PT98643A - Processo para a preparacao de uma composicao oftalmica em gotas contendo acido 3,4-dihidro-2,8-diisopropil-3-tioxo-2h-1,4-benzoxazina-4-acetico - Google Patents
Processo para a preparacao de uma composicao oftalmica em gotas contendo acido 3,4-dihidro-2,8-diisopropil-3-tioxo-2h-1,4-benzoxazina-4-aceticoInfo
- Publication number
- PT98643A PT98643A PT98643A PT9864391A PT98643A PT 98643 A PT98643 A PT 98643A PT 98643 A PT98643 A PT 98643A PT 9864391 A PT9864391 A PT 9864391A PT 98643 A PT98643 A PT 98643A
- Authority
- PT
- Portugal
- Prior art keywords
- thioxo
- diisopropyl
- dihydro
- acetic acid
- benzoxazine
- Prior art date
Links
- CLDJCRWXLDLJLO-UHFFFAOYSA-N 2-[2,8-di(propan-2-yl)-3-sulfanylidene-1,4-benzoxazin-4-yl]acetic acid Chemical compound C1=CC=C2N(CC(O)=O)C(=S)C(C(C)C)OC2=C1C(C)C CLDJCRWXLDLJLO-UHFFFAOYSA-N 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21482790 | 1990-08-13 | ||
| JP16285491 | 1991-07-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT98643A true PT98643A (pt) | 1992-07-31 |
| PT98643B PT98643B (pt) | 1999-01-29 |
Family
ID=26488494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98643A PT98643B (pt) | 1990-08-13 | 1991-08-12 | Processo para a preparacao de uma composicao oftalmica em gotas contendo acido 3,4-dihidro-2,8-diisopropil-3-tioxo-2h-1,4-benzoxazina-4-acetico |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5663170A (pt) |
| EP (1) | EP0472327B1 (pt) |
| JP (1) | JP2769253B2 (pt) |
| KR (1) | KR920003971A (pt) |
| AT (1) | ATE121295T1 (pt) |
| AU (1) | AU633754B2 (pt) |
| CA (1) | CA2048942A1 (pt) |
| DE (1) | DE69109021T2 (pt) |
| DK (1) | DK0472327T3 (pt) |
| ES (1) | ES2071227T3 (pt) |
| FI (1) | FI97777C (pt) |
| HU (1) | HU207950B (pt) |
| NO (1) | NO177845C (pt) |
| PT (1) | PT98643B (pt) |
| RU (1) | RU2068260C1 (pt) |
| TW (1) | TW200402B (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018764A2 (en) * | 1992-03-18 | 1993-09-30 | Coopervision Pharmaceuticals, Inc. | VERAPAMIL HCl FORMULATION AND OTHER OPHTHALMIC SOLUTIONS WITH BUFFER SYSTEM FOR OCULAR ADMINISTRATION |
| US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| WO1994010976A1 (en) * | 1992-11-16 | 1994-05-26 | Ciba Vision Ag, Hettlingen | Polyvinyl alcohol/borate ophthalmic drug delivery system |
| US5494901A (en) * | 1993-01-05 | 1996-02-27 | Javitt; Jonathan C. | Topical compositions for the eye comprising a β-cyclodextrin derivative and a therapeutic agent |
| SE501482C2 (sv) * | 1993-06-24 | 1995-02-27 | Leiras Oy | Komposition för topisk administration av bispilokarpinsyradiestrar till ögat i form av en vattenlösning |
| AU7371894A (en) * | 1993-07-28 | 1995-02-28 | Insite Vision Incorporated | Suspensions for delivery of medicament |
| US5631297A (en) * | 1994-07-11 | 1997-05-20 | Pate; David W. | Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same |
| WO1996001558A1 (en) * | 1994-07-11 | 1996-01-25 | Pate David W | Anandamide analogue compositions and method of treating intraocular hypertention using same |
| JP3297969B2 (ja) * | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| AU690794B2 (en) * | 1995-01-20 | 1998-04-30 | Wakamoto Pharmaceutical Co., Ltd. | Anti-inflammatory eyedrops |
| KR100261585B1 (ko) * | 1995-01-20 | 2000-07-15 | 오쿠다 기요아키 | 항염증점안제 |
| US6476004B1 (en) | 1996-07-18 | 2002-11-05 | Mitsubishi Pharma Corporation | Pharmaceutical composition |
| JP2002241272A (ja) * | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
| JPH11209277A (ja) * | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
| GB9711643D0 (en) * | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| JP2002523475A (ja) * | 1998-09-02 | 2002-07-30 | アラーガン・セイルズ・インコーポレイテッド | 防腐したシクロデキストリン含有組成物 |
| PT1186302E (pt) * | 1999-06-11 | 2005-07-29 | Sankyo Co | Composicao para fazer descer a tensao ocular para administracao topica |
| JP2001125052A (ja) * | 1999-10-25 | 2001-05-11 | Lion Corp | コンタクトレンズ装着液 |
| KR100791871B1 (ko) * | 2000-06-19 | 2008-01-07 | 산텐 세이야꾸 가부시키가이샤 | 방부제 |
| US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| US6881726B2 (en) | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
| JPWO2006137433A1 (ja) * | 2005-06-21 | 2009-01-22 | わかもと製薬株式会社 | レボカバスチンを可溶化させた水性薬剤 |
| US20100069335A1 (en) * | 2005-07-15 | 2010-03-18 | Rajiv Bhushan | Prevention and Treatment of Ophthalmic Complications of Diabetes |
| MY169816A (en) | 2012-03-26 | 2019-05-16 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| JP7490570B2 (ja) * | 2018-04-27 | 2024-05-27 | アラーガン、インコーポレイテッド | 抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物 |
| JP7470791B2 (ja) * | 2019-11-21 | 2024-04-18 | サムジン ファーマシューティカル カンパニー，リミテッド | 眼疾患の予防または治療用点眼組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU602641B2 (en) * | 1986-04-17 | 1990-10-18 | Senju Pharmaceutical Co., Ltd. | Thiolactam-N-acetic acid derivatives, their production and use |
-
1991
- 1991-07-29 TW TW080105889A patent/TW200402B/zh active
- 1991-08-05 JP JP3195186A patent/JP2769253B2/ja not_active Expired - Lifetime
- 1991-08-08 DK DK91307275.7T patent/DK0472327T3/da active
- 1991-08-08 EP EP91307275A patent/EP0472327B1/en not_active Expired - Lifetime
- 1991-08-08 AT AT91307275T patent/ATE121295T1/de active
- 1991-08-08 AU AU81708/91A patent/AU633754B2/en not_active Ceased
- 1991-08-08 ES ES91307275T patent/ES2071227T3/es not_active Expired - Lifetime
- 1991-08-08 DE DE69109021T patent/DE69109021T2/de not_active Expired - Fee Related
- 1991-08-12 FI FI913811A patent/FI97777C/fi not_active IP Right Cessation
- 1991-08-12 CA CA002048942A patent/CA2048942A1/en not_active Abandoned
- 1991-08-12 PT PT98643A patent/PT98643B/pt not_active IP Right Cessation
- 1991-08-12 NO NO913136A patent/NO177845C/no unknown
- 1991-08-12 RU SU915001489A patent/RU2068260C1/ru active
- 1991-08-13 HU HU912692A patent/HU207950B/hu not_active IP Right Cessation
- 1991-08-13 KR KR1019910013973A patent/KR920003971A/ko not_active Ceased
-
1992
- 1992-07-13 US US07/912,580 patent/US5663170A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI913811A0 (fi) | 1991-08-12 |
| EP0472327A1 (en) | 1992-02-26 |
| ES2071227T3 (es) | 1995-06-16 |
| ATE121295T1 (de) | 1995-05-15 |
| AU633754B2 (en) | 1993-02-04 |
| HUT61196A (en) | 1992-12-28 |
| JP2769253B2 (ja) | 1998-06-25 |
| DK0472327T3 (da) | 1995-05-08 |
| US5663170A (en) | 1997-09-02 |
| JPH05213757A (ja) | 1993-08-24 |
| DE69109021D1 (de) | 1995-05-24 |
| CA2048942A1 (en) | 1992-02-14 |
| HU207950B (en) | 1993-07-28 |
| NO913136D0 (no) | 1991-08-12 |
| HU912692D0 (en) | 1992-01-28 |
| NO913136L (no) | 1992-02-14 |
| RU2068260C1 (ru) | 1996-10-27 |
| AU8170891A (en) | 1992-02-20 |
| FI913811L (fi) | 1992-02-14 |
| NO177845C (no) | 1995-12-06 |
| KR920003971A (ko) | 1992-03-27 |
| FI97777B (fi) | 1996-11-15 |
| PT98643B (pt) | 1999-01-29 |
| FI97777C (fi) | 1997-02-25 |
| NO177845B (no) | 1995-08-28 |
| DE69109021T2 (de) | 1995-09-21 |
| TW200402B (pt) | 1993-02-21 |
| EP0472327B1 (en) | 1995-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920327 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19981020 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000430 |