестве селективных модуляторов рецепторов CRF 1. Эти соединения полезны в лечении ряда расстройств центральной нервной системы (ЦНС) и периферических расстройств, в частности стресса, тревоги, депрессии, сердечно-сосудистых расстройств и расстройств приема пищи. Кроме того, предложены способы лечения таких расстройств, а также упакованные фармацевтические композиции. Соединения по данному изобретению также полезны в качестве зондов для локализации рецепторов CRF и в качестве стандартов в анализах связывания с рецептором CRF. Раскрыты способы применения соединений в исследованиях локализации рецепторов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50041403P | 2003-09-05 | 2003-09-05 | |
PCT/US2004/028899 WO2005023806A2 (en) | 2003-09-05 | 2004-09-03 | Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200600372A1 true EA200600372A1 (ru) | 2006-08-25 |
Family
ID=34272952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600372A EA200600372A1 (ru) | 2003-09-05 | 2004-09-03 | Конденсированные с гетероарилом пиридины, пиразины и пиримидины в качестве лигандов рецептора кортикотропин-рилизинг-фактора (crf 1) |
Country Status (19)
Country | Link |
---|---|
US (2) | US20050113379A1 (ru) |
EP (1) | EP1680424A2 (ru) |
JP (1) | JP2007504271A (ru) |
KR (1) | KR20060088534A (ru) |
CN (1) | CN1878773A (ru) |
AP (1) | AP2006003559A0 (ru) |
AR (1) | AR045582A1 (ru) |
AU (1) | AU2004270713A1 (ru) |
BR (1) | BRPI0414087A (ru) |
CA (1) | CA2537829A1 (ru) |
CR (1) | CR8274A (ru) |
EA (1) | EA200600372A1 (ru) |
EC (1) | ECSP066408A (ru) |
IL (1) | IL174084A0 (ru) |
MA (1) | MA28086A1 (ru) |
NO (1) | NO20061180L (ru) |
TW (1) | TW200530232A (ru) |
WO (1) | WO2005023806A2 (ru) |
ZA (1) | ZA200601978B (ru) |
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US8143285B2 (en) | 2005-09-06 | 2012-03-27 | Shionogi & Co., Ltd. | Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity |
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TW200812588A (en) * | 2006-05-15 | 2008-03-16 | Neurogen Corp | CRF1 receptor ligands comprising heteroaryl fused bicycles |
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2004
- 2004-09-03 CN CNA2004800327037A patent/CN1878773A/zh active Pending
- 2004-09-03 AP AP2006003559A patent/AP2006003559A0/xx unknown
- 2004-09-03 AU AU2004270713A patent/AU2004270713A1/en not_active Abandoned
- 2004-09-03 ZA ZA200601978A patent/ZA200601978B/en unknown
- 2004-09-03 AR ARP040103174A patent/AR045582A1/es unknown
- 2004-09-03 US US10/933,834 patent/US20050113379A1/en not_active Abandoned
- 2004-09-03 BR BRPI0414087-7A patent/BRPI0414087A/pt not_active IP Right Cessation
- 2004-09-03 KR KR1020067004564A patent/KR20060088534A/ko not_active Application Discontinuation
- 2004-09-03 JP JP2006526210A patent/JP2007504271A/ja active Pending
- 2004-09-03 WO PCT/US2004/028899 patent/WO2005023806A2/en active Application Filing
- 2004-09-03 EP EP04788585A patent/EP1680424A2/en not_active Withdrawn
- 2004-09-03 EA EA200600372A patent/EA200600372A1/ru unknown
- 2004-09-03 CA CA002537829A patent/CA2537829A1/en not_active Abandoned
- 2004-09-06 TW TW093126841A patent/TW200530232A/zh unknown
-
2006
- 2006-03-02 IL IL174084A patent/IL174084A0/en unknown
- 2006-03-03 CR CR8274A patent/CR8274A/es unknown
- 2006-03-03 EC EC2006006408A patent/ECSP066408A/es unknown
- 2006-03-14 NO NO20061180A patent/NO20061180L/no not_active Application Discontinuation
- 2006-03-24 US US11/389,646 patent/US20060199823A1/en not_active Abandoned
- 2006-04-05 MA MA28916A patent/MA28086A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
MA28086A1 (fr) | 2006-08-01 |
JP2007504271A (ja) | 2007-03-01 |
US20060199823A1 (en) | 2006-09-07 |
AR045582A1 (es) | 2005-11-02 |
IL174084A0 (en) | 2008-02-09 |
AU2004270713A1 (en) | 2005-03-17 |
CN1878773A (zh) | 2006-12-13 |
BRPI0414087A (pt) | 2006-10-31 |
NO20061180L (no) | 2006-03-31 |
WO2005023806A2 (en) | 2005-03-17 |
TW200530232A (en) | 2005-09-16 |
EP1680424A2 (en) | 2006-07-19 |
WO2005023806A3 (en) | 2005-06-02 |
CA2537829A1 (en) | 2005-03-17 |
ECSP066408A (es) | 2006-09-18 |
AP2006003559A0 (en) | 2006-04-30 |
CR8274A (es) | 2008-06-10 |
ZA200601978B (en) | 2007-05-30 |
US20050113379A1 (en) | 2005-05-26 |
KR20060088534A (ko) | 2006-08-04 |
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