ES2200617B1 - Derivados de urea como antagonistas de integrinas alfa 4. - Google Patents
Derivados de urea como antagonistas de integrinas alfa 4.Info
- Publication number
- ES2200617B1 ES2200617B1 ES200100126A ES200100126A ES2200617B1 ES 2200617 B1 ES2200617 B1 ES 2200617B1 ES 200100126 A ES200100126 A ES 200100126A ES 200100126 A ES200100126 A ES 200100126A ES 2200617 B1 ES2200617 B1 ES 2200617B1
- Authority
- ES
- Spain
- Prior art keywords
- antagonists
- ord
- urea derivatives
- urea
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
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- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
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- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Derivados de urea como antagonistas de integrinas
\alpha4, teniendo dichos derivados de urea la Fórmula I:
o una sal farmacéuticamente aceptable del mismo,
en donde: Y es un arilo monocíclico, o un heteroarilo monocíclico
que contiene uno o dos heteroátomos seleccionados entre N, O y S;
L1 y L2 son unos átomos o grupos de unión; W es O, S, NH,
N(Rc), o NCN; X es -(CH2)_{n}arilo-,
o
-(CH2)_{n}heteroarilo-; y Z es un grupo seleccionado entre -C(O)ORd, -P(O)_{2}ORd, -S(O)_{2}ORd, -S(O)_{2}N (Rd) (Rd), -C(O)NH_{2}, -C(O)N(Re)S(O)_{2}Rd, -S(O)_{2}N(Re)C(O)Rd, -5-tetrazolilo, o -C(O)Rd; en la fabricación de un medicamento para uso como un antagonista \alpha4\beta1 y/o \alpha4\beta7. Estos antagonistas son útiles en la inhibición de procesos de adhesión celular que incluyen activación, migración, proliferación y diferenciación celular. La presente invención
-(CH2)_{n}heteroarilo-; y Z es un grupo seleccionado entre -C(O)ORd, -P(O)_{2}ORd, -S(O)_{2}ORd, -S(O)_{2}N (Rd) (Rd), -C(O)NH_{2}, -C(O)N(Re)S(O)_{2}Rd, -S(O)_{2}N(Re)C(O)Rd, -5-tetrazolilo, o -C(O)Rd; en la fabricación de un medicamento para uso como un antagonista \alpha4\beta1 y/o \alpha4\beta7. Estos antagonistas son útiles en la inhibición de procesos de adhesión celular que incluyen activación, migración, proliferación y diferenciación celular. La presente invención
describe una serie de derivados de urea, que son
útiles en la inhibición y prevención de la adhesión leucocitaria y
patologías mediadas por la adhesión leucocitaria. Esta invención
también describe composiciones que contienen dichos compuestos,
procedimientos para su preparación, y métodos de tratamiento
utilizando tales compuestos.
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100126A ES2200617B1 (es) | 2001-01-19 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
PL02369120A PL369120A1 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
JP2002557923A JP4173003B2 (ja) | 2001-01-19 | 2002-01-15 | インテグリンα4アンタゴニストとしての尿素誘導体 |
CA002434939A CA2434939A1 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
RU2003125367/04A RU2296120C2 (ru) | 2001-01-19 | 2002-01-15 | Производные мочевины, способы их получения и фармацевтическая композиция на их основе |
NZ527031A NZ527031A (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
SK923-2003A SK9232003A3 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
DE60222647T DE60222647T2 (de) | 2001-01-19 | 2002-01-15 | Urea derivate als integrin alpha 4 antagonisten |
UA2003076827A UA81603C2 (ru) | 2001-01-19 | 2002-01-15 | ПРОИЗВОДНЫЕ МОЧЕВИНЫ КАК АНТАГОНИСТЫ б4 ИНТЕГРИНА |
CZ20031964A CZ20031964A3 (cs) | 2001-01-19 | 2002-01-15 | Deriváty močoviny jako antagonisté alfa4 integrinů |
HU0303722A HUP0303722A3 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antanists, process for their preparation and pharmaceutical compositions containing them |
AT02710010T ATE374191T1 (de) | 2001-01-19 | 2002-01-15 | Urea derivate als integrin alpha 4 antagonisten |
EP02710010A EP1383750B1 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
BR0206588-6A BR0206588A (pt) | 2001-01-19 | 2002-01-15 | Composto, processo para produzir o mesmo, uso do mesmo, composição farmacêutica, e, método para tratar um paciente afligido com uma condição patológica suscetìvel à melhora pelo antagonismo de integrinas alfa4beta1 e/ou alfa4beta7 |
MXPA03006363A MXPA03006363A (es) | 2001-01-19 | 2002-01-15 | Derivados de urea como antagonistas de integrinas alfa-4. |
PE20020000372002000023A PE20020822A1 (es) | 2001-01-17 | 2002-01-15 | Derivados de la urea como antagonistas de integrinantagonistas de receptores de histamina as o4 |
AU2002228048A AU2002228048B2 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
SI200230614T SI1383750T1 (sl) | 2001-01-19 | 2002-01-15 | Derivati uree kot integrin alfa 4 antagonisti |
ES02710010T ES2291448T3 (es) | 2001-01-19 | 2002-01-15 | Derivados de urea como antagonistas de integrina alfa-4. |
EEP200300327A EE200300327A (et) | 2001-01-19 | 2002-01-15 | Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon |
PCT/EP2002/000331 WO2002057242A2 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
DK02710010T DK1383750T3 (da) | 2001-01-19 | 2002-01-15 | Urinstofderivater som integrin a4 antagonister |
CNB028065255A CN100536839C (zh) | 2001-01-19 | 2002-01-15 | 作为整联蛋白α4的拮抗剂的脲衍生物 |
PT02710010T PT1383750E (pt) | 2001-01-19 | 2002-01-15 | Derivados de ureia como antagonistas da integrina alfa 4 |
IL15693902A IL156939A0 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
US10/466,665 US7253171B2 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin α4 antagonists |
KR1020037009578A KR100861471B1 (ko) | 2001-01-19 | 2002-01-15 | 인테그린 알파 4 길항제로서의 유레아 유도체 |
MYPI20020184A MY129423A (en) | 2001-01-19 | 2002-01-18 | Urea derivatives as integrin 4 antagonists |
UY27127A UY27127A1 (es) | 2001-01-19 | 2002-01-18 | Derivados de la urea como antagonistas de integrin alfa-4 |
ARP020100181A AR032256A1 (es) | 2001-01-19 | 2002-01-18 | Derivados de la urea como antagonistas de integrin alfa 4". |
ZA200305535A ZA200305535B (en) | 2001-01-19 | 2003-07-17 | Urea derivatives as integrin alpha 4 antagonists. |
NO20033269A NO327002B1 (no) | 2001-01-19 | 2003-07-18 | Urea-derivater som integrin-alfa-4-antagonister |
BG108004A BG108004A (bg) | 2001-01-19 | 2003-07-18 | Карбамидни производни като интегрин алфа 4 антагонисти |
EC2003004707A ECSP034707A (es) | 2001-01-19 | 2003-07-18 | Derivados de urea como antagonistas de alfa integrado |
HK04101137A HK1058361A1 (en) | 2001-01-19 | 2004-02-18 | Urea derivatives as integrin alpha 4 antagonists |
US11/802,165 US20070238763A1 (en) | 2001-01-19 | 2007-05-21 | Urea derivatives as integrin a4 antagonists |
CY20071101582T CY1107086T1 (el) | 2001-01-19 | 2007-12-13 | Παραγωγα ουριας ως ανταγωνιστες ιντεγκρινης αλφα 4 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100126A ES2200617B1 (es) | 2001-01-19 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2200617A1 ES2200617A1 (es) | 2004-03-01 |
ES2200617B1 true ES2200617B1 (es) | 2005-05-01 |
Family
ID=8496447
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100126A Expired - Fee Related ES2200617B1 (es) | 2001-01-17 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
ES02710010T Expired - Lifetime ES2291448T3 (es) | 2001-01-19 | 2002-01-15 | Derivados de urea como antagonistas de integrina alfa-4. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02710010T Expired - Lifetime ES2291448T3 (es) | 2001-01-19 | 2002-01-15 | Derivados de urea como antagonistas de integrina alfa-4. |
Country Status (33)
Country | Link |
---|---|
US (2) | US7253171B2 (es) |
EP (1) | EP1383750B1 (es) |
JP (1) | JP4173003B2 (es) |
KR (1) | KR100861471B1 (es) |
CN (1) | CN100536839C (es) |
AR (1) | AR032256A1 (es) |
AT (1) | ATE374191T1 (es) |
AU (1) | AU2002228048B2 (es) |
BG (1) | BG108004A (es) |
BR (1) | BR0206588A (es) |
CA (1) | CA2434939A1 (es) |
CY (1) | CY1107086T1 (es) |
CZ (1) | CZ20031964A3 (es) |
DE (1) | DE60222647T2 (es) |
DK (1) | DK1383750T3 (es) |
EC (1) | ECSP034707A (es) |
EE (1) | EE200300327A (es) |
ES (2) | ES2200617B1 (es) |
HK (1) | HK1058361A1 (es) |
HU (1) | HUP0303722A3 (es) |
IL (1) | IL156939A0 (es) |
MX (1) | MXPA03006363A (es) |
MY (1) | MY129423A (es) |
NO (1) | NO327002B1 (es) |
NZ (1) | NZ527031A (es) |
PL (1) | PL369120A1 (es) |
PT (1) | PT1383750E (es) |
RU (1) | RU2296120C2 (es) |
SK (1) | SK9232003A3 (es) |
UA (1) | UA81603C2 (es) |
UY (1) | UY27127A1 (es) |
WO (1) | WO2002057242A2 (es) |
ZA (1) | ZA200305535B (es) |
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2001
- 2001-01-19 ES ES200100126A patent/ES2200617B1/es not_active Expired - Fee Related
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2002
- 2002-01-15 PL PL02369120A patent/PL369120A1/xx unknown
- 2002-01-15 ES ES02710010T patent/ES2291448T3/es not_active Expired - Lifetime
- 2002-01-15 AT AT02710010T patent/ATE374191T1/de not_active IP Right Cessation
- 2002-01-15 BR BR0206588-6A patent/BR0206588A/pt not_active IP Right Cessation
- 2002-01-15 AU AU2002228048A patent/AU2002228048B2/en not_active Ceased
- 2002-01-15 CA CA002434939A patent/CA2434939A1/en not_active Abandoned
- 2002-01-15 EE EEP200300327A patent/EE200300327A/xx unknown
- 2002-01-15 NZ NZ527031A patent/NZ527031A/en unknown
- 2002-01-15 KR KR1020037009578A patent/KR100861471B1/ko not_active IP Right Cessation
- 2002-01-15 JP JP2002557923A patent/JP4173003B2/ja not_active Expired - Fee Related
- 2002-01-15 DK DK02710010T patent/DK1383750T3/da active
- 2002-01-15 UA UA2003076827A patent/UA81603C2/ru unknown
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- 2002-01-15 EP EP02710010A patent/EP1383750B1/en not_active Expired - Lifetime
- 2002-01-15 CN CNB028065255A patent/CN100536839C/zh not_active Expired - Fee Related
- 2002-01-15 RU RU2003125367/04A patent/RU2296120C2/ru not_active IP Right Cessation
- 2002-01-15 PT PT02710010T patent/PT1383750E/pt unknown
- 2002-01-15 SK SK923-2003A patent/SK9232003A3/sk not_active Application Discontinuation
- 2002-01-15 DE DE60222647T patent/DE60222647T2/de not_active Expired - Lifetime
- 2002-01-15 MX MXPA03006363A patent/MXPA03006363A/es active IP Right Grant
- 2002-01-15 CZ CZ20031964A patent/CZ20031964A3/cs unknown
- 2002-01-15 US US10/466,665 patent/US7253171B2/en not_active Expired - Fee Related
- 2002-01-15 WO PCT/EP2002/000331 patent/WO2002057242A2/en active IP Right Grant
- 2002-01-15 HU HU0303722A patent/HUP0303722A3/hu unknown
- 2002-01-18 UY UY27127A patent/UY27127A1/es unknown
- 2002-01-18 AR ARP020100181A patent/AR032256A1/es unknown
- 2002-01-18 MY MYPI20020184A patent/MY129423A/en unknown
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2003
- 2003-07-17 ZA ZA200305535A patent/ZA200305535B/en unknown
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- 2003-07-18 NO NO20033269A patent/NO327002B1/no not_active IP Right Cessation
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-
2004
- 2004-02-18 HK HK04101137A patent/HK1058361A1/xx not_active IP Right Cessation
-
2007
- 2007-05-21 US US11/802,165 patent/US20070238763A1/en not_active Abandoned
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