BR112012009292A2 - processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto - Google Patents

processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto

Info

Publication number
BR112012009292A2
BR112012009292A2 BR112012009292A BR112012009292A BR112012009292A2 BR 112012009292 A2 BR112012009292 A2 BR 112012009292A2 BR 112012009292 A BR112012009292 A BR 112012009292A BR 112012009292 A BR112012009292 A BR 112012009292A BR 112012009292 A2 BR112012009292 A2 BR 112012009292A2
Authority
BR
Brazil
Prior art keywords
compound
preparing
crystalline form
potassium salt
acetone solvate
Prior art date
Application number
BR112012009292A
Other languages
English (en)
Inventor
Matsumae Hiroaki
Bryce Strachan John
Paul Adams Joseph
Yagi Nobuhiro
Kuroda Toru
Original Assignee
Glaxo Group Ltd
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Mitsubishi Tanabe Pharma Corp filed Critical Glaxo Group Ltd
Publication of BR112012009292A2 publication Critical patent/BR112012009292A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto. um novo processo para a preparação de um derivado de fenilalanina de fórmula (i).
BR112012009292A 2009-10-21 2010-10-19 processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto BR112012009292A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25363809P 2009-10-21 2009-10-21
PCT/EP2010/065710 WO2011048091A1 (en) 2009-10-21 2010-10-19 Process for preparing a phenylalanine derivative

Publications (1)

Publication Number Publication Date
BR112012009292A2 true BR112012009292A2 (pt) 2017-06-06

Family

ID=43094582

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012009292A BR112012009292A2 (pt) 2009-10-21 2010-10-19 processo para preparação do composto, sal de potássio, solvato de acetona, forma cristalina, e, composto

Country Status (13)

Country Link
US (1) US20120203023A1 (pt)
EP (1) EP2491006A1 (pt)
JP (1) JP2013508333A (pt)
KR (1) KR20120107461A (pt)
CN (1) CN102686557A (pt)
AU (1) AU2010309891A1 (pt)
BR (1) BR112012009292A2 (pt)
CA (1) CA2777158A1 (pt)
EA (1) EA201290165A1 (pt)
IL (1) IL218932A0 (pt)
MX (1) MX2012004707A (pt)
WO (1) WO2011048091A1 (pt)
ZA (1) ZA201202722B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010679A1 (en) * 2011-07-15 2013-01-24 Novartis Ag Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors
MX360188B (es) 2011-10-17 2018-10-24 Biotheryx Inc Biaril alquil amidas sustituidas.
EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
WO2020092401A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN
US11174256B2 (en) 2018-10-30 2021-11-16 Gilead Sciences, Inc. Imidazopyridine derivatives
PE20211866A1 (es) 2018-10-30 2021-09-21 Gilead Sciences Inc Derivados de quinolina como inhibidores de la integrina alfa4beta7
WO2021030438A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020169157A1 (en) 2000-08-29 2002-11-14 Gang Liu Selective protein tyrosine phosphatatase inhibitors
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
JP4258227B2 (ja) * 2002-02-28 2009-04-30 田辺三菱製薬株式会社 フェニルアラニン誘導体の製法およびその合成中間体
MY140707A (en) * 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof

Also Published As

Publication number Publication date
EP2491006A1 (en) 2012-08-29
CA2777158A1 (en) 2011-04-28
MX2012004707A (es) 2012-06-08
ZA201202722B (en) 2013-09-25
CN102686557A (zh) 2012-09-19
US20120203023A1 (en) 2012-08-09
JP2013508333A (ja) 2013-03-07
IL218932A0 (en) 2012-07-31
WO2011048091A1 (en) 2011-04-28
AU2010309891A1 (en) 2012-05-17
EA201290165A1 (ru) 2012-11-30
KR20120107461A (ko) 2012-10-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]