AR021694A1 - Retinamidas de acido 7-aril-6-(z)heptatrienoico - Google Patents

Retinamidas de acido 7-aril-6-(z)heptatrienoico

Info

Publication number
AR021694A1
AR021694A1 ARP990106419A ARP990106419A AR021694A1 AR 021694 A1 AR021694 A1 AR 021694A1 AR P990106419 A ARP990106419 A AR P990106419A AR P990106419 A ARP990106419 A AR P990106419A AR 021694 A1 AR021694 A1 AR 021694A1
Authority
AR
Argentina
Prior art keywords
retinamids
aril
heptatrienoic acid
heptatrienoic
acid
Prior art date
Application number
ARP990106419A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR021694A1 publication Critical patent/AR021694A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos retinoides trienoicos, de formula (1), en donde R1-R7 son como se ha definido en la memoria descriptiva, poseen actividad apoptotica, y sonde utilidad para la prevencion y tratamiento del cáncer.
ARP990106419A 1998-12-17 1999-12-15 Retinamidas de acido 7-aril-6-(z)heptatrienoico AR021694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11263598P 1998-12-17 1998-12-17

Publications (1)

Publication Number Publication Date
AR021694A1 true AR021694A1 (es) 2002-07-31

Family

ID=22345024

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990106419A AR021694A1 (es) 1998-12-17 1999-12-15 Retinamidas de acido 7-aril-6-(z)heptatrienoico

Country Status (16)

Country Link
US (1) US6310247B1 (es)
EP (1) EP1149067B1 (es)
JP (1) JP2002532458A (es)
KR (1) KR20020002364A (es)
CN (1) CN1330630A (es)
AR (1) AR021694A1 (es)
AT (1) ATE260242T1 (es)
AU (1) AU771761B2 (es)
CA (1) CA2355714A1 (es)
DE (1) DE69915128D1 (es)
PE (1) PE20001350A1 (es)
TR (1) TR200101749T2 (es)
TW (1) TW455575B (es)
UY (1) UY25861A1 (es)
WO (1) WO2000035856A1 (es)
ZA (1) ZA200104271B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221261A1 (en) * 2001-11-22 2003-06-10 Mehmet Ozturk Method, antigen and antibody for distinguishing viable and apoptotic cells
ES2304112B1 (es) 2007-02-23 2009-08-13 Universidad De Zaragoza Uso de compuestos como inhibidores de la flavodoxina de helicobacter.
ES2304221B1 (es) 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas causadas por helicobacter.
ES2304220B1 (es) * 2007-03-02 2009-09-11 Universidad De Zaragoza Composicion para el tratamiento de enfermedades infecciosas.
EP2239582A1 (en) * 2009-04-09 2010-10-13 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Assay system for determining binding to hydrophobic drugs
CN102304056B (zh) * 2011-07-04 2013-12-11 浙江大学 3-甲基-4-芳基-3-烯-丁酰五氟苯胺衍生物及制备方法
RU2505492C1 (ru) * 2012-06-14 2014-01-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева" (РХТУ им. Д.И. Менделеева") Способ получения микрошариков из иттрий-алюмосиликатного стекла для радиотерапии

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399757A (en) 1993-07-20 1995-03-21 Ortho Pharmaceutical Corporation Process for the preparation of N-(4-hydroxyphenyl)-retinamide
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US6083977A (en) * 1994-12-30 2000-07-04 Ligand Pharmaceuticals Incorporated Trienoic retinoid compounds and methods
DE69516903T2 (de) * 1994-12-30 2000-10-26 Ligand Pharmaceuticals, Inc. Retinoid trienverbindungen und verfahren

Also Published As

Publication number Publication date
DE69915128D1 (de) 2004-04-01
TR200101749T2 (tr) 2001-10-22
AU771761B2 (en) 2004-04-01
CA2355714A1 (en) 2000-06-22
AU1976500A (en) 2000-07-03
UY25861A1 (es) 2001-07-31
KR20020002364A (ko) 2002-01-09
JP2002532458A (ja) 2002-10-02
PE20001350A1 (es) 2000-12-06
TW455575B (en) 2001-09-21
EP1149067B1 (en) 2004-02-25
WO2000035856A1 (en) 2000-06-22
ZA200104271B (en) 2002-08-26
ATE260242T1 (de) 2004-03-15
EP1149067A1 (en) 2001-10-31
CN1330630A (zh) 2002-01-09
US6310247B1 (en) 2001-10-30

Similar Documents

Publication Publication Date Title
PT939627E (pt) Pentafluorobenzenossulfonamidas e analogos
ES2150113T3 (es) Derivados de pirazol y procedimientos para la preparacion de los mismos.
FI950255A (fi) Venyvä absorboiva rakenne
ES2071484T3 (es) Derivados de 2,4-diaminoquinazolinas para aumentar la actividad antitumoral.
BR0200782A (pt) Compostos para o tratamento da isquemia
DE69908156D1 (de) Arylsulfonanilid-harnstoffe
PT1140944E (pt) Derivados de epotilona e sua utilizacao como agentes antitumorais
DE50010931D1 (de) Substituierte benzimidazole
BR9107070A (pt) Processo para a preparação de derivados de quinazolina uteis para melhorar a atividade antitumoral.
ES2150808T3 (es) Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico.
DE60004027D1 (de) Organische-arsenverbindungen
ATE327973T1 (de) Polyamin-analoge als cytotoxische wirkstoffe
ES2178761T3 (es) Utilizacion de 1-hidroxi-2-piridonas para el tratamiento de infe cciones cutaneas.
AR021694A1 (es) Retinamidas de acido 7-aril-6-(z)heptatrienoico
AR002272A1 (es) Uso de amidas de fenilciclohexilcarboxilicos
AR008860A1 (es) Empleo de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica
BR0013751A (pt) Processo para produção de derivados de ácido naftiridina-3-carboxìlico
DE69936052D1 (de) N1 modifizierte glycopeptide
ECSP993279A (es) Nuevas retinamidas de acido 7- aril -6 -cis- heptatrienoico
TR200200017T2 (tr) Benzofuran türevleri
HN2000000078A (es) Amidas sustituidas del acido fenilciclohexanocarboxilico y su uso como inhibidores de la incorporacion de adenosina
ES2144857T3 (es) Utilizacion de derivados benzonaftalenicos para la fabricacion de medicamentos destinados para el tratamiento de las enfermedades del sistema nervioso.
ES2060050T3 (es) Beta-tioacrilamidas s-sustituidas y su uso como microbicidas.
PT1232173E (pt) Derivados do acido fusidico
ES2195071T3 (es) Compuestos sustituidos con sulfonamida como bloqueadores del canal de k.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal