TR200101749T2 - Apoptosis'i teşvikleyici bileşikler olarak 7-aril-6(Z)heptatrienoik asit retinamidler. - Google Patents

Apoptosis'i teşvikleyici bileşikler olarak 7-aril-6(Z)heptatrienoik asit retinamidler.

Info

Publication number
TR200101749T2
TR200101749T2 TR2001/01749T TR200101749T TR200101749T2 TR 200101749 T2 TR200101749 T2 TR 200101749T2 TR 2001/01749 T TR2001/01749 T TR 2001/01749T TR 200101749 T TR200101749 T TR 200101749T TR 200101749 T2 TR200101749 T2 TR 200101749T2
Authority
TR
Turkey
Prior art keywords
retinamides
aryl
promoting compounds
apoptosis promoting
heptatrienoic acid
Prior art date
Application number
TR2001/01749T
Other languages
English (en)
Inventor
Wai-Hing Cheung Adrian
B. Ferguson Stephen
Helen Foley Louise
J. Lovey Allen
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101749T2 publication Critical patent/TR200101749T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Içerisinde yer alan R1-R7'nin açiklama içinde tarif edildigi sekilde bulundugu formül (I)'in yeni trenoik retinoid bilesikleri, apoptotik etkinlik tasir ve kanserin önlenmesi ve tedavisinde faydalidir (FORMÜL).
TR2001/01749T 1998-12-17 1999-12-10 Apoptosis'i teşvikleyici bileşikler olarak 7-aril-6(Z)heptatrienoik asit retinamidler. TR200101749T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11263598P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
TR200101749T2 true TR200101749T2 (tr) 2001-10-22

Family

ID=22345024

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01749T TR200101749T2 (tr) 1998-12-17 1999-12-10 Apoptosis'i teşvikleyici bileşikler olarak 7-aril-6(Z)heptatrienoik asit retinamidler.

Country Status (16)

Country Link
US (1) US6310247B1 (tr)
EP (1) EP1149067B1 (tr)
JP (1) JP2002532458A (tr)
KR (1) KR20020002364A (tr)
CN (1) CN1330630A (tr)
AR (1) AR021694A1 (tr)
AT (1) ATE260242T1 (tr)
AU (1) AU771761B2 (tr)
CA (1) CA2355714A1 (tr)
DE (1) DE69915128D1 (tr)
PE (1) PE20001350A1 (tr)
TR (1) TR200101749T2 (tr)
TW (1) TW455575B (tr)
UY (1) UY25861A1 (tr)
WO (1) WO2000035856A1 (tr)
ZA (1) ZA200104271B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044535A1 (en) * 2001-11-22 2003-05-30 Mehmet Ozturk Method, antigen and antibody for distinguishing viable and apoptotic cells
ES2304112B1 (es) 2007-02-23 2009-08-13 Universidad De Zaragoza Uso de compuestos como inhibidores de la flavodoxina de helicobacter.
ES2304220B1 (es) 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas.
ES2304221B1 (es) 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas causadas por helicobacter.
EP2239582A1 (en) * 2009-04-09 2010-10-13 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Assay system for determining binding to hydrophobic drugs
CN102304056B (zh) * 2011-07-04 2013-12-11 浙江大学 3-甲基-4-芳基-3-烯-丁酰五氟苯胺衍生物及制备方法
RU2505492C1 (ru) * 2012-06-14 2014-01-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева" (РХТУ им. Д.И. Менделеева") Способ получения микрошариков из иттрий-алюмосиликатного стекла для радиотерапии

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399757A (en) * 1993-07-20 1995-03-21 Ortho Pharmaceutical Corporation Process for the preparation of N-(4-hydroxyphenyl)-retinamide
FR2719041B1 (fr) 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
CA2208981C (en) * 1994-12-30 2008-08-26 Ligand Pharmaceuticals Incorporated Novel trienoic retinoid compounds and methods
US5721103A (en) * 1994-12-30 1998-02-24 Ligand Pharmaceuticals Incorporated Trienoic retinoid compounds and methods

Also Published As

Publication number Publication date
ATE260242T1 (de) 2004-03-15
KR20020002364A (ko) 2002-01-09
PE20001350A1 (es) 2000-12-06
UY25861A1 (es) 2001-07-31
CN1330630A (zh) 2002-01-09
AU771761B2 (en) 2004-04-01
JP2002532458A (ja) 2002-10-02
AU1976500A (en) 2000-07-03
WO2000035856A1 (en) 2000-06-22
AR021694A1 (es) 2002-07-31
DE69915128D1 (de) 2004-04-01
US6310247B1 (en) 2001-10-30
EP1149067B1 (en) 2004-02-25
CA2355714A1 (en) 2000-06-22
TW455575B (en) 2001-09-21
ZA200104271B (en) 2002-08-26
EP1149067A1 (en) 2001-10-31

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