IL156939A0 - Urea derivatives as integrin alpha 4 antagonists - Google Patents
Urea derivatives as integrin alpha 4 antagonistsInfo
- Publication number
- IL156939A0 IL156939A0 IL15693902A IL15693902A IL156939A0 IL 156939 A0 IL156939 A0 IL 156939A0 IL 15693902 A IL15693902 A IL 15693902A IL 15693902 A IL15693902 A IL 15693902A IL 156939 A0 IL156939 A0 IL 156939A0
- Authority
- IL
- Israel
- Prior art keywords
- antagonists
- urea derivatives
- integrin alpha
- integrin
- alpha
- Prior art date
Links
- 102100032818 Integrin alpha-4 Human genes 0.000 title 1
- 108010041012 Integrin alpha4 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
Classifications
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
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- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100126A ES2200617B1 (es) | 2001-01-19 | 2001-01-19 | Derivados de urea como antagonistas de integrinas alfa 4. |
PCT/EP2002/000331 WO2002057242A2 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
Publications (1)
Publication Number | Publication Date |
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IL156939A0 true IL156939A0 (en) | 2004-02-08 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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IL15693902A IL156939A0 (en) | 2001-01-19 | 2002-01-15 | Urea derivatives as integrin alpha 4 antagonists |
Country Status (33)
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US (2) | US7253171B2 (xx) |
EP (1) | EP1383750B1 (xx) |
JP (1) | JP4173003B2 (xx) |
KR (1) | KR100861471B1 (xx) |
CN (1) | CN100536839C (xx) |
AR (1) | AR032256A1 (xx) |
AT (1) | ATE374191T1 (xx) |
AU (1) | AU2002228048B2 (xx) |
BG (1) | BG108004A (xx) |
BR (1) | BR0206588A (xx) |
CA (1) | CA2434939A1 (xx) |
CY (1) | CY1107086T1 (xx) |
CZ (1) | CZ20031964A3 (xx) |
DE (1) | DE60222647T2 (xx) |
DK (1) | DK1383750T3 (xx) |
EC (1) | ECSP034707A (xx) |
EE (1) | EE200300327A (xx) |
ES (2) | ES2200617B1 (xx) |
HK (1) | HK1058361A1 (xx) |
HU (1) | HUP0303722A3 (xx) |
IL (1) | IL156939A0 (xx) |
MX (1) | MXPA03006363A (xx) |
MY (1) | MY129423A (xx) |
NO (1) | NO327002B1 (xx) |
NZ (1) | NZ527031A (xx) |
PL (1) | PL369120A1 (xx) |
PT (1) | PT1383750E (xx) |
RU (1) | RU2296120C2 (xx) |
SK (1) | SK9232003A3 (xx) |
UA (1) | UA81603C2 (xx) |
UY (1) | UY27127A1 (xx) |
WO (1) | WO2002057242A2 (xx) |
ZA (1) | ZA200305535B (xx) |
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WO2005019193A2 (en) * | 2003-08-20 | 2005-03-03 | Smithkline Beecham Corporation | Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk) |
JP5170386B2 (ja) | 2005-08-18 | 2013-03-27 | 日産化学工業株式会社 | スルフォニル基を有するチオフェン化合物及びその製造法 |
CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
KR100588821B1 (ko) * | 2006-01-06 | 2006-06-12 | 모악개발 주식회사 | 균일 팽창이 가능한 패커를 구비하는 하수관로 부분보수장치 |
US20080045521A1 (en) * | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
NZ578744A (en) * | 2007-01-31 | 2012-02-24 | Vertex Pharma | 2-aminopyridine derivatives useful as kinase inhibitors |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
CA2731451A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
JP5631310B2 (ja) | 2008-07-23 | 2014-11-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 三環式ピラゾロピリジンキナーゼ阻害剤 |
AU2009279611A1 (en) | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
KR101038486B1 (ko) * | 2008-09-03 | 2011-06-01 | 쌍용건설 주식회사 | 패커를 이용한 비굴착식 하수관로 보수 장치 및 방법 |
US8211401B2 (en) * | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA |
AU2010245914A1 (en) | 2009-05-06 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
FI20095678A0 (fi) * | 2009-06-16 | 2009-06-16 | Biotie Therapies Oy | Ureasubstituoituja sulfoniamidijohdannaisia |
EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
EP2528917B1 (en) | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases |
CA2787079A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
CA2787363A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
US20130273034A1 (en) * | 2010-09-03 | 2013-10-17 | Kenneth W. Bair | Novel compounds and compositions for the inhibition of nampt |
ES2968371T3 (es) | 2013-10-10 | 2024-05-09 | Eastern Virginia Medical School | Derivados de 4-((2-hidroxi-3-metoxibencil)amino) bencenosulfonamida como inhibidores de la 12-lipoxigenasa |
KR20240015737A (ko) | 2018-10-30 | 2024-02-05 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체 |
AU2019373245C1 (en) | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
CA3115820A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
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US4740611A (en) * | 1986-10-30 | 1988-04-26 | The Standard Oil Company | N,N'-disubstituted ureas |
US4705864A (en) * | 1986-11-10 | 1987-11-10 | The Standard Oil Company | Aryl oxime derivatives of hydantoins |
WO1992008464A1 (en) * | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Substituted urea and related cell adhesion modulation compounds |
EP0900211B1 (en) * | 1996-04-23 | 2003-07-02 | PHARMACIA & UPJOHN COMPANY | Thiadiazolyl(thio)ureas useful as matrix metalloprotease inhibitors |
EP0917462B1 (en) | 1996-07-25 | 2006-09-13 | Biogen Idec MA Inc. | Cell adhesion inhibitors |
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CA2291708A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
ES2206953T3 (es) | 1997-06-23 | 2004-05-16 | Tanabe Seiyaku Co., Ltd. | Inhibidores de la adherencia celular mediada por alfa 4-beta 1. |
DE69824433D1 (en) | 1997-08-28 | 2004-07-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
WO1999020617A1 (en) * | 1997-10-21 | 1999-04-29 | Active Biotech Ab | Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors |
HUP0102101A3 (en) | 1997-11-10 | 2002-11-28 | Bristol Myers Squibb Co | Protein tyrosine kinase inhibitor benzothiazole derivatives and pharmaceutical compositions containing them |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
DE69824037T2 (de) | 1997-11-24 | 2005-06-02 | Merck & Co., Inc. | Beta-alanin-derivate als zell-adhäsions-inhibitoren |
ATE298338T1 (de) | 1997-12-17 | 2005-07-15 | Merck & Co Inc | Integrin-rezeptor-antagonisten |
WO1999037604A2 (en) | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
ES2249059T3 (es) * | 1998-12-16 | 2006-03-16 | Bayer Healthcare Ag | Nuevos compuestos de bifenilo y analogos de bifenilo como antagonista de integrina. |
MXPA01007394A (es) | 1999-01-25 | 2002-04-09 | Wyeth Corp | Compuestos que inhiben la adhesion de leucocitos mediada mediante alfa4 beta1 integrina y cd49d/cd29 (vla-4). |
DE60009883T2 (de) | 1999-03-01 | 2005-04-07 | Elan Pharmaceuticals, Inc., San Francisco | Alpha-aminoessigsäure derivate als alpha 4 beta 7- rezeptor antagonisten |
DE19909979A1 (de) * | 1999-03-06 | 2000-09-07 | Bayer Ag | Verfahren zur Herstellung von Glycokonjugaten von 20(S)-Camptothecin |
DK1176956T3 (da) | 1999-05-07 | 2008-05-26 | Encysive Pharmaceuticals Inc | Carboxylsyrederivater, som inhiberer bindingen af integriner til deres receptorer |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
AU6909300A (en) * | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
-
2001
- 2001-01-19 ES ES200100126A patent/ES2200617B1/es not_active Expired - Fee Related
-
2002
- 2002-01-15 HU HU0303722A patent/HUP0303722A3/hu unknown
- 2002-01-15 MX MXPA03006363A patent/MXPA03006363A/es active IP Right Grant
- 2002-01-15 DE DE60222647T patent/DE60222647T2/de not_active Expired - Lifetime
- 2002-01-15 PL PL02369120A patent/PL369120A1/xx unknown
- 2002-01-15 BR BR0206588-6A patent/BR0206588A/pt not_active IP Right Cessation
- 2002-01-15 CN CNB028065255A patent/CN100536839C/zh not_active Expired - Fee Related
- 2002-01-15 PT PT02710010T patent/PT1383750E/pt unknown
- 2002-01-15 IL IL15693902A patent/IL156939A0/xx unknown
- 2002-01-15 AT AT02710010T patent/ATE374191T1/de not_active IP Right Cessation
- 2002-01-15 WO PCT/EP2002/000331 patent/WO2002057242A2/en active IP Right Grant
- 2002-01-15 DK DK02710010T patent/DK1383750T3/da active
- 2002-01-15 JP JP2002557923A patent/JP4173003B2/ja not_active Expired - Fee Related
- 2002-01-15 AU AU2002228048A patent/AU2002228048B2/en not_active Ceased
- 2002-01-15 KR KR1020037009578A patent/KR100861471B1/ko not_active IP Right Cessation
- 2002-01-15 RU RU2003125367/04A patent/RU2296120C2/ru not_active IP Right Cessation
- 2002-01-15 CA CA002434939A patent/CA2434939A1/en not_active Abandoned
- 2002-01-15 NZ NZ527031A patent/NZ527031A/en unknown
- 2002-01-15 US US10/466,665 patent/US7253171B2/en not_active Expired - Fee Related
- 2002-01-15 EE EEP200300327A patent/EE200300327A/xx unknown
- 2002-01-15 CZ CZ20031964A patent/CZ20031964A3/cs unknown
- 2002-01-15 UA UA2003076827A patent/UA81603C2/ru unknown
- 2002-01-15 SK SK923-2003A patent/SK9232003A3/sk not_active Application Discontinuation
- 2002-01-15 EP EP02710010A patent/EP1383750B1/en not_active Expired - Lifetime
- 2002-01-15 ES ES02710010T patent/ES2291448T3/es not_active Expired - Lifetime
- 2002-01-18 MY MYPI20020184A patent/MY129423A/en unknown
- 2002-01-18 AR ARP020100181A patent/AR032256A1/es unknown
- 2002-01-18 UY UY27127A patent/UY27127A1/es unknown
-
2003
- 2003-07-17 ZA ZA200305535A patent/ZA200305535B/en unknown
- 2003-07-18 EC EC2003004707A patent/ECSP034707A/es unknown
- 2003-07-18 NO NO20033269A patent/NO327002B1/no not_active IP Right Cessation
- 2003-07-18 BG BG108004A patent/BG108004A/bg unknown
-
2004
- 2004-02-18 HK HK04101137A patent/HK1058361A1/xx not_active IP Right Cessation
-
2007
- 2007-05-21 US US11/802,165 patent/US20070238763A1/en not_active Abandoned
- 2007-12-13 CY CY20071101582T patent/CY1107086T1/el unknown
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