PE20001350A1 - Retinamidas del acido 7-aril-6(z)-heptatrienoico como inductores de la apoptosis - Google Patents

Retinamidas del acido 7-aril-6(z)-heptatrienoico como inductores de la apoptosis

Info

Publication number
PE20001350A1
PE20001350A1 PE1999001250A PE00125099A PE20001350A1 PE 20001350 A1 PE20001350 A1 PE 20001350A1 PE 1999001250 A PE1999001250 A PE 1999001250A PE 00125099 A PE00125099 A PE 00125099A PE 20001350 A1 PE20001350 A1 PE 20001350A1
Authority
PE
Peru
Prior art keywords
alkyl
retinamides
aryl
heptatrienamide
hydroxyphenil
Prior art date
Application number
PE1999001250A
Other languages
English (en)
Inventor
Adrian Wai-Hing Cheung
Stephen B Ferguson
Louise Helen Foley
Allen J Lovey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20001350A1 publication Critical patent/PE20001350A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A RETINAMIDAS DEL ACIDO 7-ARIL-6(Z)-HEPTATRIENOICO DE FORMULA I, DONDE: R1 Y R2 SON H, HALOGENO, ALQUILO, ALCOXILO, TRIHALOMETILO; R3 ES H, ALQUILO; R4 ES H, EXCEPTO CUANDO R3 ES ALQUILO ENTONCES R4 ES ALQUILO; R5, R6, R8 Y R9 SON HALOGENO, H, HIDROXI, ALQUILO, ALQUILOXILO; R7 ES H, ALQUILO; LIBRES DE ISOMEROS TRANS. SON COMPUESTOS PREFERIDOS N-(4-HIDROXIFENIL)-(2E,4E,6Z)-7-[3,5-BIS(TRIFLUOROMETIL)FENIL]-3,7-DIMETIL-2,4,6-HEPTATRIENAMIDA; N-(4-HIDROXIFENIL)-(2E,4E,6Z)-7-[3,5-BIS(TRIFLUOROMETIL)FENIL]-3-METIL-2,4,6-HEPTATRIENAMIDA, N-(4-HIDROXIFENIL)-(2E,4E,6Z)-7-[3,5-BIS(TRIFLUOROMETIL)FENIL]-3,6,7-TRIMETIL-2,4,6-HEPTATRIENAMIDA, ENTRE OTROS. EL COMPUESTO DE FORMULA I INHIBE EL CRECIMIENTO CELULAR POR LO QUE ES UTIL EN EL TRATAMIENTO Y PREVENCION DEL CANCER
PE1999001250A 1998-12-17 1999-12-14 Retinamidas del acido 7-aril-6(z)-heptatrienoico como inductores de la apoptosis PE20001350A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11263598P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
PE20001350A1 true PE20001350A1 (es) 2000-12-06

Family

ID=22345024

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001250A PE20001350A1 (es) 1998-12-17 1999-12-14 Retinamidas del acido 7-aril-6(z)-heptatrienoico como inductores de la apoptosis

Country Status (16)

Country Link
US (1) US6310247B1 (es)
EP (1) EP1149067B1 (es)
JP (1) JP2002532458A (es)
KR (1) KR20020002364A (es)
CN (1) CN1330630A (es)
AR (1) AR021694A1 (es)
AT (1) ATE260242T1 (es)
AU (1) AU771761B2 (es)
CA (1) CA2355714A1 (es)
DE (1) DE69915128D1 (es)
PE (1) PE20001350A1 (es)
TR (1) TR200101749T2 (es)
TW (1) TW455575B (es)
UY (1) UY25861A1 (es)
WO (1) WO2000035856A1 (es)
ZA (1) ZA200104271B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044535A1 (en) * 2001-11-22 2003-05-30 Mehmet Ozturk Method, antigen and antibody for distinguishing viable and apoptotic cells
ES2304112B1 (es) 2007-02-23 2009-08-13 Universidad De Zaragoza Uso de compuestos como inhibidores de la flavodoxina de helicobacter.
ES2304221B1 (es) 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas causadas por helicobacter.
ES2304220B1 (es) 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas.
EP2239582A1 (en) * 2009-04-09 2010-10-13 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Assay system for determining binding to hydrophobic drugs
CN102304056B (zh) * 2011-07-04 2013-12-11 浙江大学 3-甲基-4-芳基-3-烯-丁酰五氟苯胺衍生物及制备方法
RU2505492C1 (ru) * 2012-06-14 2014-01-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева" (РХТУ им. Д.И. Менделеева") Способ получения микрошариков из иттрий-алюмосиликатного стекла для радиотерапии

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399757A (en) 1993-07-20 1995-03-21 Ortho Pharmaceutical Corporation Process for the preparation of N-(4-hydroxyphenyl)-retinamide
FR2719041B1 (fr) 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US6083977A (en) * 1994-12-30 2000-07-04 Ligand Pharmaceuticals Incorporated Trienoic retinoid compounds and methods
MX9704878A (es) * 1994-12-30 1997-11-29 Ligand Pharm Inc Nuevos compuestos retinoides trienoicos y metodos de uso.

Also Published As

Publication number Publication date
TW455575B (en) 2001-09-21
AU1976500A (en) 2000-07-03
AR021694A1 (es) 2002-07-31
US6310247B1 (en) 2001-10-30
CN1330630A (zh) 2002-01-09
CA2355714A1 (en) 2000-06-22
WO2000035856A1 (en) 2000-06-22
ZA200104271B (en) 2002-08-26
UY25861A1 (es) 2001-07-31
TR200101749T2 (tr) 2001-10-22
ATE260242T1 (de) 2004-03-15
AU771761B2 (en) 2004-04-01
JP2002532458A (ja) 2002-10-02
KR20020002364A (ko) 2002-01-09
DE69915128D1 (de) 2004-04-01
EP1149067B1 (en) 2004-02-25
EP1149067A1 (en) 2001-10-31

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