EA201991121A1 - АЗОЛАМИДЫ И АЗОЛАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV - Google Patents

АЗОЛАМИДЫ И АЗОЛАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV

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EA201991121A1
EA201991121A1 EA201991121A EA201991121A EA201991121A1 EA 201991121 A1 EA201991121 A1 EA 201991121A1 EA 201991121 A EA201991121 A EA 201991121A EA 201991121 A EA201991121 A EA 201991121A EA 201991121 A1 EA201991121 A1 EA 201991121A1
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compounds
asolamines
asolamides
integrin inhibitors
pharmaceutical compositions
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EA201991121A
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящем изобретении предусматриваются соединения формулы (I)или их стереоизомеры, таутомеры или фармацевтически приемлемые соли или сольваты, причём все эти переменные имеют значение по определению в настоящей заявке. Эти соединения являются ингибиторами αV-содержащих интегринов. Настоящее изобретение также относится к фармацевтическим композициям, содержащим эти соединения, и к способам лечения заболевания, расстройства или патологического состояния, ассоциированного с дисрегуляцией αV-содержащих интегринов, такого как патологический фиброз, отторжение трансплантата, раковое заболевание, остеопороз и воспалительные расстройства, с применением этих соединений и фармацевтических композиций.
EA201991121A 2016-11-08 2017-11-07 АЗОЛАМИДЫ И АЗОЛАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV EA201991121A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662418838P 2016-11-08 2016-11-08
PCT/US2017/060390 WO2018089358A1 (en) 2016-11-08 2017-11-07 Azole amides and amines as alpha v integrin inhibitors

Publications (1)

Publication Number Publication Date
EA201991121A1 true EA201991121A1 (ru) 2019-11-29

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Application Number Title Priority Date Filing Date
EA201991121A EA201991121A1 (ru) 2016-11-08 2017-11-07 АЗОЛАМИДЫ И АЗОЛАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV

Country Status (14)

Country Link
US (1) US10851098B2 (ru)
EP (1) EP3538527B1 (ru)
JP (1) JP7128811B2 (ru)
KR (1) KR102510858B1 (ru)
CN (1) CN110167933B (ru)
AU (1) AU2017359028A1 (ru)
BR (1) BR112019009245A2 (ru)
CA (1) CA3042684A1 (ru)
EA (1) EA201991121A1 (ru)
ES (1) ES2898835T3 (ru)
IL (1) IL266465A (ru)
MA (1) MA46746A (ru)
MX (1) MX2019005234A (ru)
WO (1) WO2018089358A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3509590A4 (en) 2016-09-07 2020-12-02 Pliant Therapeutics, Inc. N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING
JP2020504120A (ja) 2016-12-29 2020-02-06 セントルイス ユニバーシティ インテグリンアンタゴニスト
RU2769702C2 (ru) 2017-02-28 2022-04-05 Морфик Терапьютик, Инк. Ингибиторы интегрина avb6
MA47692A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
MX2021002181A (es) 2018-08-29 2021-07-15 Morphic Therapeutic Inc Inhibicion de la integrina alfa v beta 6.
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CA3148613A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin
GB202010626D0 (en) * 2020-07-10 2020-08-26 Univ Nottingham Compound
US20240174603A1 (en) * 2021-02-08 2024-05-30 Rappta Therapeutics Oy Modulators of protein phosphatase 2a (pp2a) and methods using same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
ZA972195B (en) 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
WO1999026945A1 (en) * 1997-11-26 1999-06-03 Du Pont Pharmaceuticals Company 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS αvβ3 ANTAGONISTS
AU736026B2 (en) 1997-12-17 2001-07-26 Merck & Co., Inc. Integrin receptor antagonists
WO2000009503A1 (en) 1998-08-13 2000-02-24 Merck & Co., Inc. Integrin receptor antagonists
DE60035779T2 (de) * 1999-06-02 2008-04-30 Merck & Co., Inc. Alpha v integrin-rezeptor antagonisten
JP2004511434A (ja) * 2000-06-15 2004-04-15 ファルマシア・コーポレーション インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸
CA2436130A1 (en) 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
ES2355139T3 (es) * 2002-08-16 2011-03-23 Janssen Pharmaceutica Nv Compuestos de piperidinilo que unen selectivamente a receptores de integrinas.
KR101191068B1 (ko) * 2003-10-01 2012-10-15 메르크 파텐트 게엠베하 항섬유제로서의 알파ｖ베타3 및 알파ｖ베타6 인테그린길항제
WO2006108040A1 (en) 2005-04-05 2006-10-12 Janssen Pharmaceutica, N.V. Substituted indoles and their use as integrin antagonists
WO2007141473A1 (en) 2006-06-09 2007-12-13 Astrazeneca Ab N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
WO2008125811A1 (en) 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
ITFI20100019A1 (it) * 2010-02-12 2011-08-13 Univ Firenze Inibitori peptidomimetici di integrine basati sull'1,2,3-triazolo per la diagnosi e terapia dei tumori.
CN104640850A (zh) 2012-10-26 2015-05-20 霍夫曼-拉罗奇有限公司 3,4-二取代的1h-吡唑和4,5-二取代的噻唑的syk抑制剂
DK2953948T3 (en) * 2013-02-07 2017-12-18 Scifluor Life Sciences Inc FLUORINATED INTEGRIN ANTAGONISTS
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
RU2017132433A (ru) 2015-02-19 2019-03-19 Сайфлуор Лайф Сайенсиз, Инк. Фторированные производные тетрагидронафтиридинилнонановой кислоты и их применение
JP2018515424A (ja) 2015-03-10 2018-06-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗アルファｖベータ１インテグリン阻害剤及び使用方法
DK3538525T3 (da) * 2016-11-08 2022-08-29 Bristol Myers Squibb Co 3-substituerede propionsyrer som alpha-v-integrinhæmmere

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CN110167933B (zh) 2022-06-21
MX2019005234A (es) 2019-08-12
AU2017359028A1 (en) 2019-06-20
EP3538527B1 (en) 2021-10-13
IL266465A (en) 2019-07-31
KR20190076030A (ko) 2019-07-01
JP2019537603A (ja) 2019-12-26
US20190256513A1 (en) 2019-08-22
CA3042684A1 (en) 2018-05-17
JP7128811B2 (ja) 2022-08-31
US10851098B2 (en) 2020-12-01
ES2898835T3 (es) 2022-03-09
MA46746A (fr) 2019-09-18
EP3538527A1 (en) 2019-09-18
KR102510858B1 (ko) 2023-03-15
BR112019009245A2 (pt) 2019-07-16
WO2018089358A1 (en) 2018-05-17
CN110167933A (zh) 2019-08-23

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