CN103435581B - 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 - Google Patents
吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 Download PDFInfo
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- CN103435581B CN103435581B CN201310379906.4A CN201310379906A CN103435581B CN 103435581 B CN103435581 B CN 103435581B CN 201310379906 A CN201310379906 A CN 201310379906A CN 103435581 B CN103435581 B CN 103435581B
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- HEVHWWWNAKXTAH-IAKZHMBXSA-O CC(C)(C)[SH+]CCc1ccc(Cc2cc([C@@H]([C@@H](C3O)O)OC(CO)[C@H]3O)ccc2C)cc1 Chemical compound CC(C)(C)[SH+]CCc1ccc(Cc2cc([C@@H]([C@@H](C3O)O)OC(CO)[C@H]3O)ccc2C)cc1 HEVHWWWNAKXTAH-IAKZHMBXSA-O 0.000 description 1
- BNAXKQBIOPQVSH-ILOBPARPSA-N CC(C)[Si+](C(C)C)(C(C)C)C#Cc1ccc(Cc2cc([C@@H]([C@@H]([C@H]3OC(C)=O)OC(C)=O)O[C@@H](COC(C)=O)[C@H]3OC(C)=O)ccc2F)cc1 Chemical compound CC(C)[Si+](C(C)C)(C(C)C)C#Cc1ccc(Cc2cc([C@@H]([C@@H]([C@H]3OC(C)=O)OC(C)=O)O[C@@H](COC(C)=O)[C@H]3OC(C)=O)ccc2F)cc1 BNAXKQBIOPQVSH-ILOBPARPSA-N 0.000 description 1
- IOZHMTVDLSUGTF-NAFODODRSA-O CCOc1cc(C(C)[SH+](C(C)C)(C(C)C)C#Cc2ccc(C([C@@H]([C@H]3OC(C)=O)OC(C)=O)(OC)O[C@H](COC(C)=O)[C@H]3OC(C)=O)cc2C2)c2cc1 Chemical compound CCOc1cc(C(C)[SH+](C(C)C)(C(C)C)C#Cc2ccc(C([C@@H]([C@H]3OC(C)=O)OC(C)=O)(OC)O[C@H](COC(C)=O)[C@H]3OC(C)=O)cc2C2)c2cc1 IOZHMTVDLSUGTF-NAFODODRSA-O 0.000 description 1
- NFBXCZKWHMFEDS-UHFFFAOYSA-N Clc(cc1)c(Cc(cc2)ccc2I)cc1Br Chemical compound Clc(cc1)c(Cc(cc2)ccc2I)cc1Br NFBXCZKWHMFEDS-UHFFFAOYSA-N 0.000 description 1
- VIMJDCATJCRVAP-LDDTYFGWSA-N Nc1ccc(C([C@@H](C2O)O)OC(CO)[C@H]2O)cc1Cc(cc1)ccc1OC1CCOCC1 Chemical compound Nc1ccc(C([C@@H](C2O)O)OC(CO)[C@H]2O)cc1Cc(cc1)ccc1OC1CCOCC1 VIMJDCATJCRVAP-LDDTYFGWSA-N 0.000 description 1
- QVSYTXSTWQFDCC-MKSZZOGSSA-N OC[C@H]([C@H](C([C@H]1O)O)O)O[C@H]1c(cc1Cc(cc2)ccc2OC2CCC2)ccc1Cl Chemical compound OC[C@H]([C@H](C([C@H]1O)O)O)O[C@H]1c(cc1Cc(cc2)ccc2OC2CCC2)ccc1Cl QVSYTXSTWQFDCC-MKSZZOGSSA-N 0.000 description 1
- CSQCYSDEAYXXTN-UHFFFAOYSA-N Oc1ccc(Cc2cc(Br)ccc2Cl)cc1 Chemical compound Oc1ccc(Cc2cc(Br)ccc2Cl)cc1 CSQCYSDEAYXXTN-UHFFFAOYSA-N 0.000 description 1
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
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- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004012676A DE102004012676A1 (de) | 2004-03-16 | 2004-03-16 | Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE102004012676.3 | 2004-03-16 | ||
| DE102004040168.3 | 2004-08-18 | ||
| DE102004040168A DE102004040168A1 (de) | 2004-08-18 | 2004-08-18 | Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE102004061145.9 | 2004-12-16 | ||
| DE102004061145A DE102004061145A1 (de) | 2004-12-16 | 2004-12-16 | Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP05002628.5 | 2005-02-09 | ||
| EP05002628 | 2005-02-09 | ||
| CNA2005800069449A CN1930141A (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800069449A Division CN1930141A (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103435581A CN103435581A (zh) | 2013-12-11 |
| CN103435581B true CN103435581B (zh) | 2015-08-19 |
Family
ID=34962236
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012105151009A Pending CN103030617A (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| CN201310379906.4A Ceased CN103435581B (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| CN201310368328.4A Ceased CN103467423B (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| CN201310414119.9A Ceased CN103450129B (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012105151009A Pending CN103030617A (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310368328.4A Ceased CN103467423B (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| CN201310414119.9A Ceased CN103450129B (zh) | 2004-03-16 | 2005-03-11 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
Country Status (33)
Families Citing this family (252)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| ME01422B (me) * | 2004-03-16 | 2013-12-20 | Boehringer Ingelheim Int | Derivati benzola supstituisani glukopiranozilom, ljekovi koji sadrže navedena jedinjenja, njihova primjena i njihov postupak proizvodnje |
| US7393836B2 (en) * | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| WO2006010557A1 (de) * | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| JP2008524162A (ja) * | 2004-12-16 | 2008-07-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換ベンゼン誘導体、該化合物を含む薬物、その使用及びその製造方法 |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| WO2006089872A1 (en) * | 2005-02-23 | 2006-08-31 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted ( (hetero)arylethynyl-benzyd-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors |
| WO2006108842A1 (en) * | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
| US7723309B2 (en) * | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| UA91546C2 (uk) * | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7772191B2 (en) * | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| TW200726755A (en) * | 2005-07-07 | 2007-07-16 | Astellas Pharma Inc | A crystalline choline salt of an azulene derivative |
| DE602006014411D1 (de) | 2005-07-27 | 2010-07-01 | Boehringer Ingelheim Pharma | Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters (sglt) |
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