BR8907583A - Processo para preparacao de 2',3'-dideoxinucleosideos - Google Patents

Processo para preparacao de 2',3'-dideoxinucleosideos

Info

Publication number
BR8907583A
BR8907583A BR898907583A BR8907583A BR8907583A BR 8907583 A BR8907583 A BR 8907583A BR 898907583 A BR898907583 A BR 898907583A BR 8907583 A BR8907583 A BR 8907583A BR 8907583 A BR8907583 A BR 8907583A
Authority
BR
Brazil
Prior art keywords
dideoxinucleosideos
preparation process
preparation
dideoxinucleosideos preparation
Prior art date
Application number
BR898907583A
Other languages
English (en)
Inventor
Chung K Chu
Original Assignee
Univ Georgia Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia Res Found filed Critical Univ Georgia Res Found
Publication of BR8907583A publication Critical patent/BR8907583A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
BR898907583A 1988-08-02 1989-07-28 Processo para preparacao de 2',3'-dideoxinucleosideos BR8907583A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/227,163 US4987224A (en) 1988-08-02 1988-08-02 Method of preparation of 2',3'-dideoxynucleosides
PCT/US1989/003275 WO1990001492A1 (en) 1988-08-02 1989-07-28 Method of preparation of 2',3'-dideoxynucleosides

Publications (1)

Publication Number Publication Date
BR8907583A true BR8907583A (pt) 1991-07-02

Family

ID=22852017

Family Applications (1)

Application Number Title Priority Date Filing Date
BR898907583A BR8907583A (pt) 1988-08-02 1989-07-28 Processo para preparacao de 2',3'-dideoxinucleosideos

Country Status (7)

Country Link
US (1) US4987224A (pt)
EP (1) EP0427773A1 (pt)
JP (1) JPH04501558A (pt)
BR (1) BR8907583A (pt)
ES (1) ES2015432A6 (pt)
PT (1) PT91343A (pt)
WO (1) WO1990001492A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931575A (en) * 1987-03-13 1990-06-05 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Chiral glycerol derivatives
US6175008B1 (en) 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
CA2039403A1 (en) * 1990-04-04 1991-10-05 Gerald Saischek Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
JPH04368382A (ja) * 1991-06-14 1992-12-21 Japan Tobacco Inc ２′，３′−ジデオキシ−β−ヌクレオシドの製造方法
US5506349A (en) * 1992-05-13 1996-04-09 Ribozyme Pharmaceuticals, Inc. Chemical synthesis of 2', 3'-dideoxycytidine
AU4234193A (en) * 1992-05-13 1993-12-13 Ribozyme Pharmaceuticals, Inc. Synthesis of nucleotide monomers
US5466787A (en) * 1993-11-15 1995-11-14 Bristol-Myers Squibb Company Process for preparing AZT
ATE254126T1 (de) 1998-12-23 2003-11-15 Shire Biochem Inc Antivirale nukleosidanaloga
US6927291B2 (en) * 2001-03-01 2005-08-09 Pharmasset, Ltd. Method for the synthesis of 2′,3′-dideoxy-2′,3′-didehydronucleosides
JP5504179B2 (ja) 2008-03-03 2014-05-28 トスク インコーポレーティッド 毒性を低減するためのメトトレキセートアジュバントおよびその使用法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282921A (en) * 1964-06-04 1966-11-01 Syntex Corp Halo-deoxynucleosides and processes for the preparation thereof
US3755295A (en) * 1969-10-24 1973-08-28 Syntex Corp 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3755397A (en) * 1971-06-01 1973-08-28 Dow Corning Silylating agent
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
US4230689A (en) * 1979-05-01 1980-10-28 Sue Choy Hair grooming composition of matter
US4604382A (en) * 1983-01-17 1986-08-05 Research Corporation 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3687069T2 (de) * 1985-03-16 1993-03-25 Wellcome Found Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen.
AU595832B2 (en) * 1985-09-17 1990-04-12 Wellcome Foundation Limited, The Therapeutic nucleosides
EP0594223B1 (en) * 1985-09-17 2000-03-01 The Wellcome Foundation Limited Combination of therapeutic nucleosides and further therapeutic agents.

Also Published As

Publication number Publication date
JPH04501558A (ja) 1992-03-19
ES2015432A6 (es) 1990-08-16
US4987224A (en) 1991-01-22
EP0427773A1 (en) 1991-05-22
PT91343A (pt) 1990-03-08
WO1990001492A1 (en) 1990-02-22

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Legal Events

Date Code Title Description
FD3 Appl. lapsed due to non-payment of renewal fee