DE69124798D1 - 3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel - Google Patents

3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel

Info

Publication number
DE69124798D1
DE69124798D1 DE69124798T DE69124798T DE69124798D1 DE 69124798 D1 DE69124798 D1 DE 69124798D1 DE 69124798 T DE69124798 T DE 69124798T DE 69124798 T DE69124798 T DE 69124798T DE 69124798 D1 DE69124798 D1 DE 69124798D1
Authority
DE
Germany
Prior art keywords
analogs
acid derivatives
aryl
hydroxypropionic acid
hypoglycaemic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124798T
Other languages
English (en)
Other versions
DE69124798T2 (de
Inventor
Bernard Hulin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69124798D1 publication Critical patent/DE69124798D1/de
Publication of DE69124798T2 publication Critical patent/DE69124798T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
DE69124798T 1990-06-14 1991-05-31 3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel Expired - Fee Related DE69124798T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/537,673 US5089514A (en) 1990-06-14 1990-06-14 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
PCT/US1991/003858 WO1991019702A1 (en) 1990-06-14 1991-05-31 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

Publications (2)

Publication Number Publication Date
DE69124798D1 true DE69124798D1 (de) 1997-04-03
DE69124798T2 DE69124798T2 (de) 1997-06-12

Family

ID=24143633

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124798T Expired - Fee Related DE69124798T2 (de) 1990-06-14 1991-05-31 3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel

Country Status (21)

Country Link
US (3) US5089514A (de)
EP (1) EP0533781B1 (de)
JP (2) JPH075513B2 (de)
KR (1) KR930700492A (de)
AT (1) ATE149156T1 (de)
AU (1) AU646052B2 (de)
CA (1) CA2084898A1 (de)
DE (1) DE69124798T2 (de)
DK (1) DK0533781T3 (de)
ES (1) ES2098356T3 (de)
FI (1) FI925640A0 (de)
GR (1) GR3022714T3 (de)
HU (1) HUT65603A (de)
IE (1) IE912003A1 (de)
IL (1) IL98447A (de)
MY (1) MY106380A (de)
NO (1) NO924799L (de)
NZ (1) NZ238528A (de)
PT (1) PT97950B (de)
WO (1) WO1991019702A1 (de)
ZA (1) ZA914519B (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151439A (en) * 1990-05-04 1992-09-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
TW222626B (de) 1991-07-22 1994-04-21 Pfizer
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
PL174610B1 (pl) * 1992-07-03 1998-08-31 Smithkline Beecham Plc Nowe związki heterocykliczne
US5232945A (en) * 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
GB9225386D0 (en) * 1992-12-04 1993-01-27 Smithkline Beecham Plc Novel compounds
GB9311661D0 (en) * 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
GB9311644D0 (en) * 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
GB9315148D0 (en) * 1993-07-22 1993-09-08 Smithkline Beecham Plc Novel compounds
GB9326171D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Novel compounds
BR9508468A (pt) * 1994-07-29 1997-11-25 Smithkline Beecham Plc Composto processo para a preparação do mesmo composição farmacéutica processos para o tratamento e/ou profilaxia de hiperglicemia em um mamifero humano ou não humano e para o tratamento de hiperlípidemia hipertensão doença cardiovascular alguns distúrbios de alimentação o tratamento e/ou profilaxia de doença renal a prevenção revers o estabilização ou retardo da progressão de microalbuminuria em um mamifero humano ou não humano uso do composto e composto intermediário
US5827865A (en) * 1995-03-09 1998-10-27 Smithkline Beecham P.L.C. Heterocyclic compounds as pharmaceutical
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
EP0916651B1 (de) * 1996-04-04 2003-10-15 Sankyo Company, Limited Phenylalkylcarbonsäure-derivate
AU3719997A (en) * 1996-07-01 1998-01-21 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
EP1019378B1 (de) * 1996-07-01 2004-09-29 Eli Lilly And Company Blutzuckersenkende und lipidsenkende verbindungen
CZ53699A3 (cs) * 1996-08-19 1999-07-14 Japan Tobacco Inc. Deriváty propionové kyseliny a jejich použití
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
WO1998028254A1 (fr) * 1996-12-24 1998-07-02 Nippon Chemiphar Co., Ltd. Derives d'acide propionique
UA67743C2 (uk) 1997-06-18 2004-07-15 Смітклайн Бічам П.Л.С. Фармацевтична композиція, що містить тіазолідиндіон і сульфонілсечовину, для лікування діабету
EP0903343B1 (de) * 1997-09-19 2003-05-28 SSP Co., Ltd. Alfa-substituierte Phenylpropionsäurederivate und diese enthaltende Arzneimittel
CN1280561A (zh) 1997-10-02 2001-01-17 三共株式会社 酰胺基羧酸衍生物
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
BR9812770A (pt) 1997-10-27 2000-12-12 Reddy Research Foundation Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos
AU749505B2 (en) * 1997-10-27 2002-06-27 Dr. Reddy's Laboratories Limited Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
EP1124807A1 (de) 1997-10-27 2001-08-22 Dr. Reddy's Research Foundation Heterocyclische verbindungen und ihre verwendung als arzneimittel, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
US6265401B1 (en) 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
EP1051403A1 (de) * 1998-01-29 2000-11-15 Dr. Reddy's Research Foundation Alkansaüren und deren verwendung in heilmittel, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
CN1308621A (zh) * 1998-05-12 2001-08-15 美国家用产品公司 用于治疗胰岛素抗性和高血糖的苯基氧代－乙酸
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CN100357281C (zh) * 1998-05-27 2007-12-26 雷迪实验室有限公司 双环化合物、其制备方法和包含它们的药物组合物
MA26634A1 (fr) * 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
EP1108713A4 (de) 1998-08-27 2006-04-05 Ono Pharmaceutical Co Carbonsäurederivate und sie als aktiven bestandteil enthaltende medikamente
US6589969B1 (en) 1998-10-16 2003-07-08 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
NZ511614A (en) 1998-11-12 2003-12-19 Smithkline Beecham P Modified release pharmaceutical composition containing the insulin sensitiser 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione and the antidiabetic agent metaformin
AR023699A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
US6528507B1 (en) 1999-04-16 2003-03-04 Dr. Reddy's Laboratories Limited Polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them
WO2000063189A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate
BR0010683A (pt) * 1999-04-16 2003-07-01 Reddy Research Foundation Formas polimórficas de um agente antidiabético: processo para seu preparo e composições farmacêuticas contendo o mesmo
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
DE60007310D1 (de) * 1999-06-04 2004-01-29 Elan Pharma Int Ltd Zusammensetzungen und methoden zur verhinderung des zelltods
WO2001011072A1 (en) * 1999-08-05 2001-02-15 Novo Nordisk A/S Process for the preparation of substituted 3-phenyl-propanoic acid esters and substituted 3-phenyl-propanoic acids
WO2001016111A2 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Hypoglycemic sulfonyl pyrazolones and pyrazolines
ES2204684T3 (es) * 1999-08-27 2004-05-01 Eli Lilly And Company Derivados de biaril-oxa(tia)zol y su uso como modulares de ppar.
US6541495B1 (en) 1999-08-27 2003-04-01 Pfizer Carboxylic acid derivatives as inhibitors of hyperproliferation diseases
EP1250323B1 (de) * 2000-01-19 2014-01-01 Cadila Healthcare Limited Verbindungen mit hypolipidemischen und hypocholesterolemischen Wirkungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
GB0002667D0 (en) * 2000-02-04 2000-03-29 Glaxo Group Ltd medicamesnts
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
US6908908B2 (en) 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
ES2288957T3 (es) 2000-05-12 2008-02-01 Ortho-Mcneil Pharmaceutical, Inc. 4h-benzo(1.4)oxazin-3-ina biologicamente activas.
AU2001259747A1 (en) * 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
EP1280783A2 (de) * 2000-05-12 2003-02-05 Ortho-McNeil Pharmaceutical, Inc. Verfahren zur behandlung mit aktivierten rezeptor-gamma-modulatoren von peroxisomproliferatoren
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
ES2288982T3 (es) * 2000-08-23 2008-02-01 Eli Lilly And Company Derivados de acido oxazolil-ariloxiacetico y su uso como agonistas ppar.
KR20030027054A (ko) * 2000-08-23 2003-04-03 일라이 릴리 앤드 캄파니 옥사졸릴-아릴프로피온산 유도체 및 ｐｐａｒ효능제로서의 그의 용도
ES2295200T3 (es) * 2000-08-23 2008-04-16 Eli Lilly And Company Derivados de acido oxazolil-arilpropionico y su uso como agonistas de ppar.
DK1392295T3 (da) 2001-05-15 2006-10-02 Hoffmann La Roche Carboxylsyre-substituerede oxazol-derivater til anvendelse som PPAR-alpha og -gamma-aktivatorer i behandlingen af diabetes
ES2275887T3 (es) * 2001-06-07 2007-06-16 Eli Lilly And Company Moduladores de receptores activados por proliferadores de peroxisoma (ppar).
KR20040012905A (ko) 2001-06-07 2004-02-11 일라이 릴리 앤드 캄파니 페록시좀 증식제 활성화 수용체의 조절제
US6987123B2 (en) * 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US20030055076A1 (en) * 2001-07-30 2003-03-20 Lone Jeppesen Novel compounds, their preparation and use
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
IL160304A0 (en) * 2001-08-10 2004-07-25 Nippon Chemiphar Co ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR delta
US20030171377A1 (en) * 2001-08-29 2003-09-11 Bigge Christopher Franklin Antidiabetic agents
FR2830012B1 (fr) * 2001-09-21 2003-10-31 Servier Lab Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharamaceutiques qui les contiennent
ES2326411T3 (es) * 2001-10-12 2009-10-09 Nippon Chemiphar Co., Ltd. Activador del receptor delta activado por proliferadores de peroxisomas.
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
KR100621294B1 (ko) * 2002-07-03 2006-09-06 에프. 호프만-라 로슈 아게 옥사졸 유도체 및 이의 인슐린 증감제로서의 용도
WO2004011446A1 (en) * 2002-07-26 2004-02-05 Bayer Pharmaceuticals Corporation Indane, dihydrobenzofuran, and tetrahydronaphthalene carboxylic acid derivatives and their use as antidiabetics
US8268352B2 (en) * 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US8216609B2 (en) * 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
CN100475810C (zh) * 2002-08-30 2009-04-08 霍夫曼-拉罗奇有限公司 作为PPARα和PPARγ激动剂的新型2-芳基噻唑化合物
PL375878A1 (en) * 2002-09-12 2005-12-12 F.Hoffmann-La Roche Ag N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
TWI343915B (en) 2002-10-07 2011-06-21 Hoffmann La Roche Chirale ppar agonists
JP4551222B2 (ja) * 2002-11-08 2010-09-22 エフ．ホフマン−ラ ロシュ アーゲー Ｐｐａｒアゴニストとしての置換４−アルコキシオキサゾール誘導体
ATE420079T1 (de) * 2002-11-15 2009-01-15 Cadila Healthcare Ltd Substituierte aralkyl verbindungen
ATE405560T1 (de) * 2002-11-25 2008-09-15 Hoffmann La Roche Indolderivaten
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
EP1597248B1 (de) * 2003-02-14 2007-12-26 Eli Lilly And Company Sulfonamid-derivate als ppar-modulatoren
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
WO2004103959A2 (en) * 2003-05-16 2004-12-02 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP1627873A4 (de) 2003-05-29 2007-12-05 New Ind Res Organization Benzofuranverbindung und medizinische zusammensetzung, die diese enthält
GB0314131D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB2414294B (en) 2004-05-20 2006-08-02 Teraview Ltd Apparatus and method for investigating a sample
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
AU2006266711A1 (en) * 2005-07-06 2007-01-11 Nippon Chemiphar Co., Ltd. Activator of peroxisome proliferator activated receptor delta
JP2009531280A (ja) 2006-01-25 2009-09-03 ウェルスタット セラピューティクス コーポレイション 代謝障害を処置するための化合物
NZ572268A (en) * 2006-04-18 2011-09-30 Nippon Chemiphar Co Activating agent for peroxisome proliferator activated receptor delta (ppar)
DE102006021878A1 (de) * 2006-05-11 2007-11-15 Sanofi-Aventis Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8648208B2 (en) * 2008-04-15 2014-02-11 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor
CA2769291A1 (en) * 2009-07-07 2011-01-13 Firestar Engineering Llc Detonation wave arrestor
RU2012109545A (ru) * 2009-08-14 2013-09-20 Серенис Терапьютикс С.А. Использование лигандов ppar дельта для лечения или предотвращения воспалений или заболеваний, связанных с метаболизмом/выработкой энергии
GB201002243D0 (en) * 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
CN101941950B (zh) * 2010-08-05 2012-12-26 上海交通大学 2-取代苯并[d]噁唑-5-丙酸化合物及其制备和应用
SI2670486T1 (sl) 2011-01-31 2016-09-30 Cadila Healthcare Limited Zydus Tower Satellite Cross Roads Zdravljenje lipodistrofije
AU2013387996B2 (en) 2013-04-22 2015-12-10 Cadila Healthcare Limited A novel composition for nonalcoholic fatty liver disease (NAFLD)
WO2014195967A2 (en) 2013-05-30 2014-12-11 Cadila Healthcare Limited A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
TW201636015A (zh) 2013-07-05 2016-10-16 卡地拉保健有限公司 協同性組成物
IN2013MU02470A (de) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
IN2013MU02905A (de) 2013-09-06 2015-07-03 Cadila Healthcare Ltd
WO2016022446A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [5,6]-fused bicyclic antidiabetic compounds
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
BR112019011740A2 (pt) 2016-12-09 2019-10-29 Cadila Healthcare Ltd composição farmacêutica e método para o tratamento de colangite biliar primária

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
JPS57144254A (en) * 1981-03-03 1982-09-06 Sagami Chem Res Center 2-substituted-2-oxoazetidine derivative and its preparation
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
GB8713861D0 (en) * 1987-06-13 1987-07-15 Beecham Group Plc Compounds
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
WO1989008652A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

Also Published As

Publication number Publication date
US5306726A (en) 1994-04-26
PT97950B (pt) 1998-11-30
AU7995691A (en) 1992-01-07
FI925640A (fi) 1992-12-11
ATE149156T1 (de) 1997-03-15
KR930700492A (ko) 1993-03-15
JPH05507920A (ja) 1993-11-11
EP0533781A1 (de) 1993-03-31
GR3022714T3 (en) 1997-06-30
US5438074A (en) 1995-08-01
NZ238528A (en) 1993-07-27
NO924799D0 (no) 1992-12-11
ES2098356T3 (es) 1997-05-01
CA2084898A1 (en) 1991-12-15
FI925640A0 (fi) 1992-12-11
DE69124798T2 (de) 1997-06-12
JPH07149636A (ja) 1995-06-13
IL98447A0 (en) 1992-07-15
EP0533781B1 (de) 1997-02-26
JPH075513B2 (ja) 1995-01-25
NO924799L (no) 1992-12-14
HUT65603A (en) 1994-07-28
IE912003A1 (en) 1991-12-18
AU646052B2 (en) 1994-02-03
HU9203943D0 (en) 1993-03-29
ZA914519B (en) 1993-01-27
US5089514A (en) 1992-02-18
PT97950A (pt) 1992-03-31
JP2581523B2 (ja) 1997-02-12
DK0533781T3 (da) 1997-07-07
WO1991019702A1 (en) 1991-12-26
MY106380A (en) 1995-05-30
IL98447A (en) 1995-12-31

Similar Documents

Publication Publication Date Title
DE69124798T2 (de) 3-aryl-2-hydroxypropionsäurederivate und analoge als hypoglykämische mittel
NO922566D0 (no) Implantasjonsmateriale som gir naer vaskularisering
DE69106714T2 (de) Hypoglykämische hydroxyharnstoffderivate.
AU6949594A (en) Substituted oxazolyl compounds for the treatment of inflammation
NO914117D0 (no) Fungicide oxazolidinoner
DE69625926D1 (de) Absorbierende zusammensetzung und saugfähiges wegwerfkleidungsstück, welches dasselbe enthält
TR199701212T1 (xx) �drar� tutamama halinin tedavisi i�in alfa IL- agonistlerinin kullan�lmas�.
DE69004242D1 (de) Laktoferrinhydrolysat zur Verwendung als antibakterielles Mittel.
DE59106558D1 (de) Aryl- und aralkylsulfid-, -sulfoxid- oder -sulfonverbindungen als ladungssteuermittel.
BR9502224A (pt) Composição de uso tópico e utilização de uma associação de um agente antioxidante e de ao menos um extrato de bactérias filamentosas não fotossintéticas e não frutificantes
ATE157869T1 (de) Antiöstrogene 2-phenyl-3-aroylbenzothiophene als hypoglykämische mittel
DK0971709T3 (da) Hidtil ukendte forbindelser nyttige som neurobeskyttende midler
KR910019620A (ko) 15-케토-프로스타글란딘 화합물을 사용한 췌장 질병의 치료
BR9911458A (pt) Console multifunção para bom manuseio de porta
PT796618E (pt) Tratamento e profilaxia da pancreatite
DE68918944T2 (de) Künstliche rezeptor-analoge.
DE68915112D1 (de) Spiro-isochinolin-pyrrolidin-tetrone und Analoge davon, verwendbar als Aldosereduktase-Inhibitoren.
DK0842165T3 (da) Thiazolidin-4-carboxylsyrederivater som cytobeskyttende midler
TR199901386T2 (en) �midazopiridazinler.
RS49837B (sr) Upotreba 8a-azalida u veterini kao antimikrobna sredstva
TR200101749T2 (tr) Apoptosis'i teşvikleyici bileşikler olarak 7-aril-6(Z)heptatrienoik asit retinamidler.
DE69012742D1 (de) Azolderivate und fungizide Medikamente, diese als wirkende Komponente enthaltend.
PT1104419E (pt) Derivados de azabicicloheptano substituidos no azoto sua preparacao e utilizacao
RU1839137C (ru) Портальный станок
NO905292L (no) Fremgangsmaate for behandling av slam som oppstaar ved elektroplettering av metaller.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee