WO2007133756A3 - Crf1 receptor ligands comprising heteroaryl fused bicycles - Google Patents

Crf1 receptor ligands comprising heteroaryl fused bicycles Download PDF

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Publication number
WO2007133756A3
WO2007133756A3 PCT/US2007/011588 US2007011588W WO2007133756A3 WO 2007133756 A3 WO2007133756 A3 WO 2007133756A3 US 2007011588 W US2007011588 W US 2007011588W WO 2007133756 A3 WO2007133756 A3 WO 2007133756A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
compounds
heteroaryl fused
receptor ligands
useful
Prior art date
Application number
PCT/US2007/011588
Other languages
French (fr)
Other versions
WO2007133756A2 (en
Inventor
Raymond F Horvath
Lu Yan Zhang
Original Assignee
Neurogen Corp
Raymond F Horvath
Lu Yan Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Raymond F Horvath, Lu Yan Zhang filed Critical Neurogen Corp
Publication of WO2007133756A2 publication Critical patent/WO2007133756A2/en
Publication of WO2007133756A3 publication Critical patent/WO2007133756A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Substituted heteroaryl fused pyridine and pyrazine compounds that act as selective modulators of CRFl receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, gastrointestinal disorders, and eating disorders. Methods of treatment of such disorders as well as packaged pharmaceutical compositions are also provided. Compounds provided herein are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
PCT/US2007/011588 2006-05-15 2007-05-15 Crf1 receptor ligands comprising heteroaryl fused bicycles WO2007133756A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74724106P 2006-05-15 2006-05-15
US60/747,241 2006-05-15

Publications (2)

Publication Number Publication Date
WO2007133756A2 WO2007133756A2 (en) 2007-11-22
WO2007133756A3 true WO2007133756A3 (en) 2008-01-03

Family

ID=38694534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011588 WO2007133756A2 (en) 2006-05-15 2007-05-15 Crf1 receptor ligands comprising heteroaryl fused bicycles

Country Status (2)

Country Link
TW (1) TW200812588A (en)
WO (1) WO2007133756A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7421507B2 (en) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド Heterocyclic and heteroaryl compounds for treating Huntington's disease

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EA201800367A1 (en) 2015-12-10 2019-02-28 ПиТиСи ТЕРАПЬЮТИКС, ИНК. METHODS OF TREATMENT OF HUNTINGTON'S DISEASE
CA3066224A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics Inc. Compounds for treating huntington's disease
CN111163838B (en) 2017-06-28 2023-03-28 Ptc医疗公司 Methods for treating huntington's disease
MX2019015578A (en) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Methods for treating huntington's disease.
WO2019191092A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001808A (en) * 1996-08-19 1999-12-14 Metatron, Inc. Method of treating herpes virus infections with spermostatic gramicidin
US20050113379A1 (en) * 2003-09-05 2005-05-26 Ping Ge Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001808A (en) * 1996-08-19 1999-12-14 Metatron, Inc. Method of treating herpes virus infections with spermostatic gramicidin
US20050113379A1 (en) * 2003-09-05 2005-05-26 Ping Ge Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7421507B2 (en) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス， インコーポレイテッド Heterocyclic and heteroaryl compounds for treating Huntington's disease

Also Published As

Publication number Publication date
WO2007133756A2 (en) 2007-11-22
TW200812588A (en) 2008-03-16

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