BR9814658A - Processo de alquilação direta, em uma única etapa, em posição 7 e 10 simultaneamente das duas funções hidroxilas da 10-desacetilbacatina ou dos derivados desta última em posição 13 - Google Patents

Processo de alquilação direta, em uma única etapa, em posição 7 e 10 simultaneamente das duas funções hidroxilas da 10-desacetilbacatina ou dos derivados desta última em posição 13

Info

Publication number
BR9814658A
BR9814658A BR9814658-0A BR9814658A BR9814658A BR 9814658 A BR9814658 A BR 9814658A BR 9814658 A BR9814658 A BR 9814658A BR 9814658 A BR9814658 A BR 9814658A
Authority
BR
Brazil
Prior art keywords
derivatives
deacetylbaccatin
single step
direct alkylation
hydroxyl functions
Prior art date
Application number
BR9814658-0A
Other languages
English (en)
Other versions
BRPI9814658B8 (pt
BRPI9814658B1 (pt
Inventor
Eric Didier
Gilles Oddon
Denis Pauze
Patrick Leon
Didier Riguet
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR9814658A publication Critical patent/BR9814658A/pt
Publication of BRPI9814658B1 publication Critical patent/BRPI9814658B1/pt
Publication of BRPI9814658B8 publication Critical patent/BRPI9814658B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"PROCESSO DE ALQUILAçãO DIRETA, EM UMA úNICA ETAPA, EM POSIçãO 7 E 10 SIMULTANEAMENTE DAS DUAS FUNçõES HIDROXILAS DA 10-DESACETILBACATINA OU DOS DERIVADOS DESTA úLTIMA EM POSIçãO 13". A presente invenção refere-se a um novo processo de preparação de derivados dialcoxilados da classe dos taxóides por alquilação direta das duas posições 7 e 10 da desacetilbacatina ou dos derivados esterificados na posição 13 desta última.
BRPI9814658A 1997-11-18 1998-11-16 processo para preparar um derivado dimetóxi de 10-desacetilbacatina iii ou derivado da 10-desacetilbacatina iii esterificado na posição 13 BRPI9814658B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714442A FR2771092B1 (fr) 1997-11-18 1997-11-18 Procede de preparation de derives de la classe des taxoides
PCT/FR1998/002432 WO1999025704A1 (fr) 1997-11-18 1998-11-16 Procede de preparation de derives de la classe des taxoides

Publications (3)

Publication Number Publication Date
BR9814658A true BR9814658A (pt) 2000-10-03
BRPI9814658B1 BRPI9814658B1 (pt) 2016-07-19
BRPI9814658B8 BRPI9814658B8 (pt) 2021-05-25

Family

ID=9513490

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9814658A BRPI9814658B8 (pt) 1997-11-18 1998-11-16 processo para preparar um derivado dimetóxi de 10-desacetilbacatina iii ou derivado da 10-desacetilbacatina iii esterificado na posição 13

Country Status (44)

Country Link
US (1) US5962705A (pt)
EP (1) EP1032565B1 (pt)
JP (1) JP4359386B2 (pt)
KR (1) KR100581656B1 (pt)
CN (1) CN100375744C (pt)
AP (1) AP1198A (pt)
AR (1) AR017639A1 (pt)
AT (1) ATE232855T1 (pt)
AU (1) AU755376B2 (pt)
BG (1) BG64281B1 (pt)
BR (1) BRPI9814658B8 (pt)
CA (1) CA2304833C (pt)
CO (1) CO4771105A1 (pt)
CZ (1) CZ292642B6 (pt)
DE (1) DE69811530T2 (pt)
DK (1) DK1032565T3 (pt)
DZ (1) DZ2653A1 (pt)
EA (1) EA002622B1 (pt)
EE (1) EE04277B1 (pt)
ES (1) ES2192795T3 (pt)
FR (1) FR2771092B1 (pt)
GE (1) GEP20022822B (pt)
HU (1) HU228188B1 (pt)
ID (1) ID24620A (pt)
IL (1) IL135512A (pt)
IN (1) IN191018B (pt)
IS (1) IS2272B (pt)
MA (1) MA24817A1 (pt)
MX (1) MXPA00002244A (pt)
MY (1) MY121031A (pt)
NO (1) NO325664B1 (pt)
NZ (1) NZ504125A (pt)
OA (1) OA11384A (pt)
PL (1) PL191240B1 (pt)
PT (1) PT1032565E (pt)
SI (1) SI1032565T1 (pt)
SK (1) SK283932B6 (pt)
TN (1) TNSN98207A1 (pt)
TR (1) TR200001415T2 (pt)
TW (1) TW518329B (pt)
UA (1) UA56275C2 (pt)
UY (1) UY25256A1 (pt)
WO (1) WO1999025704A1 (pt)
ZA (1) ZA9810511B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
FR2859996B1 (fr) 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
EP2493466B1 (en) 2009-10-29 2021-03-10 Sanofi Mature IP Novel antitumoral use of cabazitaxel
US8791279B2 (en) 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
KR20140018917A (ko) 2011-04-12 2014-02-13 플러스 케미칼스, 에스.에이. 카바지탁셀의 고상 형태 및 이의 제조 방법
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
CN103012329A (zh) * 2011-09-23 2013-04-03 复旦大学 一种制备紫杉醇类抗癌药Cabazitaxel XRP6258的方法
CN103012330A (zh) * 2011-09-23 2013-04-03 复旦大学 一种紫杉醇类抗癌药xrp6258的制备方法
EP2760848B1 (en) * 2011-09-26 2018-11-28 Fresenius Kabi Oncology Limited Processes for the preparation of cabazitaxel involving c(7)-oh and c(13)-oh silylation or just c(7)-oh silylation
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
US8722900B2 (en) 2011-10-31 2014-05-13 Scinopharm Taiwan, Ltd. Process for cabazitaxel, and intermediates thereof
CN103159704B (zh) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 卡巴他赛中间体及卡巴他赛中间体的制备方法
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
US9403785B2 (en) 2012-01-03 2016-08-02 Shilpa Medicare Limited Process for preparing amorphous cabazitaxel
CN102786502B (zh) * 2012-08-21 2014-05-14 江苏红豆杉生物科技有限公司 一种紫杉烷药物7,10-甲氧基多西他赛的合成方法
EP2917192B1 (en) 2012-11-09 2019-03-20 Intas Pharmaceuticals Limited Process for the preparation of cabazitaxel and its intermediates
KR101407353B1 (ko) 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (en) 2012-12-13 2014-06-18 INDENA S.p.A. New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof
CN103012331A (zh) * 2012-12-28 2013-04-03 北京科莱博医药开发有限责任公司 卡巴他赛及其中间体的制备方法
WO2014199401A2 (en) * 2013-06-14 2014-12-18 Hetero Research Foundation Process for cabazitaxel
CN106632158B (zh) * 2013-08-28 2018-11-06 江苏恒瑞医药股份有限公司 7β,10β-二甲氧基-10-去乙酰基浆果赤霉素III的制备方法
CN103450117A (zh) * 2013-09-18 2013-12-18 江苏红豆杉药业有限公司 一种7,10-二甲氧基紫杉烷化合物的制备方法
KR101490738B1 (ko) 2013-10-15 2015-02-11 (주)한국해양기상기술 플랑크톤 검사장치
EP2865675A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
EP2865674A1 (en) 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
WO2015096553A1 (zh) * 2013-12-24 2015-07-02 于跃 抗多药耐药紫杉烷类抗肿瘤化合物及其制备方法
CN104817522A (zh) * 2015-04-01 2015-08-05 江苏红豆杉药业有限公司 一种7,10-二甲氧基-10DabⅢ的合成方法
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927118A (en) * 1973-12-21 1975-12-16 Crown Zellerbach Corp Process for monoetherification of polyhydric benzenes
EP0304244A3 (en) * 1987-08-18 1990-01-10 Takeda Chemical Industries, Ltd. Propanediol derivatives, their production and use
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
WO1995029926A1 (en) * 1994-04-28 1995-11-09 Allelix Biopharmaceuticals Inc. Guanidino-substituted compounds
IT1274250B (it) * 1995-02-21 1997-07-15 Himont Inc Dieteri utilizzabili nella preparazione di catalizzatori ziegler-natta
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis

Also Published As

Publication number Publication date
BRPI9814658B8 (pt) 2021-05-25
WO1999025704A1 (fr) 1999-05-27
JP4359386B2 (ja) 2009-11-04
NO20002443L (no) 2000-05-11
FR2771092A1 (fr) 1999-05-21
UA56275C2 (uk) 2003-05-15
PL340579A1 (en) 2001-02-12
TW518329B (en) 2003-01-21
EP1032565B1 (fr) 2003-02-19
ZA9810511B (en) 1999-05-25
JP2001523673A (ja) 2001-11-27
AP1198A (en) 2003-08-27
BG64281B1 (bg) 2004-08-31
MY121031A (en) 2005-12-30
EE04277B1 (et) 2004-04-15
TNSN98207A1 (fr) 2005-03-15
EP1032565A1 (fr) 2000-09-06
US5962705A (en) 1999-10-05
CA2304833C (fr) 2007-03-27
MXPA00002244A (es) 2002-04-24
DK1032565T3 (da) 2003-06-02
TR200001415T2 (tr) 2001-01-22
SI1032565T1 (en) 2003-06-30
NO325664B1 (no) 2008-07-07
OA11384A (fr) 2004-01-27
KR20010032138A (ko) 2001-04-16
DE69811530T2 (de) 2003-10-02
DZ2653A1 (fr) 2003-03-15
SK7102000A3 (en) 2000-11-07
ES2192795T3 (es) 2003-10-16
CA2304833A1 (fr) 1999-05-27
FR2771092B1 (fr) 1999-12-17
AP2000001816A0 (en) 2000-06-30
HUP0100519A1 (hu) 2001-06-28
CZ292642B6 (cs) 2003-11-12
HU228188B1 (en) 2013-01-28
IS2272B (is) 2007-07-15
MA24817A1 (fr) 1999-12-31
PL191240B1 (pl) 2006-04-28
ID24620A (id) 2000-07-27
UY25256A1 (es) 2001-08-27
AR017639A1 (es) 2001-09-12
KR100581656B1 (ko) 2006-05-23
IS5471A (is) 2000-04-26
NO20002443D0 (no) 2000-05-11
CN100375744C (zh) 2008-03-19
EA002622B1 (ru) 2002-06-27
NZ504125A (en) 2002-10-25
SK283932B6 (sk) 2004-05-04
HUP0100519A3 (en) 2002-09-30
IL135512A (en) 2004-06-20
IL135512A0 (en) 2001-05-20
EE200000155A (et) 2001-06-15
CN1270586A (zh) 2000-10-18
ATE232855T1 (de) 2003-03-15
AU1242299A (en) 1999-06-07
BG104455A (en) 2001-02-28
GEP20022822B (en) 2002-10-25
EA200000539A1 (ru) 2000-12-25
IN191018B (pt) 2003-09-13
DE69811530D1 (de) 2003-03-27
CO4771105A1 (es) 1999-04-30
PT1032565E (pt) 2003-07-31
AU755376B2 (en) 2002-12-12
CZ20001789A3 (cs) 2000-11-15
BRPI9814658B1 (pt) 2016-07-19

Similar Documents

Publication Publication Date Title
BR9814658A (pt) Processo de alquilação direta, em uma única etapa, em posição 7 e 10 simultaneamente das duas funções hidroxilas da 10-desacetilbacatina ou dos derivados desta última em posição 13
BR0116599A (pt) Modo de processador para limitar a operação de software convidado executado em uma máquina virtual compatìvel com um monitor de máquina virtual
EE9700073A (et) Pulbiseebist saadavad steroolsed kompositsioonid
BR9913406A (pt) Processo de tratamento de infecção causada por pelo menos um vìrus da famìlia flaviviridae e de doença associada com a citada infecção em um hospedeiro vivo possuindo a citada infecção
PT98643A (pt) Processo para a preparacao de uma composicao oftalmica em gotas contendo acido 3,4-dihidro-2,8-diisopropil-3-tioxo-2h-1,4-benzoxazina-4-acetico
BR0108871A (pt) Composto, processo de preparação de compostos, e, composição farmacêutica
PT1032398E (pt) Tratamento da mulher na pos-menopausa por utilizacao de doses muito reduzidas de estrogenio
PT92123A (pt) Processo para a preparacao de composicoes para controlar a hipertensao ocular com esteroides angiostaticos
PT93758A (pt) Processo para a preparacao de uma composicao de condicionamento de tecido que compreende complexos perfume/ciclodextrina
WO1997030677A3 (en) Pentafluorobenzenesulfonamides and analogs
DK0429381T3 (da) Landbrugsmaskine med forbedret ophængningsanordning for gruppen af arbejdsorganer
PT98734A (pt) Processo de preparacao de compostos 1,2,5,6-tetra-hidropiridina e de composicoes farmaceuticas que os contem
BR9714720A (pt) Composição para o tratamento de cabelo.
DE69124798D1 (de) 3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel
BR9812653A (pt) Derivados de carboxamidotiazóis, sua preparação, as composições farmacêuticas que os contêm
BR9907879A (pt) "fecho de porta"
PT98735A (pt) Processo de preparacao de compostos azaciclicos e de composicoes farmaceuticas que os contem
BR0016855A (pt) Composição utilizável para umidificar a pele e processo para aumentar o nìvel de umidade da pele
BR9906819A (pt) Amidas aromáticas, processo de preparação das mesmas e aplicação das mesmas como medicamentos
BRPI9814894A (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxílicos.
BR9611231A (pt) Composição para a primeira etapa de um processo de deformação permanente das fibras queratínicas e processo de tratamento das matérias queratínicas
BR0211635A (pt) Composto, composição farmacêutica, uso de um composto, e, método de tratamento de um indivìduo sofrendo de ou propenso à doença de alzheimer
BR9908195A (pt) Derivado do grupo b das estreptograminas, processo para a preparação do mesmo, composições farmacêuticas, e, associações de derivados de estreptograminas.
TR200001927T2 (tr) Beta 3 adrenoreseptörü agonistleri olarak faydalı olan karboksil ikameli kromon türevleri.
DK0435177T3 (da) 4-Benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-oner samt deres anvendelse som antikonvulsive midler

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO, VISTO QUE O PRESENTE PEDIDO ENCONTRA-SE EM DASACORDO COM OS ARTS. 8O,13, 24 E 25 DA LPI 9279/96

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/07/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/11/1998 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 16/11/2018