CN100375744C - 紫杉化合物类衍生物的制备方法 - Google Patents

紫杉化合物类衍生物的制备方法 Download PDF

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Publication number
CN100375744C
CN100375744C CNB98809181XA CN98809181A CN100375744C CN 100375744 C CN100375744 C CN 100375744C CN B98809181X A CNB98809181X A CN B98809181XA CN 98809181 A CN98809181 A CN 98809181A CN 100375744 C CN100375744 C CN 100375744C
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China
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carbon atom
group
alkyl
atom
randomly
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Expired - Lifetime
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CNB98809181XA
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English (en)
Chinese (zh)
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CN1270586A (zh
Inventor
E·迪迪尔
G·奥当
D·波兹
P·莱昂
D·里古特
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Aventis Pharma SA
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Aventis Pharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB98809181XA 1997-11-18 1998-11-16 紫杉化合物类衍生物的制备方法 Expired - Lifetime CN100375744C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714442A FR2771092B1 (fr) 1997-11-18 1997-11-18 Procede de preparation de derives de la classe des taxoides
FR97/14442 1997-11-18

Publications (2)

Publication Number Publication Date
CN1270586A CN1270586A (zh) 2000-10-18
CN100375744C true CN100375744C (zh) 2008-03-19

Family

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Family Applications (1)

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CNB98809181XA Expired - Lifetime CN100375744C (zh) 1997-11-18 1998-11-16 紫杉化合物类衍生物的制备方法

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US (1) US5962705A (enExample)
EP (1) EP1032565B1 (enExample)
JP (1) JP4359386B2 (enExample)
KR (1) KR100581656B1 (enExample)
CN (1) CN100375744C (enExample)
AP (1) AP1198A (enExample)
AR (1) AR017639A1 (enExample)
AT (1) ATE232855T1 (enExample)
AU (1) AU755376B2 (enExample)
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CA (1) CA2304833C (enExample)
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ES (1) ES2192795T3 (enExample)
FR (1) FR2771092B1 (enExample)
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UY (1) UY25256A1 (enExample)
WO (1) WO1999025704A1 (enExample)
ZA (1) ZA9810511B (enExample)

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MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
FR2859996B1 (fr) 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2926551A1 (fr) 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
EP2331140B1 (en) 2008-08-11 2018-07-04 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
JP5566466B2 (ja) 2009-10-29 2014-08-06 アバンテイス・フアルマ・エス・アー カバジタキセルの新規の抗腫瘍的使用
US8791279B2 (en) 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
KR20140018917A (ko) 2011-04-12 2014-02-13 플러스 케미칼스, 에스.에이. 카바지탁셀의 고상 형태 및 이의 제조 방법
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
CN103012330A (zh) * 2011-09-23 2013-04-03 复旦大学 一种紫杉醇类抗癌药xrp6258的制备方法
CN103012329A (zh) * 2011-09-23 2013-04-03 复旦大学 一种制备紫杉醇类抗癌药Cabazitaxel XRP6258的方法
CN104039771B (zh) * 2011-09-26 2017-10-27 Kabi费森尤斯肿瘤学有限公司 包括c(7)‑oh和c(13)‑oh甲硅烷基化或仅c(7)‑oh甲硅烷基化的用于制备卡巴他赛的方法
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
WO2013072766A2 (en) 2011-10-31 2013-05-23 Scinopharm Taiwan, Ltd. Process for cabazitaxel and intermediates thereof
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
CN103159704B (zh) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 卡巴他赛中间体及卡巴他赛中间体的制备方法
WO2013111157A1 (en) 2012-01-03 2013-08-01 Shilpa Medicare Limited Process for preparing amorphous cabazitaxel
CN102786502B (zh) * 2012-08-21 2014-05-14 江苏红豆杉生物科技有限公司 一种紫杉烷药物7,10-甲氧基多西他赛的合成方法
ES2719497T3 (es) 2012-11-09 2019-07-10 Intas Pharmaceuticals Ltd Procedimiento para la preparación de cabazitaxel y sus compuestos intermedios
KR101407353B1 (ko) * 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
CN103012331A (zh) * 2012-12-28 2013-04-03 北京科莱博医药开发有限责任公司 卡巴他赛及其中间体的制备方法
EP3008047B1 (en) * 2013-06-14 2019-01-09 Hetero Research Foundation Process for cabazitaxel
CN106632158B (zh) * 2013-08-28 2018-11-06 江苏恒瑞医药股份有限公司 7β,10β-二甲氧基-10-去乙酰基浆果赤霉素III的制备方法
CN103450117A (zh) * 2013-09-18 2013-12-18 江苏红豆杉药业有限公司 一种7,10-二甲氧基紫杉烷化合物的制备方法
KR101490738B1 (ko) 2013-10-15 2015-02-11 (주)한국해양기상기술 플랑크톤 검사장치
EP2865675A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
CN105121419B (zh) * 2013-12-24 2016-08-03 于跃 Cabazitaxel类抗多药耐药紫杉烷类抗肿瘤化合物及其制备方法
CN104817522A (zh) * 2015-04-01 2015-08-05 江苏红豆杉药业有限公司 一种7,10-二甲氧基-10DabⅢ的合成方法
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1086512A (zh) * 1989-05-31 1994-05-11 佛罗里达州立大学 紫杉酚中间体的制备方法
WO1996030355A1 (fr) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

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EP0304244A3 (en) * 1987-08-18 1990-01-10 Takeda Chemical Industries, Ltd. Propanediol derivatives, their production and use
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TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
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WO1996030355A1 (fr) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

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Publication number Publication date
EA200000539A1 (ru) 2000-12-25
NO325664B1 (no) 2008-07-07
CN1270586A (zh) 2000-10-18
IS5471A (is) 2000-04-26
JP2001523673A (ja) 2001-11-27
HUP0100519A1 (hu) 2001-06-28
PT1032565E (pt) 2003-07-31
ES2192795T3 (es) 2003-10-16
HU228188B1 (en) 2013-01-28
AP2000001816A0 (en) 2000-06-30
CA2304833C (fr) 2007-03-27
DE69811530D1 (de) 2003-03-27
UY25256A1 (es) 2001-08-27
AU1242299A (en) 1999-06-07
IL135512A (en) 2004-06-20
SK283932B6 (sk) 2004-05-04
BG104455A (en) 2001-02-28
MY121031A (en) 2005-12-30
FR2771092B1 (fr) 1999-12-17
BRPI9814658B1 (pt) 2016-07-19
HUP0100519A3 (en) 2002-09-30
ATE232855T1 (de) 2003-03-15
WO1999025704A1 (fr) 1999-05-27
CO4771105A1 (es) 1999-04-30
NO20002443L (no) 2000-05-11
KR100581656B1 (ko) 2006-05-23
ZA9810511B (en) 1999-05-25
TW518329B (en) 2003-01-21
IS2272B (is) 2007-07-15
EA002622B1 (ru) 2002-06-27
BG64281B1 (bg) 2004-08-31
ID24620A (id) 2000-07-27
PL340579A1 (en) 2001-02-12
MA24817A1 (fr) 1999-12-31
BR9814658A (pt) 2000-10-03
GEP20022822B (en) 2002-10-25
TNSN98207A1 (fr) 2005-03-15
KR20010032138A (ko) 2001-04-16
FR2771092A1 (fr) 1999-05-21
CZ20001789A3 (cs) 2000-11-15
NO20002443D0 (no) 2000-05-11
AU755376B2 (en) 2002-12-12
DK1032565T3 (da) 2003-06-02
AP1198A (en) 2003-08-27
IN191018B (enExample) 2003-09-13
EE200000155A (et) 2001-06-15
DE69811530T2 (de) 2003-10-02
US5962705A (en) 1999-10-05
SK7102000A3 (en) 2000-11-07
UA56275C2 (uk) 2003-05-15
SI1032565T1 (en) 2003-06-30
CZ292642B6 (cs) 2003-11-12
MXPA00002244A (es) 2002-04-24
DZ2653A1 (fr) 2003-03-15
CA2304833A1 (fr) 1999-05-27
EE04277B1 (et) 2004-04-15
OA11384A (fr) 2004-01-27
TR200001415T2 (tr) 2001-01-22
EP1032565B1 (fr) 2003-02-19
PL191240B1 (pl) 2006-04-28
JP4359386B2 (ja) 2009-11-04
AR017639A1 (es) 2001-09-12
NZ504125A (en) 2002-10-25
EP1032565A1 (fr) 2000-09-06
IL135512A0 (en) 2001-05-20
BRPI9814658B8 (pt) 2021-05-25

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Granted publication date: 20080319