CL2023001369A1 - Derivados de quinolina como inhibidores de la integrina alfa4beta7 - Google Patents
Derivados de quinolina como inhibidores de la integrina alfa4beta7Info
- Publication number
- CL2023001369A1 CL2023001369A1 CL2023001369A CL2023001369A CL2023001369A1 CL 2023001369 A1 CL2023001369 A1 CL 2023001369A1 CL 2023001369 A CL2023001369 A CL 2023001369A CL 2023001369 A CL2023001369 A CL 2023001369A CL 2023001369 A1 CL2023001369 A1 CL 2023001369A1
- Authority
- CL
- Chile
- Prior art keywords
- quinoline derivatives
- formula
- integrin inhibitors
- compound
- present description
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
La presente descripción proporciona un compuesto de Fórmula (I): (I); una sal farmacéuticamente aceptable del mismo como se describe en el presente documento. La presente descripción también proporciona composiciones farmacéuticas que comprenden un compuesto de Fórmula (I), procesos para preparar compuestos de Fórmula (I) y métodos terapéuticos para tratar enfermedades inflamatorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862752805P | 2018-10-30 | 2018-10-30 | |
US201962823987P | 2019-03-26 | 2019-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023001369A1 true CL2023001369A1 (es) | 2023-12-15 |
Family
ID=68583545
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001098A CL2021001098A1 (es) | 2018-10-30 | 2021-04-28 | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
CL2023001369A CL2023001369A1 (es) | 2018-10-30 | 2023-05-11 | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001098A CL2021001098A1 (es) | 2018-10-30 | 2021-04-28 | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
Country Status (20)
Country | Link |
---|---|
US (3) | US11116760B2 (es) |
EP (1) | EP3873884A1 (es) |
JP (2) | JP7192139B2 (es) |
KR (2) | KR102630416B1 (es) |
CN (1) | CN112969687A (es) |
AU (2) | AU2019373240B2 (es) |
BR (1) | BR112021007213A2 (es) |
CA (1) | CA3116769C (es) |
CL (2) | CL2021001098A1 (es) |
CO (1) | CO2021005532A2 (es) |
CR (1) | CR20210213A (es) |
DO (1) | DOP2021000077A (es) |
IL (1) | IL282545A (es) |
MX (1) | MX2021005050A (es) |
PE (1) | PE20211866A1 (es) |
PH (1) | PH12021550825A1 (es) |
SG (1) | SG11202103484RA (es) |
TW (2) | TWI734240B (es) |
UA (1) | UA127769C2 (es) |
WO (1) | WO2020092375A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3773573A4 (en) | 2018-04-12 | 2022-04-06 | Morphic Therapeutic, Inc. | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4) (BETA7) |
AU2019373245C1 (en) * | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
JP7214882B2 (ja) | 2018-10-30 | 2023-01-30 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリン阻害剤としてのイミダゾピリジン誘導体 |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
US11104661B1 (en) | 2019-10-16 | 2021-08-31 | Morphic Therapeutic, Inc. | Inhibiting human integrin (α-4) (β-7) |
CN111518192A (zh) * | 2020-05-26 | 2020-08-11 | 成都圣诺生物制药有限公司 | 一种Apraglutide的制备方法 |
CN112142661B (zh) * | 2020-09-02 | 2022-04-12 | 苏州康润医药有限公司 | 3-氨基喹啉-5-羧酸甲酯的合成方法 |
Family Cites Families (231)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU675689B2 (en) | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU2958195A (en) | 1994-06-29 | 1996-01-25 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
KR19990036271A (ko) | 1995-08-08 | 1999-05-25 | 토마스 네프 | 콜라겐 과다생산과 연관된 질환의 치료에 이용되는 c-프로테나제 저해물질 |
AU3738597A (en) | 1996-07-25 | 1998-02-20 | Biogen, Inc. | Molecular model for vla-4 inhibitors |
WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
JP2002512625A (ja) | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
EP1017382B1 (en) | 1997-05-29 | 2006-03-01 | Merck & Co., Inc. (a New Jersey corp.) | Biarylalkanoic acids as cell adhesion inhibitors |
CA2291708A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
US6482849B1 (en) | 1997-06-23 | 2002-11-19 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
NZ502582A (en) | 1997-07-31 | 2002-07-26 | American Home Prod | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
CN1265672A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的磺酰化二肽化合物 |
NZ502580A (en) | 1997-07-31 | 2001-06-29 | Elan Pharm Inc | 4-amino-phenylalanine compounds which inhibit leukocyte adhesion mediated by VLA-4 |
KR20010022413A (ko) | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Vla-4에 의해 매개되는 백혈구 부착을 억제하는 벤질화합물 |
WO1999013898A1 (en) | 1997-08-15 | 1999-03-25 | Stefan Niewiarowski | EC-3, AN INHIBITOR OF α4β1 AND α4β7 INTEGRINS |
BR9811988A (pt) | 1997-08-22 | 2000-09-05 | Hoffmann La Roche | Derivados de n-alcanoilfenilalanina |
ATE267801T1 (de) | 1997-08-22 | 2004-06-15 | Hoffmann La Roche | N-alkanoylphenylalaninderivate |
WO1999025731A1 (fr) | 1997-11-13 | 1999-05-27 | Toray Industries, Inc. | Peptides cycliques et leur utilisation medicinale |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
ATE267168T1 (de) | 1997-11-24 | 2004-06-15 | Merck & Co Inc | Beta-alanin-derivate als zell-adhäsions- inhibitoren |
WO1999026615A1 (en) | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | Cyclic amino acid derivatives as cell adhesion inhibitors |
WO1999030713A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
KR20010087125A (ko) | 1998-04-16 | 2001-09-15 | 데이비드 비. 맥윌리암스 | 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물 |
SI1082302T1 (en) | 1998-05-28 | 2004-06-30 | Biogen, Inc. | A vla-4 inhibitor: omepupa-v |
GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
AU8059598A (en) | 1998-06-11 | 1999-12-30 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
TW591026B (en) | 1998-06-23 | 2004-06-11 | Upjohn Co | Inhibitors of alpha4beta1 mediated cell adhesion |
WO2000002903A1 (en) | 1998-07-10 | 2000-01-20 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
JP2002521375A (ja) | 1998-07-23 | 2002-07-16 | アストラゼネカ アクチエボラーク | 化合物 |
CN1323295A (zh) | 1998-08-26 | 2001-11-21 | 阿文蒂斯药物有限公司 | 调节细胞粘着抑制作用的氮杂双环化合物 |
BR9916211A (pt) | 1998-12-14 | 2001-09-11 | American Home Prod | Derivados de 3,4-diamino-3-ciclobuteno-1,2-diona que inibem adesão de leucócito mediada por vla-4 |
GB9828074D0 (en) | 1998-12-18 | 1999-02-17 | Glaxo Group Ltd | Therapeutically useful compounds |
JP2002535304A (ja) | 1999-01-22 | 2002-10-22 | エラン ファーマシューティカルズ,インコーポレイテッド | Val−4により媒介される白血球接着を阻害する多環式化合物 |
AU769741B2 (en) | 1999-01-22 | 2004-02-05 | Elan Pharmaceuticals, Inc. | Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4 |
WO2000043372A1 (en) | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat vla-4 related disorders |
ATE323102T1 (de) | 1999-01-26 | 2006-04-15 | Elan Pharm Inc | Pyroglutaminsäurederivate und damit verwandte verbindungen, die die durch vla-4 vermittelte leukozytenadhäsion verringern |
PT1154993E (pt) | 1999-02-18 | 2005-01-31 | Hoffmann La Roche | Derivados de tioamida |
EP1161416B1 (en) | 1999-03-01 | 2004-04-14 | Elan Pharmaceuticals, Inc. | Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 - receptor antagonists |
US6265572B1 (en) | 1999-04-20 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrrolidincarbonylamino cyclic disulfide anti-inflammatory agents |
GB9909409D0 (en) | 1999-04-24 | 1999-06-23 | Zeneca Ltd | Chemical compounds |
JP5132855B2 (ja) | 1999-05-07 | 2013-01-30 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | インテグリンのその受容体への結合を阻害するカルボン酸誘導体 |
IL146288A0 (en) | 1999-06-30 | 2002-07-25 | Daiichi Seiyaku Co | Vla-4 inhibitor compounds |
JP3795305B2 (ja) | 1999-07-19 | 2006-07-12 | 田辺製薬株式会社 | 医薬組成物 |
CA2382757A1 (en) | 1999-07-26 | 2001-02-01 | Toray Industries, Inc. | Carboxylic acid derivatives and adhesion molecule inhibitors which contain the same as effective ingredients |
CA2380817A1 (en) | 1999-08-13 | 2001-02-22 | Biogen, Inc. | Cell adhesion inhibitors |
AU6903200A (en) | 1999-08-16 | 2001-03-13 | Merck & Co., Inc. | Heterocycle amides as cell adhesion inhibitors |
WO2001014328A2 (en) | 1999-08-20 | 2001-03-01 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
US6469047B1 (en) * | 1999-09-24 | 2002-10-22 | Genentech, Inc. | Tyrosine derivatives |
AU7961200A (en) | 1999-10-29 | 2001-05-14 | Kaken Pharmaceutical Co., Ltd. | Urea derivative, process for producing the same, and medicine containing the urea derivative |
AU1416501A (en) | 1999-11-18 | 2001-05-30 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
KR100492111B1 (ko) | 1999-12-06 | 2005-06-01 | 에프. 호프만-라 로슈 아게 | 4-피리디닐-n-아실-l-페닐알라닌 |
EP1237878B1 (en) | 1999-12-06 | 2007-03-21 | F. Hoffmann-La Roche Ag | 4-pyrimidinyl-n-acyl-l-phenylalanines |
EP2332578A1 (en) | 1999-12-16 | 2011-06-15 | Biogen Idec MA Inc. | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
DE19962936A1 (de) | 1999-12-24 | 2001-06-28 | Bayer Ag | Neue beta-Aminosäureverbindungen als Integrinantagonisten |
AU2224901A (en) | 1999-12-28 | 2001-07-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
GB0001348D0 (en) | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
GB0001346D0 (en) | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
AU2882801A (en) | 2000-01-28 | 2001-08-07 | Kaken Pharmaceutical Co., Ltd. | Azepine derivatives |
HUP0300544A3 (en) | 2000-02-03 | 2005-03-29 | Eisai Co Ltd | Pharmaceutical compositions containing integrin expression inhibitors |
AU2001234741A1 (en) | 2000-02-04 | 2001-08-14 | Biogen, Inc. | Integrin antagonists |
WO2001068586A2 (en) | 2000-03-14 | 2001-09-20 | Novartis Ag | α4β1 AND α4β7 INTEGRIN INHIBITORS |
EP1270547A4 (en) | 2000-03-23 | 2005-07-13 | Ajinomoto Kk | NEW PHENYL ALANIDE DERIVATIVES |
US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
PE20020384A1 (es) | 2000-07-21 | 2002-05-28 | Schering Corp | PEPTIDOS COMO INHIBIDORES DE LA PROTEASA SERINA NS3/NS4a DEL VIRUS DE LA HEPATITIS C |
US6794506B2 (en) | 2000-07-21 | 2004-09-21 | Elan Pharmaceuticals, Inc. | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 |
WO2002008206A1 (en) | 2000-07-21 | 2002-01-31 | Elan Pharmaceuticals, Inc. | 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors |
JP5046466B2 (ja) | 2000-08-11 | 2012-10-10 | 科研製薬株式会社 | 2,3−ジフェニルプロピオン酸誘導体またはその塩、それを用いた医薬および細胞接着阻害剤ならびにその使用方法 |
CA2419580A1 (en) | 2000-08-18 | 2002-02-28 | Genentech, Inc. | Integrin receptor inhibitors |
DE60143984D1 (de) | 2000-08-18 | 2011-03-17 | Ajinomoto Kk | Neue phenylalanin-derivate |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
WO2002022563A1 (fr) | 2000-09-14 | 2002-03-21 | Toray Industries, Inc. | Derive d'uree et inhibiteur de molecule adhesive contenant celui-ci en tant que substance active |
AU8811401A (en) | 2000-09-25 | 2002-04-02 | Toray Industries | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient |
WO2002028830A1 (fr) | 2000-09-29 | 2002-04-11 | Ajinomoto Co.,Inc. | Nouveaux derives de phenylalanine |
CN100471838C (zh) | 2000-12-28 | 2009-03-25 | 第一制药株式会社 | Vla-4抑制剂 |
ES2200617B1 (es) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | Derivados de urea como antagonistas de integrinas alfa 4. |
ATE350660T1 (de) | 2001-02-21 | 2007-01-15 | Eisai Co Ltd | Verfahren zur untersuchung der wirkung eines angionegesis-hemmers unter vermittlung durch hemmung der integrin-expression |
GB2387845B (en) | 2001-02-22 | 2005-05-11 | Celltech R&D Ltd | Phenylalanine enamide derivatives |
EP1441006B1 (en) | 2001-06-20 | 2009-09-23 | Asahi Kasei Kabushiki Kaisha | Thermoplastic resin composition |
JP2005022976A (ja) | 2001-07-18 | 2005-01-27 | Ajinomoto Co Inc | カルボン酸誘導体 |
US7557130B2 (en) | 2001-07-26 | 2009-07-07 | Ucb Pharma, S.A. | Bicyclic heteroaromatic alanines |
JP4164871B2 (ja) | 2001-07-26 | 2008-10-15 | 味の素株式会社 | 新規フェニルプロピオン酸誘導体 |
JP2003048889A (ja) | 2001-08-01 | 2003-02-21 | Ajinomoto Co Inc | 新規核酸系化合物 |
EP1424558A4 (en) | 2001-08-17 | 2004-12-15 | Eisai Co Ltd | REAGENT FOR TESTING LAMININE-5-ANTIGENS IN A BIOLOGICAL SAMPLE AND TEST PROCEDURE |
JPWO2003024933A1 (ja) | 2001-09-12 | 2004-12-24 | 科研製薬株式会社 | 2−フェニル−3−ヘテロアリールプロピオン酸誘導体またはその塩、それを用いた医薬 |
GB0127423D0 (en) | 2001-11-15 | 2002-01-09 | Glaxo Group Ltd | Process |
AU2002354224A1 (en) | 2001-12-13 | 2003-07-09 | Ajinomoto Co., Inc. | Novel phenylalanine derivative |
JP4470219B2 (ja) | 2002-02-20 | 2010-06-02 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
JP4233353B2 (ja) | 2002-02-27 | 2009-03-04 | 田辺三菱製薬株式会社 | 医薬組成物 |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
JP2003277340A (ja) | 2002-03-22 | 2003-10-02 | Toray Ind Inc | 接着分子阻害剤及び新規アミノ酸誘導体 |
CN1656095A (zh) | 2002-03-22 | 2005-08-17 | 东丽株式会社 | 螺衍生物和包含其作为活性组分的粘着分子抑制剂 |
WO2003089410A1 (fr) | 2002-04-19 | 2003-10-30 | Kyowa Hakko Kogyo Co., Ltd. | Derive de phenylalanine |
AU2003232472B2 (en) | 2002-04-30 | 2008-09-18 | Ucb Pharma | 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as VLA-4 inhibitors |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
GB0216571D0 (en) | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
GB0216568D0 (en) | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
GB0216574D0 (en) | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
JP2005535710A (ja) | 2002-08-09 | 2005-11-24 | トランス テック ファーマ,インコーポレイテッド | アリールおよびヘテロアリール化合物ならびに凝固を調節する方法 |
GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
CA2851462A1 (en) | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
SK50642005A3 (sk) | 2003-01-24 | 2006-02-02 | Elan Pharmaceuticals, Inc. | Kompozícia na liečenie demyelizačných ochorení a paralýzy podávaním remyelizačných látok |
EP1595870B1 (en) | 2003-02-20 | 2015-09-23 | Ajinomoto Co., Inc. | Process for producing phenylalanine derivative having quinazolinedione skeleton and intermediate for the same |
JP2004277338A (ja) | 2003-03-14 | 2004-10-07 | Nippon Soda Co Ltd | N−アシルアミノ酸類の製造方法 |
ES2219177B1 (es) | 2003-05-05 | 2006-02-16 | Almirall Prodesfarma, S.A. | Derivados de n-(2-feniletil) sulfamida como antagonistas de la integrina alfa4. |
US7015323B2 (en) | 2003-05-20 | 2006-03-21 | Genentech, Inc. | Thiocarbamate inhibitors of alpha-4 integrins |
US20050074451A1 (en) | 2003-06-25 | 2005-04-07 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
TWI340134B (en) | 2003-07-24 | 2011-04-11 | Daiichi Seiyaku Co | Cyclohexanecarboxylic acids |
US7501538B2 (en) | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
WO2005040135A1 (ja) | 2003-10-24 | 2005-05-06 | Ono Pharmaceutical Co., Ltd. | 抗ストレス薬およびその医薬用途 |
US20050176755A1 (en) | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
JP5105578B2 (ja) | 2003-11-05 | 2012-12-26 | サーコード バイオサイエンス インコーポレイテッド | 細胞接着のモジュレーター |
WO2005046697A1 (ja) | 2003-11-14 | 2005-05-26 | Ajinomoto Co., Inc. | フェニルアラニン誘導体の徐放性経口投与製剤 |
WO2005046696A1 (ja) | 2003-11-14 | 2005-05-26 | Ajinomoto Co., Inc. | フェニルアラニン誘導体の固体分散体または固体分散体医薬製剤 |
CN1886385B (zh) | 2003-11-27 | 2013-02-27 | 味之素株式会社 | 苯丙氨酸衍生物的结晶及其制造方法 |
GB0329584D0 (en) | 2003-12-20 | 2004-01-28 | Tanabe Seiyaku Co | Novel compounds |
CA2550843C (en) | 2003-12-22 | 2013-04-02 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
EP1706399A1 (en) | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
WO2005077915A1 (en) | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica, N.V. | Pyridazinones as antagonists of a4 integrins |
US20050209232A1 (en) | 2004-02-10 | 2005-09-22 | Kent Barbay | Pyridazinone ureas as antagonists of alpha4 integrins |
AU2005222074B2 (en) | 2004-03-10 | 2011-02-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
CA2561164A1 (en) | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
EP1735000A2 (en) | 2004-04-16 | 2006-12-27 | Genentech, Inc. | Method for augmenting b cell depletion |
US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
TW200610754A (en) | 2004-06-14 | 2006-04-01 | Daiichi Seiyaku Co | Vla-4 inhibitor |
KR101273614B1 (ko) | 2004-07-08 | 2013-06-12 | 엘란 파마슈티칼스, 인크. | 중합체 부분을 포함하는 다가 vla―4 길항제 |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
JP4649476B2 (ja) | 2004-08-16 | 2011-03-09 | メルク・シャープ・エンド・ドーム・コーポレイション | Vla−4拮抗薬 |
EP1805210A4 (en) | 2004-09-09 | 2007-10-24 | Auckland Uniservices Ltd | NOVEL PEPTIDES AND METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASE |
US7618983B2 (en) | 2004-11-10 | 2009-11-17 | Janssen Pharmaceutica, N.V. | Bicyclic triazole α4 integrin inhibitors |
EP1832580A4 (en) | 2004-12-20 | 2009-03-11 | Eisai R&D Man Co Ltd | 1-CYCLOPROPYLMETHYL-4-Ý2- (3,3,5,5) -TETRAMETHYLCYCLOHEXYL) PHENYL PIPERAZINE CRYSTAL AND SALT |
WO2006066780A1 (en) | 2004-12-22 | 2006-06-29 | F. Hoffmann-La Roche Ag | Combinations of valategrast and montelukast for treating asthma |
EP1840121B1 (en) | 2004-12-24 | 2012-08-29 | Toray Industries, Inc. | Glycine derivative and use thereof |
WO2006081986A1 (en) | 2005-02-07 | 2006-08-10 | F.Hoffmann-La Roche Ag | Bambuterol and integrin inhibitor combination |
WO2006090234A1 (en) | 2005-02-22 | 2006-08-31 | Ranbaxy Laboratories Limited | Heterocyclic derivatives as cell adhesion inhibitors |
WO2006096807A1 (en) | 2005-03-08 | 2006-09-14 | Janssen Pharmaceutica N.V. | Aza-bridged-bicyclic amino acid derivatives as alpha 4 integrin antagonists |
CN101155798A (zh) | 2005-04-14 | 2008-04-02 | 默克公司 | Vla-4拮抗剂 |
WO2006112738A1 (en) | 2005-04-19 | 2006-10-26 | Auckland Uniservices Limited | Novel peptides and methods for the treatment of inflammatory disorders |
US20090069376A1 (en) | 2005-04-21 | 2009-03-12 | Ping Liu | VLA-4 Antagonists |
WO2006127584A1 (en) | 2005-05-20 | 2006-11-30 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives as vla-4 antagonists |
ATE478854T1 (de) | 2005-05-25 | 2010-09-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung von ä2-(3,3,5,5- tetramethylcyclohexyl)phenylüpiperazin |
AU2006250388A1 (en) | 2005-05-25 | 2006-11-30 | Eisai R & D Management Co., Ltd. | Intermediate in production of [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound |
NZ563739A (en) | 2005-06-09 | 2009-12-24 | Ucb Pharma Sa | 2,6 Quinolinyl derivatives, processes for preparing them and their use as medicament |
ES2416354T3 (es) | 2005-06-21 | 2013-07-31 | Ajinomoto Co., Inc. | Cristal de derivado de fenilalanina, método de producción del mismo y uso del mismo |
TW200726767A (en) | 2005-07-04 | 2007-07-16 | Astrazeneca Ab | Chemical compounds 2 |
JP5107724B2 (ja) | 2005-12-13 | 2012-12-26 | 第一三共株式会社 | Vla−4阻害薬 |
EP1978928B1 (en) | 2006-01-18 | 2010-03-31 | F. Hoffmann-la Roche AG | Pharmaceutical valatograst compositions and process for manufacturing them |
EP1996559A1 (en) | 2006-02-27 | 2008-12-03 | Elan Pharmaceuticals Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
EP2007392A4 (en) | 2006-02-28 | 2010-04-07 | Elan Pharm Inc | METHOD FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES WITH ALPHA-4-INHIBITABLE COMPOUNDS |
BRPI0718988A2 (pt) | 2006-11-22 | 2014-02-11 | Ajinomoto Kk | Método para preparar um derivado de fenilalanina, e, composto |
WO2008064830A1 (en) | 2006-11-27 | 2008-06-05 | Ucb Pharma, S.A. | Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses |
CN104030990B (zh) | 2007-03-12 | 2017-01-04 | Ym生物科学澳大利亚私人有限公司 | 苯基氨基嘧啶化合物及其用途 |
WO2008125210A1 (en) | 2007-04-12 | 2008-10-23 | Ucb Pharma, S.A. | Quinoline and naphthalene derivatives, processes for their preparation and their use in treatment of inflammatory diseases |
CA2934114A1 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
EP2231185A4 (en) | 2007-12-07 | 2012-06-27 | Elan Pharm Inc | METHOD AND COMPOSITIONS FOR TREATING LIQUID TUMORS |
WO2009124755A1 (en) | 2008-04-08 | 2009-10-15 | European Molecular Biology Laboratory (Embl) | Compounds with novel medical uses and method of identifying such compounds |
CA2724413C (en) | 2008-05-15 | 2016-10-18 | Duke University | Compositions and methods relating to heat shock transcription factor activating compounds and targets thereof |
DK2604693T3 (en) | 2008-07-21 | 2016-05-30 | Apogenix Gmbh | Single-chain TNFSF molecules |
KR20100101054A (ko) | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
ES2634431T3 (es) | 2009-03-16 | 2017-09-27 | The Governing Council Of The University Of Toronto | Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas |
GB0905641D0 (en) | 2009-04-01 | 2009-05-13 | Serodus As | Compounds |
MX2011011326A (es) | 2009-04-27 | 2012-02-13 | Elan Pharm Inc | Antagonistas de piridinona de las integrinas alfa-4. |
BR112012009292A2 (pt) | 2009-10-21 | 2017-06-06 | Glaxo Group Ltd | processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
JP6109568B2 (ja) | 2010-03-29 | 2017-04-05 | Eaファーマ株式会社 | フェニルアラニン誘導体の塩の結晶 |
ES2768349T3 (es) | 2010-03-29 | 2020-06-22 | Ea Pharma Co Ltd | Preparación farmacéutica que comprende un derivado de fenilalanina |
JP2013528374A (ja) | 2010-05-10 | 2013-07-11 | パーシード セラピューティクス リミテッド ライアビリティ カンパニー | Vla4のポリペプチド阻害剤 |
WO2011150499A1 (en) | 2010-05-31 | 2011-12-08 | The Governing Council Of The University Of Toronto | A method to insert molecular fragments into cyclic molecules |
WO2011159781A2 (en) | 2010-06-17 | 2011-12-22 | Senomyx, Inc. | Bitter taste modulators |
WO2012011123A1 (en) | 2010-07-20 | 2012-01-26 | Council Of Scientific & Industrial Research | Pyridin- 2 - yl sulfanyl acid esters and process for the preparation thereof |
EP2881392B1 (en) | 2010-11-16 | 2018-06-06 | Texas Heart Institute | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
US9249087B2 (en) | 2011-02-01 | 2016-02-02 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
EP2775840A4 (en) | 2011-11-09 | 2015-06-10 | Aestus Therapeutics Inc | METHOD FOR TREATING SCHIZOPHRENIA WITH PHENYLALANINE ENAMIDE DERIVATIVE INHIBITORS FROM 4 INTEGRIN WITH A CYCLOBUTEN GROUP |
MX351015B (es) | 2012-01-27 | 2017-09-28 | Hoffmann La Roche | Conjugados de antagonista de la integrina para su suministro dirigido a celulas que expresan vla-4. |
KR20140120316A (ko) | 2012-01-27 | 2014-10-13 | 에프. 호프만-라 로슈 아게 | 표적화된 전달을 위한 소분자 인테그린 안타고니스트와 공유 결합된 키토산 |
US20130303763A1 (en) | 2012-03-30 | 2013-11-14 | Michael D. Gershon | Methods and compositions for the treatment of necrotizing enterocolitis |
MX351225B (es) | 2012-04-24 | 2017-10-05 | Ea Pharma Co Ltd | Derivado de sulfonamida y uso medicinal del mismo. |
US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
EP2900228A1 (en) | 2012-09-26 | 2015-08-05 | KFLP Biotech, LLC | Compounds for the treatment and prevention of retroviral infections |
JPWO2014051056A1 (ja) | 2012-09-28 | 2016-08-22 | 東レ株式会社 | グリシン誘導体の結晶及びその医薬用途 |
US20150045435A1 (en) | 2013-08-06 | 2015-02-12 | Indiana University Research And Technology Corporation | Compounds and methods for treating diabetes |
JP6399874B2 (ja) | 2013-09-20 | 2018-10-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 化合物の抗炎症効果または免疫抑制効果を予測する方法 |
RU2667520C9 (ru) | 2013-10-29 | 2019-03-05 | ЕА Фарма Ко., Лтд. | Производное сульфонамида и его применение в медицине |
CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
WO2015172196A1 (en) | 2014-05-13 | 2015-11-19 | Monash University | Heterocyclic compounds and use of same |
JP2016037468A (ja) | 2014-08-07 | 2016-03-22 | 味の素株式会社 | スルホンアミド誘導体及びその医薬用途 |
JP2016037467A (ja) | 2014-08-07 | 2016-03-22 | 味の素株式会社 | スルホンアミド誘導体及びその医薬用途 |
KR20230026515A (ko) | 2014-09-10 | 2023-02-24 | 에피자임, 인코포레이티드 | Smyd 억제제 |
EA034956B1 (ru) | 2014-09-29 | 2020-04-10 | Эа Фарма Ко., Лтд. | Способ для лечения язвенного колита |
US10383842B2 (en) | 2015-02-13 | 2019-08-20 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
EP3268369A4 (en) | 2015-03-10 | 2018-08-08 | The Regents of The University of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
KR102440162B1 (ko) | 2015-07-08 | 2022-09-02 | 악세로비젼, 인크. | 안구 염증 병태의 치료에 사용하기 위한 인테그린 알파4 길항제를 포함하는 제약 조성물 |
SI3364958T1 (sl) | 2015-10-23 | 2023-05-31 | Navitor Pharmaceuticals, Inc. | Modulatorji interakcije sestrina in gator2 ter njihova uporaba |
CN105483206B (zh) | 2016-01-06 | 2019-09-13 | 北京汉氏联合生物技术股份有限公司 | 一种用vcam-1检测msc促内皮细胞增殖能力的方法 |
JP6809713B2 (ja) | 2016-01-20 | 2021-01-06 | 国立大学法人 岡山大学 | 炎症性腸疾患抑制剤 |
CN106995439B (zh) | 2016-01-26 | 2019-09-20 | 镇江圣安医药有限公司 | 氘取代3-(甲磺酰基)-l-苯丙氨酸衍生物及其药物组合物、药物制剂和用途 |
US20180369330A1 (en) | 2016-01-29 | 2018-12-27 | La Jolla Institute For Allergy And Immunology | Methods and compositions using integrin-based therapeutics |
TW201731824A (zh) | 2016-02-05 | 2017-09-16 | Ea Pharma Co Ltd | α4β7整合蛋白抑制劑 |
AU2017214589B2 (en) | 2016-02-05 | 2020-09-03 | Ea Pharma Co., Ltd. | Sulfonamide derivative and pharmaceutical composition containing same |
WO2018049068A1 (en) | 2016-09-07 | 2018-03-15 | Pliant Therapeutics, Inc. | N-acyl amino acid compounds and methods of use |
SG10201912574WA (en) | 2016-09-28 | 2020-02-27 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
WO2018085574A2 (en) | 2016-11-02 | 2018-05-11 | Washington University | Compositions comprising an integrin inhibitor and agents which interact with a chemokine and methods of use thereof |
WO2018085552A1 (en) | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
US11014922B2 (en) | 2016-11-08 | 2021-05-25 | Bristol-Myers Squibb Company | Cyclobutane- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors |
EA201991121A1 (ru) | 2016-11-08 | 2019-11-29 | АЗОЛАМИДЫ И АЗОЛАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV | |
EA201991123A1 (ru) | 2016-11-08 | 2019-11-29 | ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV | |
EP3538528B1 (en) | 2016-11-08 | 2020-12-23 | Bristol-Myers Squibb Company | Pyrrole amides as alpha v integrin inhibitors |
PE20191647A1 (es) | 2016-11-08 | 2019-11-07 | Bristol Myers Squibb Co | Acidos propionicos 3-sustituidos como inhibidores de la integrina alfa v |
CA3054604A1 (en) | 2017-02-28 | 2018-09-07 | Morphic Therapeutic, Inc. | Inhibitors of .alpha.v.beta.6 integrin |
MA47692A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
US10246451B2 (en) | 2017-04-26 | 2019-04-02 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
EP3615019A4 (en) | 2017-04-26 | 2021-01-27 | Navitor Pharmaceuticals, Inc. | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF |
US10875875B2 (en) | 2017-04-26 | 2020-12-29 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
JP2019031449A (ja) | 2017-08-04 | 2019-02-28 | Eaファーマ株式会社 | スルホンアミド誘導体及びそれを含有する医薬組成物 |
CN109721605B (zh) | 2017-10-31 | 2022-03-11 | 维眸生物科技(上海)有限公司 | 一种免疫细胞迁徙抑制剂 |
AU2018365793A1 (en) | 2017-11-07 | 2020-06-18 | Bristol-Myers Squibb Company | Pyrrolopyrazine derivatives as alpha V integrin inhibitors |
CR20200452A (es) | 2018-03-07 | 2020-11-19 | Pliant Therapeutics Inc | Compuestos de aminoacidos y métodos de uso |
EP3765005A4 (en) | 2018-03-13 | 2022-02-23 | The Regents of the University of California | INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHOD OF USE |
EP3773573A4 (en) | 2018-04-12 | 2022-04-06 | Morphic Therapeutic, Inc. | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4) (BETA7) |
AU2019316562B2 (en) | 2018-08-08 | 2024-03-28 | The General Hospital Corporation | Integrin antagonists |
SI3613739T1 (sl) | 2018-08-17 | 2021-02-26 | Oxurion NV | Integrinski antagonisti |
WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
AU2019327475A1 (en) | 2018-08-29 | 2021-03-11 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
WO2020047207A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutics, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
JP7214882B2 (ja) | 2018-10-30 | 2023-01-30 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリン阻害剤としてのイミダゾピリジン誘導体 |
AU2019373245C1 (en) | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
-
2019
- 2019-10-29 CN CN201980071854.XA patent/CN112969687A/zh active Pending
- 2019-10-29 MX MX2021005050A patent/MX2021005050A/es unknown
- 2019-10-29 EP EP19805484.3A patent/EP3873884A1/en active Pending
- 2019-10-29 US US16/667,306 patent/US11116760B2/en active Active
- 2019-10-29 BR BR112021007213-6A patent/BR112021007213A2/pt unknown
- 2019-10-29 CA CA3116769A patent/CA3116769C/en active Active
- 2019-10-29 WO PCT/US2019/058573 patent/WO2020092375A1/en unknown
- 2019-10-29 SG SG11202103484RA patent/SG11202103484RA/en unknown
- 2019-10-29 AU AU2019373240A patent/AU2019373240B2/en active Active
- 2019-10-29 KR KR1020217016023A patent/KR102630416B1/ko active Application Filing
- 2019-10-29 CR CR20210213A patent/CR20210213A/es unknown
- 2019-10-29 UA UAA202101839A patent/UA127769C2/uk unknown
- 2019-10-29 JP JP2021548529A patent/JP7192139B2/ja active Active
- 2019-10-29 KR KR1020247002760A patent/KR20240015737A/ko active Application Filing
- 2019-10-29 PE PE2021000605A patent/PE20211866A1/es unknown
- 2019-10-29 US US17/289,614 patent/US20220119383A1/en not_active Abandoned
- 2019-10-30 TW TW108139358A patent/TWI734240B/zh active
- 2019-10-30 TW TW110123631A patent/TW202138353A/zh unknown
-
2021
- 2021-04-08 PH PH12021550825A patent/PH12021550825A1/en unknown
- 2021-04-21 IL IL282545A patent/IL282545A/en unknown
- 2021-04-28 CO CONC2021/0005532A patent/CO2021005532A2/es unknown
- 2021-04-28 CL CL2021001098A patent/CL2021001098A1/es unknown
- 2021-04-28 DO DO2021000077A patent/DOP2021000077A/es unknown
- 2021-07-19 US US17/379,175 patent/US20230041518A1/en active Pending
-
2022
- 2022-12-07 JP JP2022195576A patent/JP2023016976A/ja active Pending
-
2023
- 2023-05-11 CL CL2023001369A patent/CL2023001369A1/es unknown
- 2023-07-17 AU AU2023204712A patent/AU2023204712A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220119383A1 (en) | 2022-04-21 |
TWI734240B (zh) | 2021-07-21 |
PH12021550825A1 (en) | 2021-10-04 |
US20230041518A1 (en) | 2023-02-09 |
CN112969687A (zh) | 2021-06-15 |
BR112021007213A2 (pt) | 2021-08-10 |
PE20211866A1 (es) | 2021-09-21 |
UA127769C2 (uk) | 2023-12-27 |
AU2019373240B2 (en) | 2023-04-20 |
IL282545A (en) | 2021-06-30 |
TW202033492A (zh) | 2020-09-16 |
KR20210087961A (ko) | 2021-07-13 |
AU2019373240A1 (en) | 2021-05-13 |
EP3873884A1 (en) | 2021-09-08 |
JP2023016976A (ja) | 2023-02-02 |
TW202138353A (zh) | 2021-10-16 |
US20200155538A1 (en) | 2020-05-21 |
DOP2021000077A (es) | 2021-06-15 |
CR20210213A (es) | 2021-06-24 |
SG11202103484RA (en) | 2021-05-28 |
CL2021001098A1 (es) | 2021-11-26 |
US11116760B2 (en) | 2021-09-14 |
JP7192139B2 (ja) | 2022-12-19 |
KR102630416B1 (ko) | 2024-02-01 |
CA3116769A1 (en) | 2020-05-07 |
AU2023204712A1 (en) | 2023-08-10 |
CO2021005532A2 (es) | 2021-05-10 |
JP2022509507A (ja) | 2022-01-20 |
CA3116769C (en) | 2023-08-22 |
MX2021005050A (es) | 2021-06-15 |
KR20240015737A (ko) | 2024-02-05 |
WO2020092375A1 (en) | 2020-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2023001369A1 (es) | Derivados de quinolina como inhibidores de la integrina alfa4beta7 | |
DOP2022000124A (es) | Derivados de pirazolilo útiles como agentes anticancerígenos | |
CL2019002204A1 (es) | Compuestos inhibidores del vih. | |
CR20160191A (es) | Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de fgfr4 | |
EA201691803A1 (ru) | Ингибиторы калликреина плазмы человека | |
PH12016502382A1 (en) | Substituted indazole compounds as irak4 inhibitors | |
CR20150628A (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades | |
CO2020004301A2 (es) | Derivados de 1-benzil-2-imino-4-fenil-5-oxoimidazolidina como inhibidores de la proteasa del vih | |
EA201592256A1 (ru) | Производные имидазопирролидинона и их применение при лечении заболеваний | |
EA201690223A1 (ru) | Ингибиторы фактора в комплемента на основе производных пиперидинилиндола и их применение | |
UY37900A (es) | Nuevos derivados de rapamicina | |
MX2019003143A (es) | Compuesto heterociclico sustituido con alquinilo, su metodo de preparacion y su uso medico. | |
ECSP17007208A (es) | Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble | |
AR103680A1 (es) | Inhibidores selectivos de bace1 | |
PH12020552017A1 (en) | 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof | |
CY1124251T1 (el) | Παραγωγα καρβοξαμιδιου | |
EA201592254A1 (ru) | Производные пиразолопирролидин-4-она и их применение при лечении заболевания | |
BR112017016817A2 (pt) | derivados heterocíclicos formilados como inibidores de fgfr4 | |
UY36123A (es) | Derivados de carboxamida | |
MX2020003732A (es) | Derivado de anillo fusionado como inhibidor del receptor a2a. | |
UY37837A (es) | Nuevos compuestos heterocíclicos como inhibidores de cdk8/19 | |
EA201792264A1 (ru) | Способы лечения воспалительных заболеваний | |
EA201691058A1 (ru) | Производные пирролопирролона и их применение для лечения заболеваний | |
MX2018015990A (es) | Compuestos terapeuticos. | |
EA202190689A1 (ru) | Производные хинолина в качестве ингибиторов интегрина альфа4бета7 |